994 resultados para 191-1179C
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Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are plasma cell disorders of aging. The landscape of the diagnosis and management of MM and MGUS are rapidly changing. This article provides an updated understanding of the clinical presentation, evaluation, diagnosis, and management of older adults with MM and MGUS. Because most oncology providers are not formally trained in geriatric medicine, geriatricians play a key role in providing oncologists with a broader understanding of patient health status in the hope of improving outcomes for older adults with MM.
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En el presente trabajo se aborda el estudio de la variación de una función cualquiera cuando se tiene sólo su representación gráfica y no se conoce su representación algebraica, así como la relación de la función con su primera y su segunda derivada y la relación entre tales derivadas, esto es, la información que puede proporcionar cada derivada acerca de la función y la información que aporta cada derivada con respecto a la otra.
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Trends in sample extremes are of interest in many contexts, an example being environmental statistics. Parametric models are often used to model trends in such data, but they may not be suitable for exploratory data analysis. This paper outlines a semiparametric approach to smoothing example extremes, based on local polynomial fitting of the generalized extreme value distribution and related models. The uncertainty of fits is assessed by using resampling methods. The methods are applied to data on extreme temperatures and on record times for the womens 3000m race.