Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes

Bifunctional chiral primary amine 8 containing an (S,S)-trans-cyclohexane-1,2-diamine scaffold and a 2-benzimidazole unit is used as a general organocatalyst for the Michael addition of α,α-branched aldehydes to nitroalkenes and maleimides. The reactions take place, with 20 mol % of catalyst in dichloromethane at rt for nitroalkenes and with 15 mol % catalyst loading in toluene at 10 °C for maleimides, in good yields and enantioselectivities. DFT calculations demonstrate the bifunctional character of this organocatalyst activating the aldehyde by enamine formation and the Michael acceptor by double hydrogen bonding.

Small archaeohyracids (Typotheria, Notoungulata) from Chubut Province, Argentina, and central Chile : implications for Trans-Andean temporal correlation / Marcelo Reguero -- [et al.].

n.s. no.48(2003)

O que queremos ser quando crescermos? Diálogos imaginários com um trans-humanista

Through an imaginary dialogue with a defender of the transhumanism – whose most significant representative is the philosopher Nick Bostrom – this paper aims to critically evaluate the ethical legitimacy of becoming a posthuman when we grow up. After a characterization of the transhumanist project and a definition of posthuman condition, the axiological reasons that underlie the desire to become a posthuman are examined.In a second momentit will be discussed the issue of whether we should want to be a posthuman when we grow up. A comparison is carried out between the relative strength of the arguments for the legitimacy of the transhumanist project and the possible objections, which are mainly based in an appeal to the idea of human nature, that are usually produced by the critics of transhumanism, such as Francis Fukuyama. Finally, the real possibilities of becoming a post human are outlined and, considering the uncertainty about the future and the difference between what can and what should be done, we are asked toreally think about what we want to be.

The Impact of Visa Liberalisation in Eastern Partnership Countries, Russia and Turkey on Trans-Border Mobility. CEPS Liberty and Security in Europe No. 63, March 2014

Schengen Visa liberalisation in the Eastern Partnership countries, Russia and Turkey has proven to have a huge transformative potential across the justice, liberty and security policies of the countries where it has been deployed. Far-reaching technical reforms in the fields of document security, irregular migration and border management, public order security and fundamental rights have to be implemented so that visa-free travel can be allowed. Evidence provided by visa applications data reveals that visa liberalisation is a logical step, provided that the technical reforms are adopted and implemented. This study analyses the current state of play of the implementation of the EU visa policy instruments and assesses the positive impact of visa-free travel on trans-border mobility according to current visa application statistics.