988 resultados para Stiles, William, d. 1845.


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Willard says that the town of Deerfield voted to keep him as a preacher at their church, and explains that it will probably be a generous salary, although he does not know if he will accept. He also describes the duties he will be expected to perform and the expectations the congregation will have of him.

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Willard mentions that he has been anxious because he has heard that “there was such a dreadful sickness in…Petersham, but I have not been able to learn many particulars about it,” and asks for news. He also comments on the weather and lack of snow throughout the past winter.

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The collection contains a four-page handwritten poem titled "Invention" composed by graduate William Richardson for the 1797 Harvard College Commencement, and an 1806 letter of introduction written by Richardson. The rhyming poem begins, “Long had creations anthem peal been rung…” and contains classical references, and mentions scientists and philosophers including Voltaire, Franklin and Newton. The poem is accompanied by a one-page handwritten letter of introduction for lawyer Benjamin Ames (Harvard AB 1803) written by William M. Richardson to Reverend William Jenks (Harvard AB 1797). The letter is dated November 10, 1806.

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This layer is a georeferenced raster image of the historic paper map entitled: Topographical map of the city and county of New-York and the adjacent country : with views in the border of the principal buildings and interesting scenery of the island, engraved & printed by S. Stiles & Co. It was published by Sherman & Smith in 1845. Scale [ca. 1:16,000]. Covers Manhattan and adjacent portions of Brooklyn and New Jersey. This layer is image 2 of 3 total images of the three sheet source map, representing the middle portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as topography, ground cover, roads, drainage, selected public buildings, forts, city wards, squares, parks, and more. Relief is shown by hachures. Includes inset views: Broadway from the park -- Nieuw Amsterdam, 1659. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: Topographical map of the city and county of New-York and the adjacent country : with views in the border of the principal buildings and interesting scenery of the island, engraved & printed by S. Stiles & Co. It was published by Sherman & Smith in 1845. Scale [ca. 1:16,000]. Covers Manhattan and adjacent portions of Brooklyn and New Jersey. This layer is image 1 of 3 total images of the three sheet source map, representing the southern portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as topography, ground cover, roads, drainage, selected public buildings, forts, city wards, squares, parks, and more. Relief is shown by hachures. Includes inset views: Broadway from the park -- Nieuw Amsterdam, 1659. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: Topographical map of the city and county of New-York and the adjacent country : with views in the border of the principal buildings and interesting scenery of the island, engraved & printed by S. Stiles & Co. It was published by Sherman & Smith in 1845. Scale [ca. 1:16,000]. Covers Manhattan and adjacent portions of Brooklyn and New Jersey. This layer is image 3 of 3 total images of the three sheet source map, representing the northern portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as topography, ground cover, roads, drainage, selected public buildings, forts, city wards, squares, parks, and more. Relief is shown by hachures. Includes inset views: Broadway from the park -- Nieuw Amsterdam, 1659. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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La maladie du greffon contre l’hôte (GvHD) est un effet secondaire sérieux de la transplantation de cellules souches hématopoïétiques (HSCT). Cette maladie entraine une haute mortalité et ses symptômes sont dvastateurs. Les traitements actuels de la GvHD comportent plusieurs produits, tels les corticostéroïdes, mais ces derniers sont immunosuppresseurs et leurs effets secondaires sont aussi très dommageables pour les patients et leur guérison. Les cellules stromales mésenchymateuses (MSC) représentent une alternative ou une addition potentielle de traitement pour la GvHD et ces cellules ne semblent pas posséder les effets secondaires des traitements classiques. Un nombre important détudes cliniques faisant l’objet des MSC ont été enregistrées. Malgré cet engouement, le mécanisme de leur immunomodulation reste encore à élucider. Notre objectif est donc de mieux dfinir ce mécanisme. Nous avons utilisé un modle simplifié pour simuler la GvHD in vitro. Ce modle se base sur la stimulation de lymphocytes CD4+ par des cellules dendritiques allogéniques. La mesure de la prolifération de ces cellules stimulées sert dindicateur de leur réactivité. Selon les résultats obtenus par la technologie CRISPR de génie génétique, les MSC exerceraient leur immunosuppression sur les cellules T CD4+ principalement par la sécrétion de l’enzyme IDO1. Les MSC seraient également capables dinduire certaines cellules CD4+ en cellules régulatrices, un processus indpendant de la sécrétion dIDO1. Toutefois, ces cellules ne semblent pas correspondre aux cellules Treg conventionnelles.