The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Ultrastructural Morphology and Morphometry of Phrenic Nerve in Rats

Despite numerous literature reports on the morphometry of the myelinated fibers of phrenic nerves in rats, a systematic study of the longitudinal and lateral symmetry of the unmyelinated fibers morphometry is not available. In this study, we have undertaken ultrastructural and morphometric studies of the phrenic nerve in adult rats, assessing two different levels (proximal and distal) from both right and left sides. Phrenic nerves of adult male Wistar rats were prepared for epoxy resin embedding and transmission electron microscopy. Morphometric analysis was performed with the aid of computer software, which took into consideration the unmyelinated fiber number, density, area, and diameter, as well as ratio between myelinated and unmyelinated fibers, and the percentage of the fascicular area occupied by the myelinated and unmyelinated fibers. Comparison of data from proximal and distal segments on the same side and from the same levels between sides was performed. Differences were considered significant when P < 0.05. The most important finding is that morphometric parameters of the phrenic nerve unmyelinated fibers in adult rats are both longitudinally and laterally symmetric. This study adds important morphometric information about the unmyelinated fibers of the phrenic nerves in adult rats for proximal and distal levels on both sides of the animal. Anat Rec, 292:513-517, 2009. (C) 2008 Wiley-Liss, Inc.

Charles Handy: The exemplary guru

Among many managers Charles Handy might well be described as a ‘world class’ management thinker. He is certainly the first British management author to have achieved international guru status. The author of widely-commended management best-sellers and MBA set texts, known through broadcasting and management videos, he has presented himself more recently as a self-styled ‘social philosopher’. But just how philosophical is he? Does he offer genuinely new ideas? And what explains his vast appeal? Ashly Pinnington considers three works from Handy’s social philosopher period. He argues that they are conservative and focused on the interests of managers and business owners rather than employees or society as a whole. Like a mediaeval friar seeking converts, Handy uses mythic structures and exempla to invest his claims and propositions with plausibility and authority. Drawing on research into management gurus as a phenomenon, Ashly Pinnington concludes that when we read authors like Handy we should attend not merely to the ‘philosophy’ but also to the way narrative techniques are used in conveying ideological and moral messages.

Como manter um bolo sempre fresco

(...) Um exemplo curioso prende-se com a forma como são partidas as fatias de um bolo e como são distribuídas pelos convidados numa festa. (...) Desde logo, para evitar que alguém se possa queixar do resultado da partilha, o melhor método designa-se por "um parte, outro escolhe" (...) Mas, se o problema se colocar a mais de dois convidados? A solução já não é assim tão simples. O desenvolvimento deste tipo de algoritmos acaba por ter aplicações em muitas outras áreas, desde a simples partilha de uma herança às negociações de desarmamento ou ao estabelecimento de fronteiras entre países. (...) Vejamos, agora, um método muito interessante para manter um bolo sempre fresco. Note-se que a forma tradicional de cortar um bolo é propícia a que, com o passar do tempo, este fique seco junto da zona de corte. O método inovador foi inventado por Francis Galton (1822-1911), matemático e estatístico inglês, primo de Charles Darwin. O seu texto "Cutting a Round Cake on Scientific Principles", publicado na edição de 20 de dezembro de 1906 da conceituada revista Nature, foi divulgado recentemente por Alex Bellos (...) As fatias devem ser cortadas de um lado ao outro do bolo (...) Se olharmos de cima, o bolo utilizado tem o formato de um c��rculo. Cada fatia cortada é limitada por duas retas paralelas e deve conter o centro do c��rculo. A ideia é cortar uma fatia e, de seguida, juntar as duas partes que sobraram, unindo-as, se necessário, com um elástico, de modo a sobrepor as zonas do corte (...) Da próxima vez que nos queiramos deliciar novamente com o bolo, devemos fazer novo corte com as mesmas características do anterior, mas agora com direção perpendicular (...)

The wedding of Prince Charles and Camilla Parker-Bowles: royal mediation and press mediatization

Bearing in mind the relationship between discourse and society at large, this article addresses the way the British monarchy represented Charles’s second marriage and the way the media constructed their accounts in the period from 10 February (announcement) until 9 April 2005 (wedding) in relation to wider issues such as power relations, newspaper economic structures and popular culture. Particular attention is paid to the multifunctional features of discourse (i.e. its ideational, interpersonal and textual functions), which requires a contextualized reading of a dual process of mediation: on the one hand, the staging of the ceremony by St. James’s Palace and its strategy for attaining monologic closure and, on the other hand, discursive representations by the British press open to a polyphony of voices and discursive frames

Plantae Wilsonianae :an enumeration of the woody plants collected in western China for the Arnold arboretum of Harvard university during the years 1907, 1908, and 1910 /by E. H. Wilson, ed. by Charles Sprague Sargent.

1916 v.2

Plantae Wilsonianae :an enumeration of the woody plants collected in western China for the Arnold arboretum of Harvard university during the years 1907, 1908, and 1910 /by E. H. Wilson, ed. by Charles Sprague Sargent.

1917 v.3

Plantae Wilsonianae :an enumeration of the woody plants collected in western China for the Arnold arboretum of Harvard university during the years 1907, 1908, and 1910 /by E. H. Wilson, ed. by Charles Sprague Sargent.

1913 v.1

Commentationes botanicae :observationes botanique /dédiées a la Société d'horticulture de Tournay par B.-C. Dumortier.

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Pesquisa de marcadores para os genes da cadeia pesada da beta-miosina cardíaca e da proteína C de ligação à miosina em familiares de pacientes com cardiomiopatia hipertrófica

OBJETIVO: Estudar os marcadores moleculares para os genes da cadeia pesada da beta-miosina cardíaca e da proteína-C de ligação à miosina em familiares de portadores de cardiomiopatia hipertrófica. MÉTODOS: Foram estudadas 12 famílias que realizaram anamnese, exame físico, eletrocardiograma, ecocardiograma e coleta de sangue para o estudo genético através da reação em cadeia da polimerasse. RESULTADOS: Dos 227 familiares 25% eram acometidos, sendo 51% do sexo masculino com idade média de 35±19 (2 a 95) anos. A análise genética mostrou ligação com o gene da b-miosina cardíaca em uma família e, em outra, ligação com o gene da proteína C de ligação à miosina. Em cinco famílias foram excluídas ligações com os dois genes; em duas, a ligação com o gene da proteína C de ligação à miosina, porém para o gene da b-miosina os resultados foram inconclusivos; em duas famílias os resultados foram inconclusivos para os dois genes e em uma foi excluída ligação para o gene da b-miosina mas ficou inconclusivo para o gene da proteína C de ligação à miosina. CONCLUSÃO: Em nosso meio, talvez predominem outros genes que não aqueles descritos na literatura, ou que existam outras diferenças genéticas relacionadas com a origem de nossa população e/ou fatores ambientais.