Desperdício de dieta enteral em UTI: análise de modo de falhas e efeitos de danos ao paciente grave

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Análise do uso das águas de uma empresa do ramo petroquímico via análise de sobrevivência

Pós-graduação em Biometria - IBB

Avaliação dos efeitos de aloe-emodin em células uroteliais imortalizadas e neoplásicas cultivadas in vitro

Aloe vera (Aloe barbadensis Miller), popularly known in Brazil as babosa, has a long history of use as medicinal plant for different therapeutic purposes. The components of the plant extract are present in various products of human use, mainly for nutritional and cosmetics purposes. However, some studies suggest that this extract might also have carcinogenic activity. The aloe vera extract is a complex mixture of bioactive compounds. The study of isolated compounds may contribute to elucidate contradictory results about the effects related to the consumption of the plant, as well as their mechanisms of action. One of the most important compound from Aloe vera is aloe-emodin, which is a secondary metabolite generated in the intestinal tract. Putative antimicrobial and antitumor effects were previously attributed to aloe-emodin. Although the exposure of urothelial cells to aloe-emodin was already reported in the literature, only one study showed its effects on urothelial cells, suggesting that aloe-emodin inhibits the viability of T24 cancer cells due to apoptosis induction. Since there is no sufficient information about the effects of aloe-emodin on urothelial cells, and low efficiency in the treatment of bladder cancer currently, the present study aims to evaluate the hypothesis that the treatment with aloe-emodin could impact the behavior of other urothelial cell lines in vitro. Therefore, the in vitro IC50 exposure of aloe-emodin to human immortalized neoplastic urothelial cells will be determinated in order to verify possible differences in the behavior of urothelial cells in vitro treated with aloe-emodin in comparison with untreated cells. Furthermore, differences between cell lines will be also evaluated

Efeitos da inibição da cox-2 no sistema cardiovascular de cães

Os anti-inflamatórios não esteroidais (AINEs) estão entre os medicamentos mais prescritos em todo o mundo, tanto na medicina humana, como na medicina veterinária. Atualmente os AINEs são classificados em não seletivos (convencionais ou clássicos), que são os mais antigos, e seletivos para COX-2 ou coxibes. Alguns estudos constataram uma possível relação entre os inibidores COX-2 seletivos e os efeitos adversos no sistema cardiovascular. Devido a isso, objetivou-se realizar um levantamento de pesquisas que comprovem os efeitos cardiovasculares ocasionados por essa classe farmacológica utilizando livros e artigos das bases de dados PubMed, Periódicos da Capes e SciELO que respondessem à pergunta: a inibição da COX-2 acarreta efeitos adversos para o sistema cardiovascular?. Do total de resultados encontrados, foram utilizados 16 artigos. Os trabalhos mostraram que o uso de inibidores da COX-2 alterou o perfil de coagulação para uma tendência trombótica, além de diminuir a resposta vasodilatadora gerada na resposta inflamatória. Diante dos resultados obtidos através desses estudos, conclui-se que a COX-2 desempenha papel fisiológico no sistema cardiovascular, facilitando a não formação de trombos nos vasos sanguíneos, e, portanto, que sua inibição favorece a coagulação. Assim, os fármacos que inibem a COX-2 devem ser prescritos com cautela, levando-se em consideração o perfil de coagulação do paciente

Perfil de uso de recursos ergogênicos em academias da cidade de Bauru/SP

The increasing number of gyms and their patrons increasingly concerned about the health, appearance and aesthetics propagated by the media and the supply of ergogenic both food as hormonal some without proof of its effects generated interest for the study of consumption of such ergogenic goers by academies of Bauru/SP; objective was also to assess whether the Physical Education professionals are prepared to guide properly, such as the use of these goers ergogenic. To this end, a questionnaire specific to each category was used, to be answered voluntarily and anonymously, with closed and open questions divided into two parts: one for socio demographic characterization and another in which were discussed issues regarding the use/orientation ergogenic. The research involved a sample of 12 academies and 205 attendees, including 152 men (74.15%) and 53 (25.85) women. Among men, 61.18% (n=93) did use ergogenic(s) food(s), while among women, this percentage was 33.96% (n=18). Regarding the use of hormonal resources, only 4.61% (n=7) of men said they used; there were no cases of women using hormonal resources. Were also interviewed 19 assessors/trainers/teachers, two which fifteen (15) men and four (4) women. Most consumers of ergogenic: (1) is understood in the age group 21-30 years and the socioeconomic classification bands called B1 and B2; (2) practice bodybuilding and consumption ergogenic resources with purpose of muscular hypertrophy; (3) practicing bodybuilding for a period between 1 and 5 years, consumes ergogenic(s) for a period less than one year, and perhaps the most significant event, starts the consumption of ergogenic(s) in a period of less than one year after starting the practice of bodybuilding, and that there are consumers who start consuming ergogenic as soon begin the practice of bodybuilding; (4) has as its main source of indication for the use of ergogenic, the gym instructor, among which, some respondents reported...

Efeitos do aparelho de Herbst no tratamento proecoce da má oclusão classe II de Angle

Due to its high prevalence in general population, Angle Class II malocclusion has been widely studied by several authors, as well as the methods for its treatment. Among the possible treatment methods stands out the Herbst appliance. Reintroduced more than three decades ago in the orthodontics community, it became the most utilized appliance because it does not require patient compliance, and provides continued action through bilateral telescopic tubes. The objective of the present article was to demonstrate the early treatment of Class II Division 1 malocclusion with mandibular retrusion using Herbst appliance.