959 resultados para cascade of pi-circuits
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Includes index.
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Mode of access: Internet.
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20 fotoipicheskikh Tablits rab fot. P. Pavlova. So snimkov N.V. Bogoiavlenskago.
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Mode of access: Internet.
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"Prepared by the Massachusetts Institute of Technology, Laboratory for Insulation Research, Cambridge, Massachusetts, under USAF Contract AF 33(615)-2199."
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The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that is currently undergoing clinical evaluation in cancer patients. As well as it's anticancer properties, 1 displays a number of other interesting biological activities. A series of analogues of 1 were synthesized with a single carbon (pentasaccharide) backbone to facilitate structural characterization and interpretation of biological results. In a fashion similar to 1, all compounds were able to inhibit heparanase and to bind tightly to the proangiogenic growth factors FGF-1, FGF-2, and VEGF. The compounds also inhibited the infection of cells and cell-to-cell spread of herpes simplex virus (HSV-1). Preliminary pharmacokinetic data indicated that the compounds displayed different pharmacokinetic behavior compared with 1. Of particular note was the n-octyl derivative, which was cleared 3 times less rapidly than 1 and may provide increased systemic exposure.