998 resultados para calcium signals integration


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Organizing is a general problem for global firms. Firms are seeking a balance between responsiveness at the local level and efficiency through worldwide integration. In this, supply management is the focal point where external commercial supply market relations are connected with the firm's internal functions. Here, effective supplier relationship management (SRM) is essential. Global supply integration processes create new challenges for supply management professionals and new capabilities are required. Previous research has developed several models and tools for managers to manage and categorize different supplier relationship types, but the role of the firm's internal capability of managing supplier relationships in their global integration has been a clearly neglected issue. Hence, the main objective of this dissertation is to clarify how the capability of SRM may influence the firm's global competitiveness. This objective is divided into four research questions aiming to identify the elements of SRM capability, the internal factors of integration, the effect of SRM capability on strategy and how SRM capability is linked with global integration. The dissertation has two parts. The first part presents the theoretical approaches and practical implications from previous research and draws a synthesis on them. The second part comprises four empirical research papers addressing the research questions. Both qualitative and quantitative methods are utilized in this dissertation. The main contribution of this dissertation is that it aggregates the theoretical and conceptual perspectives applied to SRM research. Furthermore, given the lack of valid scales to measure capability, this study aimed to provide a foundation for an SRM capability scale by showing that the construct of SRM capability is formed of five separate elements. Moreover, SRM capability was found to be the enabler in efforts toward value chain integration. Finally, it was found that the effect of capability on global competitiveness is twofold: it reduces conflicts between responsiveness and integration, and it creates efficiency. Thus, by identifying and developing the firm's capabilities it is possible to improve performance, and hence, global competitiveness.

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Workflow management systems aim at the controlled execution of complex application processes in distributed and heterogeneous environments. These systems will shape the structure of information systems in business and non-business environments. E business and system integration is a fertile soil for WF and groupware tools. This thesis aims to study WF and groupware tools in order to gather in house knowledge of WF to better utilize WF solutions in future, and to focus on SAP Business Workflow in order to find a global solution for Application Link Enabling support for system integration. Piloting this solution in Nokia collects the experience of SAP R/3 WF tool for other development projects in future. The literary part of this study will guide to the world of business process automation providing a general description of the history, use and potentials of WF & groupware software. The empirical part of this study begins with the background of the case study describing the IT environment initiating the case by introducing SAP R/3 in Nokia, the communication technique in use and WF tool. Case study is focused in one solution with SAP Business Workflow. This study provides a concept to monitor communication between ERP systems and to increase the quality of system integration. Case study describes a way create support model for ALE/EDI interfaces. Support model includes monitoring organization and the workflow processes to solve the most common IDoc related errors.

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Power electronic converter drives use, for the sake of high efficiency, pulse-width modulation that results in sequences of high-voltage high-frequency steep-edged pulses. Such a signal contains a set of high harmonics not required for control purposes. Harmonics cause reflections in the cable between the motor and the inverter leading to faster winding insulation ageing. Bearing failures and problems with electromagnetic compatibility may also result. Electrical du/dt filters provide an effective solution to problems caused by pulse-width modulation, thereby increasing the performance and service life of the electrical machines. It is shown that RLC filters effectively decrease the reflection phenomena in the cable. Improved (simple, but effective) solutions are found for both differential- and common-mode signals; these solutions use a galvanic connection between the RLC filter star point and the converter DC link. Foil chokes and film capacitors are among the most widely used components in high-power applications. In actual applications they can be placed in different parts of the cabinet. This fact complicates the arrangement of the cabinet and decreases the reliability of the system. In addition, the inductances of connection wires may prevent filtration at high frequencies. This thesis introduces a new hybrid LC filter that uses a natural capacitance between the turns of the foil choke based on integration of an auxiliary layer into it. The main idea of the hybrid LC filter results from the fact that both the foil choke and the film capacitors have the same roll structure. Moreover, the capacitance between the turns (“intra capacitance”) of the foil inductors is the reason for the deterioration of their properties at high frequencies. It is shown that the proposed filter has a natural cancellation of the intra capacitance. A hybrid LC filter may contain two or more foil layers isolated from each other and coiled on a core. The core material can be iron or even air as in the filter considered in this work. One of the foils, called the main foil, can be placed between the inverter and the motor cable. Other ones, called auxiliary foils, may be connected in star to create differential-mode noise paths, and then coupled to the DC link midpoint to guarantee a traveling path, especially for the common-mode currents. This way, there is a remarkable capacitance between the main foil and the auxiliary foil. Investigations showed that such a system can be described by a simple equivalent LC filter in a wide range of frequencies. Because of its simple hybrid construction, the proposed LC filter can be a cost-effective and competitive solution for modern power drives. In the thesis, the application field of the proposed filter is considered and determined. The basics of hybrid LC filter design are developed further. High-frequency behaviour of the proposed filter is analysed by simulations. Finally, the thesis presents experimental data proving that the hybrid LC filter can be used for du/dt of PWM pulses and reduction of common-mode currents.

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Software integration is a stage in a software development process to assemble separate components to produce a single product. It is important to manage the risks involved and being able to integrate smoothly, because software cannot be released without integrating it first. Furthermore, it has been shown that the integration and testing phase can make up 40 % of the overall project costs. These issues can be mitigated by using a software engineering practice called continuous integration. This thesis work presents how continuous integration is introduced to the author's employer organisation. This includes studying how the continuous integration process works and creating the technical basis to start using the process on future projects. The implemented system supports software written in C and C++ programming languages on Linux platform, but the general concepts can be applied to any programming language and platform by selecting the appropriate tools. The results demonstrate in detail what issues need to be solved when the process is acquired in a corporate environment. Additionally, they provide an implementation and process description suitable to the organisation. The results show that continuous integration can reduce the risks involved in a software process and increase the quality of the product as well.

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The purpose of this study was to analyze how different stakeholders, such as the European Central Bank, the European Commission, the European Central Securities Depositories Association, the Bank of International Settlements and the International Monetary Fund, have influenced the European financial integration in the area of securities clearing and settlement since the introduction of the single currency. The results show that the contribution differs from stakeholder to another and can take the form of standards and recommendations, legislation, research and publications, risk analysis etc. The Eurosystem has been particularly active in this area by proving and planning central bank services, such as TARGET2, CCMB2 and T2S. Along the way the development has and continues to face challenges that need to be solved by European authorities. Coordination is a key factor for the future as we have seen during the recent financial turmoil.

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The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.

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Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.

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Two soybean (Glycine max) cultivars were used in this study, Ocepar 4, rated as moderately resistant to Meloidogyne incognita race 3 but susceptible to M. javanica, and 'BR 16', susceptible to both nematodes. The effect of nematodes infection on the uptake and transport of N, P and Ca to the shoot was studied in plants growing in a split root system. The upper half was inoculated with 0, 3,000, 9,000 or 27,000 eggs/plant while the lower half received 15N, 32P or 45Ca. Infected plants showed an increase of root but a decrease of shoot mass with increasing inoculum levels. In general, total endogenous nutrients increased in the roots and tended to decrease in the shoots with increasing inoculum levels. When concentrations were calculated, there was an increase in the three nutrients in the roots, and an increase of Ca but no significant variation of N and P was observed in the shoots. The total amount of 15N in the roots increased at the highest inoculum levels but 32P and 45Ca decreased. In the shoots there was a reduction of 32P and 45Ca. The specific concentrations of the labelled nutrients (abundance or radioactivity/tissue mass) also showed a decrease of 32P and 45Ca in the shoots and roots of infected plants and an increase of 15N in the shoots. Considering that overall nutrient concentrations reflect cumulative nutrient uptake and the data from labelled elements gave information at a specific moment of the infection, thus nematodes do interfere with nutrient uptake and translocation.

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Gray mold of roses (Rosa hibrida) caused by Botrytis cinerea requires many management strategies for its control. The effect of pulsing rose cv. Kiss with solutions of citric acid, salicylic acid, sucrose, calcium sulfate, and silver thiosulfate (STS) on disease severity and vase life of the flowers was evaluated. The solutions were applied to cut stems at different stages of harvest, the variation in the opening stage of harvest did not affect the results. Pulsing with STS reduced the values of area under the disease progress curve (AUDPC) and of severity of disease by 15% and 55%, respectively, and increased the vase life of the flowers by 20%. Calcium sulfate consistently reduced AUDPC by 66% and maximum severity by 88%, and increased vase life of the flowers by 37%. Therefore, pulsing rose buds with solutions of STS and calcium sulfate is potentially useful in reducing losses due to gray mold after harvest and in extending the vase life.

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Tämän väitöskirjatyön aiheena on maantuntemuksellisten sisältöjen integrointi ja välittäminen vieraan kielen opetuksessa. Maantuntemuksellisilla sisällöillä tarkoitetaan vieraan kielen opetuksessa ei-kielellisiä sisältöjä, jotka ylittävät pelkän kielitiedon, kieliopin ja sanaston, välittämisen rajat. Tutkimuskirjallisuudessa näitä ei-kielellisiä sisältöjä nimitetään monin eri tavoin, esimerkiksi maantuntemukseksi (Landeskunde), sosiokulttuurisiksi tiedoiksi ja taidoiksi (soziokulturelles Wissen) tai yksinkertaisesti kulttuuriksi (Kultur). Väitöskirjatyö jakautuu teoreettiseen kehykseen (luvut 1–4), julkaistujen artikkeleiden tutkimusmetodien ja tuloksien käsittelyyn (luvut 5–6) sekä julkaistuihin artikkeleihin. Teoreettisen kehyksen ensisijaisia tutkimuskysymyksiä ovat, miten maantuntemuksellisten sisältöjen välittäminen konkretisoituu eri näkökulmista (opettajat, oppijat, oppimateriaalit) tarkasteltuna, miten kulttuurienvälinen maantuntemus ilmentyy vieraan kielen opetuksessa ja mitkä sisällöt ovat merkittäviä vieraan kielen opetuksessa. Metodisina lähestymistapoina tutkimuksessa on käytetty oppikirja-analyysiä, opetuksen tarkkailua sekä kyselytutkimuksia. Liitteenä oleville julkaistuille artikkeleille on yhteistä se, että jokainen niistä käsittelee jotakin erityistä maantuntemuksellisiin sisältöihin liittyvää aihetta empiriisestä näkökulmasta erityisesti saksan kielen opetuksen kannalta. Artikkelien tutkimusongelmia ovat kulttuuristen ja kielellisten sisältöjen yhdistäminen, kulttuurienvälisen viestinnän konkretisoituminen, kielellisen ja kulttuurisen variaation huomioiminen, stereotyyppien asema sekä sukupuolierojen merkitys vieraan kielen opetuksessa. Väitöskirjatyön teoreettisessa kehyksessä luodaan aluksi historiallinen katsaus maantuntemuksen asemaan vieraan kielen opetuksessa ja selvitetään tarkemmin erityisesti vieraan kielen didaktiikan uusimpien traditioiden, kuten konstruktivismin ja sosiokulttuurisen teorian, yhteyttä maantuntemuksen oppimiseen. Tässä yhteydessä käsitellään myös kulttuurienvälisen oppimisen traditiota ja maantuntemusta sen sovellusalueena. Tämän lisäksi selvitetään konkreettisia vieraan kielen opetuksessa ilmeneviä maantuntemukseen liittyviä didaktis-metodisia kysymyksiä, erityisesti opettajan roolia ja sitä, miten kulttuurienvälisen tradition mukainen maantuntemuksen välittäminen konkretisoituu yhtäältä yksittäisinä tehtävinä ja harjoituksina sekä toisaalta elektronisten viestimien välityksellä. Teoreettisen kehyksen ytimen muodostaa maantuntemuksellisten aiheiden valintaan ja merkittävyyteen liittyvä tutkimuskirjallisuuden pohjalta tehtävä pohdinta. Vieraan kielen opetuksessa kieliopilliset sisällöt opetetaan pääosin vakiintuneessa järjestyksessä, mutta maantuntemuksellisten sisältöjen opettamisessa ja oppimisessa ei ole säännönmukaisuuksia. Yhteenvetona esitetään teesejä, joiden tarkoituksena on antaa ehdotuksia, suosituksia ja didaktisia neuvoja maantuntemuksen opetukseen ja oppimiseen. Väitöskirjatyössä paneudutaan vaikeuksiin määritellä maantuntemuksen oppimisen kannalta merkittävät aiheet erityisesti saksan kielen opetusta silmällä pitäen. Arkipäivän kulttuurin käsittelyn tärkeyteen käytännön opetuksessa viittaavat oppikirjojen aihepiirit, opettajien ja opiskelijoiden käsitykset sekä Eurooppalaisen viitekehyksen suositukset. Tutkimuksessa selvitettiin tarkemmin myös aihepiirien valintaa kohderyhmän mukaan ja kartoitettiin oppijoiden käsityksiä maantuntemuksellisista sisällöistä ja heidän näihin kohdistuvia toiveitaan. Kyselytulosten mukaan aikuisten oppijoiden mieliin jäivät saksan kielen oppitunnilla erityisesti sellaiset kulttuuriin liittyvät asiat, jotka oppijat kokivat autenttisiksi tai jotka herättivät tunnilla keskustelua ja olivat kohdekulttuurissa erilaisia kuin omassa kulttuurissa. Tutkimuksessa selvitettiin myös kulttuurienvälisen oppimisen aspekteja vieraan kielen opetuksessa ja oppimateriaaleissa, erityisesti ”oman” ja ”vieraan” kulttuurin kokemisesta ja niiden vastakkainasettelusta. Näyttää siltä, että kulttuurienvälisen oppimisen mahdollisuudet tutkimissani saksan kielen oppikirjoissa rajoittuvat siihen, että oppijoille tarjotaan mahdollisuus eläytyä kohdekulttuurin arkeen oppikirjojen henkilöiden kautta ja että oppijoita kehotetaan kertomaan omasta kulttuuristaan. Tutkimuksessa pohditaan myös tarkemmin, voivatko sähköiset oppimateriaalit ja internet johtaa takaisin faktoihin keskittyvään maantuntemuksen oppimiseen. Virtuaaliset oppimisympäristöt, esimerkiksi oppikirjojen internetsivustot, antavat kaikesta huolimatta uusia mahdollisuuksia tutkivaan oppimiseen. Tällaisia ovat esimerkiksi ”minitutkimustehtävät” ja sellaiset harjoitustyypit, jotka eivät oppikirjoissa ole mahdollisia, kuten virtuaaliset kaupunkikierrokset. Opettajien ja oppimateriaalien laatijoiden pitäisi suunnitella sellaisia tehtäviä ja harjoituksia, jotka antavat riittävästi mahdollisuuksia myös kulttuurienväliselle pohdinnalle. Oppijan oma ja kohdekulttuuri voidaan opetuksessa nostaa samanaikaisesti esille esimerkiksi käsittelemällä kielellisiä ja kulttuurisia variaatioita. Tutkimustulosten mukaan kulttuurienvälisen oppimisen traditionkin aikana maantuntemusta välitetään yhä perinteisellä tavalla faktatietoihin painottuen, eli käytännössä kieltenopetusta ohjaa vielä edelleenkin hyvin perinteinen käsitys kielestä ja kielitaidosta. Kielten opettajien koulutuksessa olisi huomioitava se, että opettajien tulisi olla kokonaisvaltaisia kulttuurin asiantuntijoita, eli myös historia, yhteiskunta, politiikka ja myös ”arkipäiväisen elämän” tuntemus ovat tärkeitä opettajan ammattitaidossa.

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A flow-injection system with sample and reagent addition by the synchronous merging zones approach for calcium determination in milk by flame AAS is proposed. Main parameters were optimized using a factorial design with central point. The optimum conditions were 2.5% (m/v) for La concentration, 8 mL min-1 for the carrier flow-rate, 20 cm for coiled reactor and 250 ìL for sample volume. Different sample preparation procedures were evaluated such as dilution in water or acid and microwave-assisted decomposition using concentrated or diluted acids. The optimized flow system was applied to determine Ca in eleven commercial milk samples and two standard reference materials diluted in water. Similar calcium levels were encountered comparing the results obtained by the proposed method (dilution in water) with those obtained using microwave-oven digestion. Results obtained in two standard reference materials were in agreement at 95% confidence level with those certified. Recoveries of spiked samples were in the 93% - 116% range. Relative standard deviation (n = 12) was < 5.4% and the sample throughput was 150 measurements per hour, corresponding to a consumption of 250 µL of sample and 6.25 mg La per determination.