Ac2PIM-responsive miR-150 and miR-143 Target Receptor-interacting Protein Kinase 2 and Transforming Growth Factor Beta-activated Kinase 1 to Suppress NOD2-induced Immunomodulators

Specific and coordinated regulation of innate immune receptor-driven signaling networks often determines the net outcome of the immune responses. Here, we investigated the cross-regulation of toll-like receptor (TLR)2 and nucleotide-binding oligomerization domain (NOD)2 pathways mediated by Ac2PIM, a tetra-acylated form of mycobacterial cell wall component and muramyl dipeptide (MDP), a peptidoglycan derivative respectively. While Ac2PIM treatment of macrophages compromised their ability to induce NOD2-dependent immunomodulators like cyclooxygenase (COX)-2, suppressor of cytokine signaling (SOCS)-3, and matrix metalloproteinase (MMP)-9, no change in the NOD2-responsive NO, TNF-alpha, VEGF-A, and IL-12 levels was observed. Further, genome-wide microRNA expression profiling identified Ac2PIM-responsive miR-150 and miR-143 to target NOD2 signaling adaptors, RIP2 and TAK1, respectively. Interestingly, Ac2PIM was found to activate the SRC-FAK-PYK2-CREB cascade via TLR2 to recruit CBP/P300 at the promoters of miR-150 and miR-143 and epigenetically induce their expression. Loss-of-function studies utilizing specific miRNA inhibitors establish that Ac2PIM, via the miRNAs, abrogate NOD2-induced PI3K-PKC delta-MAPK pathway to suppress beta-catenin-mediated expression of COX-2, SOCS-3, and MMP-9. Our investigation has thus underscored the negative regulatory role of Ac2PIM-TLR2 signaling on NOD2 pathway which could broaden our understanding on vaccine potential or adjuvant utilities of Ac2PIM and/or MDP.

Evaluación sobre crecimiento, desarrollo y rendimiento de catorce accesiones criollas de frijol común (Phaseolus vulgaris L.) y el testigo comercial revolución-84 en La Compañía, Carazo, Postrera 1993

I. INTRODUCCION II. MATERIALES Y METODOS 2.1 Descripción del lugar 2.2 Descripción del diseño experimental 2.3 Tratamientos en estudio 2.4 Variables a medir en los tratamientos. 2.4.1 Sobre crecimiento y desarrollo. 2.4.2 Sobre el rendimiento 2.4.3 Estudio de enfermedades. 2.5 Análisis estadístico 2.6 Métodos de fitotecnia. 2.6.1 Preparación del suelo. 2.6.2 Fertilización. 2.6.3 Siembra. 2.6.4 Manejo de malezas 2.6.5 Manejo de plagas y enfermedades. 2.6.6 Cosecha. III.- RESULTADOS Y DISCUSION. 3.1 Sobre crecimiento y desarrollo 3.1.1 Porcentaje de emergencia 3.1.2 Diámetro del tallo 3.1.3 Longitud del tallo. 3.1.4 Número de nudos por planta. 3.13 Días a la floración. 3.1.6 Días a la madurez fisiológica. 3.1.7 Días a la cosecha. 3.1.8 Hábito de crecimiento. 3.2 Sobre el rendimiento y sus componentes. 3.2.1 Número de plantas cosechadas por parcela útil 3.2.2 Número de vainas por planta 3.2.3 Numero de granos por vaina. 3.2.4 índice de cosed/a. 3.2.5 Peso de grano malo. 3.2.6 Peso de grano bueno. 3.2.7 Peso de mil granos. 3.2.8 Rendimiento de grano 3.3 Estudio de enfermedades. IV CONCLUSIONES V. RECOMEMACIONES. VI REFERENCIAS BIBLIOGRAFICAS VII. ANEXOS

水平动载下桶型基础周围土体软化的离心机模拟

为了探讨海洋平台桶形基础在水平动载荷下的响应特性,为实际工程设计提供依据,本文以等效动冰载作用为例,对饱和砂土地基上桶形基础的动力响应进行了离心机实验研究。通过实验发现,沿深度方向,孔隙水压力从土体表层到土体下部逐渐减小,当土体表层已液化,下部土体(桶底面高程位置)的孔隙水压力增加还很小,桶的总承载力降低约17%。;沿水平方向,孔隙水压力发展从桶壁近区到远处逐渐衰减,在离桶壁3%桶直径处,液化指数(孔隙水压力除以初始有效应力)已为1.0,在离桶壁23%桶直径处,液化指数为0.4。随载荷幅值增加,土体软化、液化发展加快;在实验范围内,随压重增加,上部土体影响增加;在桶直径一定条件下,土体响应随桶高的减小而增加。

STREAM Journal, Vol. 2, No. 3, pp 1-18. July-September 2003

CONTENTS: Livelihood Improvements through fisheries in the Pode community in Pokhara, Nepal, by Tek Bahadur Gurung and Jay Dev Bista. Women’s participation in coastal resources management and livelihoods in Khanh Hoa Province, Vietnam, by Nguyen Thu Hue, Than Thi Hien, Pham Thi Phuong Hoa, Nguyen Viet Vinh and Dao Viet Long. Supporting people’s efforts and interactions in coastal resources management in Indonesia, by Tabitha Yulita. Planning for a community fisheries M&E system, by Heather Airlie and Haiko Meelis. Identifying needs and recommendations for efficient stakeholder communications through an information access survey, by Elizabeth M. Gonzales, Malene Felsing and Erwin L Pador. IEC seminar-workshop in support of fisheries ordinance implementation in Roxas City, Philippines, by Belinda M. Garrido and Elizabeth M. Gonzales.

Proceedings of the Nineteenth Annual Symposium on Sea Turtle Conservation and Biology, 2-6 March 1999 South Padre Island, Texas, U.S.A.

The 19th Annual Symposium on Sea Turtle Biology and Conservation was the largest to date. The beautiful venue was the South Padre Island Convention Centre on South Padre Island, Texas from March 2-6, 1999. Key features of the 19th were invited talks on the theme The Promise, the Pain, and the Progress of 50 years of Sea Turtle Research and Conservation, a mini-symposium on the Kemp's ridley and an increased emphasis on high quality poster sessions. Hosts for the meeting included Texas A&M University, the Texas Sea Grant College Program, The Gladys Porter Zoo and Sea Turtle, Inc. Co-sponsors included the National Marine Fisheries Service-Southeast Fisheries Science Center, the National Marine Fisheries Service-Protected Resources Branch, Padre Island National Seashore and the U.S. Fish and Wildlife Service. With the assistance of Jack Frazier, we were fortunate to obtain a $30,000 grant from the David and Lucile Packard Foundation. This grant provided travel support to 49 individuals from 24 nations who presented a total of 50 presentations. (PDF contains 309 pages)

Assistance in poverty alleviation through improved aquatic resources management in Asia-Pacific: GVT/NACA-STREAM/FAO International Workshop on livelihoods approaches and analysis. Ranchi, Jharkhand, India, 2-6 Feb. 2004

This is the report of the “GVT/NACA-STREAM/FAO International Workshop on Livelihoods Approaches and Analysis” that was conducted in Ranchi, India from 2-6 February 2004. The purpose of the workshop was to develop and document mechanisms for training in livelihoods approaches and analysis, and to build national capacity to conduct livelihoods analysis. The workshop in Ranchi was a joint India-Nepal event, with colleagues coming to participate from Kathmandu and other areas of Nepal. The workshop in Ranchi was the second in a series, the first of which was held in Iloilo City, Philippines, in November 2003. Subsequent workshops will take place in other countries in the region, including Lao PDR, Myanmar and Yunnan, China. (Pdf contains 48 pages).

Assistance in poverty alleviation through improved aquatic resources management in Asia-Pacific: Yunnan DOA/NACA-STREAM/FAO Workshop on livelihoods approaches and analysis. Mengzi, Yunnan, China, 6-10 Sep. 2004

This is the report of the “Yunnan DOA/NACA-STREAM/FAO Workshop on Livelihoods Approaches and Analysis” that was conducted in Mengzi, Yunnan from 6-10 September 2004. The purpose of the workshop was to develop and document mechanisms for training in livelihoods approaches and analysis, and to build national capacity to conduct livelihoods analysis. The workshop in Yunnan was the first STREAM event in China, with colleagues coming to participate from throughout the province. It was the fifth workshop in a series, the first of which was held in Iloilo City, Philippines, in November 2003, the second in Ranchi, India, in February 2004, third in Vientiane, Lao PDR, in March 2004 and the fourth in Yangon, Myanmar, in May 2004. (Pdf contains 44 pages).

Aquaculture Asia, Vol.14, No.3, pp.1-44, July-September 2009

Sustainable aquaculture Contrasting community management and revenue sharing practices of culture-based fisheries in Lao PDR Saphakdy, B., Phomsouvanh, A., Davy, B., Nguyen, T.T.T. and De Silva, S.S.; Floodplain aquaculture in Begumgonj: New horizon for rural livelihoods in Bangladesh Hossain, M. S.; Promoting small-scale inland aquaculture in Papua New Guinea Edwards, P.; Group approach to shrimp farming: The key to sustainability Kumaran, M.; Research and farming techniques Native catfish culture - a technology package for fish farmers Haniffa, M. A.; An assessment on the influence of salinity in the growth of black clam (Villorita cyprinoides) in cages in Cochin estuary with a special emphasis on the impact of Thennermukkom Salinity Barrier Arun, A. U.; Aquatic animal health EUS in Asia and Africa: Stimulus for regional initiatives!!! Mohan, C.V. Marine Finfish Aquaculture Network Offshore opportunities for artisanal aquaculture Stock, C.; Grouper aquaculture in Brazil Sanches, E.G. and Von Seckendorff, R.W. NACA Newsletter

Diurnal periodicity of activity in the spawning perch P. fluviatilis L. [Translation from: Kalamies 1972(7) 3, 1972]

Diurnal periodicity of spawning in the perch so far are rather meagre and found to be partly contrary to experiences of perch anglers. Therefore a study was made on the spawning during a 5-day period in the spring of 1971 in the Kuusamo area. Observations were made during the main spawning season, between 4- 9 June 1971. The perch were often measured, weighed and then released back into the water. The differences between spawning and non-spawning perch were studied as well as the time of roe discharge in a 24 hour period. Activity and environmental factors such as light intensity were also taken into consideration.

2-氨基-6-乙氧基苯并噻唑类偶氮染料及其金属鏊合物的合成及光学热学性能研究

合成了2-（2-氨基-6-乙氧基苯并噻唑基偶氮）-5-（N,N-二乙基氨基）三氟甲基磺酰苯胺偶氮染料（EBTDATFS）及其与乙酸镍、乙酸钴、乙酸铜、乙酸锌等金属盐鏊合的金属鏊合物。通过红外光谱、紫外-可见吸收光谱和MALDI质谱等对染料及其金属鏊合物进行了结构表征;使用旋涂方法在K9玻璃和抛光的单晶硅基片上制备薄膜;研究了镍金属鏊合物的热学性能;使用椭偏仪研究了Ni和Zn鏊合物的光学常数。结果表明：4种金属鏊合物薄膜最大吸收光谱为621-629nm,且长波边吸收峰陡峭;TGA-DSC测试结果表明镍金属鏊

Efectos de la hipoxia intermitente en el entrenamiento de resistencia

El objetivo de este trabajo es estudiar los efectos que puede tener la utilización de protocolos de hipoxia intermitente para el entrenamiento de la resistencia. Para ello, se ha realizado una búsqueda bibliográfica en la base de datos de PUBMED con el fin de poder encontrar diferente información sobre el tema tratado. Los protocolos de hipoxia intermitente, usados en la bibliografía encontrada, consistían en 10/15 sesiones de 1 h/ 1 h 30 min cada una, con una relación de hipoxia y normoxia de 5:5 min, 6:4 min y 7:3 min según estudios. Tras analizar los resultados obtenidos, vemos que los efectos producidos en la mejora del rendimiento no son claros, pudiendo ser la causa de ello, la falta de sujetos involucrados en los estudios.

The juvenile salmonid populations of the River Lune catchment, 1981 to 1985

The aim of this study was to assess the status of the juvenile salmonid populations of the River Lune and its tributaries. There was special emphasis on juvenile salmon stocks in view of the implementation of a net limitation order in 1980. The number of licensed instruments were reduced as follows: (1) Drift, hang or whammel nets - from 12 to 10 (2) Draft or seine nets - from 3 to 1 (3) Heave or haaf nets - from 4 6 to 2 6 For the purpose of this report, the River Lune system has been divided into 13 subcatchments and these are examined with a view to detecting any trends in the data such as subcatchment productivity, partitioning between salmon and trout nursery streams, and whether the restrictions on salmon fishing had any discernible effects on juvenile salmon productivity. The effect of flow and instream obstructions on salmonid densities are also investigated as these have been shown to be important factors affecting abundance. Throughout the study period a programme of enhancement stocking took place primarily with salmon ova and fry. The possible impact of this on the results of the surveys has been assessed. The distribution and abundance of juvenile salmon was found to be relatively consistent in each of the 13 subcatchments studied over the 1981-1985 period.

甘木通治疗心血管疾病的研究

自1972年9月至1975年5月，共收治高血压病人101例，其中显效81例，占80.2％；有效6例，占5％；基本无效14例，占14％，总有效率为85.2％。并对由于高血压所引起的症状如头痛、头昏、脑胀、四肢麻木、失眠等有较好疗效，其总有效率为91.7％。同时也初步观察到对冠心病患者和脑血管意外引起的偏瘫患者均有治疗作用。

Baines Pool Hen Pike caught 7.3.1950

A fisherman with a hen pike caught on the 7.3.1950 at Baines Pool, North West of England, UK. This photo is part of a photo album that includes pictures from 1935 to 1954.