939 resultados para SYSTEMS ANALYSIS


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Increasing building energy efficiency is one the most cost-effective ways to reduce emissions. The use of thermal insulation materials mitigates heat loss in buildings, therefore minimising heat energy needs. In recent years, several papers were published on the subject of foam alkali-activated cements with enhanced thermal conductivity. However, on those papers cost analysis was strangely avoided. This paper presents experimental results on one-part alkali-activated cements. It also includes global warming potential assessment and cost analysis. Foam one-part alkali-activated cements cost simulations considering two carbon dioxide social costs scenarios are also included. The results show that one-part alkali-activated cements mixtures based on 26%OPC + 58.3%FA + 8%CS + 7.7%CH and 3.5% hydrogen peroxide constitute a promising cost-efficient (67 euro/m3), thermal insulation solution for floor heating systems. This mixture presents a low global warming potential of 443 KgCO2eq/m3. The results confirm that in both carbon dioxide social cost scenarios the mixture 26 OPC + 58.3 FA + 8 CS + 7.7 CH with 3.5% hydrogen peroxide foaming agent is still the most cost efficient.

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Dissertação de mestrado em Structural Analysis of Monuments and Historical Constructions

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Dissertação de mestrado integrado em Biomedical Engineering Biomaterials, Biomechanics and Rehabilitation

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Zeolites Y (faujasite) and MOR (mordonite) were used as hosts for temozolomide (TMZ), a current good-standard chemotherapeutic agent used in the treatment of glioblastoma brain tumors. TMZ was loaded into zeolites by liquid-phase adsorption at controlled pH. FTIR, 1H NMR, MS, SEM, UV/vis and chemical analysis demonstrated the successful loading of TMZ into zeolite hosts. The hydrolysis of TMZ in MTIC (TMZ metabolite) after the preparation of drug delivery systems (DDS) was observed in simulated body fluid. The effect of zeolites and DDS were evaluated on the viability of glioblastoma cell lines. Unloaded Y zeolite presented toxicity to cancer cells in contrast to MOR. In accordance, the best results in potentiation of the TMZ effect was obtained with MOR. We found that mordonite loaded with 0.026 mmol of TMZ was able to decrease the half maximal inhibitory concentrations (IC50) at least 3-fold in comparison to free temozolomide both in vitro and in vivo.

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Dissertação de mestrado integrado em Engenharia Mecânica

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Tese de Doutoramento em Biologia Ambiental e Molecular

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PhD thesis in Biomedical Engineering

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Partition behavior of eight small organic compounds and six proteins was examined in poly(ethylene glycol)-8000sodium sulfate aqueous two-phase systems containing 0.215 M NaCl and 0.5 M osmolyte (sorbitol, sucrose, TMAO) and poly(ethylene glycol)-10000sodium sulfate0.215 M NaCl system, all in 0.01 M sodium phosphate buffer, pH 6.8. The differences between the solvent properties of the coexisting phases (solvent dipolarity/polarizability, hydrogen bond donor acidity, and hydrogen bond acceptor basicity) were characterized with solvatochromic dyes using the solvatochromic comparison method. Differences between the electrostatic properties of the phases were determined by analysis of partitioning of sodium salts of dinitrophenylated (DNP-) amino acids with aliphatic alkyl side-chain. The partition coefficients of all compounds examined (including proteins) were described in terms of solutesolvent interactions. The results obtained in the study show that solutesolvent interactions of nonionic organic compounds and proteins in polyethylene glycolsodium sulfate aqueous two-phase system change in the presence of NaCl additive.

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"Series: Solid mechanics and its applications, vol. 226"

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"Series Title: IFIP - The International Federation for Information Processing, ISSN 1868-4238"

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La programación concurrente es una tarea difícil aún para los más experimentados programadores. Las investigaciones en concurrencia han dado como resultado una gran cantidad de mecanismos y herramientas para resolver problemas de condiciones de carrera de datos y deadlocks, problemas que surgen por el mal uso de los mecanismos de sincronización. La verificación de propiedades interesantes de programas concurrentes presenta dificultades extras a los programas secuenciales debido al no-determinismo de su ejecución, lo cual resulta en una explosión en el número de posibles estados de programa, haciendo casi imposible un tratamiento manual o aún con la ayuda de computadoras. Algunos enfoques se basan en la creación de lenguajes de programación con construcciones con un alto nivel de abstración para expresar concurrencia y sincronización. Otros enfoques tratan de desarrollar técnicas y métodos de razonamiento para demostrar propiedades, algunos usan demostradores de teoremas generales, model-checking o algortimos específicos sobre un determinado sistema de tipos. Los enfoques basados en análisis estático liviano utilizan técnicas como interpretación abstracta para detectar ciertos tipos de errores, de una manera conservativa. Estas técnicas generalmente escalan lo suficiente para aplicarse en grandes proyectos de software pero los tipos de errores que pueden detectar es limitada. Algunas propiedades interesantes están relacionadas a condiciones de carrera y deadlocks, mientras que otros están interesados en problemas relacionados con la seguridad de los sistemas, como confidencialidad e integridad de datos. Los principales objetivos de esta propuesta es identificar algunas propiedades de interés a verificar en sistemas concurrentes y desarrollar técnicas y herramientas para realizar la verificación en forma automática. Para lograr estos objetivos, se pondrá énfasis en el estudio y desarrollo de sistemas de tipos como tipos dependientes, sistema de tipos y efectos, y tipos de efectos sensibles al flujo de datos y control. Estos sistemas de tipos se aplicarán a algunos modelos de programación concurrente como por ejemplo, en Simple Concurrent Object-Oriented Programming (SCOOP) y Java. Además se abordarán propiedades de seguridad usando sistemas de tipos específicos. Concurrent programming has remained a dificult task even for very experienced programmers. Concurrency research has provided a rich set of tools and mechanisms for dealing with data races and deadlocks that arise of incorrect use of synchronization. Verification of most interesting properties of concurrent programs is a very dificult task due to intrinsic non-deterministic nature of concurrency, resulting in a state explosion which make it almost imposible to be manually treat and it is a serious challenge to do that even with help of computers. Some approaches attempts create programming languages with higher levels of abstraction for expressing concurrency and synchronization. Other approaches try to develop reasoning methods to prove properties, either using general theorem provers, model-checking or specific algorithms on some type systems. The light-weight static analysis approach apply techniques like abstract interpretation to find certain kind of bugs in a conservative way. This techniques scale well to be applied in large software projects but the kind of bugs they may find are limited. Some interesting properties are related to data races and deadlocks, while others are interested in some security problems like confidentiality and integrity of data. The main goals of this proposal is to identify some interesting properties to verify in concurrent systems and develop techniques and tools to do full automatic verification. The main approach will be the application of type systems, as dependent types, type and effect systems, and flow-efect types. Those type systems will be applied to some models for concurrent programming as Simple Concurrent Object-Oriented Programming (SCOOP) and Java. Other goals include the analysis of security properties also using specific type systems.

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El presente proyecto plantea utilizar integralmente la técnica de Resonancia Magnética Nuclear en sólidos como un medio experimental que permite entender fenómenos de la física fundamental, como así también realizar aplicaciones de interés en el campo de la química, los desarrollos farmacéuticos y la biología. Novedosas técnicas experimentales serán empleadas, en conjunción con otras más tradicionales, en la caracterización de nuevas estructuras poliméricas acomplejadas a metales, membranas biológicas y compuestos de interés farmacéutico en vías de desarrollo, los cuales presentan el fenómeno de polimorfismo . Esto se llevará a cabo complementando los resultados de RMN en sólidos con técnicas tanto espectroscópicas como analíticas (Infrarrojo, Difracción de Rayos X, Calorimetría, RMN en solución) y trabajo interdisciplinario. Paralelamente al desarrollo de estos temas, profundizaremos mediante investigación básica, en la compresión de la dinámica cuántica y el surgimiento de la irreversibilidad en sistemas de espines nucleares. Observaremos en particular la generación, evolución y control de las coherencias cuánticas múltiples en sistemas cuánticos abiertos, lo cual nos da información sobre tamaño de clusters de espines. Esto permitirá la correcta implementación de secuencias de pulsos sofisticadas, como así también desarrollar nuevos métodos de medición aplicados a la caracterización estructural y a la dinámica molecular de sólidos complejos. Debemos resaltar que este proyecto está conectado con aspectos tanto básicos como aplicados de la RMN en sólidos como técnica experimental, la cual se desarrolla en el país únicamente en FaMAF-UNC. Se nutre además de trabajo multidisciplinario promoviendo la colaboración con investigadores y becarios de distintas áreas (física, química, farmacia, biología) provenientes de distintos puntos del país. Finalmente podemos afirmar que este plan impulsa la aplicación de la física básica proyectada a diferentes áreas del conocimiento, en el ámbito de la provincia de Córdoba. The aim of the present proyect is to use Nuclear Magnetic Resonance (NMR) as a complete techique that allows the understanding of fundamental physics phenomena and, at the same time, it leads to important applications in the fields of chemistry, pharmaceutical developments and biology. New experiments will be used together with traditional ones, in the characterization of new metal-polymer complexes, biological membranes and pharmaceutical compounds, some of them presenting polymorfism. NMR experiments will be complemented with diverse spectroscopic and analytical techniques: Infrared, X ray Diffraction, Thermal Analysis, solution NMR, as well as multidisciplinary investigation. Additionally, the present proyect plans to study in depth several aspects of quantum dynamics phenomena and decoherence in nuclear spin systems. The present proyect is connected with basic and applied aspects of the solid state NMR technique, developed in our country, only at FaMAF-UNC. It is is composed by multidisciplinary work and it promotes the collaboration with researchers and students coming from different fields (physics, chemistry, pharmaceutical developments, biology) and different points of our country.

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This thesis details the findings of a study into the spatial distribution and speciation of 238U, 226Ra and 228Ra in the soils of the Cronamuck valley, County Donegal . The region lies on the north-eastern edge of the Barnesmore granite and has been the subject of uranium prospecting efforts in the past. The results of the project provide information on the practicability of geostatistical techniques as a means of estimating the spatial distribution of natural radionuclides and provide insight into the behaviour of these nuclides and their modes of occurrence and enrichment in an upland bog environment. The results of the geostatistical survey conducted on the area indicate that the primary control over the levels of the studied nuclides in the soil of the valley is the underlying geology. Isopleth maps of nuclide levels in the valley indicate a predominance of elevated nuclide levels in the samples drawn from the granite region, statistical analysis of the data indicating that levels of the nuclides in samples drawn from the granite are greater than levels drawn from the non-granite region by up to a factor of 4.6 for 238U and 4.9 for 226Ra. Redistribution of the nuclides occurs via drainage systems within the valley, this process being responsible for transport of nuclides away from the granite region resulting in enrichment of nuclides in soils not underlain by the granite. Distribution of the nuclides within the valley is erratic, the effect of drainage f lows on the nuclides resulting in localized enriched areas within the valley. Speciation of the nuclides within one of the enriched areas encountered in the study indicates that enrichment is as a result of saturation of the soil with drainage water containing trace amounts of radionuclides. 238U is primarily held within the labile fractions (exchangeable cat ions + easily oxidisable organics + amorphous iron oxides ) of the soil , 226Ra being associated with the non- labile fractions, most probably the resistant organic material. 228Ra displays a significant occurrence in both the labile and non- labile fractions. The ability of the soil to retain uranium appears to be affected largely by the redox status of the soil, samples drawn from oxidizing environments tending to have little or no uranium in the easily oxidisable and amorphous iron oxide fractions. This loss of uranium from oxidised soil samples is responsible for the elevated 226Ra /238U disequilibrium encountered in the enriched areas of the valley. Analysis of the data indicates that samples displaying elevated 226Ra/238U ratios also exhibit elevated 228Ra/238U ratios indicating a loss of uranium from the samples as opposed to an enrichment of 226Ra.