The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.

Cyclosporin but not tacrolimus significantly increases salivary cytokine contents in rats

Background: Cyclosporin (CsA) and tacrolimus (FK-506) are immunosuppressive drugs that specifically inhibit T-cell activation via calcineurin inhibition. Gingival overgrowth is a common side effect following the administration of CsA. The severity of gingival overgrowth seen in patients taking FK-506 is less than that observed with CsA. Little is known about the involvement of saliva in drug-induced gingival overgrowth. The purpose of this study was to investigate the salivary contents of tumor growth factor β1 (TGF-β1), epidermal growth factor (EGF), and interleukin-6 (IL-6) as well as the hystometry of gingival tissue obtained from rats treated with either FK-506 or CsA. Methods: For 30 or 60 days rats received daily subcutaneous injection doses of either CsA or FK-506 (10 mg/kg). The concentrations of TGF-β1, EGF, and IL-6 in saliva were determined by enzyme-linked immunosorbent assay, and after histological processing, the oral epithelium and connective tissue were assessed at the region of the lower first molars. Results: The levels of TGF-β1, EGF, and IL-6 in saliva were not significantly altered by any of the treatments after 30 days. After 60 days of treatment with CsA, gingival overgrowth and significant increase in salivary TGF-β1, EGF, and IL-6 concentrations were observed; no statistically significant changes were induced by FK-506. Conclusion: Within the limits of this experimental study, it can be concluded that CsA, but not FK-506, induced gingival overgrowth associated with an increase of the salivary levels of the cytokines TGF-β1, EGF, and IL-6.

Comentarios a la presentación de Ricardo Hausmann "futuro de la estrategia de crecimiento de América Latina"

Incluye Bibliografía

Comentario a la presentação do Ricardo Hausmann "O futuro da estratégia de crescimento da América Latina"

Incluye Bibliografía

La planificación para el desarrollo y los instrumentos reales de acción gubernamental

Publicado como documento INST/S.9/L.12

Políticas macroeconómicas y brecha externa: América Latina en los años ochenta

Incluye Bibliografía

Restricción externa y ajuste: opciones y políticas en América Latina

Incluye Bibliografía

Areas económicas locales y mercado de trabajo en Argentina: estudio de tres casos

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Ahorro e inversión bajo restricción externa y fiscal: el caso de Chile, 1982-1987

Incluye Bibliografía

Manual para la preparación del cuestionario sobre las medidas que afectan al comercio de servicios en el hemisferio

Incluye Bibliografía

Demanda por grupos, psicologia e controle

Este artigo traz uma reflexão sobre uma capacitação para o trabalho grupal, destinado às equipes das UBSs (Unidades Básica de Saúde) do SUS (Sistema Único de Saúde) e agentes comunitários de saúde de um município do interior do Estado de São Paulo. Trata-se de analisar o pedido explicitado pela equipe, de mostrar a reflexão a respeito desse pedido, as circunstâncias dos problemas colocados, a experiência dos vários trabalhadores da equipe e a escuta do que se passa do lado da população. Parar para ouvir os parceiros do trabalho e refletir sobre a intervenção fez a equipe trabalhar sua sensibilidade diante das questões da população, do que vem a ser saúde e poder assumir outra postura que não seja a de servir ao controle da população e trabalhar para a construção da sociedade de controle.

Manual for completing the questionnaire on measures affecting services trade in the hemisphere

Includes bibliography

Los jóvenes y la odisea del empleo: capital social y violencia simbólica en el mercado de trabajo

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Por un contrato de cohesión social": apuntes exploratorios"

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Los programas sociales y los objetivos de desarrollo del milenio en Argentina

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