989 resultados para Industrial safety committees


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El grup de visió per computadora de la Universitat de Girona, disposava d’un manipulador lineal com a sistema de posicionament, per poder inspeccionar mitjançant visió artificial, la superfície de diverses peces. El control es realitzava a partir d’un PLC, controlant la posició de la plataforma de posicionament a partir d’un servomotor, un servocontrolador i una targeta d’entrada i sortida de polsos. Es pretén la recuperació d’aquest sistema de posicionament lineal a partir de la recopilació de la informació inicial. El nou ús serà enfocat al posicionament i a la classificació de diversos elements. D’aquesta forma es podrà estudiar el funcionament d’un servomotor governat per un servodriver i una targeta d’entrada i sortida de polsos i s’utilitzarà com a element didàctic per a la universitat. Es complementarà la documentació disponible i s’elaborarà informació tècnica

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PURPOSE Inotuzumab ozogamicin (CMC-544) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic agent. This was a phase I study to determine the maximum-tolerated dose (MTD), safety, and preliminary efficacy of inotuzumab ozogamicin in an expanded MTD cohort of patients with relapsed or refractory CD22(+) B-cell non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS Inotuzumab ozogamicin was administered intravenously as a single agent once every 3 or 4 weeks at doses ranging from 0.4 to 2.4 mg/m(2). Outcomes included MTD, safety, pharmacokinetics, response, progression-free survival (PFS), and overall survival. Results Seventy-nine patients were enrolled. The MTD was determined to be 1.8 mg/m(2). Common adverse events at the MTD were thrombocytopenia (90%), asthenia (67%), and nausea and neutropenia (51% each). The objective response rate at the end of treatment was 39% for the 79 enrolled patients, 68% for all patients with follicular NHL treated at the MTD, and 15% for all patients with diffuse large B-cell lymphoma treated at the MTD. Median PFS was 317 days (approximately 10.4 months) and 49 days for patients with follicular NHL and diffuse large B-cell lymphoma, respectively. CONCLUSION Inotuzumab ozogamicin has demonstrated efficacy against CD22(+) B-cell NHL, with reversible thrombocytopenia as the main toxicity.

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Monthly newsletter for public safety

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Monthly newsletter for public safety. Information in this document has been redacted at the request of one of the named individuals. To examine the unedited document, please contact Iowa Library Services / State Library of Iowa – Main Library, 1112 E. Grand Avenue, Des Moines, IA 50319, (515) 242-6542, 1-800-248-4483.

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