COMPARAÇÃO DE MODELOS DE AVALIAÇÃO DE DESEMPENHO DE EQUIPES MULTIFUNCIONAIS BASEADOS EM CONCEITOS DE INTERAÇÃO DE GRUPOS E FERRAMENTAS DE ANÁLISE COMPORTAMENTAL

Avaliação de desempenho de equipes multifuncionais é um conceito que tem sido abordado mais freqüentemente nas últimas duas décadas. Diversas teorias e conceitos foram desenvolvidos para tornar as avaliações menos qualitativas ou fundamentadas em percepções, compreendendo um conjunto de diferentes técnicas interpretativas que visam descrever e decodificar os componentes de um sistema complexo de significados. Com esse foco o projeto comparou três modelos de avaliação de desempenho de equipes. O primeiro modelo baseado na personalidade do participante, afirma que os resultados das equipes são influenciados pela seleção prévia dos participantes e que as características individuais desses participantes são críticas para o desempenho da equipe. O segundo modelo fundamenta suas afirmações nas relações interconectadas de positividade e negatividade; questionamento e argumentação e atuação em equipe. O terceiro modelo baseado no processo de interação de grupos também avalia as relações que influenciam o alto desempenho de equipes multifuncionais. Os três modelos foram comparados, através de um estudo de caso único em indústria química paulista, medindo-se os resultados de correlação das equipes e as interações entre os participantes das equipes. As metas atingidas pelas equipes foram utilizadas para suportar os resultados das avaliações dos modelos como sistema de avaliação de equipes. Pode-se concluir que houve uma aproximação satisfatória confirmando a influência sugerida pelos modelos avaliados. A comparação entre os três modelos não permitiu afirmar qual dos três modelos é mais eficaz para avaliação de equipes. Entretanto, é possível, sugerir que a combinação de elementos dos três modelos permitirá a construção de um processo eficaz e prático de avaliação de equipes.(AU)

ROTATIVIDADE DOCENTE EM PROGRAMAS DE PÓS-GRADUAÇÃO EM ADMINISTRAÇÃO: UM ESTUDO DE CASOS MÚLTIPLOS

Esta pesquisa analisa a rotatividade docente como uma variável dependente do contexto em que os PPGAs (Programas de Pós-Graduação em Administração) analisados estão imersos. Portanto, foi adotada a Metodologia de Estudo de Casos Múltiplos com viés em redes sociais. Considera-se que as deliberações regulatórias da CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) e símbolos tais como estatutos, regimentos e cânones dos casos analisados neste estudo, influenciam as decisões de demitir. Foram encontrados indícios de que se trata da crença em uma rotatividade funcional como prática emergente no campo das IESs confessionais (UMESP, PUC/SP e UPM) como um recurso para adaptar-se às mudanças propostas pela CAPES. Para tal, com objetivo de produzir melhoras na produtividade científica e enquadrar-se aos critérios de avaliação da CAPES, os coordenadores de PPGA-Ego atribuem à rotatividade docente em outro PPGA-Alter como principal fator de sucesso do PPGA-Alter. As evidências encontradas se fundamentam na inter-subjetividade entre coordenadores de distintos programas dos casos analisados, portanto a rotatividade funcional pode ser dependente do contexto e não se trata de em fenômeno aleatório ou mesmo atomístico. O presente trabalho também contribui para a sugestão de futuros trabalhos, como por exemplo, a rotatividade disfuncional além de outros descritos no final. Em todos os três casos PPGA UMESP, PPGA UPM e PPGA PUC-SP ocorreu mobilidade docente para instituições estatais e particulares, que segundo os coordenadores entrevistados representava um movimento desfavorável sob algum aspecto para os docentes que se demitiram. Neste sentido passa a ser necessário um trabalho específico, eventualmente uma avaliação empírica com base nos constructos de intenção em demitir-se fundamentada nos estudos de Comportamento Organizacional ou Psicologia I/O (Industrial e Organizacional) como Congruência Pessoa-Organização (ARGYRIS, 1973, KRISTOFF, 1996), Modelos de RH (ARTHUR, 1982; MOBLEY, 1982; BAUM, 1993), Modelo Steers e Mowday e outros. Porém contextualizado e estruturado.

CERTIFICAÇÃO E AVALIAÇÃO DE DESEMPENHO DE DIRETORES ESCOLARES NA BAHIA: IMPLEMENTAÇÃO POLÍTICA E A VISÃO DOS SUJEITOS AVALIADOS

Este trabalho analisa o processo de implementação das políticas de certificação ocupacional (de competências) e de avaliação de desempenho (em serviço) de dirigentes escolares, na rede estadual de ensino da Bahia. Busca também aferir a visão que os sujeitos avaliados têm sobre essas políticas. As políticas de certificação e de avaliação de desempenho de dirigentes escolares integraram o Programa Educar para Vencer, formulado em 1999, no Governo de César Borges, em consonância com a reforma gerencialista da administração pública estadual que já vinha sendo planejada, desde a gestão do Governador Antônio Carlos Magalhães (1991-1993) e com a reforma administrativa gerencialista do Estado brasileiro realizada a partir de 1995, durante a presidência de Fernando Henrique Cardoso. Para desenvolver nossa análise, abordamos inicialmente as mudanças ocorridas no mundo do trabalho, a partir da década de 1970 e suas influências nos processos de formação e certificação profissional (baseados em competências). Em seguida, discutimos sobre a lógica que vem norteando a avaliação de profissionais da educação básica no Brasil. No percurso metodológico, além da pesquisa bibliográfica, utilizamos a pesquisa documental e a pesquisa empírica. A pesquisa empírica teve como público-alvo dez diretores escolares da rede estadual de ensino do município de Salvador. Com o estudo realizado, pudemos evidenciar que as políticas de avaliação de dirigentes escolares implantadas na rede estadual de ensino baiana assumem um caráter regulatório do trabalho desses profissionais, com base no mérito individual. Os diretores entrevistados apresentam uma visão equivocada e contraditória com relação à lógica que permeia essas políticas.(AU)

Estratégias de enfrentamento e avaliação de stress em adolescentes atletas

O presente estudo teve por objetivos: a) descrever estratégias de enfrentamento (coping) utilizados por adolescentes atletas participantes de competições; b) descrever e relacionar os tipos de enfrentamento desses adolescentes segundo a prática esportiva individual e coletiva c) identificar o nível de stress desses atletas; d) relacionar as estratégias de enfrentamento com grau de stress. Selecionou-se por critério aleatório e conveniência, uma amostra de 141 atletas-adolescentes, estudantes, com idades entre 15 e 18 anos, sendo 66 meninas e 75 meninos. Estes eram estudantes do ensino médio de escolas privadas da região da Grande São Paulo, atletas que treinavam e participavam de competições esportivas de âmbito escolar e alto rendimento em categorias de base. Utilizou-se uma escala auto-aplicável de enfrentamento (coping) para adolescentes, composta por 80 itens, e um inventário de stress composto por 44 itens. Os resultados indicaram qure na amostra geral houve maior emprego da estratégia de aproximação; porém, numa separação em sub-grupos foram verificadas diferenças quanto ao gênero, pois as houve predomínio da estratégia de evitação entre as meninas. Quanto ao tipo de esporte coletivo e individual não se encontraram diferenças significativas, mestre entre meninos e meninas. O grau de stress esteve em média normal na amostra geral, porém quando se separa meninos e meninas, observou-se maior presença de sintomas entre os meninos e entre atletas praticantes da modalidade individual - xadrez. Também não foram encontradas diferenças significativas na correlação entre enfrentamento e stress. Entendeu-se que esse tipo de investigação pode auxiliar na compreensão desses jovens praticantes de esporte, bem como se levanta a hipótese de que a prática esportiva escolar, ainda que em nível de competição, pode ter uma influência positiva, tanto no enfrentamento quanto na administração do stress entre esses jovens.

Avaliação do desempenho na Polícia de Segurança Pública (PSP)- Estudo de caso do Comando Distrital da PSP de Braga

Com esta dissertação pretende-se estudar o modelo de avaliação de desempenho existente na Polícia de Segurança Pública (PSP), a nível central e a nível do Comando Distrital da PSP de Braga, bem como a forma como ambos os modelos se articulam.Tendo em conta a revisão de literatura efetuada, constata-se que a avaliação de desempenho tem vindo a assumir um papel importante na Polícia, sendo útil para melhorar os serviços prestados,apoiar na tomada de decisões, responsabilizar os gestores e prestar contas à sociedade. A literatura refere ainda que a Polícia é um serviço difícil de avaliar devido à diversidade de atividades que esta desenvolve e à dificuldade em aferir a segurança dos cidadãos e a redução da criminalidade.Para se perceber o modelo de avaliação existente na PSP propõe-se fazer um estudo de caso,através de entrevistas, contando com a colaboração do Diretor Nacional Adjunto da Unidade Orgânica de Recursos Humanos, do 2º Comandante Distrital do Comando Distrital de Braga e do Diretor do Gabinete de Estudos e Planeamento da Direção Nacional da PSP.Neste estudo verifica-se que o modelo de avaliação de desempenho da PSP é um modelo centralizado uma vez que é a Direção Nacional (DN) da PSP que define os objetivos estratégicos, os objetivos operacionais, os indicadores e as metas para todo o seu universo. Os resultados desta avaliação são apresentados no Relatório de Atividades da PSP. A nível central também é utilizado o Sistema Integrado de Gestão e Avaliação de Desempenho na Administração Pública – Quadro de Avaliação e Responsabilidades (SIADAP – QUAR). Por outro lado, ao nível do Comando Distrital de Braga verifica-se que não existe um modelo de avaliação de desempenho. Estes recebem a informação sobre os objetivos operacionais, os indicadores e as metas a atingir estabelecidas pela DN, que tentam cumprir num determinado período e no final comunicam-lhes os resultados. A DN agrega todos os resultados a nível Nacional e faz a avaliação global do desempenho da PSP.O estudo mostra ainda que há uma forte predisposição para a implementação de um modelo de avaliação de desempenho baseado na metodologia Balanced Scorecard (BSC), por este ser considerado um modelo eficaz, com larga utilização a nível mundial e com bons resultados alcançados. Atualmente a DN já define o seu quadro estratégico baseado nas quatro perspetivas do BSC: perspetiva do cliente, perspetiva financeira, perspetiva dos processos internos e perspetiva da aprendizagem. Contudo, até ao momento não são apresentados os resultados desta avaliação de acordo com o modelo BSC. Conclui-se, por isso, que o modelo de avaliação existente na PSP é um modelo extremamente centralizado na DN, sendo reduzido o envolvimento dos Comandos Distritais neste processo.

Evidências de validade do Millon Behavioral Medicine Diagnostic: avaliação de indicadores de adesão ao tratamento em pacientes com hipertensão

Systemic Arterial Hypertension – SAH – is defined as the syndrome which its main feature is the presence of high tensional levels, associated with alterations of functional or structural levels in the organs that it strikes. Its specific causes are not very well bounded and have an asymptomatic character. Due to its chronicity it requires adherence to the treatment plan in a systematic and permanent manner, implicating in lifestyle changes, combined or not with the use of medication. The personality inventories have been largely used in the lineation of indicative traits of difficulties with the adherence to the treatment. In this sense, developed by Theodore Millon, the Millon Behavioural Medicine Diagnostic – MBMD is an instrument made from the consensus among healthcare professionals, aiming at identifying psychological factors that may compromise medical treatment so that they can be conducted in a way to enable a better adherence. Objective: evaluation of the evidence of validity of the Millon Behavioural Medicine Diagnostic – MBMD for a public of patients with hypertension, aiming at investigating the indicators implicated in the adherence or not to the anti-hypertensive treatment. Method: there was a group of 200 participants in a university hospital in the city of Natal/RN, males and females, ranging from 20 to 70 years old. An interview protocol was administered in order to obtain information about socio-demographic data, clinical history, healthcare habits and way of conducting treatment, and after, the administration of the MBMD followed. Results: by means of Factor Analysis it was verified that the organization proposed by the factors is favorable and it adjusts to the theory, allowing the visualization of other underlying constructs to the scales, with adequate adjustment indexes and satisfactory Cronbach’s alpha indicators. Besides, the MBMD revealed itself sensitive to the intragroup differences relative to the sex, age, schooling, marital status, profession, income, SAH history, diagnostic time, medication use, comorbidity presence, hyposodic diet, social support and adherence criteria variables. The utilization of such instrument in the evaluation of the adherence to the anti-hypertensive treatment show, therefore, indicators of validity.

Programa Nacional de Incentivo à Leitura - PROLER: avaliação da implementação pelo Comitê Potiguar

The National Reading Incentive Program (PROLER) is a national initiative to promote and encourage reading throughout the country, linked to the National Library Foundation (FBN) of the Ministry of Culture (MinC). This research aims to assess the PROLER’s implementation process in the state of Rio Grande do Norte, from the actions of their local committee. The framework is based on contextualize the policies that seek to encourage the book and reading, as well as the processes of implementation and evaluation of public policies. The research is understood as a qualitative descriptive-exploratory study, comprising a single case study. Makes use of semi-structured interview as a tool for data collection, which was attended by 8 members of Potiguar Committee as respondents. The techniques of bibliographical and documentary analysis were used for the analysis and discussion of data obtained from surveys and documents on PROLER; as to the content of the interviews, the technique used was the analysis of conversations. As for the results, the existence of four barriers to program implementation in the state that are worth mentioning is observed: a) the political-administrative discontinuity; b) the limited resources and few partnerships; c) the management of school libraries and absence from the post of librarian in the state and; d) the absence of a process or assessment tool able to evaluate the results or the impacts of actions taken by the Potiguar Committee. It was noticed that these limiting four come PROLER making the implementation of the Rio Grande do Norte a process that, although complying with the national regulations of teacher training and follow school libraries and their needs, not flawed to develop assessments that can measure program impacts, making the feedback process of ineffective policy. Another observation of this study is seen in the fact that the Committee did not get enough to supply their shares resources, as well as not being able to articulate new partnerships, thus contributing negatively to the scope of the program form and, consequently, for the effectiveness of their actions. Has even mentioning the fact that the Committee do nothing regarding the mismanagement of the libraries that are in their care, ie, do not use the power of coercion as guaranteed by the National Policy on Reading and federal laws that treat the school library, and is therefore ineffective in relation to compliance with the program guidelines

Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal

Parkinson disease (PD) is associated with motor symptoms and dopaminergic cell loss in the nigrostriatal pathway. Alpha-synuclein is the major component of the Lewy bodies, the biological hallmarks of disease, and has been associated with familial cases of PD. Recently, the spinal cord stimulation (SCS) showed to be effective to alleviate the Parkinson symptoms in animal models and human patients. In this project, we characterized the motor and electrophysiological effects of alpha-synuclein overexpression in the substantia nigra of rats. We further investigated the effects of spinal electrical stimulation, AMPT and L-dopa administration in this model. Method: Sprague-Dawley rats were injected with empty viral vector or the vector carrying the gene for alpha-synuclein in the substantia nigra, and were tested weekly for 10 weeks in the open field and cylinder tests. A separated group of animals implanted with bilateral electrode arrays in the motor cortex and the striatum were recorded in the open field, during the SCS sessions and the pharmacological experiments. Results: Alpha-synuclein expression resulted in motor asymmetry, observed as the reduction in use of contralateral forepaw in the cylinder test. Animals showed an increase of local field potential activity in beta band three and four weeks after the virus injection, that was not evident after the 5th week. AMPT resulted in a sever parkinsonian state, with reduction in the locomotor activity and significant peak of oscillatory activity in cortex and striatum. SCS was effective to alleviate the motor asymmetry at long term, but did not reduce the corticostriatal low frequency oscillations observed 24 hs after the AMPT administration. These oscillations were attenuated by L-dopa that, even as SCS, was not effective to restore the locomotor activity during the severe dopaminergic depletion period. Discussion: The alpha-synuclein model reproduces the motor impairment and the progressive neurodegenerative process of PD. We demonstrated, by the first time, that this model also presents the increase in low frequency oscillatory activity in the corticostriatal circuit, compatible with parkinsonian condition; and that SCS has a therapeutic effect on motor symptom of this model.

Avaliação da estrutura e processo de trabalho dos centros de atenção psicossocial

Objective: Evaluate the work structure and process in Psychos ocial Care Centers (CAPS) and the professionals profile, the satisfaction, conditions and work overload. Methods: Cross - sectional study conducted in five CAPS in Campina Grande city. The study sample consisted of five coordinators, 42 graduate professional s, 26 mid - level (technical and auxiliary nurses, and caregivers), and the medical records pertaining to 413 users followed up. Data were collected using validated questionnaires (CAPSUL - rating CAPS in southern Brazil) and adapted to the study, between July and October 2014. The questionnaires were double entered and submitted to validation in the sub - program “Validate Epi Info 3.5.4” , used along with the “SPSS 17.0” for processing the statistical analyzes. Measures of central tendency and dispersion were ap plied to the descriptive analyzes; “Fisher's” exact test to check the CAPS impact on hospital admissions and the “Bonferroni” adjusted to verify the diagnoses according to sex. 5% significance level was adopted. The study was approved by the Ethics Committ ee of the Rio Grande do Norte Federal University (UFRN), protocol 719.435, of 05.30.2014. Results: From the structure analysis were identified contextual factors that influenced the work process of CAPS professionals, such as: deficiencies with regard to h uman resources; forms of health professionals employment and qualifications; temporary contract existence. As to process dimension, it was found that the home visits performance by health professionals shows to be ineffective, given its insufficiency and i rregularity, which can be explained by the high demand, reduced staff and transportation lack. It was low coverage of items inherent to Therapeutic Individual Project, as the income generation program, insertion at work and home visit. The reference and co unter reference flow are still not satisfactorily organized. There was statistically significant difference for the diagnosis, with a predominance of mood disorders related to stress among women and those related to alcohol and other drugs among men (p <0. 05). There was an association between the degree of health professionals satisfaction and working conditions, overload and factors related to the content and working conditions, the security measures, comfort and CAPS appearance, contact between the teams and users, families treatment by the teams, temporary employment relationship. Conclusion: The data collected indicate the need for the CAPS organization through increased investments in the sector in order to enhance the infrastructure as potentiating el ement of practices with a view to changing the care model for mental health proposed by the Psychiatric Reform. It is hoped therefore that this research will contribute to better planning in CAPS unit management, with another tool to improve the dimensions involving the structure and the professional work process and improve this mental health care model.

Padronização de testes para avaliação do estado de mania e potencial anti-maníaco de um agonista do receptor NOP

Bipolar disorder is characterized by mood impairment, alternating between mania/hypomania and depression, and its exact pathophysiology is already unknown. The treatment of bipolar disorder is based on prevention of the manic and depressive episodes using mood stabilizers. Nociceptin/orfanin FQ (N/OFQ) is an endogenous heptadecapeptide which binds as an agonist to NOP receptor, which is a G-coupled inhibitory receptor. N/OFQ and its receptor modulate a lot of functions in the organism, including emotional processes. It is known that the plasmatic concentration of N/OFQ is altered in patients in both phases depressive and manic of bipolar disorder and it is assumed that this system has a role on the etiology of this disorder. Concerning mania, the animal models used in research tend to focus in an unique aspect of the manic behavior, as hyperactivity or agressivity. In the 60’s, the hole board test was proposed, and it consists of an apparatus with holes where a behavior known as head-dippings is measured. High levels of head-dippings are suggestive of neophilia, while low levels can be characteristic of an anxious-like behavior. As the increase of exploratory and goal-directed behavior are characteristics of manic behavior, this test could help in mania research. Thus, this work was organized in 3 steps and aims to: (1) investigate the induction of a manic-like state promoted by ouabain, a Na+/K+-ATPase inhibitor, in the mouse open field test; (2) set up the hole board as a test to measure manic-like behaviors; and (3) investigate the N/OFQ effects in prevention of this kind of behavior on hole board. Male Swiss mice were used in this study, and they take part of only one of the described steps. Depending on the step performed, mice received one or more of the following treatments: (1) ouabain 10-6 , 10-5 , 10-4 , 10-3 or 10-2 M, intracerebroventricular (icv); (2) sodium valproate 300 mg/kg, intraperitoneal (ip); (3) sodium valproate 400 mg/kg, ip; (4) diazepam 1 mg/kg, ip; (5) methylphenidate 10 mg/kg, ip; and (6) N/OFQ 0,1 or 1 nmol, icv. The results suggest that hole board can be used to evaluate a manic state, through analysis of different animal behaviors. However, it was not possible to standard the model of Na+ /K+ -ATPase dysfunction through ouabain administration in mice. Moreover, the data suggest that N/OFQ, at the doses tested, has not affected the methylphenidate-induced mania-like behavior. Taken together, the results point to a new approach of manic research, through the hole board using. However, more studies are necessary in order to verify the role of N/OFQ system on bipolar disorder.

Avaliação dos efeitos do extrato de Passiflora cincinnata Masters em camundongos: efeito na ansiedade e potencial neuroprotetor

Anxiety disorders and Parkinson’s disease (PD) affect a large portion of the world population. Indeed, therapeutic alternatives available do not contribute to improve most clinical conditions and/or are linked with undesirable side effects. Thus, there is a great demand for the development of new drugs to treatment of these diseases. Passiflora cincinnata Mast. is a native species present in several Brazilian states, popularly known as “maracujá do mato”, “maracujá tubarão” or “maracujá mochila”. Additionally, species of Passiflora genus are traditionally known for their exotic flowers, edible fruits with pronounced flavor and for their sedative, tranquilizer and anxiolytic properties reported by folk medicine. These plants possess important organic compounds such as phenols, cyanogenic glycosides, flavonoids and alkaloids, which are responsible for the anxiolytic, antioxidant, anti-inflammatory, antihyperglycemic, among others activities when tested in mammals. Despite this fact, only a few studies have been conducted to investigate the possible in vivo biological effects of Passiflora cincinnata Mast extracts. Thereby, in this study we evaluated the effects of the alcoholic extract of this plant in anxiety and PD animal model. Mice acutely or chronically administered with ethanolic extract of P. cincinnata do not showed any anxiogenic- or anxyolitic-like effect in elevated plus maze (EPM). In order to reproduce PD symptom’s in mice, we administered repeated injections of reserpine which progressively induced motor impairments such as increase in catalepsy, oral movements, and reduction of the average speed of the animals in the open field, as well as depleted dopamine prodution in SNpc cells. Furthermore, this treatment resulted in the loss of aversive memory recall in mice when undergoing PMDAT. Yet, passiflora group also show this amnesic profile. However, animals treated concomitantly with the alcoholic extract of Passiflora cincinnata Mast. showed higher latency for the onset of motor impairment evaluated by catalepsy. Thus, our results shows that the alcoholic extract of the plant P. cincinnata was able to delay the onset of the catalepsy induced by reserpine administration, plus reverted the depletion of dopamine production in SNpc cells.

Análise fitoquímica e avaliação das atividades anti-inflamatória, antipeçonhenta e citotóxica de extratos aquosos de Aspidosperma pyrifolium e Ipomoea asarifolia

Envenomation caused by venomous animals, mainly scorpions and snakes, are a serious matter of public health. Tityus serrulatus is considered the most venomous scorpion in South America because of the high level of toxicity of its venom. It is responsible for causing serious accidents, mainly with kids. The species Bothrops jararaca is a serpent that has in its venom a complex mixture of enzyme, peptides and other molecules. The toxins of the venom of B. jararaca induce local and systemic inflammatory responses. The treatment chosen to serious cases of envenomation is the intravenous administration of the specific antivenom. However, the treatment is not always accessible to those residents in rural areas, so that they use medicinal plant extracts as the treatment. In this context, aqueous extracts, fractions and isolated compounds of Aspidosperma pyrifolium (pereiro) and Ipomoea asarifolia (salsa, salsa-brava), used in popular medicine, were studied in this research to evaluate the anti-inflammatory activity in the peritonitis models induced by carrageenan and peritonitis induced by the venom of the T. serrulatus (VTs), and in the local oedema model and inflammatory infiltrate induced by the venom of the B. jararaca, administrated intravenously. The results of the assays of cytotoxicity, using the MTT, showed that the aqueous extracts from the plant species presented low toxicity to the cells that came from the fibroblast of the mouse embryo (3T3).The chemical analysis of the extracts by High Performance Liquid Chromatography revealed the presence of the rutin flavonoid, in A. pyrifoliu, and rutin, clorogenic acid and caffeic acid, in I. asarifolia. Concerning the pharmacological evaluation, the results showed that the pre-treatment using aqueous extracts and fractions reduced the total leukocyte migration to the abdominal cavity in the peritonitis model caused by the carrageenan and in the peritonitis model induced by the T. serulatus venom. Yet, these groups presented anti-oedematous activity, in the local oedema model caused by the venom of the B. jararaca, and reduced the inflammatory infiltrate to the muscle. The serum (anti-arachnid and anti-bothropic) specific to each venom acted inhibiting the inflammatory action of the venoms and were used as control. The compounds identified in the extracts were also tested and, similar to the plant extracts, showed meaningful anti-inflammatory effects, in the tested doses. Thus, these results are indicating the potential anti-inflammatory activity of the plants studied. This is the first research that evaluated the possible biological effects of the A. pyrifolium and I. asarifolia, showing the biological potential that these species have.

Avaliação anti-inflamatória e antipeçonhenta das espécies Hancornia speciosa e Mimosa tenuiflora em modelos experimentais de inflamação e envenenamento induzidos por Bothrops jararaca e Tityus serrulatus

Accidents caused by venomous animals represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world by the frequency with which they occur and the mortality they cause. The use of plant extracts as an antidote for poisoning cases is an ancient practice used in many communities that have no access to antivenom. Medicinal plants represent an important source of obtaining bioactive compounds able to assist directly in the treatment of poisoning or indirectly supplementing serum therapy currently used. The aim of this study was to evaluate the effect of extracts, fractions and isolated compounds from M. tenuiflora and H. speciosa in the inflammatory process induced by carrageenan and the venom of B. jararaca and T. serrulatus. The results showed that both M. tenuiflora and H. speciosa were capable of inhibiting cell migration and cytokines levels in peritonitis induced by carrageenin and venom of T. serrulatus. In poisoning by B. jararaca model, mice treated with the plants in studies decreased the leukocyte influx into the peritoneal cavity. Finally the M. tenuiflora and H. speciosa had antiphlogistic activity, reducing edema formation and exerted inhibitory action of leukocyte migration in local inflammation induced by the venom of B. jararaca. Through of Thin Layer Chromatography (TLC) analysis was possible identified the presence of flavonoids ,saponins and/or terpenes in aqueous extract of M. tenuiflora. By High Performance Liquid Chromatography analysis, it was possible to identify the presence of rutin and chlorogenic acid in aqueous extract of H. speciosa. We conclude that the administration of extracts, fractions and isolated compounds of H. speciosa and M. tenuiflora resulted in inhibition of the inflammatory process in different experimental models. This study demonstrates for the first time the effect of M. tenuiflora and H. speciosa in inhibition of the inflammation caused by B. jararaca and T. serrulatus venom.

Spondias tuberosa Arr. (UMBU): estudo fitoquímico e avaliação do potencial anti-inflamatório

Spondias tuberosa Arruda (Anacardiaceae) is a fruitful tree popularly known as umbuzeiro, tapereba or umbu. It is a native and endemic species from Brazil, widespread in Brazilian Northeast. The species is important in folk medicine of the semi-arid Northeast, where it is mainly used to treat various inflammatory conditions, digestive problems as well as viral and bacterial infections. However, despite the common use in folk medicine, there are scarce pharmacological and phytochemicals studies that afford scientific evidence to its popular use. Therefore, this study aimed to characterize the chemical markers in S. tuberosa leaves extract, obtained by maceration ethanol:water (70:30, [v/v]), and evaluate its anti-inflammatory potential in vivo. The phytochemical profile in TLC analysis suggested the occurence of the flavonoids rutin and isoquercitrin. HPLC analysis enabled us to confirm the presence of flavonoids and also, were detected the phenolic acids, chlorogenic acid and caffeic acid. In addition was developed and validated a HPLC method to evaluate the content of the identified compounds in S. tuberosa leaves extract according to RDC 899/2003 of ANVISA and ICH Guidelines 2005. In order to evaluate the anti-inflammatory potential of S. tuberosa leaves extract, the peritonitis and paw edema models induced by carrageenan were used, administration i.p. in mice. The results highlighted the anti-inflammatory property in vivo at 125, 250 and 500 mg/kg since a decrease in leukocyte influx to the site of inflammation, diameter of the edema and the level of myeloperoxidase were observed when compared to the drug control dexamethasone (2 mg/kg, i.p. route). Taken together, the results pointed out S. tuberosa as a potential species for developing phytotherapic derivatives in according to its popular use. With regard to the characterization markers, chlorogenic acid, caffeic acid, rutin and isoquercitrin were identified and quantified in Spondias tuberosa leaves extract so they could be used in quality control analyses of the raw material and extracts of this species.

Preceptoria em profissionais de saúde: viabilizando meios para uma formação pedagógica em hospitais públicos em Natal-RN

This study aimed to construct and carry out a distance course of pedagogical training for health professional performing preceptorship functions in public health institutions. The preceptorship in health is a pedagogical practice that occurs in workplace, led by assistance professionals with teaching position or not, where the vast majority of these acts intuitively, reproducing their own training, confusing transmitting information with education. These preceptors often do not dominate the pedagogical knowledge, necessary for the organization of training activities, such as the various teaching-learning processes and the different assessment types. Student supervision is essential in the training process of students in the health field, and on the occasion of supervised internships that the teaching-learning process is based on practical experience with participation in real life situations and professional work. It was realized an exploratory study, descriptive with qualitative approach, with the development of tutoring teaching course in health as final product. Applied semi structured research instrument from may to july 2014. It were evaluated 162 health professionals who perform the preceptorship, which made it possible define the preceptor's profile and identify the educational requirements related to the educational process, which justified the construction of the program content and the professionals’ perception analysis about preceptorship through identification of three categories: clinic knowledge valuation; valuation of professional orientation and valuation of professional future. The course was available on distance mode through Moodle platform with forty hours of work load from October to November 2014. With the aim of capacitate the health professionals to development of necessary abilities and skills to tutoring performance through thoughts about tutoring concepts, professional training within the curricular guidelines and SUS precepts, the role of health professionals as educators, application of active teaching methodologies, and evaluation methods. The applications were done online through the provided link; 300 vacancies offered, 243 professionals applied, chosen 134 that works on tutoring, where 49 represented professionals that works on the location of the study. The course lasted 45 days, and counted with tutors responsible to interact and evaluate the students. 28 professionals joined the course, 12 concluded. Opportunities were identified to stimulate the involvement, however the professionals’ satisfaction shows that, make an investment on tutors education, starting from the Permanent Education precepts, will provide a bigger appropriation of the knowledge to the education and therefore the awareness of their role as an educator on work ambit, proportioning essential tools to tutors act while enabler of integration between theory and practice and result better teaching-learning process.