963 resultados para Farmhouses -- Repair and reconstruction -- Catalonia -- Garrotxa
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Giant cell-rich osteolytic lesions may have overlapping clinical, radiologic, and histopathologic features, with an important degree of difficulty of diagnosis and treatment. We report a case of double osteolytic lesion at the middle-finger in a young man without previous history of hand trauma. He underwent en-bloc resection of the bone lesions and reconstruction by graft of hydroxyapatite, resulting in a good morpho-functional result. Histological diagnosis was giant cell reparative granuloma (GCRG), although several features were considered atypical, including the appearance of the giant cells and the areas of the stroma that more closely resembled a giant cell tumor. GCRG is a benign rare intraosseous lesion and the true nature is controversial and unknown. The theories are that it could be a reactive lesion, a developmental anomaly or a benign neoplasm. It appears as an osteolytic lesion that must be considered in the differential diagnosis of other critical bone lesions similar in clinical, as well as radiologic and pathological appearance. Further characterization studies are helpful and necessary for the proper management.
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A demanda na procura da reabilitao esttica um dos focos da histria da humanidade ao longo das eras, mas que teve a sua acentuao nestes ltimos dois sculos. Sendo a face um dos pontos que nos permite avaliar esteticamente uma pessoa, cabe ao mdico dentista, como um dos profissionais que trabalha nessa zona do corpo humano, avaliar e procurar satisfazer as necessidades estticas da populao. Assim, por parte dos profissionais de Medicina Dentria, tem de haver uma procura constante para a satisfao das exigncias estticas, no s no conhecimento como no aprimoramento da tcnica. Nos ltimos tempos, com a necessidade de desenvolvimento de materiais para colmatar a cada vez maior busca para a perfeio esttica, as facetas surgiram como tratamento de excelncia. O presente trabalho teve como objectivo a comparao entre resina composta e cermica, na elaborao de restauraes estticas. Para os dois tipos de materiais foram avaliados a esttica e o comportamento biomecnico. Foram comparados benefcios e desvantagens, contra-indicaes, indicaes, plano de tratamento, diagnstico e procedimentos clnicos dos dois materiais, utilizados na confeco das facetas cermicas e de resina composta. Foram utilizados os seguintes parmetros de comparao: biocompatibilidade, adaptao marginal, preparao, resistncia, cor, acabamento, potencial de reparao, custo e esttica. A utilizao de facetas cermicas tem sido um dos principais focos de desenvolvimento da Medicina Dentria no mbito cientfico. A sua utilizao permite uma maior predictibilidade e uma maior longevidade clnica. A sua qualidade esttica, resistncia fractura, biodisponibilidade e estabilidade de cor, so as suas maiores vantagens na utilizao clnica. Em sentido inverso, as facetas de resina composta apresentam menor custo, maior resistncia abraso, possibilidade de reparao fcil e menor desgaste de estrutura dentria durante a sua preparao. Contudo apresentam menor estabilidade de cor. Portanto, torna-se esclarecedor que a escolha do material a utilizar na confeco de facetas, deve ser adaptada s especificidades de cada caso.
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Este artculo presenta los resultados de una investigacin donde se usan la justicia ambiental y la comunicacin para el cambio social como ejes tericos. Se desarrolla con metodologas participativas en el contexto de las zonas rurales de Medelln durante el 2013. Su objetivo es identificar y clasificar las percepciones de los actores sociales que participan en la poltica de ordenamiento territorial. Los resultados que se encuentran son: (i) una gran diversidad de actores sociales, (ii) un alto nivel de dispersin de acciones en todo el territorio rural y (iii) unas identidades locales en constante cambio y reconstruccin, pero siempre asociadas a la ruralidad.El artculo finaliza subrayando algunas percepciones colectivas en respuesta a los efectos ambientales del modelo de expansin urbana y cmo los actores sociales de las cinco zonas rurales del municipio de Medelln cuentan con un legado de procesos de participacin comunitaria con potencialidad para incidir con acciones locales en una justicia ambiental.
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The complex known as Oplontis B lies in the shadow of Vesuvius, about 3 kilometers west of Pompeii and 300 meters from the well-known Villa A. Since its first excavation and reconstruction in the 1970s and 1980s, Oplontis B has languished in abandonment virtually unstudied. The Oplontis Project, led by John Clarke and Michael Thomas, began investigating the site in 2012 after completing its work on Villa A. The documentation of the complex is a primary task. In the past few years members of the Project team have cataloged the previously excavated materials, recording over 1200 wine amphorae as well as a variety of other artifacts. At the same time, Marcus Abbott has laser-scanned the building to produce a detailed plan of the site. The excavations have similar aims: to record the 79 CE level of the complex and to investigate its development. This paper discusses the preliminary results of the last two seasons of excavations and cataloging efforts which build on our previous work conducted in 2012 and 2013.
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Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the "sum-over-trips" approach [Abbott, L.F., Fahri, E., Gutmann, S.: The path integral for dendritic trees. Biological Cybernetics 66, 49--60 (1991)]. To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an $I_{h}$ current contributes to a voltage overshoot at the soma.
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Tese de Doutoramento, Educao (Sociologia da Educao), 11 de Julho 2013, Universidade dos Aores.
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The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The "hybrid" detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data collected during operations, such as the status of the fluorescence detector, background light and atmospheric conditions, that are used in both simulation and reconstruction. (C) 2010 Elsevier B.V. All rights reserved.
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Paper based on the text to be published in Moniz, A.B. and Okuwada, K. (2016), Technology Assessment in Japan and Europe, Karlsruhe, KIT Scientific Publishing
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The sequencing of the genome of Chromobacterium violaceum identified one single circular chromosome of 4.8 Mb, in which approximately 40% of the founded ORFs are classified as hypothetical conserved or hypothetical. Some genic regions of biotechnological and biological interest had been characterized, e. g., environmental detoxification and DNA repair genes, respectively. Given this fact, the aim of this work was to identify genes of C. violaceum related to stress response, as the ones involved with mechanisms of DNA repair and/or genomic integrity maintenance. For this, a genomic library of C. violaceum was built in Escherichia coli strain DH10B (RecA-), in which clones were tested to UVC resistance, resulting in five candidates clones. In the PLH6A clone were identified four ORFs (CV_3721 to 3724). Two ORFs, CV_3722 and CV_3724, were subcloned and a synergic complementation activity was observed. The occurrence of an operon was confirmed using cDNA from C. violaceum in a RT-PCR assay. Further, it was observed the induction of the operon after the treatment with UVC. Thus, this operon was related to the stress response in C. violaceum. The mutagenesis assay with rifampicin after the treatment with UVC light showed high frequency of mutagenicity for the ORF CV_3722 (Pol III subunit). In this way, we propose that the C. violaceum subunit can act in DH10B in the translesion synthesis using Pol IV in a RecA independent-manner pathway. In growth curve assays other four clones (PLE1G, PLE7B, PLE10B and PLE12H) were able to complement the function at the dose 5 J/m2 and in mutagenicity assays PLE7B, PLE10B and PLE12H showed frequencies of mutation with significant differences upon the control (DH10B), demonstrating that in some way they are involved with the stress response in C. violaceum. These clones appear to be interrelated, probably regulated by a messenger molecule (eg., nucleotide c-di-GMP) and/or global regulatory molecule (eg., S subunit of RNA polymerase).The results obtained contribute for a better genetic knowledge of this specie and its response mechanisms to environmental stress.
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Despite advances in antibiotic therapy, bacterial meningitis (BM) remains with high mortality and morbidity rates in worldwide. One important mechanism associated to sequels during disease is the intense inflammatory response which promotes an oxidative burst and release of reactive oxygen species, consequently leading to cell death. Activation of DNA repair enzymes during oxidative stress has been demonstrated in several neurological disorders. APE1/Ref-1 is a multifunctional protein involved in DNA repair and plays a redox function on transcription factors such as NFkB and AP-1.The aim of this study was assess the role of APE1/Ref-1 on inflammatory response and the possibility of its modulation to reduce the sequels of the disease. Firstly it was performed an assay to measure cytokine in cerebrospinal fluid of patients with BM due to Streptococcus pneumoniae and Neisseriae meningitides. Further, a cellular model of inflammation was used to observe the effect of the inhibition of the endonuclease and redox activity of APE1/Ref-1 on cytokine levels. Additionally, APE1/Ref-1 expression in cortex and hippocampus of rat with MB after vitamin B6 treatment was evaluated. Altogether, results showed a similar profile of cytokines in the cerebrospinal fluid of patients from both pathogens, although IFNy showed higher expression in patients with BM caused by S. pneumoniae. On the other hand, inhibitors of APE1/Ref-1 reduced cytokine levels, mainly TNF-. Reduction of oxidative stress markers was also observed after introduction of inhibitors in the LPS-stimulated cell. In the animal model, BM increased the expression of the protein APE1/Ref-1, while vitamin B6 promoted reduction. Thereby, this data rise important factors to be considered in pathogenesis of BM, e.g., IFNy can be used as prognostic factor during corticosteroid therapy, APE1/Ref-1 can be an important target to modulate the level of inflammation and VIII oxidative stress, and vitamin B6 seems modulates several proteins related to cell death. So, this study highlights a new understanding on the role of APE1/Ref-1 on the inflammation and the oxidative stress during inflammation condition
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Este trabalho tem por objetivo discutir as ambigidades identitrias vivenciadas pelos atores sociais, representantes de organizaes familiares que se agrupam na Feira Hippie de Belo Horizonte (Minas Gerais/Brasil). O embasamento terico da discusso est ancorado na abordagem de identidade e nos processos de identificao social, enquanto que o material emprico provm de uma investigao em organizaes familiares. O mtodo de pesquisa adotado foi o qualitativo, baseado na Anlise do Discurso e na histria de vida dos gestores familiares ao longo dos seus 36 anos de atuao na Feira. A anlise evidenciou os processos de construo e desconstruo de determinadas identificaes por parte dos gestores familiares em relao Feira em determinados contextos ao longo de sua histria. Alm disso, foi possvel perceber que tais processos de identificao mantiveram uma estreita relao com a dinmica dos grupos sociais na ocupao de um dado espao fsico e simblico onde os dois elementos: os grupos e o espao desempenharam papel ativo na construo dessas identificaes sociais e organizacionais, no incio como feira de artesanato e depois como feira de variedades.
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En endodoncia durante las ltimas dcadas se han realizado avances en el campo de los materiales biocermicos que pueden ser utilizados para: obturacin retrgrada, recubrimiento pulpar, reparacin de perforaciones, tratamiento de dientes con pices abiertos, reparacin de defectos de reabsorcin y tambin se usan como cementos selladores, atribuyndoseles grandes ventajas comparadas con los selladores tradicionales. Los materiales biocermicos han demostrado la capacidad de superar algunas de las limitaciones de las generaciones anteriores de materiales de endodoncia, pues presentan excelentes propiedades fisicoqumicas y biolgicas por lo que en la actualidad su uso es recomendado ampliamente en la prctica clnica. Este artculo se centra en la revisin de los nuevos materiales biocermicos utilizados en endodoncia, sus caractersticas fisicoqumicas, biolgicas, sus ventajas y desventajas, as como su uso en aplicaciones clnicas.
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Lmergence du postmodernisme aux Etats-unis, mouvement esthtique rejetant les dogmes modernistes, date des annes 1960. En simposant, durant les dernires dcennies du 20me sicle, comme le paradigme esthtique de larchitecture, des arts et de la littrature, le postmodernisme a galement cr les conditions propres une renaissance du roman historique. Cependant, la fiction historique postmoderne constitue maintenant une nouvelle forme du genre base sur la parodie, lironie et le scepticisme envers les discours dominants. Cette nouvelle forme ne se limite plus la prsentation des rcits dans un cadre historique raliste. Elle remet plutt en question la validit et par consquent la nature mme du discours historique, problmatisant et mettant ainsi lavant le processus dinterprtation et de reconstruction du pass. Dans cette optique, la fiction historique contemporaine reflte les dbats actuels sur les formes de lhistoriographie, dbats lancs par Hayden White. Dans les annes 1980, la fiction historique a de nouveau fleuri dans l'espace culturel allemand tout comme ailleurs. Le prsent mmoire analyse des formes postmodernes de la fiction historique en se basant sur trois romans historiques de langue allemande parus entre 1981 et 2005: Die Schrecken des Eises und der Finsternis de Christoph Ransmayr, Die Vermessung der Welt de Daniel Kehlmann et Marbot : Eine Biographie de Wolfgang Hildesheimer. Lanalyse s'appuie sur divers modles de la fiction postmoderne, en particulier sur le schma de catgorisation du roman historique labor par Ansgar Nnning. Le mmoire montre dans quelle mesure ces romans appliquent des moyens stylistiques typiques pour le postmodernisme et portent un regard critique ou comique sur lhistoire et la culture allemande et autrichienne.
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Mobile sensor networks have unique advantages compared with wireless sensor networks. The mobility enables mobile sensors to flexibly reconfigure themselves to meet sensing requirements. In this dissertation, an adaptive sampling method for mobile sensor networks is presented. Based on the consideration of sensing resource constraints, computing abilities, and onboard energy limitations, the adaptive sampling method follows a down sampling scheme, which could reduce the total number of measurements, and lower sampling cost. Compressive sensing is a recently developed down sampling method, using a small number of randomly distributed measurements for signal reconstruction. However, original signals cannot be reconstructed using condensed measurements, as addressed by Shannon Sampling Theory. Measurements have to be processed under a sparse domain, and convex optimization methods should be applied to reconstruct original signals. Restricted isometry property would guarantee signals can be recovered with little information loss. While compressive sensing could effectively lower sampling cost, signal reconstruction is still a great research challenge. Compressive sensing always collects random measurements, whose information amount cannot be determined in prior. If each measurement is optimized as the most informative measurement, the reconstruction performance can perform much better. Based on the above consideration, this dissertation is focusing on an adaptive sampling approach, which could find the most informative measurements in unknown environments and reconstruct original signals. With mobile sensors, measurements are collect sequentially, giving the chance to uniquely optimize each of them. When mobile sensors are about to collect a new measurement from the surrounding environments, existing information is shared among networked sensors so that each sensor would have a global view of the entire environment. Shared information is analyzed under Haar Wavelet domain, under which most nature signals appear sparse, to infer a model of the environments. The most informative measurements can be determined by optimizing model parameters. As a result, all the measurements collected by the mobile sensor network are the most informative measurements given existing information, and a perfect reconstruction would be expected. To present the adaptive sampling method, a series of research issues will be addressed, including measurement evaluation and collection, mobile network establishment, data fusion, sensor motion, signal reconstruction, etc. Two dimensional scalar field will be reconstructed using the method proposed. Both single mobile sensors and mobile sensor networks will be deployed in the environment, and reconstruction performance of both will be compared.In addition, a particular mobile sensor, a quadrotor UAV is developed, so that the adaptive sampling method can be used in three dimensional scenarios.
Resumo:
Lmergence du postmodernisme aux Etats-unis, mouvement esthtique rejetant les dogmes modernistes, date des annes 1960. En simposant, durant les dernires dcennies du 20me sicle, comme le paradigme esthtique de larchitecture, des arts et de la littrature, le postmodernisme a galement cr les conditions propres une renaissance du roman historique. Cependant, la fiction historique postmoderne constitue maintenant une nouvelle forme du genre base sur la parodie, lironie et le scepticisme envers les discours dominants. Cette nouvelle forme ne se limite plus la prsentation des rcits dans un cadre historique raliste. Elle remet plutt en question la validit et par consquent la nature mme du discours historique, problmatisant et mettant ainsi lavant le processus dinterprtation et de reconstruction du pass. Dans cette optique, la fiction historique contemporaine reflte les dbats actuels sur les formes de lhistoriographie, dbats lancs par Hayden White. Dans les annes 1980, la fiction historique a de nouveau fleuri dans l'espace culturel allemand tout comme ailleurs. Le prsent mmoire analyse des formes postmodernes de la fiction historique en se basant sur trois romans historiques de langue allemande parus entre 1981 et 2005: Die Schrecken des Eises und der Finsternis de Christoph Ransmayr, Die Vermessung der Welt de Daniel Kehlmann et Marbot : Eine Biographie de Wolfgang Hildesheimer. Lanalyse s'appuie sur divers modles de la fiction postmoderne, en particulier sur le schma de catgorisation du roman historique labor par Ansgar Nnning. Le mmoire montre dans quelle mesure ces romans appliquent des moyens stylistiques typiques pour le postmodernisme et portent un regard critique ou comique sur lhistoire et la culture allemande et autrichienne.
