1000 resultados para DIFERENCIAÇÃO PEDAGÓGICA


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Os dicionários para aprendizes de línguas estrangeiras são obras relativamente recentes no mercado editorial e atendem uma demanda por obras pedagógicas que foi ignorada pelos lexicógrafos durante muito tempo. Esse segmento do mercado lexicográfico vem se revelando promissor, com diversas possibilidades de inovações. A fim de delinear o campo de desenvolvimento da Lexicografia Pedagógica, este artigo analisa-a sob duas perspectivas: a de suas interfaces com outras áreas da Lingüística e a de seus atores, pessoas cuja atuação influencia a produção de suas obras. Esta exposição tem o objetivo de despertar o interesse de pesquisadores brasileiros pela Lexicografia Pedagógica e, indiretamente, promover a produção nacional de dicionários pedagógicos.

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In this paper, we consider Meneghetti & Bicudo's proposal (2003) regarding the constitution of mathematical knowledge and analyze it with respect to the following two focuses: in relation to conceptions of mathematical knowledge following the fundamentalist crisis in mathematics; and in the educational context of mathematics. The investigation of the first focus is done analyzing new claims in mathematical philosophy. The investigation of the second focus is done firstly via a theoretical reflection followed by an examination of the implementation of the proposal in the process of development of didactic materials for teaching and learning Mathematics. Finally, we present the main results of the application of one of those materials.

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A tubular adenocarcinoma of the colon with solid area composed by small cells that was found by immunohistochemistry study using antibody to neuron-specific enolase (NSE) to possess neuroendocrine differentiation is related. In another areas of the tumor were visualized keratinizing squamous cells. The presence of neuro-endocrine and squamous cells features provide further evidence that neoplastic colonic cells have the capacity for multi-directional differentiation. The implications of this combination in relation to theories of tumor origin and differentiation and the prognostic significance of neuro-endocrine cells in malignant neoplasms of the gastrointestinal tract are discussed.

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Some recent articles have reported that mesenchymal stem cells (MSCs) can be induced to express hepatocyte markers by transplanting them into animal models of liver damage, or by in vitro culture with growth factors and cytokines. In this study, the aim is to evaluate the behavior of MSCs subjected to induction of hepatocyte differentiation. The MSCs were isolated from the bone marrow of 4 normal donors, characterized and subjected to both in vitro and in vivo induction of hepatocyte differentiation. The in vitro induced cells showed morphological changes, acquiring hepatocyte-like features. However, the immunophenotype of these cells was not modified. The induced cells exhibited no increase in albumin, cytokeratin 18 or cytokeratin 19 transcripts, when analyzed by real-time RT-PCR. The expression of albumin, cytokeratin 18 and alpha fetoprotein was also unchanged, according to immunofluorescence tests. In vivo, the MSC demonstrated a potential to migrate to damaged liver tissue in immunodeficient mice. Taken together, the results suggest that bone marrow MSCs are incapable of in vitro differentiation into hepatocytes by the approach used here, but are capable of homing to damaged hepatic tissue in vivo, suggesting a role for them in the repair of the liver. This contribution to tissue repair could be associated with a paracrine effect exerted by these cells.

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We present in this paper a pedagogical-didactic proposal for the teaching of Laplace Probability. The starting point for building the concept of probability is a game situation associated with the methodology of problem-solving. The theoretical reference for the concept of game is constructivist teaching of mathematics. Mathematical knowledge is constructed based on problems that generate new concepts and / or new content. The proposed game is original. Our proposal can be used both in the last cycle of basic education but also in high school, and may inform the practice of teachers who teach basic concepts of probability.

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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Pós-graduação em Educação - IBRC

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Pós-graduação em Educação - IBRC

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)