Influência do tempo e da temperatura de estocagem de amostras de sangue nas variáveis hematológicas de cães portadores de enfermidade renal crônica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Portaferramentas para torneamento com refrigeração interna baseada na mudança de fase do fluido

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Um dispositivo mecânico para avaliação da rigidez de tornozelo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise da intensidade e frequencia dos ruídos articulares da articulação temporomandibular no movimento de lateralidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Concepção e dimensionamento de uma plataforma de acessibilidade do tipo plano inclinado para pessoas usuárias de cadeira de rodas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estimando o desfecho no recém-nascido grave através da Lógica Fuzzy

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo e desenvolvimento de cerâmicas porosas de dióxido de titânio aditivadas com proteínas de soja

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo e implementação do método de Ewins-Gleeson para identificação de parâmetros modais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Sistema de captação de imagens para avaliação dos movimentos biomecânicos das articulações temporomandibulares

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação de cálculos urinários em per-operatórios por imagem digital e técnicas físico-químicas e analíticas

Pós-graduação em Engenharia Mecânica - FEG

Diferenciação de osteoblastos cultivados sobre superfícies de titânio modificados por irradiação com laser Yb: YAG pulsado de alta potencia

Pós-graduação em Reabilitação Oral - FOAR

Electrochemical feasibility study of methyl parathion determination on graphite-modified basal plane pyrolytic graphite electrode

A low-cost electrochemical method was developed for the determination of trace-level of methyl parathion (MP) based on the properties of graphite-modified basal plane pyrolytic graphite electrode (graphite-bppg). A combination of graphite-bppg with square-wave voltammetric (SWV) analysis resulted in an original, sensitive and selective electrochemical method for determination of MP pesticide in drinking water. The electrode was constructed and the electrochemical behavior of MP was studied. Immobilization is achieved via film modification from dispersing graphite powder in deionized water and through pipeting a small volume onto the electrode surface allowing the solvent to volatilize. The strong affinity of the graphite modifier for the phosphorous group of the MP allowed the deposition of a significant amount of MP in less than 60 seconds. The cyclic voltammetric results indicate that the graphite-bppg electrode can enhance sensitivity in current intensity towards the quasi-reversible redox peaks of the products of the cathodic reduction of the nitro group at negative potential (peak I = 0.077 V and peak II = –0.062 V) and that the cathodic irreversible peak (peak III = –0.586 V) in comparison with bare bppg electrode and is also adsorption controlled process. Under optimized conditions, the concentration range and detection limit for MP pesticide are respectively 79.0 to 263.3 mmol L-1 and 3.00 mmol L-1. The proposed method was successfully applied to MP determination in drinking water and the performance of this electrochemical sensor has been evaluated in terms of analytical figures of merit.

Inovação do método MIA-QSAR: aplicação para doenças tropicais negligenciadas

Multivariate image analysis applied to the quantitative structure-activity relationships (MIA-QSAR) is a 2D QSAR technique that has been presenting promising outcomes for the development of new drug candidates, due to its simplicity, rapidity and low cost. In this way, the present study aims at introducing, consolidating and improving the new dimensions named aug-MIA-QSAR and aug-MIA-QSARcolor, as well as applying them to the study of neglected diseases, in order to obtain new drug targets using chemico-biological interpretation of the MIA molecular descriptors. Four compound data sets with experimental bioactivities against Chagas disease, malaria, dengue and schistosomiasis were evaluated using three approaches: MIA-QSARt, aug-MIA-QSAR and aug-MIA-QSARcolor. In general, representations of atoms as spheres with different colors and sizes proportional to the corresponding van der Waals radii (aug-MIA approaches) improved the predictive ability and interpretability in all data sets. The use of colors proportional to the Pauling´s electronegativity showed that MIA descriptors are capable of identifying periodic properties relevant for the studied activity. Finally, solid colors instead of spotlighted atoms allowed a correct identification of atoms by means of pixel values in the studies for malaria, dengue and schistosomiasis, which were, subsequently, useful for the chemical interpretation related to the bioactivity. It can be inferred that semicarbazones and thiosemicarbazones derivative with a tri-substituted ring in R1 group and a trifluoro methyl group in the R 3 position instead of a chlorine antitripanossoma resulted in higher activity. The antimalarial activity of quinolon-4(1H)imines can be improved if: 1) R1 and R2 are electron donor groups, 2) R3 has long aminoalkyl chains, and 3) R4 possesses substituents with big atomic volume. In the study for dengue, it was found that tetrapeptides with unbranched small size amino acids in the A1 and A4 positions can increase the substrate affinity (Km) to the NS3 protein, and when in A1 and A2 positions, the substrate cleavage rate (kcat). On the other hand, acidic amino acids in the A2 and A4 positions were found to be related with low substrate affinity to the NS3 protein and when present in A1, with low substrate cleavage rate. Finally, the presence of metoxy substituents in R1 (or R2) and R5 in the neolignan backbone can favor their antischistosomal activity.

Síntese de novos derivados de quitosa para aplicação como biofungicida contra os fungos Aspergillus flavus e Aspergillus parasiticus

Pós-graduação em Química - IBILCE

Modulação das propriedade ópticas de semicondutores pela incorporação de íons terras raras

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)