O espaço público como elemento agregador de uma augi

Dissertação para obtenção do grau de Mestre em Arquitectura, apresentada na Universidade de Lisboa - Faculdade de Arquitectura.

Envelope C2-V3-C3-specific antibodies from HIV-1 infected patients from Angola correlate with neutralization activity in plasma

Poster presented at the 2015 Keystone Symposia Conference X5: HIV Vaccines. Banff, Alberta, Canada, 22-27 March 2015

CADENA DEL CAFÉ DE LOS SANTOS, COSTA RICA

Resumen La operación de las actividades económicas y su competitividad, analizadas desde una perspectiva de cadenas globales de mercancías, dependen del funcionamiento de los mercados de crédito, tanto nacionales como internacionales. La operación normal de los negocios requiere crédito para fortalecer sus recursos propios y hacer las compras de materia prima, insumos, pago de salarios e inversión. En todos los casos, el crédito puede ser utilizado para mejorar el diseño de productos, impulsar el acceso a nuevos mercados y aumentar la competitividad. A los productores de la región de Los Santos en Costa Rica se les reconoce por innovadores, y al café de la zona por ser un café de altura y de gran calidad. El artículo explora las necesidades de financiamiento de productores, beneficiadores y exportadores de café de Los Santos, sus fuentes de financiamiento y el uso dado a los recursos obtenidos. Entre las necesidades orientadas al mejoramiento de la competitividad se encontraron la renovación de cafetales entre los productores, el mantenimiento de proyectos y tecnología entre los beneficios y la generación de microbeneficios y búsqueda de nichos de mercado entre los exportadores. Abstract From a global commodity chains perspective, economic activities and their competitiveness depend upon the functioning of credit markets, both international and domestic. Current businesses operations require credit to enhance their own resources in order to buy raw material and inputs, pay wages and make investment. Credit may also be used to improve product design, enter new markets and boost competitiveness as a result. High altitude grown coffee from Los Santos, Costa Rica is widely known for its quality, and their growers as innovative. This paper addresses credit needs of coffee growers, processors and exporters in Los Santos, the credit sources they have access to, and the kind of uses the credit is given. Improving competitiveness uses of credit were found among growers, processors and exporters, such as crop and technology improvement, micro processing facilities and new markets search as well.

Análisis crítico de la planificación urbana de la Ciudad de Cuenca

Las ciudades de todo el mundo deben mantener un entorno urbano habitable. Nueva York y Barcelona fueron una vez ejemplos a seguir, pero la visión urbana de expansión durante las últimas décadas ha dado lugar a un paradigma que comprende pobremente las tendencias de desarrollo de finales del siglo 20 e inicios del siglo 21. La planificación urbana insuficientemente pondera las aspiraciones de los ciudadanos y las funciones socioeconómicas de la ciudad, generando desequilibrios, caracterizados por el aumento de congestiones de tráfico, injusticia social y económica, y degradación medioambiental. En el caso de la ciudad de Cuenca, el desarrollo urbano ilustra claramente una expansión deficientemente controlada con graves fricciones en los mercados de trabajo y de vivienda, con pocos espacios verdes dentro y alrededor de la ciudad, como fue en el pasado. Este estudio intenta ilustrar la discrepancia entre la teoría y la práctica en el campo de la planificación urbana utilizando como caso de estudio a la ciudad andina de Cuenca. Mientras que la nueva doctrina de planificación urbana habla de un intrincado equilibrio entre las funciones socioeconómicas y ambientales en el espacio urbano, la ciudad se ve cada día más desorganizada. Además, para explicar la situación actual de la planificación de la ciudad de Cuenca, basada en razones teóricas y filosóficas, se identificaron las deficiencias en la planificación urbana. Las buenas prácticas de diseño y planificación urbana deben basarse en una buena comprensión del carácter dinámico y complejo de las ciudades. Con el manuscrito el autor tiene como objetivo impulsar la discusión científica sobre la planificación urbana desde la visión medioambiental y sustentable.

Guía de prácticas sobre agrupación de datos y gráficos en estadística, con la calculadora CASIOFX 7400 para los estudiantes de la carrera de Matemáticas y Física de la Universidad de Cuenca

El presente trabajo titulado: Guía de Prácticas sobre Agrupación de Datos y Gráficos en Estadística, con la calculadora Casiofx-7400 para los estudiantes de la carrera de Matemáticas y Física de la Universidad de Cuenca tiene por objetivo crear una guía de prácticas, que sirva de apoyo a los estudiantes en el aprendizaje deEstadística. La guía consta de tres capítulos: Fundamentación Teórica, Análisis Estadístico y la Propuesta. En el primer capítulo se da conocer: el marco teórico el cual fundamenta este trabajo, basado en el enfoque constructivista como corriente pedagógica;la importancia de las guías didácticas como recurso en la acción educativa; el empleo de las TIC(tecnologías de la Información y Comunicación) dentro de las aulas de clase y los beneficios de la calculadora graficadora. En el capítulo dos: Análisis Estadístico; se presenta información recolectada mediante una encuesta. La información tabulada se muestra en tablas y gráficos estadísticos, seguido de sus respectivas interpretaciones, con la cual se da validez a ésta propuesta. En el tercer capítulo se desarrolla la guía de prácticas para el uso de la calculadora graficadoraCasiofx-7400GII para el aprendizaje de Agrupación de Datos y Gráficos en Estadística; enfocada en la corriente constructivista. La guía está dividida en tres apartados: 1. Conceptos básicos de Estadística y descripción de la calculadora graficadora. 2. Agrupación de datos. 3. Gráficos estadísticos. Para potenciar el uso de la calculadora graficadora dentro del aula de clase cada apartado contiene objetivos y evaluaciones.

Las denominaciones de origen del café mexicano y sus cuestionamientos como modelo de desarrollo regional

Resumen En este artículo se analiza la evolución de las denominaciones de origen (DO) para el café mexicano, estrategia que ha sido seguida tras el éxito comercial que ha tenido el tequila. Sin embargo, los resultados que se han observado en el caso del café no han sido muy alentadores, más bien decepcionantes, por lo que se cuestiona sobre la importancia de dicha estrategia para impulsar el desarrollo de las regiones cafetaleras. Abstract This article analyzes the evolution of appellations of origin (DO) for Mexican coffee, a strategy that has been followed after the commercial success that had the tequila. However, the results that have been observed in the case of coffee have not been very encouraging, rather disappointing, so that many questions arise about the importance of this strategy to boost the development of coffee growing regions.

Dinâmica das integrações de minicírculos de kDNA de Trypanosoma Cruzi no genoma hospedeiro

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2016.

Agroindustria rural, acción colectiva y SIALES: ¿Desarrollo o lucha contra la pobreza?

El desarrollo y reforzamiento de los sistemas agroalimentarios localizados, conjuntos de pequeñas unidades de agroindustria rural, pueden considerarse como un medio importante de reducción de la pobreza en las regiones rurales de América Latina.   Sin embargo, la validez de tal propuesta tiene que ser valorada, teniendo en cuenta los siguientes elementos: La dinámica de los SIALES radica en procesos de activación de recursos específicos, que son productos de la acción colectiva. Forman parte de cadenas con una gobernabilidad caracterizada por el dominio de actores de debajo de la cadena, tal como las grandes distribuidoras. La pobreza no se define únicamente por la falta de recursos monetarios, sino también por la falta de capacidades.   La eficacia de la acción colectiva de activación de los recursos específicos yace en la capacidad de control de estos recursos por parte de los actores involucrados, hasta con el diseño de dispositivos de exclusión acerca de ellos, lo que puede con llevar la marginalización de otros actores. Es una necesidad tanto más apremiante cuanto más ubica el SIAL en un contexto de mercado globalizado. El caso de las señales de calidad basadas en el origen territorial de los productos lo ilustra. Por otra parte, la dinámica de los SIALES puede conllevar a profundizar las capacidades, especialmente a través de procesos de aprendizaje. Las políticas públicas pueden reforzar el proceso, proporcionando bienes públicos y fomentando procesos participativos a nivel local.   Al final el desarrollo de los SIALES no constituye de por sí una garantía de reducción de las desigualdades, pero refuerza las capacidades y además es un tipo de cambio estructural, de los que se suelen asociar con la noción de desarrollo.   ABSTRACT The development of Local agri-food systems (LAS), as clusters of small rural food-processing units, can be seen as a powerful means of poverty alleviation in rural areas of Latin America.   The relevance of such a statement must, nevertheless, be assessed in the light of the following elements: LAS dynamics rest on activation processes of specific resources, as a result of collective action. LAS are part of commodity chains whose governance is characterized by the domination of downstream actors such as large retailers. Poverty does not only refer to the shortage of monetary income, but also to the absence of capacities.   The efficiency of collective action involved in the activation process of specific resources depends on the capacity of relevant actors to control the access. As a result, other actors can be cast aside in the process. It is true that these resources must be valorized in a globalized market. The case of quality signals based on geographical origin can be an example of that. On the other side, LAS dynamics can boost the development of capacities, particularly by promoting learning by doing. Public policies can channel tis process by delivering public goods and promoting participation at a local level.   All in all, the development of LAS is not per se a guarantee against the deepening of inequality. But it is a capacity-building factor and entails structural changes which are yhe essence of development processes.

AN ENERGY BASED MINIMUM-TIME OPTIMAL CONTROL OF DC-DC CONVERTERS

Time-optimal response is an important and sometimes necessary characteristic of dynamic systems for specific applications. Power converters are widely used in different electrical systems and their dynamic response will affect the whole system. In many electrical systems like microgrids or voltage regulators which supplies sensitive loads fast dynamic response is a must. Minimum time is the fastest converter to compensate the step output reference or load change. Boost converters as one of the wildly used power converters in the electrical systems are aimed to be controlled in optimal time in this study. Linear controllers are not able to provide the optimal response for a boost converter however they are still useful and functional for other applications like reference tracking or stabilization. To obtain the fastest possible response from boost converters, a nonlinear control approach based on the total energy of the system is studied in this research. Total energy of the system considers as the basis for developing the presented method, since it is easy and accurate to measure besides that the total energy of the system represents the actual operating condition of the boost converter. The detailed model of a boost converter is simulated in MATLAB/Simulink to achieve the time optimal response of the boost converter by applying the developed method. The simulation results confirmed the ability of the presented method to secure the time optimal response of the boost converter under four different scenarios.

A COMPARATIVE STUDY AND EVALUATION OF COLLABORATIVE RECOMMENDATION SYSTEMS

Consumers currently enjoy a surplus of goods (books, videos, music, or other items) available to purchase. While this surplus often allows a consumer to find a product tailored to their preferences or needs, the volume of items available may require considerable time or effort on the part of the user to find the most relevant item. Recommendation systems have become a common part of many online business that supply users books, videos, music, or other items to consumers. These systems attempt to provide assistance to consumers in finding the items that fit their preferences. This report presents an overview of recommendation systems. We will also briefly explore the history of recommendation systems and the large boost that was given to research in this field due to the Netflix Challenge. The classical methods for collaborative recommendation systems are reviewed and implemented, and an examination is performed contrasting the complexity and performance among the various models. Finally, current challenges and approaches are discussed.

SVPWM SWITCHING PATTERN FOR Z-SOURCE INVERTER, SIMULATION AND APPLICATION

The voltage source inverter (VSI) and current voltage source inverter (CSI) are widely used in industrial application. But the traditional VSIs and CSIs have one common problem: can’t boost or buck the voltage come from battery, which make them impossible to be used alone in Hybrid Electric Vehicle (HEV/EV) motor drive application, other issue is the traditional inverter need to add the dead-band time into the control sequence, but it will cause the output waveform distortion. This report presents an impedance source (Z-source network) topology to overcome these problems, it can use one stage instead of two stages (VSI or CSI + boost converter) to buck/boost the voltage come from battery in inverter system. Therefore, the Z-source topology hardware design can reduce switching element, entire system size and weight, minimize the system cost and increase the system efficiency. Also, a modified space vector pulse-width modulation (SVPWM) control method has been selected with the Z-source network together to achieve the best efficiency and lower total harmonic distortion (THD) at different modulation indexes. Finally, the Z-source inverter controlling will modulate under two control sequences: sinusoidal pulse width modulation (SPWM) and SVPWM, and their output voltage, ripple and THD will be compared.

Measurement of the inclusive and differential t/t cross sections at 13 TeV in the all-jets boosted regime with CMS

The t/t production cross section is measured with the CMS detector in the all-jets channel in $pp$ collisions at the centre-of-mass energy of 13 TeV. The analysis is based on the study of t/t events in the boosted topology, namely events in which decay products of the quark top have a high Lorentz boost and are thus reconstructed in the detector as a single, wide jet. The data sample used in this analysis corresponds to an integrated luminosity of 2.53 fb-1. The inclusive cross section is found to be sigma(t/t) = 727 +- 46 (stat.) +115-112 (sys.) +- 20~(lumi.) pb, a value which is consistent with the theoretical predictions. The differential, detector-level cross section is measured as a function of the transverse momentum of the leading jet and compared to the QCD theoretical predictions. Finally, the differential, parton-level cross section is reported, measured as a function of the transverse momentum of the leading parton, extrapolated to the full phase space and compared to the QCD predictions.

In silico adjuvant design and validation

Adjuvants are substances that boost the protective immune response to vaccine antigens. The majority of known adjuvants have been identified through the use of empirical approaches. Our aim was to identify novel adjuvants with well-defined cellular and molecular mechanisms by combining a knowledge of immunoregulatory mechanisms with an in silico approach. CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) inhibit the protective immune responses to vaccines by suppressing the activation of antigen presenting cells such as dendritic cells (DCs). In this chapter, we describe the identification and functional validation of small molecule antagonists to CCR4, a chemokine receptor expressed on Tregs. The CCR4 binds the chemokines CCL22 and CCL17 that are produced in large amounts by activated innate cells including DCs. In silico identified small molecule CCR4 antagonists inhibited the migration of Tregs both in vitro and in vivo and when combined with vaccine antigens, significantly enhanced protective immune responses in experimental models.

Ontology forecasting in scientific literature:semantic concepts prediction based on innovation-adoption priors

The ontology engineering research community has focused for many years on supporting the creation, development and evolution of ontologies. Ontology forecasting, which aims at predicting semantic changes in an ontology, represents instead a new challenge. In this paper, we want to give a contribution to this novel endeavour by focusing on the task of forecasting semantic concepts in the research domain. Indeed, ontologies representing scientific disciplines contain only research topics that are already popular enough to be selected by human experts or automatic algorithms. They are thus unfit to support tasks which require the ability of describing and exploring the forefront of research, such as trend detection and horizon scanning. We address this issue by introducing the Semantic Innovation Forecast (SIF) model, which predicts new concepts of an ontology at time t + 1, using only data available at time t. Our approach relies on lexical innovation and adoption information extracted from historical data. We evaluated the SIF model on a very large dataset consisting of over one million scientific papers belonging to the Computer Science domain: the outcomes show that the proposed approach offers a competitive boost in mean average precision-at-ten compared to the baselines when forecasting over 5 years.

Characterization of the immune response induced by a commercially available inactivated bluetongue virus serotype 1 vaccine in sheep

The protective immune response generated by a commercial monovalent inactivated vaccine against bluetongue virus serotype 1 (BTV1) was studied. Five sheep were vaccinated, boost-vaccinated, and then challenged against BTV1 ALG/2006. RT-PCR did not detect viremia at any time during the experiment. Except a temperature increase observed after the initial and boost vaccinations, no clinical signs or lesions were observed. A specific and protective antibody response checked by ELISA was induced after vaccination and boost vaccination. This specific antibody response was associated with a significant increase in B lymphocytes confirmed by flow cytometry, while significant increases were not observed in T lymphocyte subpopulations (CD4(+), CD8(+), and WC1(+)), CD25(+) regulatory cells, or CD14(+) monocytes. After challenge with BTV1, the antibody response was much higher than during the boost vaccination period, and it was associated with a significant increase in B lymphocytes, CD14(+) monocytes, CD25(+) regulatory cells, and CD8(+) cytotoxic T lymphocytes.