A selection from the correspondence of Abraham Hayward, Q.C., from 1834 to 1884. With an account of his early life.

Mode of access: Internet.

Nomination of William D. Ruckelshaus : hearings before the Committee on Environment and Public Works, United States Senate, Ninety-eighth Congress, first session, on the nomination of William D. Ruckelshaus, to be Administrator of the Environmental Protection Agency, May 3, 4, and 5, 1983.

Includes bibliographical references.

Nomination of Stephen J. Gage : hearing before the Committee on Environment and Public Works, United States Senate, Ninety-fifth Congress, second session, on the nomination of Stephen J. Gage to be assistant administrator for Research and Development, Environmental Protection Agency, January 24, 1978.

"Serial no. 95-H45."

Whole works, to which is prefixed, A life of the author,

Mode of access: Internet.

A grammar of the Arabic language ,

Mode of access: Internet.

Preformations of the Amazonian: Strong Women in German Literature of the Early Enlightenment

Thesis (Ph.D.)--University of Washington, 2016-06

Comparability of perceptual analysis of speech characteristics in Australian and Swedish speakers with multiple sclerosis

The aims of the present study were to compare the perceptual assessments of deviant speech signs (dysarthria) exhibited by Australian and Swedish speakers with multiple sclerosis (MS) and to explore whether judgements of dysarthria differed depending on whether the speakers and the judges spoke the same or different languages. Ten Australian and 10 Swedish individuals with MS (matched as closely as possible for age, gender, progression type and severity of dysarthria) were assessed by 2 Australian and 2 Swedish clinically experienced judges using a protocol including 33 speech parameters. Results show that the following perceptual dimensions were identified by both pairs of judges in both groups of speakers to a just noticeable or moderate degree: imprecise consonants, inappropriate pitch level, reduced general rate, and glottal fry. The reliability (Spearman rank-order correlation) of the consensus ratings from the Australian and the Swedish judges was high, with a mean rho of 85.7 for the Australian speakers and mean rho of 84.3 for the Swedish speakers. The most difficult perceptual parameters to assess (i.e. to agree on) included harshness, level of pitch and loudness, precision of consonants and general stress pattern. The study indicated that perceptual assessments of speech characteristics in individuals with MS are informative and can be achieved with high inter-judge reliability irrespective of the judge's knowledge of the speaker's language. Copyright (C) 2003 S. Karger AG, Basel.

Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma imembrane following EGF stimulation

Sorting nexins are a large family of proteins that contain the phosphoinositide-binding Phox homology (PX) domain. A number of sorting nexins are known to bind to PtdIns(3)P, which mediates their localization to membranes of the endocytic pathway. We show here that sorting nexin 5 (SNX5) can be recruited to two distinct membrane compartments. In non-stimulated cells, the PX domain was independently targeted to endosomal structures and colocalized with full-length SNX5. The membrane binding of the PX domain was inhibited by the PI 3-kinase inhibitor, wortmannin. Although SNX5 colocalized with a fluid-phase marker and was found predominantly within a PtdIns(3)P-rich endosomal domain, very little colocalization was observed between SNX5 and the PtdIns(3)P-binding protein, EEA1. Using liposome-based binding assays, we have shown that the PX domain of SNX5 interacts not only with PtdIns(3)P but also with PtdIns(3,4)P-2. In response to EGF stimulation, either the SNX5-PX domain or full-length SNX5 was rapidly recruited to the plasma membrane. The localization of SNX1, which does not bind PtdIns(3,4)P-2, was unaffected by EGF signalling. Therefore, SNX5 is localized to a subdomain of the early endosome distinct from EEA1 and, following EGF stimulation and elevation of PtdIns(3,4)P-2, is also transiently recruited to the plasma membrane. These results indicate that SNX5 may have functions not only associated with endosomal sorting but also with the phosphoinositide-signalling pathway.

Cross-language Perception of Word-final Stops by Native Vietnamese Listeners: Preliminary Results on the Role of Specific, Non-native Phonetic Experience

This study examined the discrimination of word-final stop contrasts (/p/-/t/, /p/-/k/, /t/-/k/) in English and Thai by 12 listeners who speak Vietnamese as their first language (L1). Vietnamese shares specific phonetic realization of stops with Thai, i.e., unreleased final stop and differs from English which allows both released and unreleased final stops. These 12 native Vietnamese (NV) listeners’ discrimination accuracy was compared to that of the two listener groups (Australian English (AE), native Thai (NT)) tested in previous studies. The NV group was less accurate than the native group in discriminating both English and Thai stop contrasts. In particular, for the Thai /t/-/k/ contrast, they were significantly less accurate than the AE listeners. The present findings suggest that experience with specific (i.e., unreleased) and native phonetic realization of sounds may be essential in accurate discrimination of final stop contrasts. The effect of L1 dialect on cross-language speech perception is discussed.

Identifying reliable, valid markers of authorship: a response to Chaski

In response to Chaski’s article (published in this volume) an examination is made of the methodological understanding necessary to identify dependable markers for forensic (and general) authorship attribution work. This examination concentrates on three methodological areas of concern which researchers intending to identify markers of authorship must address. These areas are sampling linguistic data, establishing the reliability of authorship markers and establishing the validity of authorship markers. It is suggested that the complexity of sampling problems in linguistic data is often underestimated and that theoretical issues in this area are both difficult and unresolved. It is further argued that the concepts of reliability and validity must be well understood and accounted for in any attempts to identify authorship markers and that largely this is not done. Finally, Principal Component Analysis is identified as an alternative approach which avoids some of the methodological problems inherent in identifying reliable, valid markers of authorship.

The optimisation of legacy water treatment works to produce a more consistent final water quality

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