Increased body fat is independently and negatively related with cardiorespiratory fitness levels in children and adolescents with normal weight.

Body mass index (BMI) is related with cardiorespiratory fitness (CRF), but less is known regarding the combined relationships between BMI and body fat (BF) on CRF. Cross-sectional study included 2361 girls and 2328 boys aged 10–18 years living in the area of Lisbon, Portugal. BMI was calculated by measuring height and weight, and obesity was assessed by international criteria. BF was assessed by bioimpedance. CRF was assessed by the 20-m shuttle run and the participants were classified as normal-to-high or low-CRF level according to Fitness gram criterion-referenced standards. The prevalence of low CRF was 47 and 39% in girls and boys, respectively. The corresponding values for the prevalence of obesity were 4.8 and 5.6% (not significant) and of excess BF of 12.1 and 25.1% (P <0.001), respectively. In both sexes, BMI and BF were inversely related with CRF: r = – 0.53 and – 0.45 for BMI and % BF, respectively, in boys and the corresponding values in girls were – 0.50 and – 0.33 (all P <0.01). When compared with a participant with normal BMI and BF, the odds ratios (95% confidence interval) for low CRF were 1.94 (1.46–2.58) for a participant with normal BMI and high BF, and 6.19 (5.02–7.63) for a participant with high BMI and high BF. The prevalence of low-CRF levels is high in Portuguese youths. BF negatively influences CRF levels among children/adolescents with normal BMI.

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Index philosophique : philosophie et sciences annexes : biologie, neurologie, psychiatrie : publication de la Revue de philosophie / par N. Vaschide,... et von Buschan,...

1903 (A2).

Index philosophique : philosophie et sciences annexes : biologie, neurologie, psychiatrie : publication de la Revue de philosophie / par N. Vaschide,... et von Buschan,...

Périodicité : Annuel

Index philosophique : philosophie et sciences annexes : biologie, neurologie, psychiatrie : publication de la Revue de philosophie / par N. Vaschide,... et von Buschan,...

1902 (A1).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/04/15 (T1,N3).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/02/15 (T1,N1).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/11 (T1,N10).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/05/15 (T1,N4).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/09 (T1,N8).

Index Rosenwald (Paris)

Etat de collection : 1,1903(1)-2,1904(8)

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/08/15 (T1,N7).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1904/01 (T1,N12).

Index Rosenwald : sommaires-tables des principaux journaux de médecine et bibliographie médicale / docteur L. Rosenwald, dir.

1903/06/15 (T1,N5).