Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Autoria(s): Willer, C.J.; Speliotes, E.K.; Loos, R.J.; Li, S.; Lindgren, C.M.; Heid, I.M.; Berndt, S.I.; Elliott, A.L.; Jackson, A.U.; Lamina, C.; Lettre, G.; Lim, N.; Lyon, H.N.; McCarroll, S.A.; Papadakis, K.; Qi, L.; Randall, J.C.; Roccasecca, R.M.; Sanna, S.; Scheet, P.; Weedon, M.N.; Wheeler, E.; Zhao, J.H.; Jacobs, L.C.; Prokopenko, I.; Soranzo, N.; Tanaka, T.; Timpson, N.J.; Almgren, P.; Bennett, A.; Bergman, R.N.; Bingham, S.A.; Bonnycastle, L.L.; Brown, M.; Burtt, N.P.; Chines, P.; Coin, L.; Collins, F.S.; Connell, J.M.; Cooper, C.; Smith, G.D.; Dennison, E.M.; Deodhar, P.; Elliott, P.; Erdos, M.R.; Estrada, K.; Evans, D.M.; Gianniny, L.; Gieger, C.; Gillson, C.J.; Guiducci, C.; Hackett, R.; Hadley, D.; Hall, A.S.; Havulinna, A.S.; Hebebrand, J.; Hofman, A.; Isomaa, B.; Jacobs, K.B.; Johnson, T.; Jousilahti, P.; Jovanovic, Z.; Khaw, K.T.; Kraft, P.; Kuokkanen, M.; Kuusisto, J.; Laitinen, J.; Lakatta, E.G.; Luan, J.; Luben, R.N.; Mangino, M.; McArdle, W.L.; Meitinger, T.; Mulas, A.; Munroe, P.B.; Narisu, N.; Ness, A.R.; Northstone, K.; O'Rahilly, S.; Purmann, C.; Rees, M.G.; Ridderstråle, M.; Ring, S.M.; Rivadeneira, F.; Ruokonen, A.; Sandhu, M.S.; Saramies, J.; Scott, L.J.; Scuteri, A.; Silander, K.; Sims, M.A.; Song, K.; Stephens, J.; Stevens, S.; Stringham, H.M.; Tung, Y.C.; Valle, T.T.; Van Duijn, C.M.; Vimaleswaran, K.S.; Vollenweider, P.; Waeber, G.; Wallace, C.; Watanabe, R.M.; Waterworth, D.M.; Watkins, N.; Witteman, J.C.; Witteman, J.C.; Zeggini, E.; Zhai, G.; Zillikens, M.C.; Altshuler, D.; Caulfield, M.J.; Chanock, S.J.; Farooqi, I.S.; Ferrucci, L.; Guralnik, J.M.; Hattersley, A.T.; Hu, F.B.; Jarvelin, M.R.; Laakso, M.; Mooser, V.; Ong, K.K.; Ouwehand, W.H.; Salomaa, V.; Samani, N.J.; Spector, T.D.; Tuomi, T.; Tuomilehto, J.; Uda, M.; Uitterlinden, A.G.; Wareham, N.J.; Deloukas, P.; Frayling, T.M.; Groop, L.C.; Hayes, R.B.; Hunter, D.J.; Mohlke, K.L.; Peltonen, L.; Schlessinger, D.; Strachan, D.P.; Wichmann, H.E.; McCarthy, M.I.; Boehnke, M.; Barroso, I.; Abecasis, G.R.; Hirschhorn, J.N.
Data(s)

2009
Resumo

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Identificador

https://serval.unil.ch/notice/serval:BIB_F8992FC64167

info:pmid:19079261

https://serval.unil.ch/resource/serval:BIB_F8992FC64167.P001/REF

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F8992FC641673

urn:nbn:ch:serval-BIB_F8992FC641673
Idioma(s)

eng
Fonte

Nature Genetics41125-34
Palavras-Chave #Alleles; Anthropometry; Body Mass Index; Body Weight; Central Nervous System; Cohort Studies; Gene Dosage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Meta-Analysis as Topic; Obesity; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Quantitative Trait, Heritable; Colaus Study
Tipo

info:eu-repo/semantics/article

article
Formato

application/pdf
Direitos

info:eu-repo/semantics/openAccess

Copying allowed only for non-profit organizations

https://serval.unil.ch/disclaimer
Acesso ao item digital