Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

Background: We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. Methods: We report the screening of an in-house drug library to identify known drugs that selectively inhibit AKR1C3 over the closely related isoforms AKR1C1, 1C2 and 1C4. This screen initially identified tetracycline as a potential AKR1C3-selective inhibitor. However, mass spectrometry and nuclear magnetic resonance studies identified that the active agent was a novel breakdown product (4-methyl(de-dimethylamine)-tetracycline (4-MDDT)). Results: We demonstrate that, although 4-MDDT enters AML cells and inhibits their AKR1C3 activity, it does not recapitulate the anti-leukaemic actions of the pan-AKR1C inhibitor medroxyprogesterone acetate (MPA). Screens of the NCI diversity set and an independently curated small-molecule library identified several additional AKR1C3-selective inhibitors, none of which had the expected anti-leukaemic activity. However, a pan AKR1C, also identified in the NCI diversity set faithfully recapitulated the actions of MPA. Conclusions: In summary, we have identified a novel tetracycline-derived product that provides an excellent lead structure with proven drug-like qualities for the development of AKR1C3 inhibitors. However, our findings suggest that, at least in leukaemia, selective inhibition of AKR1C3 is insufficient to elicit an anticancer effect and that multiple AKR1C inhibition may be required. © 2014 Cancer Research UK. All rights reserved.

Using structural equation modeling to assess two theoretical models that explain dropout

This study evaluated the relative fit of both Finn's (1989) Participation-Identification and Wehlage, Rutter, Smith, Lesko and Fernandez's (1989) School Membership models of high school completion to a sample of 4,597 eighth graders taken from the National Educational Longitudinal Study of 1988, (NELS:88), utilizing structural equation modeling techniques. This study found support for the importance of educational engagement as a factor in understanding academic achievement. The Participation-Identification model was particularly well fitting when applied to the sample of high school completers, dropouts (both overall and White dropouts) and African-American students. This study also confirmed the contribution of school environmental factors (i.e., size, diversity of economic and ethnic status among students) and family resources (i.e., availability of learning resources in the home and parent educational level) to students' educational engagement. Based on these findings, school social workers will need to be more attentive to utilizing macro-level interventions (i.e., community organization, interagency coordination) to achieve the organizational restructuring needed to address future challenges. The support found for the Participation-Identification model supports a shift in school social workers' attention from reactive attempts to improve the affective-interpersonal lives of students to proactive attention to their academic lives. The model concentrates school social work practices on the central mission of schools, which is educational engagement. School social workers guided by this model would be encouraged to seek changes in school policies and organization that would facilitate educational engagement. ^

Rich and poor, white and black, free and slave: The social history of Cuba's tobacco farmers, 1763--1817

Tobacco was of primary importance to Spain, and its impact on Cuba's economy and society was greater than just the numbers of farms, workers, or production, demonstrated by the Spanish crown's outlay of monies for capital assets, bureaucrats' salaries, and payments to farmers for their crop. This study is a micro- and macro-level study of rural life in colonial Cuba and the interconnected relationships among society, agricultural production, state control, and the island's economic development. ^ By placing Cuba's tobacco farmers at the forefront of this social history, this work revisits and offers alternatives to two prevailing historiographical views of rural Cuba from 1763 (the year Havana returned to Spanish control following the Seven Years' War) to 1817 (the final year of the 100-year royal monopoly on Cuban tobacco). Firstly, it argues against the primacy of sugar over other agricultural crops, a view that has shaped decades of scholarship, and challenges the thesis which maintains the Cuban tobacco farmer was almost exclusively poor, white, and employed free labor, rather than slaves, in the production of their crop. ^ This study establishes the importance of tobacco as an agricultural product, and argues that Cuban tobacco growers were a heterogeneous group, revealing the role that its cultivation may have played in helping some slaves earn their freedom. ^

A New Vision: U.S Travel and Tourism Industry

Greg Farmer, U.S. Under Secretary of Commerce for Travel and Tourism, envisions a new proactive role for travel and tourism in the U.S. He has written this article especially for the FIU Hospitality Review.

Process inventory and pollution prevention overview for the citrus industry

Florida citrus represents approximately 70 percent of the industry production in the United States; therefore, any associated agricultural and industrial contamination is of concern and a focus of attention. The use of synthetic organic chemicals has become a farmer's necessity in order to supply consumers with high quality products, free of pest damage. However, industrial citrus wastes and chemical residual levels worry not only government agencies but also consumers since they indicate a serious habitat risk. This study assesses citrus industrial processes and the paths that chemical substances follow from the time the citrus seed is planted until consumers get a final product as either fresh fruit or processed product. The study is built on information from United States Environmental Protection Agency (US EPA) manuals, Dade County Environmental Resources Management (DERM) inspection records, United States Food and Drug Administration (US FDA) regulations, Florida standards, journal publications, and research reports. Pollution prevention (P2 or prevention-of-pollution) alternatives are identified; alternatives are proposed, evaluated, and included. Strategies are described and pollution prevention opportunities proposed to minimize citrus wastes generation, chemical residuals in products, their environmental impact and health risk aspects while maximizing product quality.

Consórcio de cártamo e feijão caupi: alternativa para a produção de biodiesel na agricultura familiar

The new development strategies should operate mainly in the areas of energy efficiency and sustainable agriculture. Thus, the substitution of fossil fuels with biofuels, such as biodiesel, is increasingly on the agenda. The cultivation of oilseed plants for biodiesel production must take place in integrated systems that enable best environmental benefits and are more economically significant. The objectives of this study were to assess the morphological, anatomic, and physiological characteristics of safflower (Carthamus tinctorius L., promising oilseed for biodiesel production) grown in monoculture and intercropping with cowpea bean (Vigna unguiculata L. Walp.); and identify socioeconomic family farmers and verify their acceptance about safflower as an energy crop. The methodology used for the analysis of safflower growth in monoculture and intercropped with beans, were morphoanatomical and histochemical analyzes, made with samples of plants grown in the field in two cropping systems throughout the range of the life cycle of these plants. There were no changes in growth and anatomy of plants, even in the consortium, which is satisfactory to indicate the intercropping system for those crops and can be a good alternative for the family farmer, who may have safflower as a source of income without giving up planting their livelihood. To check the acceptance of safflower by farmers, interviews were made to family farmers by Canudos agrovila in Ceará-Mirim/RN. It was noticed that many of them accept the introduction of safflower as oil crop, although unaware of the species, and that, being more resistant to drought, safflower help in the stability of families who depend on the weather conditions for success their current crops. In general, it is concluded that safflower has features that allows it to be grown in consortium for biodiesel production combined with the production of food, such as cowpea, and can be used enabling better development for family farmers.

Segurança alimentar e nutricional dos agricultores familiares da associação dos produtores e produtoras orgânicas de Ceará Mirim/RN

The proposition of this research is supported by the definition of Food Safety and Nutrition (FSN), established by the II FSN National Conference. Taking this concept as reference, the research instrument aimed to analyze strategies and actions related to FSN, developed by members of Ceará Mirim Organic Producers Association, located in Rio Grande do Norte state (Brazil), from aspects related to family feeding, as well as means of access, quantity and food culture. It was aimed to answer the following questions: Do the families benefited from Ceará Mirim Organic Producers Association have strategies that assure their FSN? If so, do these strategies originate from public policies or own actions? Do these strategies focus on family revenue? In expenses with food and proper feeding? How do these strategies articulate together and which social networks do they form? In this research, there were also approached questionings which comprise market opening through the declaration of the products as Organization of Social Control (OSC), aggregate value and participation in agroecological fairs, aiming to identify and characterize if these strategies contribute for Food Safety and Nutrition of these families. The data here analyzed were obtained from semi-structured interviews, conducted in the production sites of each farmer, and have a qualitative approach. 21 questionnaires were applied to the family farmers, in seven projects of agrarian reform settlements (Carlos Marighella, Nova Esperança II, Aliança, Marcoalhado I, Santa Águeda, Santa Luzia and União). From this study, it was concluded that most of FSN strategies result from a series of distinct public policies, which potentiate the existing strategies and create new ones, such as in the case of organic production, which is the main motivation, even for the organization of the studied group. These strategies brought improvements in feeding and caused changes in eating habits, especially in the diversification of production for own consumption. This, on the other hand, is assuring greater food autonomy and increasing marketing channels, through fairs or institutional markets. It was also verified that reciprocity relations increased after the organic production, and they are indispensable to assure food in difficult times, also contributing to incentive organic production itself, through supplies exchange.

Determinação da condutividade do solo para agricultura: uma metodologia utilizando propagação de ondas AM

Agriculture is an essential activity to the human development, the tendency is that their need to increase according to the increase in world population. It is very important to take the maximum performance that is possible of each land without degrading it, a frequently monitoring is essential for the best performance. The purpose of this work is, nondestructively, to monitor the surface electrical conductivity of the soil in a demarcated area, as on a plantation, using low frequency radio waves. The conductivity is directly linked to the amount of water in the area and nutrients, therefore a periodic or even permanent monitoring increases significantly the efficient of the use of the soil. They will be used long-wave radio transmission or medium whose main characteristic to spread over the surface of the earth. It is possible to choose an AM radio with location, frequency and power of the transmission known or generate the signal. The studied method computes the conductivity of the ground in a straight line between two measured points, so it can be used in smaller or larger size fields. Measurements were carried out using an electromagnetic field strength analyzer. The data obtained in the measurements are processed by a numerical calculation program, in our case Matlab. It is concluded that the recommendations of the ITU (International Telecommunication Union) on the conductivity of soil in Brazil is far from reality, on some routes the recommendations indicate the use of the electrical conductivity of the soil 1 mS/m, while the measurements was found 19 mS/m. With the method described a precision farmer, once initial research for about a year, can monitor the humidity and salinity of the land, with the ability to predict the area and the most suitable time for irrigation and fertilization, making management more efficient and less expensive, while optimizing water use, natural resource increasingly precious.

Does market upgrading benefit farmers? : market differentiation, contract farming, and professional cooperatives in China's pork processing industry

This study tested whether contract farming or farmers professional cooperatives (FPCs) improved the social benefit of pork production and income of breeding farmers in China. The main concern of this study is whether institutional arrangement like contract farming or FPCs actually improved the welfare of farmers as expected. To answer this question accurately, we estimated the differentiated market demand of pork products in order to quantify the benefit by transaction types. Our study finds that contract farming or FPCs improved the benefits of pork products, but farmer's income remained lower than that of traditional transaction types. This finding is new in terms of quantifying distribution of the economic values among sales outlets, agro-firms and farmers. It is more reliable because it explicitly captures impacts from both demand side and supply side by structural estimation. In practice, we need to keep it mind the bargaining power of small farmers will not improve instantly even when the contract farming or FPCs are introduced.

(Table 1) Core top Globorotalia truncatulinoides d18O ratios of Atlantic Ocean samples

We investigate whether the oxygen isotope ratio in the test of Globorotalia truncatulinoides can serve as a proxy for intermediate depth (200-500 m) density. Since intermediate depth horizontal density gradients are associated with the vertical shear of upper ocean flows, this proxy could provide a tool for reconstructing past ocean circulation. The spatial pattern of core top Gr. truncatulinoides d18O in the Atlantic Ocean mimics the upper ocean density gradients associated with the major ocean currents. To better constrain the controls on the calcification depth(s) of Gr. truncatulinoides, we attempt to simulate the surface sediment data set using water column temperature and salinity conditions above the core sites. We predicted foraminiferal d18O for each core site assuming (1) the calcification occurs at a single depth and (2) the initial calcification is at the surface and the subsequent calcification is at 800 m water depth. The predicted d18O best resembles measured d18O of Gr. truncatulinoides when using (1) a single depth calcification at 350 m or (2) a two-depth approximation with 30% surface and 70% 800-m calcification. This result gives us confidence in the ability of d18O in Gr. truncatulinoides to proxy lateral density gradients at the intermediate depths associated with upper ocean flow.

Desempenho reprodutivo de varrões e matrizes suínas de diferentes linhagens durante as estações do ano

The industrial Brazilian pig farming despite of the constant advance in the genetic improvement, nutrition, and in handling, seasonality problems occur in the production of weaned piglet, mainly due to the stations of the year that can impact directly in the profitability. These problems can be deepen due to breed and line of decent used in Brazil are all source from tempered weather countries. To the pig farmer it's difficult to determine the relations between indoor temperature of the barns, relative humidity of the air and top thermal amplitude which can provide good reproductive rates for the boars and arrays lodged in conventional barns. The lack research to production of environmental indices of easy interpretation to pigs, which are not dependent of complicated handling machines and also which are not expensive is considered as a negative factor from the producers. the objective os this experiment is evaluate the effects of the stations of the year over the reproductive performance of the boars Agroceres PIC 425, Agroceres PIC 337 and D.B. Dambred LM 6200, and of arrays Agroceres Canborough 22, Penarlan Naima e DB90 Danbred, in addition develop an environmental index with easy interpretation and use to the pig farmers of the region of Uberlândia - MG, using the maxim temperatures, rainfall monthly accumulated and of the thermal amplitude of the barn. The features rated during the stations of the years 2013 and 2014 were the volume and spermatic quality of the boars and the mainly reproductive indexes of the arrays as the total number of piglets born alive and total number of weaned piglets/ array/ parturition. The station of the year which had the worst results in the reproductive feature of the boars and arrays was the spring. Boars from different line of decent are sensitive to the effects of stress of the heat of spring causing lowest volume, concentration and problems in the spermatic morphology (p<0,05). The spring prejudice the reproductive indexes of arrays from different line of decent (p<0,05) and the pig farmers of Uberlândia are subjected to operating losses and income evasion due to the thermal stress in the reproduction that added can reach $150.000,00 annual for each 1000 arrays lodged/year.

A COMUNICAÇÃO E A MEMÓRIA DO PEQUENO LAVRADOR DO MUNICÍPIO DE RIBEIRÃO GRANDE NO ESTADO DE SÃO PAULO SÃO BERNARDO DO CAMPO 2016

Estudo do processo comunicacional e o registro de fragmentos de memória do pequeno agricultor na localidade de Ribeirão Grande, região do Vale do Paranapanema, Estado de São Paulo. Esta pesquisa tem como objetivos mostrar a realidade do pequeno agricultor; investigar sobre os processos comunicacionais que influenciam na preservação dos valores ou na perda deles, conhecer a opinião dos pequenos agricultores e moradores do município de Ribeirão Grande no Estado de São Paulo, sobre sua realidade, sua comunicação, seu modelo de vida e de produção, entender como se produz a comunicação no dia a dia do pequeno agricultor, e se há uma relação de proximidade com o jornal regional, sobre a existência ou não de um meio de comunicação que trabalhe os sentimentos de pertencimento e os interesses da ―comunidade‖. A metodologia deste trabalho incorpora a pesquisa bibliográfica, pesquisa documental e o estudo do caso de um jornal regional local, além de entrevistas semiestruturadas com os lavradores. Conclui-se que o pequeno lavrador e seu estilo de vida na região tratada não possui perscpectiva de futuro, imersos nas circunstancias que se encontram. Palavras-

Tullich Aberdeenshire : a reappraisal of an early ecclesiastical site and its carved stones in the light of recent excavations

ACKNOWLEDGEMENTS The authors would like to thank Bruce Mann of Aberdeenshire Council Archaeology Service for his support throughout and for funding Area F and Historic Scotland for granting SMC for the excavation of Area A. Thanks are due to the tenant farmer Allan Adams and to Helen Rickwood, Jan Dunbar, Colin Mitchell, Sheila Young, Emma Gibson, Veronica Ross, Irvine Ross, Brian Dewar and Sheila Duthie for their work on site. We are grateful to Ian Cameron for help in gathering oral history of some of the crosses found in the 1950s/60s. John Borland, Katherine Forsyth, Simon Taylor and Ross Trench-Jellicoe have provided valuable comments on the sculpture. We would like to thank Invercauld Estate for access to their archive and permission to photograph and reproduce the Scroll Plan, and their honorary archivist, Sheila Sedgwick for her help and patience. We are grateful to Nigel Trewin for identification of the geology of the crosses. The drawings of Tullich 16 and 17 are by Jan Dunbar.

O ensino de arte pós-moderno na arte de Daniel Francisco de Souza

This thesis presents a research that links cultural history and visual culture in a sociobiographical approach. It gives a “political treatment” to the educational experience in the transition of art teaching from the modern to the postmodern. By taking into account my experiences as an educator and the poetic practice in Daniel Francisco de Souza’s visual art, I propose a dialogue with his art and a series of visual narratives this artist/student produced at the time of his education and recently. Such visual narratives were taken as research source and research subject. They were created in a rural setting in dialogue with formal art teaching in two phases: 1992–6, when Daniel Fran cisco attended elementary school in the rural area of Uberlândia, MG; and 2008–10, when he attended Visual Arts graduation at Federal University of Uberlândia city. I analyze historical processes related to art and teaching, from the early sixteenth century to the present times, to realize residues in students’ poetic experiences. I relate Brazilian educational public policies with experi- ences in that rural school. I try to show the extent to which our educational practices triggered experiences — from ones common to intense ones — and promoted forms of “emancipation-knowledge” or “regulation-knowledge” and how the “selective tradition” was and how art predetermined history images gave way to everyday visual references, pointing to the “broad field” of visual culture. I make an effort to show Daniel Francisco’s work as an adult by tak- ing it according to different approaches. In a poetic reading, first, I emphasixe the material and the symbolic in his art. In a second look, I approach his work through the intertwining experiences of three characters from different times and places that participated in the making of his art: the artist farmer, the artist teacher and the teacher researcher. I assume the existence of a mutual cultural incompleteness in these three characters; which means that parts of their “structures of feeling” built on the interrelationship among them are part of the artist’ work as a historical content decanted. Thirdly, I demonstrate how the artist sees his place as a key re ference to his poetic creation. His work does not reflect the rural bucolic as something untouched. In showing the difficulty in distinguishing the archaic residual, I identify emerging issues in his work. I conclude that the artist — Daniel Francisco — and the researcher — myself — present maverick features: both are scavengers; their productions approach the working with scraps in art and in the academy; even momentarily, they live in exile in the warmth of the borders or the edges, from where one sees the center clearly. In these spaces, when certain structures and normative codes enter into coalition, they fragment pre-established strategies and stimulate the creation of survival tactics.

"Sub Tiberio quies"? Judaea’s Political Situation under the Prefects (6-41 c.e.), between Reality and Ideology

Deeply conflicting views on the political situation of Judaea under the Roman prefects (6-41 c.e.) have been offered. According to some scholars, this was a period of persistent political unrest and agitation, whilst according to a widespread view it was a quiescent period of political calm (reflected in Tacitus’ phrase sub Tiberio quies). The present article critically examines again the main available sources –particularly Josephus, the canonical Gospels and Tacitus– in order to offer a more reliable historical reconstruction. The conclusions drawn by this survey calls into question some widespread and insufficiently nuanced views on the period. This, in turn, allows a reflection on the non-epistemic factors which might contribute to explain the origin of such views.