Metal nanoparticles as better protein-aggregation prevention agents than chaperones

Prevention or suppression of protein aggregation is of great importance in the context of protein storage, transportation and delivery. Traditionally chaperones or other chemically active agents are used to stop or diffuse native protein aggregation. We have used gold nanoparticles to prevent thermal aggregation of alcohol dehydrogenase (ADH), a protein that maintains the alcohol level in the liver and stomach. A light-scattering assay has been used to investigate the effect of gold nanoparticles on thermal aggregation of ADH and the result of our study has been summarized in Fig. 1. The scattered light intensity from the solution containing ADH decreases when 45 nm gold nanoparticles are added prior to heating (thermal denaturation) the solution, which indicates prevention of aggregation. The aggregation of the protein is suppressed to the extent of 96% with picomolar concentration of 45 nm gold nanoparticles while micromolar amounts of other proteins and biological substances are necessary to achieve the same effect. The extent varies with the size and the concentration of the gold NPs for the same protein concentration.

Combined inhalation and oral supplementation of Vitamin A and Vitamin D: A possible prevention and therapy for tuberculosis

Tuberculosis is continuing as a problem of mankind. With evolution, MDR and XDR forms of tuberculosis have emerged from drug sensitive strain. MDR and XDR strains are resistant to most of the antibiotics, making the management more difficult. BCG vaccine is not providing complete protection against tuberculosis. Therefore new infections are spreading at a tremendous rate. At the present moment there is experimental evidence to believe that Vitamin A and Vitamin D has anti-mycobacterial property. It is in this context, we have hypothesized a host based approach using the above vitamins that can cause possible prevention and cure of tuberculosis with minimal chance of resistance or toxicity. (C) 2015 Elsevier Ltd. All rights reserved.

Probabilistic Prediction based Scheduling for Delay Sensitive Traffic in Internet of Things

This paper proposes a probabilistic prediction based approach for providing Quality of Service (QoS) to delay sensitive traffic for Internet of Things (IoT). A joint packet scheduling and dynamic bandwidth allocation scheme is proposed to provide service differentiation and preferential treatment to delay sensitive traffic. The scheduler focuses on reducing the waiting time of high priority delay sensitive services in the queue and simultaneously keeping the waiting time of other services within tolerable limits. The scheme uses the difference in probability of average queue length of high priority packets at previous cycle and current cycle to determine the probability of average weight required in the current cycle. This offers optimized bandwidth allocation to all the services by avoiding distribution of excess resources for high priority services and yet guaranteeing the services for it. The performance of the algorithm is investigated using MPEG-4 traffic traces under different system loading. The results show the improved performance with respect to waiting time for scheduling high priority packets and simultaneously keeping tolerable limits for waiting time and packet loss for other services. Crown Copyright (C) 2015 Published by Elsevier B.V.

The “Centre for Child Protection” of the Gregorian University/Rome. First experiences, results and reflections in setting up a global e-learning-program for the prevention of sexual abuse of minors

Resumen: El Centro para la Protección Infantil ha sido fundado en cooperación con el Instituto de Psicología de la Universidad Gregoriana (Roma, Italia), el Departamento para la Psiquiatría/Psicoterapia Infantil y Adolescente del Hospital de la Universidad de Ulm (Alemania) y la Arquidiócesis de Múnich (Alemania). Su tarea principal es la creación de un centro global de entrenamiento e-learning para profesiones de pastoral que respondan al abuso sexual de los menores, tomando en consideración asuntos multilingüísticos e interculturales. Dentro de tres años el Centro desarrollado e implementado un programa e-learning en cuatro lenguas. Ocho socios del proyecto internacional asumen un papel en el reclutamiento de participantes y en la evaluación en curso del programa. En esta fase, personas-test son incluidas en el desarrollo y la evaluación del programa, como parte de la formación (en curso) de sacerdotes y de otros coagentes de pastoral

O parlamento aberto na era da internet : pode o povo colaborar com o Legislativo na elaboração da leis?

Aborda as principais questões da atual reflexão sobre a democracia participativa. Tem como base o estudo de dois casos em especial de práticas participativas digitais desenvolvidas por parlamentos: o programa e-Democracia, da Câmara dos Deputados brasileira, e o projeto Senador Virtual, do Senado chileno.

The open parliament in the age of the internet : can the people now collaborate with legislatures in lawmaking?

This work seeks to address those questions and evaluate other international experiences and experiments designed to achieve the same ends. The book is based on a study of two particular cases where parliamentary bodies designed and implemented participatory digital processes, namely, the e-Democracy Program developed by the Brazilian House of Representatives, and the Virtual Senator Program developed by the Chilean Senate. The text unfolds in the form of a systematic analysis of institutional aspects embracing political and organizational elements as well as the social aspects associated to the application of digital democracy in parliaments. The investigation shows that at the stage they found themselves in 2010 those projects had only brought in very incipient results in regard to the aspects of enhancing representativity in decision making processes, aggregating collective intelligence to the legislative process or transparency to parliamentary performances, even though all of those are precious components of any democracy that deems itself to be participatory and deliberative. Nevertheless, such experiences have had the merit of contributing towards the gradual construction of more effective participatory mechanisms, complementary to the political representation system in place.

El parlamento abierto em la era de la Internet : ¿Puede el pueblo colaborar com el Legislativo en la elaboración de las leyes?

¿Es viable la coexistencia de acciones de participación y deliberación con el ejercicio de la representación parlamentaria? ¿De qué manera la tecnologia de la información y comunicación ha auxiliado el proceso de interacción entre la sociedad y el parlamento en el cotidiano dei legislativo? ¿Estamos cercanos a un sistema híbrido de democracia representativa y participativa con la incorporación en la agenda legislativa de maneras efectivas de coproducción de leyes? Esta obra intenta responder a estas preguntas, además de evaluar otras experiencias intemacionales con este mismo objetivo. El libro tiene como base el estudio de dos casos en especial de prácticas participativas digitales desarrolladas por parlamentos: el programa e-Democracia de la Cámara de Diputados brasileños y el proyecto Senador Virtual dei Senado chileno. El texto se desarrolla mediante el análisis sistemático de los aspectos institucionales que abarcan elementos organizacionales y políticos, así como de los aspectos sociales comprometidos en la aplicación de la democracia digital en parlamentos. La investigación indica que estos proyectos, en el punto en que se encontraban en el año 2010 presentaron resultados aunque incipientes en lo que concieme a la mejoría de la representatividad en la toma de decisiones, de agregación de inteligencia colectiva, en el proceso legislativo y de la transparencia por parte de la actuación parlamentaria, elementos apreciados por la democracia participativa y deliberativa. No obstante, dichas experiencias poseen el mérito de contribuir con la construcción gradual de mecanismos participativos más efectivos y complementarios ai sistema político.

Internet e educação : a compressão espaço-temporal e o civismo

Discute a relação entre a Internet e a educação para o civismo. Parte-se de uma análise do processo de compressão espaço-temporal, que se acirra com o advento das Tecnologias de Informação e Comunicação (TIC). A imaterialidade das relações e o individualismo são consequências de um mesmo processo que afasta os homens do mundo e os vincula a simulacros, e a presença da técnica tende a dar força a esse processo. Dessa forma, a velocidade das trocas simbólicas realizadas através das infovias acaba por exercer diversos impactos nos processos educacionais, destacando-se a falta de cultura política. Trata-se de uma situação difícil de ser modificada, no entanto, ao debater a relação entre a Internet e a educação, o texto também procura apontar caminhos para a constituição de um civismo a partir da presença das TIC no cotidiano.

Exigência de contratação de provedor de serviço de conexão à internet para o acesso em banda larga

Consultoria Legislativa - Área XIV - Comunicação Social, Informática, Telecomunicações, Sistema Postal, Ciência e Tecnologia.