Clinical benefit and quality of life in patients with advanced pancreatic cancer receiving gemcitabine plus capecitabine versus gemcitabine alone: a randomized multicenter phase III clinical trial--SAKK 44/00-CECOG/PAN.1.3.001.

PURPOSE: To compare clinical benefit response (CBR) and quality of life (QOL) in patients receiving gemcitabine (Gem) plus capecitabine (Cap) versus single-agent Gem for advanced/metastatic pancreatic cancer. PATIENTS AND METHODS: Patients were randomly assigned to receive GemCap (oral Cap 650 mg/m(2) twice daily on days 1 through 14 plus Gem 1,000 mg/m(2) in a 30-minute infusion on days 1 and 8 every 3 weeks) or Gem (1,000 mg/m(2) in a 30-minute infusion weekly for 7 weeks, followed by a 1-week break, and then weekly for 3 weeks every 4 weeks) for 24 weeks or until progression. CBR criteria and QOL indicators were assessed over this period. CBR was defined as improvement from baseline for >or= 4 consecutive weeks in pain (pain intensity or analgesic consumption) and Karnofsky performance status, stability in one but improvement in the other, or stability in pain and performance status but improvement in weight. RESULTS: Of 319 patients, 19% treated with GemCap and 20% treated with Gem experienced a CBR, with a median duration of 9.5 and 6.5 weeks, respectively (P < .02); 54% of patients treated with GemCap and 60% treated with Gem had no CBR (remaining patients were not assessable). There was no treatment difference in QOL (n = 311). QOL indicators were improving under chemotherapy (P < .05). These changes differed by the time to failure, with a worsening 1 to 2 months before treatment failure (all P < .05). CONCLUSION: There is no indication of a difference in CBR or QOL between GemCap and Gem. Regardless of their initial condition, some patients experience an improvement in QOL on chemotherapy, followed by a worsening before treatment failure.

Contribution of (sub)domains of Staphylococcus aureus fibronectin-binding protein to the proinflammatory and procoagulant response of human vascular endothelial cells.

The Staphylococcus aureus fibronectin (Fn) -binding protein A (FnBPA) is involved in bacterium-endothelium interactions which is one of the crucial events leading to infective endocarditis (IE). We previously showed that the sole expression of S. aureus FnBPA was sufficient to confer to non-invasive Lactococcus lactis bacteria the capacity to invade human endothelial cells (ECs) and to launch the typical endothelial proinflammatory and procoagulant responses that characterize IE. In the present study we further questioned whether these bacterium-EC interactions could be reproduced by single or combined FnBPA sub-domains (A, B, C or D) using a large library of truncated FnBPA constructs expressed in L. lactis. Significant invasion of cultured ECs was found for L. lactis expressing the FnBPA subdomains CD (aa 604-877) or A4(+16) (aa 432-559). Moreover, this correlates with the capacity of these fragments to elicit in vitro a marked increase in EC surface expression of both ICAM-1 and VCAM-1 and secretion of the CXCL8 chemokine and finally to induce a tissue factor-dependent endothelial coagulation response. We thus conclude that (sub)domains of the staphylococcal FnBPA molecule that express Fn-binding modules, alone or in combination, are sufficient to evoke an endothelial proinflammatory as well as a procoagulant response and thus account for IE severity.

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.

Sodium transport via epithelial sodium channels (ENaC) expressed in alveolar epithelial cells (AEC) provides the driving force for removal of fluid from the alveolar space. The membrane-bound channel-activating protease 1 (CAP1/Prss8) activates ENaC in vitro in various expression systems. To study the role of CAP1/Prss8 in alveolar sodium transport and lung fluid balance in vivo, we generated mice lacking CAP1/Prss8 in the alveolar epithelium using conditional Cre-loxP-mediated recombination. Deficiency of CAP1/Prss8 in AEC induced in vitro a 40% decrease in ENaC-mediated sodium currents. Sodium-driven alveolar fluid clearance (AFC) was reduced in CAP1/Prss8-deficient mice, due to a 48% decrease in amiloride-sensitive clearance, and was less sensitive to beta(2)-agonist treatment. Intra-alveolar treatment with neutrophil elastase, a soluble serine protease activating ENaC at the cell surface, fully restored basal AFC and the stimulation by beta(2)-agonists. Finally, acute volume-overload increased alveolar lining fluid volume in CAP1/Prss8-deficient mice. This study reveals that CAP1 plays a crucial role in the regulation of ENaC-mediated alveolar sodium and water transport and in mouse lung fluid balance.

Stability and robustness of blood variables in an antidoping context.

Introduction:  With the setting up of the newly Athlete's Biological Passport antidoping programme, novel guidelines have been introduced to guarantee results beyond reproach. We investigated in this context, the effect of storage time on the variables commonly measured for the haematological passport. We also wanted to assess for these variables, the within and between analyzer variations. Methods:  Blood samples were obtained from top level male professional cyclists (27 samples for the first part of the study and 102 for the second part) taking part to major stage races. After collection, they were transported under refrigerated conditions (2 °C < T < 12 °C), delivered to the antidoping laboratory, analysed and then stored at approximately 4 °C to conduct analysis at different time points up to 72 h after delivery. A mixed-model procedure was used to determine the stability of the different variables. Results:  As expected haemoglobin concentration was not affected by storage and showed stability for at least 72 h. Under the conditions of our investigation, the reticulocytes percentage showed a much better stability than previous published data (> 48 h) and the technical comparison of the haematology analyzer demonstrated excellent results. Conclusion:  In conclusion, our data clearly demonstrate that as long as the World Anti-Doping Agency's guidelines are followed rigorously, all blood results reach the quality level required in the antidoping context.

Molist, N. (ed.). La intervenció al sector 01 del Conjunt Històric d'Olèrdola. De la prehistòria a l'etapa romana (campanyes 1995-2006). Monografies d'Olèrdola, 2.

En muchas ocasiones, el conocimiento y la importancia de los grandes yacimientos arqueológicos son dos conceptos diferentes. La adecuación museográfica y las referencias específicas a materiales o intervenciones puntuales pueden enmascarar el valor real de los datos científicos que se conocen sobre ellos, limitando así su importancia dentro del conjunto de la información necesaria para la realización de síntesis y el conocimiento exhaustivo de un período histórico. En muchos casos, se añade la prolongación en el tiempo de excavaciones e intervenciones de consolidación cuyos resultados tardan en ser publicados o bien no llegan nunca a ver la luz, por lo que permanecen en los intrincados vericuetos del circuito científico, quedando como referencias de transmisión personal y provocando innecesarios vacíos en el conocimiento.

Vizcaíno Sánchez, Jaime: La presencia bizantina en Hispania (siglos VI-VII): la documentación arqueológica. Antigüedad y Cristianismo. Monógrafías sobre la Antigüedad tardía XXIV, Murcia, 2009.

La serie editada por la Universidad de Murcia, especializada en trabajos sobre la antigüedad tardía y cristianismo, publica este nuevo libro que aborda la presencia de Bizancio en Hispania. Se trata de un tema de larga trayectoria historiográfica en la investigación histórica en España, que desde el estudio de M. Vallejo Girvés en 1993 se ha visto renovado y enriquecido con nuevas líneas interpretativas que persiguen la contextualización de las referencias aportadas por las fuentes escritas y, al mismo tiempo, la ampliación de las perspectivas de estudio con diversos argumentos de análisis, como es la discusión abierta en torno al componente social del proceso.

Roman amphora trade across the Straits of Gibraltar: An ancient 'anti-economic practice'?

Summary. Olive oil and fish products from the south of Hispania and North Africa played an important role in the Roman economy. The authors call attention to the asymmetrical distribution of archaeological data available on this subject, in particular the location of amphora kilns, and try to give an explanation, based on the evolution of European archaeology in the twentieth century.

Un solidus de la época de Severo III procedente de Esterri d'Aneu

Las circunstancias del hallazgo de esta moneda son completamente fortuitas. Se encontró junto al embalse de La Torrassa (La Guingueta), cerca de la localidad de Esterri d'Aneu, Pallars Sobira, provincia de LIeida, siendo sus descubridores los hijos de don Pascual Massanet. Las características de la moneda son las siguientes: es de oro y muy poco desgastada, prácticamente «flor de cuño», conservando casi su peso originario que es de 4,110 gr., siendo su diámetro de 21 mm. Las leyendas del anverso y del reverso se leen perfectamente.

Una nueva forma de sigillata hispánica

Al estudiar un lote de sigillatas procedentes de Río Tinto (Huelva), encontramos parte de un vaso de terra sigillata hispánica lisa (n.o 111 de nuestro inventario), que conserva todo su perfil, desde el borde hasta el pie.

Cambios en el predominio de los distintos valores monetarios en la circulación monetaria en la Hispania alto-imperial

En los últimos años hemos venido definiendo las grandes líneas de la circulación monetaria en Hispania durante el largo período imperial,! Trazos que por el momentó debemos dar como buenos a la espera de la aparición de estudios sobre nuevos materiales que cambien el panorama o confirmen lo expuesto hasta el momento. En espera de estos nuevos trabajos debemos comenzar a pensar en un estudio más profundo de la circulación, para poder completar estas líneas generales que parecen bastante claras, pero que nos dejan vislumbrar toda una serie de problemas cuya solución tan sólo podemos obtenerla mediante una especialización superior en los distintos trabajos a realizar.

Ordenación tipológica del instrumental de pesca en bronce ibero-romano

Tradicionalmente, las noticias sobre actividades pesqueras y sus industrias derivadas de salazón y conservas han estado circunscritas en la Península Ibérica a la zona del sudeste, en relación directa con la presencia colonial fénico-púnica y el posterior desarrollo de idénticas actividades en época romana. Por el contrario, y en relación con el litoral catalán, solamente Avieno, al citar la «marisma feraz siempre en peces», situada en las cercanías de Callípolis y Tito Livio, al hablar de que los colonos griegos de Ampurias «al principio para 'mantenerse se fiaban delmar», comentan las posibilidades piscícolas de la zona.

Avaliação de repertórios brasileiros em agricultura, ciência da informação e direito: uma análise de conteúdo

Avaliação da análise de conteúdo que apresentam repertórios brasileiros em Agricultura (Agrobase e Base de Dados da Pesquisa Agropecuária), Ciência da Informação (Lici), e Direito (Bibliografia Brasileira de Direito). Após identificar os antecedentes, natureza, usuários potenciais e tipo de produto oferecido por cada um dos repertórios, mediu-se a percentagem da exaustividade de sua cobertura. As tarefas relativas à avaliação da indexação e do resumo se fizeram a partir da seleção de 20 registros de cada um deles, que foram comparados mediante inspeção direta com os correspondentes originais. Utilizou-se também um questionário para determinar a linguagem documental e os critérios utilizados para fazer a análise. Atendeu-se especialmente ao exame da indexação e do resumo feitos no original, assim como sua profundidade e pertinência, medindo-se inclusive o índice de consistência quando possível. Os resumos foram estudados de acordo com o translado da superestrutura do original e a sua qualidade técnica, medindo-se os seus fatores de legibilidade. Os resultados foram apresentados por meio de dados comparativos.

Necrotizing fasciitis: contribution and limitations of diagnostic imaging.

Necrotizing fasciitis is a rare, rapidly spreading, deep-seated infection causing thrombosis of the blood vessels located in the fascia. Necrotizing fasciitis is a surgical emergency. The diagnosis typically relies on clinical findings of severe sepsis and intense pain, although subacute forms may be difficult to recognize. Imaging studies can help to differentiate necrotizing fasciitis from infections located more superficially (dermohypodermitis). The presence of gas within the necrotized fasciae is characteristic but may be lacking. The main finding is thickening of the deep fasciae due to fluid accumulation and reactive hyperemia, which can be visualized using computed tomography and, above all, magnetic resonance imaging (high signal on contrast-enhanced T1 images and T2 images, best seen with fat saturation). These findings lack specificity, as they can be seen in non-necrotizing fasciitis and even in non-inflammatory conditions. Signs that support a diagnosis of necrotizing fasciitis include extensive involvement of the deep intermuscular fascias (high sensitivity but low specificity), thickening to more than 3mm, and partial or complete absence on post-gadolinium images of signal enhancement of the thickened fasciae (fairly high sensitivity and specificity). Ultrasonography is not recommended in adults, as the infiltration of the hypodermis blocks ultrasound transmission. Thus, imaging studies in patients with necrotizing fasciitis may be challenging to interpret. Although imaging may help to confirm deep tissue involvement and to evaluate lesion spread, it should never delay emergency surgical treatment in patients with established necrotizing fasciitis.

Stable isotope geochemistry and phase-equilibria of coesite-bearing whiteschists, Dora Maira massif, Western Alps

Peak metamorphic temperatures for the coesite-pyrope-bearing whiteschists from the Dora Maira Massif, western Alps were determined with oxygen isotope thermometry. The deltaO-18(SMOW) values of the quartz (after coesite) (delta O-18 = 8.1 to 8.6 parts per thousand, n = 6), phengite (6.2 to 6.4 parts per thousand, n = 3), kyanite (6.1 parts per thousand, n = 2), garnet (5.5 to 5.8 parts per thousand, n = 9), ellenbergerite (6.3 parts per thousand, n = 1) and rutile (3.3. to 3.6 parts per thousand, n = 3) reflect isotopic equilibrium. Temperature estimates based on quartz-garnet-rutile fractionation are 700-750-degrees-C. Minimum pressures are 31-32 kb based on the pressure-sensitive reaction pyrope + coesite = kyanite + enstatite. In order to stabilize pyrope and coesite by the temperature-sensitive dehydration reaction talc + kyanite = pyrope + coesite + H2O, the a(H2O) must be reduced to 0.4-0.75 at 700 750-degrees-C. The reduced a(H2O) cannot be due to dilution by CO2, as pyrope is not stable at X (CO2) > 0.02 (T = 750-degrees-C; P = 30 kb). In the absence of a more exotic fluid diluent (e.g. CH4 or N2), a melt phase is required. Granite solidus temperatures are approximately 680-degrees-C/30 kb at a(H2O) = 1.0 and are calculated to be approximately 70-degrees-C higher at a(H2O) = 0.7, consistent with this hypothesis. Kyanite-jadeite-quartz bands may represent a relict melt phase. Peak P-T-f(H2O) estimates for the whiteschist are 34 +/- 2 kb, 700-750-degrees-C and 0.4-0.75. The oxygen isotope fractionation between quartz (deltaO-18 = 11.6%.) and garnet (deltaO-18 = 8.7 parts per thousand) in the surrounding orthognesiss is identical to that in the coesite-bearing unit, suggesting that the two units shared a common, final metamorphic history. Hydrogen isotope measurements were made on primary talc and phengite (deltaD(smow) = -27 to -32 parts per thousand), on secondary talc and chlorite after pyrope (deltaD = - 39 to - 44 parts per thousand) and on the surrounding biotite (deltaD = -64 parts per thousand) and phengite (deltaD = -44 parts per thousand) gneiss. All phases appear to be in near-equilibrium. The very high deltaD values for the primary hydrous phases is consistent with an initial oceanic-derived/connate fluid source. The fluid source for the retrograde talc + chlorite after pyrope may be fluids evolved locally during retrograde melt crystallization. The similar deltaD, but dissimilar deltaO-18 values of the coesite-bearing whiteschists and hosting orthogneiss suggest that the two were in hydrogen isotope equilibrium, but not oxygen isotope equilibrium. The unusual hydrogen and oxygen isotope compositions of the coesite-bearing unit can be explained as the result of metasomatism from slab-derived fluids at depth.

Avaliação de periódicos científicos brasileiros da área da psicologia

Este trabalho apresenta a segunda versão do processo de avaliação dos periódicos brasileiros da área da psicologia, conduzida pela Comissão Editorial Capes-Anpepp. As demandas para a realização deste empreendimento, que teve a sua versão inicial realizada em 1999, são as seguintes: (a) qualificar os veículos científicos nos quais publicam pesquisadores brasileiros vinculados aos programas de pós-graduação em psicologia; (b) criar mecanismos para viabilizar a manutenção dos periódicos com melhor avaliação; (c) estabelecer parâmetros para o incremento da qualidade dos periódicos da área. Foram avaliados 51 periódicos da área citados nos relatórios dos programas de pós-graduação do período 1999-2000, usando uma ficha de avaliação contendo cinco conjuntos de itens (Normalização, Publicação, Circulação, Autoria e Conteúdo e Gestão editorial), acompanhada de instruções enviadas para os editores dos periódicos. Posteriormente, as fichas foram conferidas pela Comissão, gerando uma classificação de duas entradas, de Âmbito (Nacional/Local) e Qualidade (A/B/C). Os principais resultados indicam que houve uma perceptível melhora na classificação das revistas brasileiras da área, nos seus diversos aspectos. Questões vinculadas à avaliação e desafios para as novas etapas são discutidas.