Broadly speaking: vocabulary in semantic dementia shifts towards general, semantically diverse words

One of the cardinal features of semantic dementia (SD) is a steady reduction in expressive vocabulary. We investigated the nature of this breakdown by assessing the psycholinguistic characteristics of words produced spontaneously by SD patients during an autobiographical memory interview. Speech was analysed with respect to frequency and imageability, and a recently-developed measure called semantic diversity. This measure quantifies the degree to which a word can be used in a broad range of different linguistic contexts. We used this measure in a formal exploration of the tendency for SD patients to replace specific terms with more vague and general words, on the assumption that more specific words are used in a more constrained set of contexts. Relative to healthy controls, patients were less likely to produce low-frequency, high-imageability words, and more likely to produce highly frequent, abstract words. These changes in the lexical-semantic landscape were related to semantic diversity: the highly frequent and abstract words most prevalent in the patients' speech were also the most semantically diverse. In fact, when the speech samples of healthy controls were artificially engineered such that low semantic diversity words (e.g., garage, spanner) were replaced with broader terms (e.g., place, thing), the characteristics of their speech production came to closely resemble that of SD patients. A similar simulation in which low-frequency words were replaced was less successful in replicating the patient data. These findings indicate systematic biases in the deterioration of lexical-semantic space in SD. As conceptual knowledge degrades, speech increasingly consists of general terms that can be applied in a broad range of linguistic contexts and convey less specific information.

Alterações da default mode network provocadas pela ingestão de Ayahuasca investigadas por Ressonância Magnética Funcional

Ayahuasca is psychotropic beverage that has been used for ages by indigenous populations in South America, notably in the Amazon region, for religious and medicinal purposes. The tea is obtained by the decoction of leaves from the Psychotria viridis with the bark and stalk of a shrub, the Banisteriopsis caapi. The first is rich in N-N-dimethyltryptamine (DMT), which has an important and well-known hallucinogenic effect due to its agonistic action in serotonin receptors, specifically 5-HT2A. On the other hand, β-carbolines present in B. caapi, particularly harmine and harmaline, are potent monoamine oxidase inhibitors (MAOi). In addition, the tetrahydroharmine (THH), also present in B. caapi, acts as mild selective serotonin reuptake inhibitor and a weak MAOi. This unique composition induces a number of affective, sensitive, perceptual and cognitive changes in individuals under the effect of Ayahuasca. On the other hand, there is growing interest in the Default Mode Network (DMN), which has been consistently observed in functional neuroimaging studies. The key components of this network include structures in the brain midline, as the anterior medial frontal cortex, ventral medial frontal cortex, posterior cingulate cortex, precuneus, and some regions within the inferior parietal lobe and middle temporal gyrus. It has been argued that DMN participate in tasks involving self-judgments, autobiographical memory retrieval, mental simulations, thinking in perspective, meditative states, and others. In general, these tasks require an internal focus of attention, hence the conclusion that the DMN is associated with introspective mental activity. Therefore, this study aimed to evaluate by functional magnetic resonance imaging (fMRI) changes in DMN caused via the ingestion of Ayahuasca by 10 healthy subjects while submitted to two fMRI protocols: a verbal fluency task and a resting state acquisition. In general, it was observed that Ayahuasca causes a reduction in the fMRI signal in central nodes of DMN, such as the anterior cingulate cortex, the medial prefrontal cortex, the posterior cingulate cortex, precuneus and inferior parietal lobe. Furthermore, changes in connectivity patterns of the DMN were observed, especially a decrease in the functional connectivity of the precuneus. Together, these findings indicate an association between the altered state of consciousness experienced by individuals under the effect of Ayahuasca, and changes in the stream of spontaneous thoughts leading to an increased introspective mental activity

Neural representation and clinically relevant moderators of individualised self-criticism in healthy subjects

Many people routinely criticise themselves. While self-criticism is largely unproblematic for most individuals, depressed patients exhibit excessive self-critical thinking, which leads to strong negative affects. We used functional magnetic resonance imaging in healthy subjects (N = 20) to investigate neural correlates and possible psychological moderators of self-critical processing. Stimuli consisted of individually selected adjectives of personally negative content and were contrasted with neutral and negative non-self-referential adjectives. We found that confrontation with self-critical material yielded neural activity in regions involved in emotions (anterior insula/hippocampus-amygdala formation) and in anterior and posterior cortical midline structures, which are associated with self-referential and autobiographical memory processing. Furthermore, contrasts revealed an extended network of bilateral frontal brain areas. We suggest that the co-activation of superior and inferior lateral frontal brain regions reflects the recruitment of a frontal top-down pathway, representing cognitive reappraisal strategies for dealing with evoked negative affects. In addition, activation of right superior frontal areas was positively associated with neuroticism and negatively associated with cognitive reappraisal. Although these findings may not be specific to negative stimuli, they support a role for clinically relevant personality traits in successful regulation of emotion during confrontation with self-critical material.

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

Making decisions with the future in mind: Developmental and comparative identification of mental time travel

Mechanisms that produce behavior which increase future survival chances provide an adaptive advantage. The flexibility of human behavior is at least partly the result of one such mechanism, our ability to travel mentally in time and entertain potential future scenarios. We can study mental time travel in children using language. Current results suggest that key developments occur between the ages of three to five. However, linguistic performance can be misleading as language itself is developing. We therefore advocate the use of methodologies that focus on future-oriented action. Mental time travel required profound changes in humans' motivational system, so that current behavior could be directed to secure not just present, but individually anticipated future needs. Such behavior should be distinguishable from behavior based on current drives, or on other mechanisms. We propose an experimental paradigm that provides subjects with an opportunity to act now to satisfy a need not currently experienced. This approach may be used to assess mental time travel in nonhuman animals. We conclude by describing a preliminary study employing an adaptation of this paradigm for children. (c) 2005 Elsevier Inc. All rights reserved.

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

Intentional forgetting in depressed states

The aim of this thesis was to extend previous research on intentional forgetting in depressed states. The first experiment used the think/no-think paradigm, and found that although dysphoric individuals were significantly worse at suppressing emotional (positive and negative) words than non-dysphoric individuals, both groups were unsuccessful at direct thought suppression. However, there was no effect of rumination on dysphoric individuals' ability to intentionally forget material. Furthermore, there was also no group differences in attentional measures of Stroop and IDEO. The second experiment involved modifying the TNT task, by including the use of substitute words in the suppression phase, in order to determine whether recalling substitute words during suppression would increase the level of forgetting. The findings from the study revealed that both dysphoric and non-dysphoric individuals were successful at intentionally forgetting neutral words using a thought substitution strategy. However, both groups were impaired at suppressing words in the direct thought substitution condition. The third experiment investigated the influence of thought substitution on intentional forgetting of emotional words in dysphoria. The study replicated experiment two, but used emotional (i.e. positive and depression-relevant) words instead of neutral words. The study found that dysphoric individuals were still impaired in their ability to suppress emotional material. Furthermore, dysphoric individuals were recalling significantly more depression­ relevant respond and previously-suppressed words. The fourth experiment examined the role of executive control in intentional forgetting. In the study, dysphoric and non­ dysphoric participants were categorised as having good or poor executive control based on their scores on the operation span with words task (OSPAN). The study found that non-dysphoric individuals with good control demonstrated successful suppression. However, dysphoric individuals with good control were unsuccessful at suppression. The fifth experiment investigated whether experimentally induced changes in mood state would alter an individual's ability to intentionally forget emotional material. Non-dysphoric healthy participants were given a positive or negative autobiographical memory and music mood induction. They completed two modified think/no-think tasks, one prior to the mood induction and one after the mood induction. The study found that transient negative mood state impaired intentional forgetting of depression-relevant material. Summary: Taken together, the findings suggest that individuals in a depressed mood are impaired in their ability to intentionally forget emotional material, even with the use of a thought substitution strategy. Furthermore, the findings implicate poor executive control and negative mood state in impaired intentional forgetting. An important theme emerging from the findings was the role of an inhibitory mechanism in intentional forgetting. The findings reported in this thesis suggest that thought substitution involves engaging an inhibitory control mechanism that contributes to successful intentional forgetting. The findings have clear implications on depressed individuals everyday functioning, and suggest that even with the presence of effective distraction, dysphoric indivduals are imapired in their ability to suppress emotional material. Furthermore, it is suggested that impaired intentional forgetting of emotional material may contribute to the maintenance of depressed mood, and could potentially worsen ongoing depression.

Disowned recollections:denying true experiences undermines belief in occurrence but not judgments of remembering

Recent research findings have illustrated that false memories induced in the laboratory can be dissociated from the beliefs that the events had in fact occurred. In this study we assessed whether this dissociability is a quality peculiar to false memory, or whether it represents a general characteristic of autobiographical memory. To this end we examined whether people can be induced to stop believing in memories for true experiences. Participants observed and performed simple actions, and were later falsely informed that they had not performed some of them-that false memories for these actions had been implanted through the use of fabricated evidence. Before and after receiving this misinformation, participants rated their belief in and memory of performing those actions, other actions that they had also performed, and actions that they had not performed. Whereas the misinformation substantially undermined participants' beliefs in the specific performed actions about which they had been misinformed, it had little effect on their endorsement of remembering those actions. The misinformation thus boosted the proportion of occasions in which participants rated their memories as stronger than their beliefs, and it weakened the correlation between belief and memory ratings. Thus, this study provides the first experimental demonstration of non-believed memories of true experiences. We discuss our findings with reference to the small literature concerning the use of socially-communicated misinformation to undermine event memories, and with reference to the structure of autobiographical memory. © 2013 Elsevier B.V.

Memória autobiográfica em jovens adultos com comportamentos suicidários

2008 Dissertação de Mestrado apresentada no Instituto Superior de Psicologia Aplicada para a obtenção de grau de Mestre na especialidade de Psicologia Clínica

Relação entre as memórias autobiográficas e relações interpessoais e de vinculação: Alterações de humor nas memórias autobiográficas

Dissertação de Mestrado apresentada no ISPA - Instituto Universitário para obtenção de grau de Mestre na especialidade de Psicologia Clínica

The short and long of it: neural correlates of temporal-order memory for autobiographical events.

Previous functional neuroimaging studies of temporal-order memory have investigated memory for laboratory stimuli that are causally unrelated and poor in sensory detail. In contrast, the present functional magnetic resonance imaging (fMRI) study investigated temporal-order memory for autobiographical events that were causally interconnected and rich in sensory detail. Participants took photographs at many campus locations over a period of several hours, and the following day they were scanned while making temporal-order judgments to pairs of photographs from different locations. By manipulating the temporal lag between the two locations in each trial, we compared the neural correlates associated with reconstruction processes, which we hypothesized depended on recollection and contribute mainly to short lags, and distance processes, which we hypothesized to depend on familiarity and contribute mainly to longer lags. Consistent with our hypotheses, parametric fMRI analyses linked shorter lags to activations in regions previously associated with recollection (left prefrontal, parahippocampal, precuneus, and visual cortices), and longer lags with regions previously associated with familiarity (right prefrontal cortex). The hemispheric asymmetry in prefrontal cortex activity fits very well with evidence and theories regarding the contributions of the left versus right prefrontal cortex to memory (recollection vs. familiarity processes) and cognition (systematic vs. heuristic processes). In sum, using a novel photo-paradigm, this study provided the first evidence regarding the neural correlates of temporal-order for autobiographical events.

Visual memory loss and autobiographical amnesia: a case study.

Amnesia typically results from trauma to the medial temporal regions that coordinate activation among the disparate areas of cortex that represent the information that make up autobiographical memories. We proposed that amnesia should also result from damage to these regions, particularly regions that subserve long-term visual memory [Rubin, D. C., & Greenberg, D. L. (1998). Visual memory-deficit amnesia: A distinct amnesic presentation and etiology. Proceedings of the National Academy of Sciences of the USA, 95, 5413-5416]. We previously found 11 such cases in the literature, and all 11 had amnesia. We now present a detailed investigation of one of these patients. M.S. suffers from long-term visual memory loss along with some semantic deficits; he also manifests a severe retrograde amnesia and moderate anterograde amnesia. The presentation of his amnesia differs from that of the typical medial-temporal or lateral-temporal amnesic; we suggest that his visual deficits may be contributing to his autobiographical amnesia.

The work of memory: embodiment, materiality and home in Jeanne Bouvier’s autobiographical writings

In this paper I follow trails in the memory of work by reading the books and papers of Jeanne Bouvier, a French seamstress, ardent trade-unionist and passionate writer, who left a rich body of labour literature including four published historical studies, as well as the memoirs of her life, work and struggles. Work, action and creativity are three interrelated planes on which Bouvier situates herself, while memory and imagination are interwoven in the way she seeks to understand herself in the world with others. What emerges as a particularly striking theme from Bouvier’s papers is a material matrix of mnemonic and imaginary practices, wherein bodies, places and objects are entangled in the narrative constitution of the self of the woman worker/writer.