Neural representation and clinically relevant moderators of individualised self-criticism in healthy subjects


Autoria(s): Doerig, Nadja; Schlumpf, Yolanda; Spinelli, Simona; Späti, Jakub; Brakowski, Janis; Quednow, Boris B.; Seifritz, Erich; Grosse Holtforth, Martin
Data(s)

2014

Resumo

Many people routinely criticise themselves. While self-criticism is largely unproblematic for most individuals, depressed patients exhibit excessive self-critical thinking, which leads to strong negative affects. We used functional magnetic resonance imaging in healthy subjects (N = 20) to investigate neural correlates and possible psychological moderators of self-critical processing. Stimuli consisted of individually selected adjectives of personally negative content and were contrasted with neutral and negative non-self-referential adjectives. We found that confrontation with self-critical material yielded neural activity in regions involved in emotions (anterior insula/hippocampus-amygdala formation) and in anterior and posterior cortical midline structures, which are associated with self-referential and autobiographical memory processing. Furthermore, contrasts revealed an extended network of bilateral frontal brain areas. We suggest that the co-activation of superior and inferior lateral frontal brain regions reflects the recruitment of a frontal top-down pathway, representing cognitive reappraisal strategies for dealing with evoked negative affects. In addition, activation of right superior frontal areas was positively associated with neuroticism and negatively associated with cognitive reappraisal. Although these findings may not be specific to negative stimuli, they support a role for clinically relevant personality traits in successful regulation of emotion during confrontation with self-critical material.

Formato

application/pdf

Identificador

http://boris.unibe.ch/67372/1/1333.full.pdf

Doerig, Nadja; Schlumpf, Yolanda; Spinelli, Simona; Späti, Jakub; Brakowski, Janis; Quednow, Boris B.; Seifritz, Erich; Grosse Holtforth, Martin (2014). Neural representation and clinically relevant moderators of individualised self-criticism in healthy subjects. Social Cognitive and Affective Neuroscience, 9(9), pp. 1333-1340. Oxford University Press 10.1093/scan/nst123 <http://dx.doi.org/10.1093/scan/nst123>

doi:10.7892/boris.67372

info:doi:10.1093/scan/nst123

info:pmid:23887820

urn:issn:1749-5024

Idioma(s)

eng

Publicador

Oxford University Press

Relação

http://boris.unibe.ch/67372/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Doerig, Nadja; Schlumpf, Yolanda; Spinelli, Simona; Späti, Jakub; Brakowski, Janis; Quednow, Boris B.; Seifritz, Erich; Grosse Holtforth, Martin (2014). Neural representation and clinically relevant moderators of individualised self-criticism in healthy subjects. Social Cognitive and Affective Neuroscience, 9(9), pp. 1333-1340. Oxford University Press 10.1093/scan/nst123 <http://dx.doi.org/10.1093/scan/nst123>

Palavras-Chave #610 Medicine & health #150 Psychology
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed