547 resultados para TIR
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Özege, M. S. Eski harflerle,
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Mode of access: Internet.
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Listing of works published by Librairie of Auguste Leneveu found on 4 folded pages inserted in book.
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Le faris, tr. by the author. cf. p. 61.
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Mode of access: Internet.
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Mode of access: Internet.
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"Revu & augmenté d'un grand nombre de mots & de phrases, tant Angloises que Françoises ; et d'une Dissertation sur la prosodie.
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Dedication signed: A. Richer.
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Mode of access: Internet.
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Vol. 1 contains "Histoire des anciens traitez ... par Mr. Barbeyrac," in 2 parts, each with special t.-p. and separate paging; vols. 4-5, "Le ceremonial diplomatique des cours de l'Europe ... " with special t.-p. and general half-title.
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"Manifeste de S.M. l'empereur": p. [175]-184.
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Bibliographical foot-notes.
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Vol. 6, plates. 31 cm.
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Attaching and effacing (A/E) lesions and actin polymerization, the hallmark of enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR) infections, are dependent on the effector Tir. Phosphorylation of Tir(EPEC/CR) Y474/1 leads to recruitment of Nck and neural Wiskott-Aldrich syndrome protein (N-WASP) and strong actin polymerization in cultured cells. Tir(EPEC/CR) also contains an Asn-Pro-Tyr (NPY(454/1)) motif, which triggers weak actin polymerization. In EHEC the NPY(458) actin polymerization pathway is amplified by TccP/EspF(U), which is recruited to Tir via IRSp53 and/or insulin receptor tyrosine kinase substrate (IRTKS). Here we used C. rodentium to investigate the different Tir signalling pathways in vivo. Following infection with wild-type C. rodentium IRTKS, but not IRSp53, was recruited to the bacterial attachment sites. Similar results were seen after infection of human ileal explants with EHEC. Mutating Y471 or Y451 in Tir(CR) abolished recruitment of Nck and IRTKS respectively, but did not affect recruitment of N-WASP or A/E lesion formation. This suggests that despite their crucial role in actin polymerization in cultured cells the Tir:Nck and Tir:IRTKS pathways are not essential for N-WASP recruitment or A/E lesion formation in vivo. Importantly, wild-type C. rodentium out-competed the tir tyrosine mutants during mixed infections. These results uncouple the Tir:Nck and Tir:IRTKS pathways from A/E lesion formation in vivo but assign them an important in vivo role.
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El presente trabajo de grado, tuvo como propósito identificar los riesgos presentes en la construcción de un proyecto de infraestructura vial y analizar cuál sería su impacto en la Tasa Interna de Retorno TIR, en caso de que estos se materialicen -- Para dar cumplimiento a estos objetivos se realizó el estudio de varios proyectos de infraestructura vial apoyado en visitas aprovechando las nuevas concesiones viales que surgen en el País como es el caso de las 4G o cuarta generación de concesiones viales, al igual que se utilizaron modelos de simulación, para representar los escenarios en los cuales los riesgos se puede presentar y afectar la inversión realizada, afectando los ingresos esperados a futuro