Modelling Future Coronary Heart Disease Mortality to 2030 in the British Isles

OBJECTIVE: Despite rapid declines over the last two decades, coronary heart disease (CHD) mortality rates in the British Isles are still amongst the highest in Europe. This study uses a modelling approach to compare the potential impact of future risk factor scenarios relating to smoking and physical activity levels, dietary salt and saturated fat intakes on future CHD mortality in three countries: Northern Ireland (NI), Republic of Ireland (RoI) and Scotland.

METHODS: CHD mortality models previously developed and validated in each country were extended to predict potential reductions in CHD mortality from 2010 (baseline year) to 2030. Risk factor trends data from recent surveys at baseline were used to model alternative future risk factor scenarios: Absolute decreases in (i) smoking prevalence and (ii) physical inactivity rates of up to 15% by 2030; relative decreases in (iii) dietary salt intake of up to 30% by 2030 and (iv) dietary saturated fat of up to 6% by 2030. Probabilistic sensitivity analyses were then conducted.

RESULTS: Projected populations in 2030 were 1.3, 3.4 and 3.9 million in NI, RoI and Scotland respectively (adults aged 25-84). In 2030: assuming recent declining mortality trends continue: 15% absolute reductions in smoking could decrease CHD deaths by 5.8-7.2%. 15% absolute reductions in physical inactivity levels could decrease CHD deaths by 3.1-3.6%. Relative reductions in salt intake of 30% could decrease CHD deaths by 5.2-5.6% and a 6% reduction in saturated fat intake might decrease CHD deaths by some 7.8-9.0%. These projections remained stable under a wide range of sensitivity analyses.

CONCLUSIONS: Feasible reductions in four cardiovascular risk factors (already achieved elsewhere) could substantially reduce future coronary deaths. More aggressive polices are therefore needed in the British Isles to control tobacco, promote healthy food and increase physical activity.

Translation as an Evaluative Concept

Testing the hypothesis that the concept of translation is evaluative rather than merely descriptive, Blumczyński analyses its increasingly popular use in three areas: political discourse, life writing and biomedical publications. He argues that translation as an evaluative concept is concerned with profound rather than superficial issues: to translate something is to assert its significance and value. At the same time, translation brings to the surface real and authentic things, producing its therapeutic value: it makes us more visible to ourselves, exposes pretences and thus brings relief. Finally, translation delivers on its own ethical imperative by breaking the spell of proverbial good intentions and bringing things to completion.

Translating Values:Evaluative Concepts in Translation

This collection explores the central importance of values and evaluative concepts in cross-cultural translational encounters. Written by a group of international scholars from a diverse range of linguistic and cultural backgrounds, the chapters in this book consider what it means to translate cultures by examining core values and their relationship to key evaluative concepts (such as authenticity, clarity, home, honour, or justice) and how they influence the complex multidimensional process of translation. This book will be of interest to academics studying cross-cultural and inter-linguistic interactions, to translators and interpreters, students of translation and of modern languages, and all those dealing with multilingual and multicultural settings.

Ubiquitous Translation

In this book, Piotr Blumczynski explores the central role of translation as a key epistemological concept as well as a hermeneutic, ethical, linguistic and interpersonal practice. His argument is three-fold: (1) that translation provides a basis for genuine, exciting, serious, innovative and meaningful exchange between various areas of the humanities through both a concept (the WHAT) and a method (the HOW); (2) that, in doing so, it questions and challenges many of the traditional boundaries and offers a transdisciplinary epistemological paradigm, leading to a new understanding of quality, and thus also meaning, truth, and knowledge; and (3) that translational phenomena are studied by a broad range of disciplines in the humanities (including philosophy, theology, linguistics, and anthropology) using various, often seemingly unrelated concepts which nevertheless display a considerable degree of qualitative proximity. The common thread running through all these convictions and binding them together is the insistence that translational phenomena are ubiquitous. Because of its unconventional and innovative approach, this book will be of interest to translation studies scholars looking to situate their research within a broader transdisciplinary model, as well as to students of translation programs and practicing translators who seek a fuller understanding of why and how translation matters.

Reactivity of bulky tris(Phenylpyrazolyl) methanesulfonate copper(I) complexes towards small unsaturated molecules

Reaction of the tris(3-phenylpyrazolyl)methane sulfonate species (Tpms(Ph))Li with the copper(I) complex [Cu(MeCN)(4)][PF6] affords [Cu(Tpms(Ph))(MeCN)] 1. The latter, upon reaction with equimolar amounts of cyclohexyl-(CyNC) or 2,6-dimethylphenyl (XylNC) isocyanides, or excess CO, furnishes the corresponding Cu(I)complexes [Cu(Tpms(Ph))(CNR)] (R = Cy 2, Xyl 3) or [Cu(Tpms(Ph))(CO)] 4. The ligated isocyanide in 2 or 3 (or the acetonitrile ligand in 1)is displaced by 3-iminoisoindolin-1-one to afford 5, the first copper(I) complex containing an 3-iminoisoindolin-1-one ligand. The ligated acetonitrile in 1 undergoes nucleophilic attack by methylamine to give the amidine complex [Cu(Tpms(Ph)){MeC(NH)NHMe}] 6, whereas only the starting materials were recovered from the attempted corresponding reactions of 2 and 3 with methylamine. Complexes 1 or 6 form the trinuclear hydroxo-copper(II)species [(mu-Cu){Cu(mu-OH) (2)(Tpms(Ph))}(2)] 7 upon air oxidation in moist methanol. In all the complexes the scorpionate ligand facially caps the metal in the N,N,O-coordination mode.

Simulations magnétohydrodynamiques en régime idéal

Cette thèse s’intéresse à la modélisation magnétohydrodynamique des écoulements de fluides conducteurs d’électricité multi-échelles en mettant l’emphase sur deux applications particulières de la physique solaire: la modélisation des mécanismes des variations de l’irradiance via la simulation de la dynamo globale et la reconnexion magnétique. Les variations de l’irradiance sur les périodes des jours, des mois et du cycle solaire de 11 ans sont très bien expliquées par le passage des régions actives à la surface du Soleil. Cependant, l’origine ultime des variations se déroulant sur les périodes décadales et multi-décadales demeure un sujet controversé. En particulier, une certaine école de pensée affirme qu’une partie de ces variations à long-terme doit provenir d’une modulation de la structure thermodynamique globale de l’étoile, et que les seuls effets de surface sont incapables d’expliquer la totalité des fluctuations. Nous présentons une simulation globale de la convection solaire produisant un cycle magnétique similaire en plusieurs aspects à celui du Soleil, dans laquelle le flux thermique convectif varie en phase avec l’ ́energie magnétique. La corrélation positive entre le flux convectif et l’énergie magnétique supporte donc l’idée qu’une modulation de la structure thermodynamique puisse contribuer aux variations à long-terme de l’irradiance. Nous analysons cette simulation dans le but d’identifier le mécanisme physique responsable de la corrélation en question et pour prédire de potentiels effets observationnels résultant de la modulation structurelle. La reconnexion magnétique est au coeur du mécanisme de plusieurs phénomènes de la physique solaire dont les éruptions et les éjections de masse, et pourrait expliquer les températures extrêmes caractérisant la couronne. Une correction aux trajectoires du schéma semi-Lagrangien classique est présentée, qui est basée sur la solution à une équation aux dérivées partielles nonlinéaire du second ordre: l’équation de Monge-Ampère. Celle-ci prévient l’intersection des trajectoires et assure la stabilité numérique des simulations de reconnexion magnétique pour un cas de magnéto-fluide relaxant vers un état d’équilibre.

Le sang du ciel, un témoignage-fiction pour interroger la vérité

L'objectif de cette recherche est de réfléchir à la notion de vrai dans l'économie discursive du témoignage. C'est-à-dire que ce mémoire se concentre sur le rapport entre le discours critique et académique d'une part, et le discours littéraire de l'autre. Une première partie s'attache à délimiter les contours de du problème, à partir notamment des notions de de vrai et de vraisemblable. Une étude comparative permet d'introduire trois auteurs qui serviront d'exemple tout au long de la recherche: Primo Levi, Jorge Semprun, et Charlotte Delbo. On fait un bref survol de l'évolution des deux économies discursives depuis les tout premiers témoignages (années 40-50) jusqu'au tournant narratif symbolisé par le procès Eichmann. Cela correspond aussi à la parution d'un témoignage à part: Le sang du ciel, de Piotr Rawicz. La seconde partie est un état de la question sur le roman de Rawicz. Comment le fait qu'il s'agisse d'une fiction, notamment, a été discuté par la critique et dans les contributions universitaires qui lui sont consacrées. Cette incursion dans l'herméneutique nous permet d'identifier trois vagues critiques distinctes, selon les époques et les pays. Enfin, la dernière partie s'attache à montrer que Le sang du ciel est un témoignage pensé comme un projet esthétique, dont la modernité ne cède pas à la facilité du refus de dire de quoi on parle, mais qui au contraire pose des questions de son temps et ose aborder les sujets que l'on doit taire selon la doxa.

Self-organized sociopolitical interactions as the best way to achieve organized patterns in human social systems: going beyond the top-down control of classical political regimes

La monografía presenta la auto-organización sociopolítica como la mejor manera de lograr patrones organizados en los sistemas sociales humanos, dada su naturaleza compleja y la imposibilidad de las tareas computacionales de los regímenes políticos clásico, debido a que operan con control jerárquico, el cual ha demostrado no ser óptimo en la producción de orden en los sistemas sociales humanos. En la monografía se extrapola la teoría de la auto-organización en los sistemas biológicos a las dinámicas sociopolíticas humanas, buscando maneras óptimas de organizarlas, y se afirma que redes complejas anárquicas son la estructura emergente de la auto-organización sociopolítica.

El matrimonio y sus efectos personales según la doctrina y jurisprudencia Colombiana

Varias tendencias han regido a nuestro país en relación al vínculo matrimonial. Jurídicamente el matrimonio es una institución que regula el nacimiento y efectos de un grupo social. Por eso el matrimonio es, en esencia un fenómeno social.

The Institution of Transmission Easement in Poland

The text presents an analysis of the institution of transmission easement, which is featured from the perspective of civil-law and public-law relations. The text does not address all the issues related to the institution of transmission easement, that is, no comprehensive analysis of the issues of the grounds for easement establishment, expiry, or remuneration and compensation for easement was conducted. The text presents a general description of the establishment of transmission easement against the backdrop of the Polish Civil Code and the Bill on Transmission Corridors of 18 July 2013, which is currently being drafted. The analysis of the easement institution, apart from the synthetic approach to legal provisions, features a functional and teleological interpretation. It is worth pointing out the aim that the legislator wished to achieve with respect to the work on new considerations both in the domain of the private and public law: 1. the legislator aimed to regulate the disorderly legal status of civil-law relations, but also to avoid dispute in the future, 2. with the aid of new regulations, the legislator wished to respond to the public interest.

Katalizatory złotowo-miedziowe na nośnikach cerowych, cyrkonowych i cerowo-cyrkonowych – preparatyka, charakterystyka i zastosowanie w procesach utleniania

Wydział Chemii