MicroRNA Signature Obtained From the Comparison of Aggressive With Indolent Non-Hodgkin Lymphomas: Potential Prognostic Value in Mantle-Cell Lymphoma

Purpose Mantle-cell lymphoma (MCL) has a variable natural history but is incurable with current therapies. MicroRNAs (miRs) are useful in prognostic assessment of cancer. We determined an miR signature defining aggressiveness in B-cell non-Hodgkin lymphomas (NHL) and assessed whether this signature aids in MCL prognosis.MethodsWe assessed miR expression in a training set of 43 NHL cases. The miR signature was validated in 44 additional cases and examined on a training set of 119 MCL cases from four institutions in Canada. miRs significantly associated with overall survival were examined in an independent cohort of 114 MCL cases to determine association with patient outcome. miR expression was combined with current clinical prognostic factors to develop an enhanced prognostic model in patients with MCL.ResultsFourteen miRs were differentially expressed between aggressive and indolent NHL; 11 of 14 were validated in an independent set of NHL (excluding MCL). miR-127-3p and miR-615-3p were significantly associated with overall survival in the MCL training set. Their expression was validated in an independent MCL patient set. In comparison with Ki-67, expression of these miRs was more significantly associated with overall survival among patients with MCL. miR-127-3p was combined with Ki-67 to create a new prognostic model for MCL. A similar model was created with miR-615-3p and Mantle Cell Lymphoma International Prognostic Index scores.ConclusionEleven miRs are differentially expressed between aggressive and indolent NHL. Two novel miRs were associated with overall survival in MCL and were combined with clinical prognostic models to generate novel prognostic data for patients with MCL. (C) 2013 by American Society of Clinical Oncology

Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?

A significant proportion (up to 62) of oral squamous cell carcinomas (OSCCs) may arise from oral potential malignant lesions (OPMLs), such as leukoplakia. Patient outcomes may thus be improved through detection of lesions at a risk for malignant transformation, by identifying and categorizing genetic changes in sequential, progressive OPMLs. We conducted array comparative genomic hybridization analysis of 25 sequential, progressive OPMLs and same-site OSCCs from five patients. Recurrent DNA copy number gains were identified on 1p in 20/25 cases (80) with minimal, high-level amplification regions on 1p35 and 1p36. Other regions of gains were frequently observed: 11q13.4 (68), 9q34.13 (64), 21q22.3 (60), 6p21 and 6q25 (56) and 10q24, 19q13.2, 22q12, 5q31.2, 7p13, 10q24 and 14q22 (48). DNA losses were observed in 20 of samples and mainly detected on 5q31.2 (35), 16p13.2 (30), 9q33.1 and 9q33.29 (25) and 17q11.2, 3p26.2, 18q21.1, 4q34.1 and 8p23.2 (20). Such copy number alterations (CNAs) were mapped in all grades of dysplasia that progressed, and their corresponding OSCCs, in 70 of patients, indicating that these CNAs may be associated with disease progression. Amplified genes mapping within recurrent CNAs (KHDRBS1, PARP1, RAB1A, HBEGF, PAIP2, BTBD7) were selected for validation, by quantitative real-time PCR, in an independent set of 32 progressive leukoplakia, 32 OSSCs and 21 non-progressive leukoplakia samples. Amplification of BTBD7, KHDRBS1, PARP1 and RAB1A was exclusively detected in progressive leukoplakia and corresponding OSCC. BTBD7, KHDRBS1, PARP1 and RAB1A may be associated with OSCC progression. Proteinprotein interaction networks were created to identify possible pathways associated with OSCC progression.

A summary of the 2004 Ohio Music Education Association research forum presented by Dr. Patricia J. Flowers.

Each year, the Research Committee of the Ohio Music Education Association sponsors a half-day Research Forum prior to the beginning of the state music education association conference. In 2004, Dr. Patricia J. Flowers, Professor of Music at the Ohio State University was the guest speaker. This article summarizes her talk on the process of becoming a music education researcher

Riccoeur, Paul (2005) Sobre la traducción. Traducción y prólogo de Patricia Wilson. Buenos Aires, Paidós, 21/13, 75 p. ISBN 950-12-6544-7

Fil: Filippini, Ana María.

Imágenes del patriarcado en el teatro de Patricia Zangaro

Este trabajo se encuadra en una investigación más amplia sobre el teatro argentino contemporáneo escrito por mujeres, en la cual pretendo examinar la representación de las cuestiones de género en la textualidad de las dramaturgas argentinas y su relación con las condiciones socio-históricas de producción, circulación y reconocimiento de sus obras. En este caso, indago en las obras de Patricia Zangaro para determinar si presentan una discursividad propia del género, es decir, que intente transgredir o subvertir el discurso masculino, proponiendo una subjetividad femenina autónoma, opuesta a los estereotipos culturales relacionados con diferencias genéricas y con la representación de la mujer. Asimismo, examino si dicha transgresión responde a una ideología estético-política que pueda inferirse a partir de la poética teatral de la autora. Me enfoco en sus piezas “Por un reino", “Última luna", “Tiempo de aguas" y “La hora nona".

Patricia Funes, Salvar la Nación.Intelectuales, cultura y política en los años veinte latinoamericanos, Buenos Aires, Prometeo, 2006, 442 páginas

Fil: Sessa, Leandro. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Rodolfo Richard-Jorba, Eduardo Pérez Romagnoli, Patricia Barrio e Inés Sanjurjo. 2006. La región vitivinícola argentina. Transformaciones del territorio, la economía y la sociedad, 1870- 1914. Bernal: Universidad Nacional de Quilmes

Fil: Ospital, María Silvia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.