La Política 2.0 amb la generació Nintendo

The eruption of Web 2.0 has transformed the uses and strategies of political communication. The campaign developed by Obama's team is a good example of the electoral efficiency of these new tools whose results we are now analysing and evaluating. While our present leaders could be classified as the "fax generation", the North American experience opens the doors to a new way of relating with the electoral masses. With these new instruments of interactive communication, voters have the space to be able to make their voices heard and to be able to affect the electoral programme, something which undoubtedly benefits an election campaign's degree of democratic quality

Evolving techniques to evaluate ejaculatory function.

PURPOSE OF REVIEW: Recent findings in the physiology and neurobiology of ejaculation have expanded our understanding of male sexual function and have allowed the development of new instruments to investigate ejaculatory and orgasmic disorders. RECENT FINDINGS: The evidence-based definition of lifelong premature ejaculation has set a model in the evaluation and treatment outcome of sexual dysfunction. New instruments to objectively assess arousal, orgasm and the expulsion phase of ejaculation such as functional MRI, dynamic pelvic ultrasound, PET scans and validated questionnaires have lead to a better understanding of sexual dysfunction in men. Animal models, developments in neurobiology and clinical experience have transformed a purely psychoanalytical approach to ejaculatory and orgasmic function into a novel multidisciplinary, scientifically sound and evidence-based discipline of medicine. SUMMARY: Ejaculation is an integral part of normal sexual function. Ejaculatory dysfunction is common and may cause substantial disruption to the quality of a patient's life. A better understanding of the epidemiology, pathophysiology, neuroscience and genetics of ejaculatory and orgasmic function will eventually lead to the development of new, effective methods of treatment of disorders of ejaculation and orgasm in men.

Paperitehtaan lämpöenergianhallinta

Diplomityön tavoitteena oli kehittää oikeudenmukainen keino lämmönkulutuksen osastokohtaisen jaolle, sekä löytää lämmönkäytön tehostamismahdollisuuksia Stora Enson Summan tehtailta. Työ liittyi osana Summan tehtaille tehtyyn energiakatselmukseen. Todenmukainen lämmöntuotannon ja -kulutuksen tunteminen luo perustan oikeansuuntaisille lämpötaloutta parantaville teoille ja mahdollistaa lämpöenergian kustannusten oikean jaon osastoille. Osastokohtaisen lämmönkulutuksen selvittämiseksi tarvitaan uusia virtaus- ja lämpötilamittauksia. Tärkeintä on kuitenkin saada ensin tehtaan kokonaistase selville. Tehtaan lämmöntuotanto ja –kulutus eivät nykyisten mittausten mukaan täsmää täysin. Suurimpien höyryn massavirtojen mittaukset on saatava luotettaviksi kalibroinnein tai uusinnoin, ja vasta tehtaan kokonaislämpötaseen täsmätessä on järkevää pyrkiä täydellisiin osastokohtaisiin lämpötaseisiin. Lämmönkulutuksen pienentäminen vähentää polttoainekustannuksia, jolloin paperintuotannon kokonaiskustannukset pienenevät parantaen tehtaan kilpailukykyä. Vuonna 2005 alkava hiilidioksidipäästökauppa tulee luultavasti vaikuttamaan teollisuuden lämmönkäyttöön. Päästökaupan rasituksia voidaan vähentää pienentämällä lämmönkulutusta. Tehtaan lämmönsäästömahdollisuuksia tutkittiin systemaattisesti mm. lauhteenpalautusten järjestämisen tuomia säästöjä laskemalla, sekä osastokohtaisesti eri lämmönkulutuskohteita tarkastelemalla. Tehtaan lämmöntarvetta on mahdollista pienentää merkittävästi muutamilla toimenpiteillä.

Correlative microscopy.

In recent years correlative microscopy, combining the power and advantages of different imaging system, e.g., light, electrons, X-ray, NMR, etc., has become an important tool for biomedical research. Among all the possible combinations of techniques, light and electron microscopy, have made an especially big step forward and are being implemented in more and more research labs. Electron microscopy profits from the high spatial resolution, the direct recognition of the cellular ultrastructure and identification of the organelles. It, however, has two severe limitations: the restricted field of view and the fact that no live imaging can be done. On the other hand light microscopy has the advantage of live imaging, following a fluorescently tagged molecule in real time and at lower magnifications the large field of view facilitates the identification and location of sparse individual cells in a large context, e.g., tissue. The combination of these two imaging techniques appears to be a valuable approach to dissect biological events at a submicrometer level. Light microscopy can be used to follow a labelled protein of interest, or a visible organelle such as mitochondria, in time, then the sample is fixed and the exactly same region is investigated by electron microscopy. The time resolution is dependent on the speed of penetration and fixation when chemical fixatives are used and on the reaction time of the operator for cryo-fixation. Light microscopy can also be used to identify cells of interest, e.g., a special cell type in tissue or cells that have been modified by either transfections or RNAi, in a large population of non-modified cells. A further application is to find fluorescence labels in cells on a large section to reduce searching time in the electron microscope. Multiple fluorescence labelling of a series of sections can be correlated with the ultrastructure of the individual sections to get 3D information of the distribution of the marked proteins: array tomography. More and more efforts are put in either converting a fluorescence label into an electron dense product or preserving the fluorescence throughout preparation for the electron microscopy. Here, we will review successful protocols and where possible try to extract common features to better understand the importance of the individual steps in the preparation. Further the new instruments and software, intended to ease correlative light and electron microscopy, are discussed. Last but not least we will detail the approach we have chosen for correlative microscopy.

Kattilan ja kanaviston eristykset 3D-laitossuunnitteluohjelmassa

Työn tavoitteena oli kehittää kanavistojen ja kattilan eristyksien mallintamista 3D-laitossuunitteluohjelmassa sekä siitä saatavia materiaalilistoja. Kanavistojen eristeitä kuvastavaa geometriaa muokattiin vastaamaan eristyksen todellista tilanvarausta. Kattilan eristyksen mallintaminen on aikaisemmin jouduttu tekemään manuaalisesti, työssä kehitettiin työkalu, jonka avulla eristysten materiaalitiedot ja oikeat tilanvaraukset saadaan lisättyä 3D-malliin. Kaikkia eristyksen mallintamista ei kuitenkaan pystytä mielekkäästi toteuttamaan automaattisesti työkalujen avulla, näitä kohteita ovat tukikehikkorakenteet kuten kattilan vinttikehikko. Lisäksi täytyi selvittää, mitä tietoja eristyksien materiaalimäärälistoille vaaditaan, ja kuinka nämä tiedot saataisiin listoihin mukaan. Jotta kaikki eristettävät kohteet saadaan tuotettaviin materiaalilistoihin, on ohjelmaan lisättävä käytettäväksi uusia komponentteja. Näitä ovat uudet kanavistojen osat sekä muun muassa venturit ja huoltoluukut kanavistoille. Kattilaan asennettavat laitteet kuten näkölasit ja polttimet vaativat tukirakenteen, joka samalla toimii kotelona putkistojen taivutuksille. Näitä kohteita on aikaisemmin tuotu vanhoista projekteista tai ne on tehty suunnittelijan toimesta uusiksi. Työssä esitettiin uusi tapa mallintaa kattilan pinnat, jolloin niihin voidaan liittää koteloita erillisestä komponenttikirjastosta. Kanavistojen eristyksien materiaalimäärälistojen tuottaminen suoraan ohjelmasta auto-matisoitiin. Kattilan ja siihen liittyvien eristyskehysrakenteiden listojen tuotanto kuitenkin vaatii yhteisten toimintamallien kehittämistä. Tämän työn uudet menetelmät mahdollistavat yhä uusien työkalujen kehittämisen, esimerkiksi automaattisen eristysten teknisten piirustusten kuvatuotannon tulevaisuudessa.

Vakavaraisuussääntelyn muutosten vaikutukset paikallispankille

Tutkielman tavoitteena on selvittää muuttuvan pankkisääntelyn vaikutukset vähittäispankkitoimintaa harjoittavalle paikallispankille vakavaraisuuden näkökulmasta. Vaikutuksia vakavaraisuuteen mitataan luottoriskin osalta, sen muodostaessa merkittävimmän osan kohdepankin vakavaraisuusvaatimuksesta. Tarkoituksena on selvittää käytössä olevan standardimenetelmän ja vaihtoehtoisen sisäisten luottoluokitusten menetelmän erot luottoriskin mittaamisessa ja vaikutukset vakavaraisuuteen sekä Basel II että Basel III-säännöksillä mitattuina. Tutkielmassa huomioidaan myös Basel III -säännöksen mukaiset uudet sääntelyinstrumentit ja analysoidaan niiden vaikutusta liiketoimintaan. Sekä Basel II että Basel III -säännöksellä mitattuna sisäisten luottoluokitusten menetelmä paransi kohdepankin vakavaraisuutta. Basel III -säännöksen suurimmat vaikutukset kohdistuivat kohdepankilla omien varojen laatuvaatimuksiin, jotka heikensivät vakavaraisuutta. Laatuvaatimuksista ja nousseista pääomavaatimuksista huolimatta kohdepankin vakavaraisuus säilyi hyvällä ja vaatimukset ylittävällä tasolla. Uusien sääntelyinstrumenttien vaatimukset täyttyivät nykyisellä taserakenteella vähimmäisomavaraisuusasteen ja pysyvän varainhankinnan vaatimuksen osalta. Maksuvalmiusvaatimuksen täyttämiseksi sijoitussalkkuun pitää tehdä muutoksia, minkä odotetaan vaikuttavan heikentävästi kohdepankin tulokseen.

Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression

The biologic basis of the negative prognosis of plasmablastic myeloma is not fully understood. To determine whether histologically aggressive multiple myeloma (MM) is associated with a more angiogenic marrow environment, bone marrow samples from 50 recently diagnosed MM patients were evaluated. Twelve percent (6/50) of patients presented plasmablastic MM, and this feature correlated with moderate/strong intensity of vascular endothelial growth factor staining of plasma cells (P = 0.036). Although plasmablastic MM was not associated with increasing of microvessel density, this new evidence of increased expression of vascular endothelial growth factor on plasmablasts suggests that the adverse prognosis conferred by plasmablastic disease may be due, at least in part, to secretion of this angiogenic cytokine, also suggesting that the subset of MM patients with plasmablastic features may derive particular benefit from antiangiogenic therapies.

Certification : le manque d’indépendance des audits privés

Certains mouvements sociaux transnationaux (MSTN) militent pour le respect des normes sociales et environnementales en particulier dans les pays à bas salaires. Ils développent pour cela de nouveaux instruments, des labels et des codes de conduites. Ces mouvements sociaux transnationaux cherchent au travers ces derniers à renforcer la régulation sociale, environnementale et sa démocratisation au plan international. Mais la privatisation de la vérification des normes sociales et environnementales nuit à l’indépendance économique des auditeurs. Ainsi, ce mode de régulation s’avère contraire à leur objectif à long terme : une régulation sociale encadrée par des pouvoirs publics démocratisés.

Le rapport geste-son en musique électroacoustique

La version intégrale de ce mémoire est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l’Université de Montréal (www.bib.umontreal.ca/MU).

(Com)passo a (com)passo com o síndrome de Down

RESUMO: O presente projecto surge como trabalho final de Mestrado em “Educação Especial: Domínio Cognitivo e Motor”, relatando a concepção, realização e avaliação de um Projecto de Intervenção/Acção, no qual a Expressão Musical configura a área primordial de intervenção. O trabalho intitula-se “(Com)passo a (com)passo com a Síndrome de Down”. Baseia-se num grupo de treze crianças de educação pré-escolar, no qual está incluída uma criança com Síndrome de Down. Neste contexto reflecte-se sobre essa síndrome, segundo a perspectiva de vários autores. Descrevem-se também as metodologias de investigação utilizadas para a recolha de dados, tendo por base autores de referência. Faz-se ainda a caracterização do contexto escolar onde se desenvolveu o Projecto de Intervenção/Acção e a apresentação do respectivo Plano de Acção. Relata-se a intervenção realizada, acrescida da interpretação e avaliação dos dados obtidos a partir das vinte e três sessões de actividade levadas a cabo. A análise dos resultados permitiu inferir que as sessões de Expressão Musical se revestiram de um carácter bastante positivo, dado que se constataram mudanças consideráveis no comportamento das crianças e do grupo. Tais mudanças tornaram-se mais evidentes na área da socialização, traduzidas num maior envolvimento das crianças dentro do grupo, que provocou um maior entusiasmo e interesse em participar nas actividades propostas. ABSTRACT: The present draft appears as Masters final work in “Special Education: Cognitive and Motor Domains”, reporting the idea, implementation and evaluation of an Intervention / Action Project, in which the Musical Expression configures the primary area of intervention. The work is entitled “(Com)passo a (com)passo com a Síndrome de Down”, based on a group of thirteen children of preschool, in which is included in a child with Down Syndrome. In this context this work reflects upon this syndrome from several authors‟ perspective. It also describes the research methodologies used for data collection having for base reference authors. It‟s done, also, the characterization of the school environment where the Intervention/ Action Project and the presentation of its Action Plan were developed. It is reported the intervention, together with the interpretation and evaluation of data obtained from the twenty-three sessions of activity carried out. The results allowed inferring that Musical Expression sessions assumed a very positive character, given that significant changes were observed in the behavior of the studied children and the rest of the group. These changes became more evident in the socialization area, translated into a greater involvement of children within the group, which led to a greater enthusiasm and interest in participating in the proposed activities.

La revolución tecnológica en los medios de comunicación y los desafíos del derecho y la democracia (Tema Central)

El presente artículo aborda el impacto de la transformación tecnológica y los nuevos instrumentos de la teleinformática en los medios de comunicación masiva. La forma como se han estructurado las transnacionales mediáticas a partir del uso de instrumentos como la web, el software o el podcasting y los riesgos que su exceso conlleva respecto de la democracia al imponer sus intereses económicos y culturales por encima del interés del individuo, el interés público, la intimidad y el honor. Todo lo cual plantea nuevos desafíos al derecho y la protección de los derechos del individuo.

Aerosol Direct Radiative Impact Experiment (ADRIEX) overview

The Aerosol Direct Radiative Experiment (ADRIEX) took place over the Adriatic and Black Seas during August and September 2004 with the aim of characterizing anthropogenic aerosol in these regions in terms of its physical and optical properties and establishing its impact on radiative balance. Eight successful flights of the UK BAE-146 Facility for Atmospheric Airborne Measurements were completed together with surface-based lidar and AERONET measurements, in conjunction with satellite overpasses. This paper outlines the motivation for the campaign, the methodology and instruments used, describes the synoptic situation and provides an overview of the key results. ADRIEX successfully measured a range of aerosol conditions across the northern Adriatic, Po Valley and Black Sea. Generally two layers of aerosol were found in the vertical: in the flights over the Black Sea and the Po Valley these showed differences in chemical and microphysical properties, whilst over the Adriatic the layers were often more similar. Nitrate aerosol was found to be important in the Po Valley region. The use of new instruments to measure the aerosol chemistry and mixing state and to use this information in determining optical properties is demonstrated. These results are described in much more detail in the subsequent papers of this special issue.

Cloud information content analysis of multi-angular measurements in the oxygen A-band: application to 3MI and MSPI

The vertical distribution of cloud cover has a significant impact on a large number of meteorological and climatic processes. Cloud top altitude and cloud geometrical thickness are then essential. Previous studies established the possibility of retrieving those parameters from multi-angular oxygen A-band measurements. Here we perform a study and comparison of the performances of future instruments. The 3MI (Multi-angle, Multi-channel and Multi-polarization Imager) instrument developed by EUMETSAT, which is an extension of the POLDER/PARASOL instrument, and MSPI (Multi-angles Spectro-Polarimetric Imager) develoloped by NASA's Jet Propulsion Laboratory will measure total and polarized light reflected by the Earth's atmosphere–surface system in several spectral bands (from UV to SWIR) and several viewing geometries. Those instruments should provide opportunities to observe the links between the cloud structures and the anisotropy of the reflected solar radiation into space. Specific algorithms will need be developed in order to take advantage of the new capabilities of this instrument. However, prior to this effort, we need to understand, through a theoretical Shannon information content analysis, the limits and advantages of these new instruments for retrieving liquid and ice cloud properties, and especially, in this study, the amount of information coming from the A-Band channel on the cloud top altitude (CTOP) and geometrical thickness (CGT). We compare the information content of 3MI A-Band in two configurations and that of MSPI. Quantitative information content estimates show that the retrieval of CTOP with a high accuracy is possible in almost all cases investigated. The retrieval of CGT seems less easy but possible for optically thick clouds above a black surface, at least when CGT > 1–2 km.

"En ny musikuppfostran" : Reformpedagogiska anspråk i Siljanskolans bildningsinnehåll

 ”A new form of musical upbringing”: Pretenses of reform pedagogy content in the Siljan school In this article, I describe the Siljan school in Tällberg as a Swedish example of alternative pedagogy. The overall questions relate to the reform pedagogy content of the school and its ability to give Swedish music teaching a new form of musical upbringing. An important issue is how the Siljan school as a model for Swedish reform has been inspired by the reform pedagogy movements in USA and Germany. Te analysis is thus based on the Alm couple’s ability to give the school an international character which shines light on Swedish reforms in the greater context of reform pedagogy. With its basis in discursive education of the 1930s, two main questions are discussed: what perspective on musical education can be identifed in the personal development ethos of the Siljan school? How can the school’s relation to the reform pedagogy music movement during the start of the 1900s be understood? From a hermeneutic perspective, the article contributes by investigating how the Siljan school can have afected decisions in education politics, Swedish schooling, and Swedish musical life. In summary, the article contributes with new knowledge on a chapter in the history of Swedish music pedagogy.

Proteção aos investidores em xeque: estudos de casos do novo mercado

Esta dissertação investiga a efetividade das práticas de governança corporativa contidas no Regulamento do Novo Mercado (RNM), segmento especial de listagem da BM&FBOVESPA criado em 2000. Em tese, tais práticas deveriam assegurar a proteção efetiva dos direitos dos investidores de companhias desse segmento. Contudo, alguns casos ocorridos ao longo da primeira década do Novo Mercado lançaram dúvida sobre o respeito aos direitos dos acionistas de suas companhias. Entre eles, dois casos se destacam: Cosan, em 2007, e Tenda, em 2008. Especificamente, a presente pesquisa analisa qualitativamente e em profundidade ambos os casos a fim de verificar se as regras do RNM e as instituições responsáveis por sua aplicabilidade foram suficientes para proteger os investidores. Metodologicamente, utilizou-se a abordagem de estudo de caso de “crise corporativa” e “autopsia institucional” baseada em MILHAUPT e PISTOR (2008). Observou-se que o Novo Mercado foi resultado de um transplante jurídico e que a mera adoção de regras do segmento não foi suficiente para garantir a proteção efetiva aos investidores. Como resultado principal, concluiu-se que as operações societárias lideradas pelos controladores das companhias não só contrariaram regras do segmento (e princípios de governança que nortearam sua criação) como também podem ter infringido a regulação. Com isso, evidencia-se a falta de fiscalização do cumprimento das regras e de punição por parte da BM&FBOVESPA, bem como uma atitude insuficiente da CVM quando de potenciais infrações a dispositivos do ambiente regulatório brasileiro. Por outro lado, o Novo Mercado foi, no mínimo, indiretamente responsável pelo aprimoramento do arcabouço regulatório brasileiro na incorporação de novos instrumentos de proteção aos investidores. Os resultados deste trabalho podem auxiliar na elaboração de reformas na regulação e autorregulação a fim de facilitar a executoriedade das normas já existentes, a qual pode proporcionar maior credibilidade ao mercado de valores mobiliários e fomentar, em última instância, o desenvolvimento do mercado de capitais brasileiro. Trata-se de discussão fundamental, haja vista que a credibilidade do segmento mais exigente quanto às práticas de governança da Bolsa depende da proteção efetiva aos investidores, razão de criação do Novo Mercado.