Comprendiendo la política de seguridad internacional de Canadá: tras las huellas de los discursos liberales y realistas de una potencia media (1993-2008)

Esta investigación pretende contribuir a la comprensión de la política de seguridad internacional de Canadá. Para cumplir con dicho objetivo, esta investigación plantea dos propósitos específicos: a) ofrecer una revisión crítica del estado de conocimiento sobre esta política; y b) interpretar los discursos realistas y liberales que configuraron la política canadiense de seguridad internacional durante los gobiernos de Jean Chrétien (1993-2003), Paul Martin (2003-2006) y Stephen Harper (2006-2008). Los discursos liberales son entendidos aquí como complejos de creencias que precisan la obligación moral de comprometerse con proyectos cosmopolitas, tales como la promoción de los derechos humanos, la estabilización de los denominados Estados frágiles y fallidos o la contribución a los valores democrático-liberales. Los discursos realistas son entendidos como complejos de creencias derivados del espíritu de la realpolitik. Estas creencias señalan que los Estados deben buscar sus intereses nacionales independientemente de consideraciones morales.

O Binómio «Esquerda/Direita» no Portugal pós-25 de Abril

A esquerda e a direita estão, passados 35 anos, diferentes do que eram, mas iguais na clivagem que as distingue. PCP e CDS/PP alargaram até o grau de polarização, PS e PSD tornaram-se amiúde irmãos siameses que o eleitorado premeia ou penaliza ciclicamente, mas aos quais concede, desde 1975, o seu voto de confiança. na verdade, desde então o PCP está sozinho à esquerda e o CDS/PP à direita, aguardando sempre que um dos partidos chamados a formar governo (PS ou PSD) necessite de uma coligação.

Plant pathogens as suppressors of host defense

This chapter reviews our current knowledge about mechanisms of suppression developed by pathogens to avoid host defense responses. In general, plants perceive pathogens by diverse pathogen- or microbe- or even damage-associated molecular patterns (PAMPs, MAMPs, DAMPs) and induce a variety of defense mechanisms referred to as horizontal or basal resistance, nowadays designated PAMP-triggered immunity (PTI). In addition, plants can also recognize specific pathogen-derived effectors and have derived a highly specific defense response termed effector-triggered immunity (ETI), classically called R gene-mediated, specific or vertical resistance. Both PTI and ETI are responses to potential dangers and have common components. Fungal, oomycete, and bacterial pathogens have evolved various effector-based mechanisms of suppression that interfere with such components. Plants strongly depend on RNA gene silencing to interfere with viral pathogens. Plant viruses counteract this response by encoding suppressor proteins of RNA silencing.

Propagation of the Madden-Julian Oscillation through the Maritime Continent and scale interaction with the diurnal cycle of precipitation

The convectively active part of the Madden-Julian Oscillation (MJO) propagates eastward through the warm pool, from the Indian Ocean through the Maritime Continent (the Indonesian archipelago) to the western Pacific. The Maritime Continent's complex topography means the exact nature of the MJO propagation through this region is unclear. Model simulations of the MJO are often poor over the region, leading to local errors in latent heat release and global errors in medium-range weather prediction and climate simulation. Using 14 northern winters of TRMM satellite data it is shown that, where the mean diurnal cycle of precipitation is strong, 80% of the MJO precipitation signal in the Maritime Continent is accounted for by changes in the amplitude of the diurnal cycle. Additionally, the relationship between outgoing long-wave radiation (OLR) and precipitation is weakened here, such that OLR is no longer a reliable proxy for precipitation. The canonical view of the MJO as the smooth eastward propagation of a large-scale precipitation envelope also breaks down over the islands of the Maritime Continent. Instead, a vanguard of precipitation (anomalies of 2.5 mm day^-1 over 10^6 km^2) jumps ahead of the main body by approximately 6 days or 2000 km. Hence, there can be enhanced precipitation over Sumatra, Borneo or New Guinea when the large-scale MJO envelope over the surrounding ocean is one of suppressed precipitation. This behaviour can be accommodated into existing MJO theories. Frictional and topographic moisture convergence and relatively clear skies ahead of the main convective envelope combine with the low thermal inertia of the islands, to allow a rapid response in the diurnal cycle which rectifies onto the lower-frequency MJO. Hence, accurate representations of the diurnal cycle and its scale interaction appear to be necessary for models to simulate the MJO successfully.

A reversal of climatic trends in the North Atlantic since 2005

In the mid-1990s the North Atlantic subpolar gyre warmed rapidly, which had important climate impacts, such as increased hurricane numbers, and changes to rainfall over Africa, Europe and North America. Evidence suggests that the warming was largely due to a strengthening of the ocean circulation, particularly the Atlantic Meridional Overturning Circulation (AMOC). Since the mid-1990s direct and indirect measurements have suggested a decline in the strength of the ocean circulation, which is expected to lead to a reduction in northward heat transport. Here we show that since 2005 a large volume of the upper North Atlantic Ocean has cooled significantly by approximately -0.45C or 1.5x10^22 J, reversing the previous warming trend. By analysing observations and a state-of-the-art climate model, we show that this cooling is consistent with a reduction in the strength of the ocean circulation and heat transport, linked to record low densities in the deep Labrador Sea. The low density in the deep Labrador Sea is primarily due to deep ocean warming since 1995, but a long-term freshening also played a role. The observed upper ocean cooling since 2005 is not consistent with the hypothesis that anthropogenic aerosols directly drive Atlantic temperatures.

Holoprosencephaly and Holoprosencephaly-Like Phenotypes: Review of Facial and Molecular Findings in Patients From a Craniofacial Hospital in Brazil

Here we report on the clinical and genetic data for a large sample of Brazilian patients studied at the Hospital de Reabilitacao de Anomalas Craniofaciais-Universidade de Sao Paulo (HRAC-USP) who presented with either the classic holoprosencephaly or the holoprosencephaly-like (HPE-L) phenotype. The sample included patients without detected mutations in some HPE determinant genes such as SHH, GLI2, SIX3, TGIF, and PTCH, as well as the photographic documentation of the previously reported patients in our Center. The HPE-L phenotype has been also called of HPE ``minor forms"" or ""microforms,"" The variable phenotype, the challenge of genetic counseling, and the similarities to patients with isolated cleft lip/palate are discussed. (c) 2010 Wiley-Liss, Inc.

Angiotensin II modulates CD40 expression in vascular smooth muscle cells

The signalling pathway CD40/CD40L (CD40 ligand) plays an important role in atherosclerotic plaque formation and rupture. AngII (angiotensin II), which induces oxidative stress and inflammation, is also implicated in the progression of atherosclerosis. In the present study, we tested the hypothesis that AngII increases CD40/CD40L activity in vascular cells and that ROS (reactive oxygen species) are part of the signalling cascade that controls CD40/CD40L expression. Human CASMCs (coronary artery smooth muscle cells) in culture exposed to IL (interleukin)-1 beta or TNF-alpha (tumour necrosis factor-a) had increased superoxide generation and enhanced CD40 expression, detected by EPR (electron paramagnetic resonance) and immunoblotting respectively. Both phenomena were abolished by previous incubation with membrane-permeant antioxidants or cell transfection with P22(phox) antisense. AngII (50-200 nmol/l) induced an early and sustained increase in CD40 mRNA and protein expression in CASMCs, which was blocked by treatment with antioxidants. Increased CD40 expression led to enhanced activity of the pathway, as AngII-treated cells stimulated with recombinant CD40L released higher amounts of IL-8 and had increased COX-2 (cyclo-oxygenase-2) expression. We conclude that AngII stimulation of vascular cells leads to a ROS-dependent increase in CD40/CD40L signalling pathway activity. This phenomenon may be an important mechanism modulating the arterial injury observed in atherosclerosis-related vasculopathy.

A localização da indústria de transformação brasileira nas últimas três décadas

O propósito dessa dissertação é avaliar, numa perspectiva geográfica, os setores industriais no Brasil nas últimas três décadas. Numa primeira instância, o objetivo é verificar o nível de especialização e concentração dos estados brasileiros em termos industriais, utilizando-se os índices de Krugman e Gini, respectivamente. Com os resultados desses dois índices, os estados brasileiros são separados em quatro grupos, segundo o método de grupamento de médias K. Através de um produto interno usual entre o vetor da distribuição da produção industrial dos setores nos estados e vetores de algumas características desses setores (chamado de Viés das Características da Indústria - VCI), verifica-se em que tipos de indústrias os estados estão se especializando e/ou concentrando. Uma análise multivariada de componentes principais é feita com os VCI’s, na qual esses componentes principais são usados para verificar a similaridade dos estados. Sob outra perspectiva, busca-se investigar o nível de concentração geográfico dos setores industriais brasileiros. Para tanto, utilizaram-se o índice Gini e o índice de Venables. Nesse último, a distância entre os estados não é negligenciada para mensuração da concentração. Os setores industriais são separados em três grupos pelo método de grupamento de médias K, no qual as variáveis utilizadas são os componentes principais das características das indústrias. Utilizando outro produto interno, o Viés da Característica dos Estados (VCE), observa-se em que tipo de estados os setores industriais estão se concentrando ou não. Para visualizar como essas duas perspectivas, ou seja, como as características dos estados e das indústrias influenciam a localização dos setores industriais no território brasileiro, um modelo econométrico de dados cruzados de Midelfart-Knarvik e outros (2000) é estabelecido para o caso brasileiro. Neste modelo econométrico, é possível investigar como a interação das características das indústrias e dos estados podem determinar onde a indústria se localiza. Os principais resultados mostram que os fortes investimentos em infraestrutura na década de 70 e a abertura comercial na década de 90 foram marcantes para localização da indústria brasileira.

Fábrica de Software : um estudo de caso na Dataprev, sob a ótica da estrutura organizacional

The aim of this case study was to investigate how the evolutionary process of the development of software, especially the change of paradigm for the factory software, has affected the structure of the Board of Relacionamento, Desenvolvimento e Informações - DRD at a public company called Dataprev and also reflecting or not a return to the model taylorist-fordist of the organization on production. For this study, there were interviews and a questionnaire applied, as well as documentary and literature review on the following topics: organizational structure, factory software, taylorism and fordism. From the data collected and analyzed, in the perspective studied, it was understood that there is not a return to the model taylorist-fordist to organize the production in the process of adopting the concept of a software factory in Dataprev. In addition to that, there was a flexibility in the organizational structure of its units of development - the softwares factories Dataprev.

A Defesa Judicial do Estado Brasileiro nas Varas Federais

There is no information whatsoever of a society in which there are no demands among private people and companies, among individuals and institutions, varying only the tenor and the intensity of the issues. It would be ideal if conflicts could be solved in common aggreement. The selfcomposition, yet, does not often occurr; leaving the remaining issues for a third part, i.e., the State. Up to the English and French Revolutions, political power was exercised by limitless governors and the State did not submit to the law. After those revolutions, rules are agregated to curb Absolutism and organize the State, which starts to acccomplish its duties under the law, i.e., a Law State. As a result, today, the individual can sue the State to make the State perform or not any undesirable action. In this dissertation, one traces back from the very beginning the role of the institutions in charge of defending the State in courts of law. The judicial defense of the Brazilian State in a court of law, since 1608 to the 1988 Constitution, was a role of the Public Ministry, along with other institutional functions, including prosecution. As a consequence of this ambivalence, the results of the State defense came even to be contradictory. The promulgation of the 1988 Federal Constitution adjusted this historical dualism. The 1988 Constituent embodied significant change to the concept and operationalization of a State Advocacy, confering to a new institution , which was called 'Advocacia Geral da União' or 'General Advocacy of the Union' (article 131), the judicial and extrajudicial representation of the Union. The final object of the reflections of this study is centred on the analysis of the activities of the 'General Advocacy of the Union', in its first years of functioning, in other words, from 1993 to 1999

Design e management: um estudo de ciência e tecnologia no campo dos estudos organizacionais

Esta dissertação se propõe a cartografar as redes sociotécnicas do design no campo do management nos moldes propostos pela Teoria Ator-Rede e apresentar o processo de translação pelo qual passou o termo ao adentrar no campo. Para tal, levantou e analisou artigos publicados sobre o tema nos principais periódicos da área de organizações e publicações. Estes textos demonstram como, nas últimas décadas, o design tem passado por uma expansão de sentido e aplicação na direção do management (ou do management no sentido do design), através das abordagens denominadas design thinking, design science ou design process. A pesquisa se justifica, uma vez que este assunto está presente nos principais periódicos do management e dos estudos organizacionais, como uma importante ferramenta para solução de problemas que desafiam os sistemas organizacionais, como: a mudança, o empreendedorismo e a inovação (Stephens & Boland, 2014). É importante destacar que o design tem sido cada vez mais considerado uma atividade decisiva na batalha econômica (Callon, 1986), na determinação dos atuais estilos de vida (lifestyle) e na construção de nosso mundo futuro. No campo dos estudos organizacionais, como demonstrou esta pesquisa, o design surge como uma abordagem que supera a dicotomia entre positivismo e a abordagem crítica na teoria organizacional (Jelinek, Romme & Boland, 2008). Por fim, esta dissertação se ateve à cartografia das redes sociotécnicas e à descrição das quatro principais fases do processo de translação do design no campo do management, a saber: (a) problematização, marcada pela publicação de The Sciences of Artificial em 1969 de Herbert A. Simon, no qual, ele argumenta pelo design como uma habilidade básica para todas as especialidades profissionais, incluindo a gestão (Simon, 1996), (b) interessamento, designers defendendo um design de sistemas complexos como as organizações, (c) engajamento, designers e teóricos das organizações juntos pelo design no management como uma alternativa para a superação da dicotomia entre positivismo e os estudos críticos na administração, e, (d) mobilização, na qual os teóricos das organizações partem em defesa do design no management como um forma de dar conta de modelos organizacionais contemporâneos com fronteiras mais permeáveis e em constante reformulação

Estudo paramétrico da injeção de vapor em reservatórios delgados

Exploration of heavy oil reservoirs is increasing every year in worldwide, because the discovery of light oil reservoirs is becoming increasingly rare. This fact has stimulated the research with the purpose of becoming viable, technically and economically, the exploration of such oil reserves. In Brazil, in special in the Northeast region, there is a large amount of heavy oil reservoir, where the recovery by the so called secondary methods Water injection or gas injection is inefficient or even impracticable in some reservoirs with high viscosity oils (heavy oils). In this scenario, steam injection appears as an interesting alternative for recover of these kinds of oil reservoirs. Its main mechanism consists of oil viscosity reduction through steam injection, increasing reservoir temperature. This work presents a parametric simulation study of some operational and reservoir variables that had influence on oil recovery in thin reservoirs typically found in Brazilian Northeast Basins, that use the steam injection as improved oil recovery method. To carry out simulations, it was used the commercial software STARS (Steam, Thermal, and Advanced Processes Reservoir Simulator) from CMG (Computer Modeling Group) version 2007.11. Reservoirs variables studied were horizontal permeability, vertical and horizontal permeability ratio, water zone and pay zone thickness ratio, pay zone thickness and thermal conductivity of the rock. Whereas, operational parameters studied were distance between wells and steam injection rate. Results showed that reservoir variables that had more influence on oil recovery were horizontal permeability and water zone and pay zone thickness ratio. In relation to operational variables, results showed that short distances between wells and low steam injection rates improved oil recovery

Desenvolvimento de sistemas de pastas leves para aplicação em cimentação de poços petrolíferos com baixo gradiente de fratura

All around the world, naturally occurring hydrocarbon deposits, consisting of oil and gas contained within rocks called reservoir rocks , generally sandstone or carbonate exists. These deposits are in varying conditions of pressure and depth from a few hundred to several thousand meters. In general, shallow reservoirs have greater tendency to fracture, since they have low fracture gradient, ie fractures are formed even with relatively low hydrostatic columns of fluid. These low fracture gradient areas are particularly common in onshore areas, like the Rio Grande do Norte basin. During a well drilling, one of the most favorable phases for the occurrence of fractures is during cementing, since the cement slurry used can have greater densities than the maximum allowed by the rock structure. Furthermore, in areas which are already naturally fractured, the use of regular cement slurries causes fluid loss into the formation, which may give rise to failures cementations and formation damages. Commercially, there are alternatives to the development of lightweight cement slurries, but these fail either because of their enormous cost, or because the cement properties were not good enough for most general applications, being restricted to each transaction for which the cement paste was made, or both reasons. In this work a statistical design was made to determine the influence of three variables, defined as the calcium chloride concentration, vermiculite concentration and nanosilica concentration in the various properties of the cement. The use of vermiculite, a low density ore present in large amounts in northeastern Brazil, as extensor for cementing slurries, enabled the production of stable cements, with high water/cement ratio, excellent rheological properties and low densities, which were set at 12.5 lb / gal, despite the fact that lower densities could be achieved. It is also seen that the calcium chloride is very useful as gelling and thickening agent, and their use in combination with nanosilica has a great effect on gel strength of the cement. Hydrothermal Stability studies showed that the pastes were stable in these conditions, and mechanical resistance tests showed values of the order of up to 10 MPa

ROLE of TLR2 and TLR4 on human neutrophil functions against Paracoccidioides brasiliensis

In paracoccidioidomycosis, a systemic mycosis caused by the fungus Paracoccidioides brasiliensis (Pb), studies have focused on the role of neutrophils that are involved in the primary response to the fungus. Neutrophil functions are regulated by pro- and anti-inflammatory cytokines. Molecular mechanisms involved in this process are not fully understood, but there are strong evidences about the involvement of toll-like receptors (TLRs). We aimed at evaluating TLR2 and TLR4 expression on human neutrophils activated by GM-CSF, IL-15, TNF-alpha or IFNgamma and challenged with a virulent strain of P. brasiliensis (Pb18). Moreover, we asked if these receptors have a role on fungicidal activity, H(2)O(2) and IL-6, IL-8, TNFalpha and IL-10 production, by activating and challenging cells. All cytokines increased TLR2 and TLR4 expression. Pb18 also increased TLR2 expression, inducing an additional cytokine effect. on the contrary, it inhibited TLR4 expression. All cytokines increased neutrophil fungicidal activity and H(2)O(2) production; however, this process was not associated with TLR2 or TLR4. Neutrophil activation by GMCSF and TNF-alpha resulted in a significant increase of IL-8 production, while IL-15 and IFN-alpha have no effect. Pb18 also augmented IL-8 expression, inducing an additional effect to that of cytokines. None of the cytokines activated neutrophils by releasing IL-10. This cytokine was only detected after Pb18 challenge. Interestingly, IL-8 and IL-10 production involved TLR2 and mainly TLR4 modulation. The present results suggest that Pb18 interaction with neutrophils through TLR2 and TLR4 with consequent IL-8 and IL-10 production may be considered a pathogenic mechanism in paracoccidioidomycosis.

Role of TLR2 and TLR4 in Human Neutrophil Functions Against Paracoccidioides brasiliensis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)