A General Latent Class Model for Performance Evaluation of Diagnostic Tests in the Absence of a Gold Standard: An Application to Chagas Disease

We propose a new general Bayesian latent class model for evaluation of the performance of multiple diagnostic tests in situations in which no gold standard test exists based on a computationally intensive approach. The modeling represents an interesting and suitable alternative to models with complex structures that involve the general case of several conditionally independent diagnostic tests, covariates, and strata with different disease prevalences. The technique of stratifying the population according to different disease prevalence rates does not add further marked complexity to the modeling, but it makes the model more flexible and interpretable. To illustrate the general model proposed, we evaluate the performance of six diagnostic screening tests for Chagas disease considering some epidemiological variables. Serology at the time of donation (negative, positive, inconclusive) was considered as a factor of stratification in the model. The general model with stratification of the population performed better in comparison with its concurrents without stratification. The group formed by the testing laboratory Biomanguinhos FIOCRUZ-kit (c-ELISA and rec-ELISA) is the best option in the confirmation process by presenting false-negative rate of 0.0002% from the serial scheme. We are 100% sure that the donor is healthy when these two tests have negative results and he is chagasic when they have positive results.

Comparison of the seismic behaviour between three building tests, all based on a two storey model house

Integral Masonry System consisting of intersecting steel trusses alo ng each of the three dimensional directions of space on walls and slabs using any masonry material, had yet been backed up by the previous adobe test for seismic areas. This paper presents the comparison this last test and the adaptation of the IMS using h ollow brick. A prototype based on a two storey model house (6mx6mx6m) has being also built in two different scales in order to maximize the load and size of the shake table: the first one half size the whole building (3mx3mx3m) and the second, a quarter of the real size (3mx3mx6m). Both tests have suffered some mild to moderate damages while supporting the higher seismic action subjected by the shake table, without even fissuring the first test and with very few damages the second one. The thickness of the hollow brick wall and the diameter of the tree - dimensional truss reinforcement were scaled to the real size test in order to ascertain its great structural behaviour in relation to the previous structural model calculations. The aim of this study is to sum marize the results of the research collaboration between the ETSAM - UPM and the PUCP in whose laboratory these tests were carried out.

Supplementary tests of Masonboro Inlet fixed-bed model : hydraulic model investigation /

"General investigation of tidal inlets; a program of research conducted jointly by U.S. Army Coastal Engineering Research Center, Fort Belvoir, Virginia [and] U.S. Army Engineer Waterways Experiment Station, Vicksburg, Mississippi."

Riprap stability and navigation tests for the divide-cut section, Tennessee-Tombigbee Waterway : hydraulic model investigation /

"May 1986."

Scale effect tests for rubble-mound breakwaters : hydraulic model investigation /

"December 1969."

CRASH III model improvements: derivation of new side stiffness parameters from crash tests. Volume 2. Final report.

Mode of access: Internet.

Visibility tests of 1978 model cars. [Part 2]. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Visibility tests of 1978 model cars. [Part 1]. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Noyo River and Harbor, California design for wave protection supplemental tests : coastal model investigation /

"December 1989."

Laboratory tests of hydraulic model of filling and emptying system for the MacArthur Lock, St. Marys River, Sault Ste. Marie, Michigan; final report.

Mode of access: Internet.

Tests on a quarter scale model of a multiple-panel reinforced concrete flat plate floor /

Mode of access: Internet.

Visibility tests of 1978 model cars /

Mode of access: Internet.

On a resampling approach for tests on the number of clusters with mixture model-based clustering of tissue samples

We consider the problem of assessing the number of clusters in a limited number of tissue samples containing gene expressions for possibly several thousands of genes. It is proposed to use a normal mixture model-based approach to the clustering of the tissue samples. One advantage of this approach is that the question on the number of clusters in the data can be formulated in terms of a test on the smallest number of components in the mixture model compatible with the data. This test can be carried out on the basis of the likelihood ratio test statistic, using resampling to assess its null distribution. The effectiveness of this approach is demonstrated on simulated data and on some microarray datasets, as considered previously in the bioinformatics literature. (C) 2004 Elsevier Inc. All rights reserved.