Speaking Out Against Rape:Feminist (Her)Stories and Anti-Rape Politics

In 1976, Susan Brownmiller published 'Against Our Will', widely credited as the founding text of feminist anti-rape theory, in which she famously declared that rape was 'nothing more or less than a conscious process of intimidation by which all men keep all women in a state of fear'.While the scholarship and politics of Against Our Will have been subjected to numerous and compelling critiques, the work retains canonical and even foundational status within feminist anti-rape politics. In this article I attempt a critical re-examination of feminist (her)story telling practices. By situating the story told in Against Our Will beside and within Brownmiller's story of the creation of the book and her own coming-to-consciousness, a more general reexamination of the role of women's speech and (her)story-telling in feminist anti-rape politics is afforded. This re-reading draws out two central aspects of the politics of (her)story-telling which can be found in Brownmiller's work and in the Joan W. Scott quotation above. Firstly, the need to be recognised as a 'just source' of women's stories has resulted in the granting of epistemological primacy to stories of women's experience or personal statements. Secondly, the desire to compensate for the lack of a 'classical myth' to authorise women's claims, resulting in an attempt to imbue these feminist (her)stories with their own mythology.

Ecopoetics: The Language of Nature, The Nature of Language by Scott Knickerbocker (review)

Review of Ecopoetics: The Language of Nature, The Nature of Language by Scott Knickerbocker Boston: University of Massachusetts Press, 2012. Pp. x + 203.
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Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer

Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well documented. Here, using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1, both in vitro and in vivo with gene expression profiling, we demonstrate that nuclear ARRB1 contributes to this metabolic shift in prostate cancer cells via regulation of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase (FH) expression. ARRB1-induced pseudohypoxia may facilitate adaptation of cancer cells to growth in the harsh conditions that are frequently encountered within solid tumours. Our study is the first example of an endocytic adaptor protein regulating metabolic pathways. It implicates ARRB1 as a potential tumour promoter in prostate cancer and highlights the importance of metabolic alterations in prostate cancer.

HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network

Castrate-resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c-Myc and the E2F family also play a role in later stage disease. HES6 is a transcription co-factor associated with stem cell characteristics in neural tissue. Here we show that HES6 is up-regulated in aggressive human prostate cancer and drives castration-resistant tumour growth in the absence of ligand binding by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. In the clinical setting, we have uncovered a HES6-associated signature that predicts poor outcome in prostate cancer, which can be pharmacologically targeted by inhibition of PLK1 with restoration of sensitivity to castration. We have therefore shown for the first time the critical role of HES6 in the development of CRPC and identified its potential in patient-specific therapeutic strategies.

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

The androgen receptor (AR) is a key regulator of prostate growth and the principal drug target for the treatment of prostate cancer. Previous studies have mapped AR targets and identified some candidates which may contribute to cancer progression, but did not characterize AR biology in an integrated manner. In this study, we took an interdisciplinary approach, integrating detailed genomic studies with metabolomic profiling and identify an anabolic transcriptional network involving AR as the core regulator. Restricting flux through anabolic pathways is an attractive approach to deprive tumours of the building blocks needed to sustain tumour growth. Therefore, we searched for targets of the AR that may contribute to these anabolic processes and could be amenable to therapeutic intervention by virtue of differential expression in prostate tumours. This highlighted calcium/calmodulin-dependent protein kinase kinase 2, which we show is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by taking an unbiased interdisciplinary approach.

Scott McElveen LLP presents the South Carolina big 50

This ranks private, public and foreign-affiliated companies by the number of employees on their South Carolina payrolls as of July 1, 2008, and then compares the progress of participating companies from year to year. The South Carolina Big 50 includes financial institutions, insurance companies, retailers, retail establishments, hospitals and healthcare organizations. The South Carolina Big 50, however, does exclude government agencies and organizations. The top company remained the same as in the 2007 issue, with Wal-Mart Stores Inc. continuing to be ranked No. 1. BI-LO LLC and Palmetto Health moved from No. 3 and No. 4 to No. 2 and No. 3 respectively.

Annual message of his excellency Robert K. Scott, Governor of South Carolina, to the General Assembly, at the regular session, commencing November 28, 1871

This speech was delivered to by the Governor to give the general assembly information of the condition of the state and give them recommendations to consider measures that the Governor deems necessary or expedient. He provides the information regarding the state debt, taxes, and bonded debt. He describes the financial agent of the state as well as the expenditures of the state government.

Message of Robert K. Scott, Governor of South Carolina to the General Assembly, November 24, 1869

This speech was addressed to the people of the Senate and House of Representatives. It was delivered to inform them of the progress over the past year made to place the finances of the state on a firm and healthy basis. He gives a report on all departments and projects funded by the government in the past year.

Composers' Workshop, February 25, 1999

Concert program for Composers' Workshop, February 25, 1999

Tradução comentada do conto "Babylon revisited" de F. Scott Fitzgerald

Este Trabalho de Projeto tem como objeto a tradução para Língua Portuguesa do conto Babylon Revisited do autor norte-americano F. Scott Fitzgerald, publicado pela primeira vez em 1931 na revista semanal Saturday Evenning Post. Na primeira parte do trabalho, procedeu-se a uma apresentação da vida e obra do autor, análise do conto e do contexto histórico e sócio-económico em que ambos se inserem. Na segunda parte faz-se uma exposição das teorias de tradução que mais diretamente influenciaram o presente trabalho, assim como uma reflexão sobre as dificuldades que surgiram durante o trabalho de tradução e a justificação acerca das soluções encontradas e do processo decisivo.

De conservanda bona valetudine opusculum Scholae Salernitanae ([Reprod.]) / cum Arnoldi Novicomensis, medici & philosophi antiqui enarrationibus utilissimis ; denuo recognitis & auctis per Joan. Curionem & Jacob Crellium

[Regimen sanitatis Salernitanum (latin). 1553]

28-8-20, Colombes, Scott (américain) gagne le 800 m : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60796