Situación y tendencias recientes del mercado del cobre

Incluye Bibliografía

Rentas de recursos naturales no renovables en América Latina y el Caribe: evolución y participación estatal, 1990-2010

Incluye Bibliografía

Organosilylated complex [Eu(TTA)3(Bpy-Si)]: A bifunctional moiety for the engeneering of luminescent silica-based nanoparticles for bioimaging

A new highly luminescent europium complex with the formula [Eu(TTA) 3(Bpy-Si)], where TTA stands for the thenoyltrifluoroacetone, (C 4H3S)COCH2COCF3, chelating ligand and Bpy-Si, Bpy-CH2NH(CH2)3Si(OEt)3, is an organosilyldipyridine ligand displaying a triethoxysilyl group as a grafting function has been synthesized and fully characterized. This bifunctional complex has been grafted onto the surface of dense silica nanoparticles (NPs) and on mesoporous silica microparticles as well. The covalent bonding of [Eu(TTA)3(Bpy-Si)] inside uniform Stöber silica nanoparticles was also achieved. The general methodology proposed could be applied to any silica matrix, allowed high grafting ratios that overcome chelate release and the tendency to agglomerate. Luminescent silica-based nanoparticles SiO2-[Eu(TTA)3(Bpy-Si)], with a diameter of 28 ± 2 nm, were successfully tested as a luminescent labels for the imaging of Pseudomonas aeruginosa biofilms. They were also functionalized by a specific monoclonal antibody and subsequently employed for the selective imaging of Escherichia coli bacteria. © 2013 American Chemical Society.

La brecha de infraestructura económica y las inversiones en América Latina

E l presente Boletín FAL , tiene por objeto presentar y poner a disposición de los usuarios, la base de datos de inversiones en infraestructura económica de América Latina y el Caribe (EII-LAC-DB) construida por la Unidad de Servicios de Infraestructura de CEPAL. La información contenida en este Boletín FAL corresponde al periodo 1980-2012, según las mediciones realizadas por el Banco Mundial, la CEPAL y el acuerdo de cooperación entre CEPAL y CAF.

Aspectos metodológicos para el tratamiento estadístico de la infraestructura en América Latina y el Caribe

La disponibilidad de información cuantitativa sobre inversiones en infraestructura es imprescindible para realizar análisis e investigaciones sobre el tema y para que quienes adoptan decisiones de política puedan formular medidas pertinentes, oportunas y sostenibles. La existencia de una base de datos robusta y estandarizada podría facilitar respuestas para varias preguntas cruciales: ¿cuánto debe crecer la inversión en infraestructura para que el PIB crezca, por ejemplo, en un punto porcentual?, ¿cuál es el nivel de la inversión en infraestructura que maximiza el crecimiento?, ¿es sostenible en el largo plazo?, ¿se gasta lo suficiente en mantenimiento o reparaciones?, ¿en cuánto tiempo se espera que una determinada obra de infraestructura tenga el esperado impacto económico y social?, ¿el monto de inversión que se efectúa en infraestructura compensa el agotamiento de otro tipo de capitales?, ¿es apropiada para el desarrollo sostenible la estructura sectorial de la inversión en infraestructura?, en fin, ¿qué porcentaje de las inversiones en infraestructura se originan en rentas y otros beneficios de la extracción de recursos naturales?, entre otros.

The economic infrastructure gap and investment in Latin America

This edition of the FAL Bulletin aims to present and encourage the use of the economic infrastructure investment database for Latin America and the Caribbean (EII-LAC-DB), built by the Infrastructure Services Unit of the Economic Commission for Latin America and the Caribbean (ECLAC). The information contained refers to the period 1980-2012, in keeping with measurements undertaken by the World Bank, ECLAC and under the cooperation agreement between ECLAC and the Development Bank of Latin America (CAF).

Sealing composite with defective margins, good care or over treatment? results of a 10-year clinical trial

Purpose: The objective of this study was to clinically evaluate sealed composite restorations after 10 years and compare their behavior with respect to controls. Methods and Materials: The cohort consisted of 20 patients aged 18 to 80 years with 80 composite restorations. All participants in the sealing and no-treatment groups presented with clinical features for the marginal adaptation that deviated from the ideal and were rated Bravo (United States Public Health Service criteria). Composites with Alfa values for the marginal adaptation were used as the positive control. Results: The marginal adaptation behavior was similar between the sealing and control (+) groups, with a high frequency of Bravo values in the 10th year (80% and 51%, respectively). Most of the no-treatment (-) group maintained the Bravo values (91%) for 10 years, although some restorations (9%) progressed to Charlie values. The anatomy parameter differed significantly between the first and 10th years, with deterioration in all three groups (p,0.05). The secondary caries parameter had a similar behavior in the three groups (p.0.05). Conclusions: Sealing the margins of the composite resin restorations had no significant effect compared with the control groups, under the conditions of this study. Sealing the restorations substantially improved the marginal staining and marginal adaptation parameters, although by the tenth year they were similar to the group without intervention.

Luminescence properties of Eu-complex formations into ordered mesoporous silica particles obtained by the spray pyrolysis process

Ordered mesoporous, highly luminescent SiO2 particles have been synthesized by spray pyrolysis from solutions containing tetraethylorthosilicate (TEOS), Eu(NO3)3.6H2O, and cetyltrimethylammonium bromide (CTAB) as structure-directing agents. The 1,10-phenantroline (Phen) molecules were coordinated in a post-synthesis step by a simple wet impregnation method. In addition, other matrices were also prepared by the encapsulation of europium complex Eu(fod)3 (where fod = 6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato) into mesoporous silica, and then the Phen molecules were encapsulated by different impregnation steps, after which the luminescence properties were investigated. The obtained materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder x-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Powders with polydisperse spherical grains were obtained, displaying an ordered hexagonal array of mesochannels. Luminescence results revealed that Phen molecules had been successfully coordinated as an additional ligand in the Eu(fod)3 complex into the channels of the mesoporous particles without disrupting the structure.

Structural and Luminescence Properties of Silica-Based Hybrids Containing New Silylated-Diketonato Europium(III) Complex

A new betadiketonate ligand displaying a trimethoxysilyl group as grafting function and a diketone moiety as complexing site (TTA-Si = 4,4,4-trifluoro-2-(3-trimethoxysilyl)propyl)-1-3-butanedione (C4H3S)COCH[(CH2)(3)Si(OCH3)(3)]COCF3) and its highly luminescent europium(III) complex [Eu(TTA-Si)(3)] have been synthesized and fully characterized. Luminescent silica-based hybrids have been prepared as well with this new complex grafted on the surface of dense silica nanoparticles (28 +/- 3 nm) or on mesoporous silica particles. The covalent bonding of Eu(TTA-Si)(3) inside the core of uniform silica nanoparticles (40 +/- 5 nm) was also achieved. Luminescence properties are discussed in relation to the europium chemical environment involved in each of the three hybrids. The general methodology proposed allowed high grafting ratios and overcame chelate release and tendency to agglomeration, and it could be applied to any silica matrix (in the core or at the surface, nanosized or not, dense or mesoporous) and therefore numerous applications such as luminescent markers and luminophors could be foreseen.

APTES-Modified RE2O3:Eu3+ Luminescent Beads: Structure and Properties

Europium-doped lanthanide oxide RE2O3:Eu3+ (RE = Y or Gd) luminescent beads, with a spherical shape and a diameter of 150 +/- 15 nm, have been modified by reaction with 3-aminopropyltriethoxysilane (APTES), in order to introduce reactive amine groups at their surfaces. The direct silanation has resulted in the formation of a nanometric layer at the surface of the beads, with an optimum grafting rate of 0.055 +/- 0.005 mol APTES/mol RE2O3. Fourier transform infrared (FTIR) and X-ray photoelectron (XPS) spectroscopies confirmed the condensation of an organosilane layer, made of cross-linked -O-Si-O-Si- and of groups -O-Si-R (with R = (CH2)(3)NH2 or O-Et). Titration of the accessible amine groups has been performed by simultaneously measuring the luminescence of grafted fluorescein isothiocyanate and that of core particles: there are about 2.3 X 10(4) (2.8 X 10(4)) -NH2 per Y2O3:Eu3+ (Gd2O3:Eu3+) bead. The isoelectronic point was shifted by one pH unit after APTES modification. The surface modification by APTES at least preserved (for Gd2O3:Eu3+) or improved (for Y2O3:Eu3+) the red emission of the beads.

Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway

Nitroglycerin (GIN) has been clinically used to treat angina pectoris and acute heart episodes for over 100 years. The effects of GTN have long been recognized and active research has contributed to the unraveling of numerous metabolic routes capable of converting GIN to the potent vasoactive messenger nitric oxide. Recently, the mechanism by which minute doses of GIN elicit robust pharmacological responses was revisited and eNOS activation was implicated as an important route mediating vasodilation induced by low GTN doses (1-50 nM). Here, we demonstrate that at such concentrations the pharmacologic effects of nitroglycerin are largely dependent on the phosphatidylinositol 3-kinase, Akt/PKB, and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signal transduction axis. Furthermore, we demonstrate that nitroglycerin-dependent accumulation of 3,4,5-InsP(3), probably because of inhibition of PTEN, is important for eNOS activation, conferring a mechanistic basis for GIN pharmacological action at pharmacologically relevant doses. (C) 2011 Elsevier Inc. All rights reserved.

Cellular interference in craniofrontonasal syndrome: males mosaic for mutations in the X-linked EFNB1 gene are more severely affected than true hemizygotes

Craniofrontonasal syndrome (CFNS), an X-linked disorder caused by loss-of-function mutations of EFNB1, exhibits a paradoxical sex reversal in phenotypic severity: females characteristically have frontonasal dysplasia, craniosynostosis and additional minor malformations, but males are usually more mildly affected with hypertelorism as the only feature. X-inactivation is proposed to explain the more severe outcome in heterozygous females, as this leads to functional mosaicism for cells with differing expression of EPHRIN-B1, generating abnormal tissue boundaries-a process that cannot occur in hemizygous males. Apparently challenging this model, males occasionally present with a more severe female-like CFNS phenotype. We hypothesized that such individuals might be mosaic for EFNB1 mutations and investigated this possibility in multiple tissue samples from six sporadically presenting males. Using denaturing high performance liquid chromatography, massively parallel sequencing and multiplex-ligation-dependent probe amplification (MLPA) to increase sensitivity above standard dideoxy sequencing, we identified mosaic mutations of EFNB1 in all cases, comprising three missense changes, two gene deletions and a novel point mutation within the 5' untranslated region (UTR). Quantification by Pyrosequencing and MLPA demonstrated levels of mutant cells between 15 and 69%. The 5' UTR variant mutates the stop codon of a small upstream open reading frame that, using a dual-luciferase reporter construct, was demonstrated to exacerbate interference with translation of the wild-type protein. These results demonstrate a more severe outcome in mosaic than in constitutionally deficient males in an X-linked dominant disorder and provide further support for the cellular interference mechanism, normally related to X-inactivation in females.

Imparare il pensiero computazionale, imparare a programmare

Nell'ultimo decennio il trend topic nell'ambito dell'insegnamento dell'informatica è il pensiero computazionale. Concetto già presente, è stato risaltato nel 2006 da Jeannette Wing, che ha mostrato come l'informatica abbia portato alla scienza non solo strumenti (computer e linguaggi di programmazione) ma anche innovazioni nel modo di pensare (es. algoritmo shotgun per sequenziamento del DNA umano). Il pensiero computazionale è il processo mentale coinvolto nel formulare problemi e loro soluzioni, rappresentate in una forma che sia effettivamente eseguibile da un agente che processa informazioni. Si tratta di “pensare come un informatico” quando si affronta un problema. Dopo aver passato in rassegna la letteratura sul pensiero computazionale, viene proposta una definizione del concetto. Si prende atto che la ricerca in questi anni sia rimasta molto legata ai linguaggi di programmazione, concetto centrale dell’Informatica. Vengono allora proposte due strade. La prima strada consiste nella riesumazione di tutta una serie di studi di Psicologia della Programmazione, in particolare: studi sulle misconcezioni, che si occupano di individuare i concetti che sono compresi male dai programmatori novizi, e studi sul commonsense computing, che cercano di capire come persone che non hanno mai ricevuto nozioni di programmazione - o più in generale di informatica – esprimano (in linguaggio naturale) concetti e processi computazionali. A partire da queste scoperte, si forniscono una serie di consigli per insegnare al meglio la programmazione (con i linguaggi attuali, con nuovi linguaggi appositamente progettati, con l'aiuto di strumenti ed ambienti ad-hoc) al più ampio pubblico possibile. La seconda strada invece porta più lontano: riconoscere il pensiero computazionale come quarta abilità di base oltre a leggere, scrivere e calcolare, dandogli dunque grande importanza nell’istruzione. Si vuole renderlo “autonomo” rispetto alla programmazione, fornendo consigli su come insegnarlo senza - ma anche con - l'ausilio di un formalismo.