Search for the pathogenesis of the differing phenotype in two compound heterozygote Hungarian brothers with the same genotypic triosephosphate isomerase deficiency

In a Hungarian family with triosephosphate isomerase (TPI) deficiency, two compound heterozygote brothers were found with the same severe decrease in TPI activity, but only one of them had the classical symptoms. In search for the pathogenesis of the differing phenotype of the same genotypic TPI deficiency, an increase in red cell membrane fluidity was found. There were roughly 100% and 30% more 16:0/20:4 and 18:0/20:4 diacyl-phosphatidylcholine species in erythrocytes from the two TPI-deficient brothers than in the probes from healthy controls. The activities of acethylcholinesterase and calmodulin induced Ca2+ ATPase were significantly enhanced in erythrocytes from the propositus as compared with those of the neurologically symptom-free brother and other members of the TPI-deficient family as well as to those from healthy controls. Both enzymes are crucially involved in the function of nerve cells. The observed differences in membrane fluidity and enzyme activities between the erythrocytes from the phenotypically differing TPI-deficient brothers underline the importance of investigations into the effect of biophysical changes in the lipid environment of the membrane proteins on the development of disseminated focal neurological disorders of unknown pathogenic origin.

Slim Styles and the Brothers of the Light

Slim Styles and the Brothers of the Light consists of a short novella, intended to be part of a series, introduced by a narrative essay. The work is about the search for identity, the pursuit of happiness, and the struggle to maintain self assurance while finding a place in the world. The story follows the main character as he slowly learns the truth about an organization he joined looking for a sense of value and worth. With his back against the wall he has to return to the home he was taught to be ashamed of, face the friends he left behind, and apologize to the lover he took for granted. The manuscript is a work in progress.

Rare and remarkable animals of Scotland, represented from living subjects: with practical observations on their nature. By Sir John Graham Dalyell, baronet ...

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Alegato presentado a la Sala 1a. de la Corte de Apelaciones como abogado de los señores Rösing Brothers & Co. [et al]

At head of title: La cuestión "R. Samper y Cía".

Mary H. Graham

On verso: Ornate photographer's stamp. W. Notman. The Notman Photographic Co. 55 North Pearl St. Albany, N.Y.; 4 Park Street, Boston, Mass. Cambridge, Mass., New Haven, Conn., and Easton, Pa. (Daybook, image #26)

Graham's American monthly magazine of literature, art, and fashion.

Editors: Jan. 1841- G. R. Graham (with E. A. Poe, Jan. 1841-May 1842; C. J. Peterson, Mrs. Ann S. Stephens, 1842; R. W. Griswold, July 1842-June 1843; R. T. Conrad, Jan.-June 1848: J. R. Chandler, J. B. Taylor, Oct. 1848-Dec. 1849).

Calendar of Alexander Graham Bell correspondence in the Volta bureau,

Mode of access: Internet.

Latest contemporary portraits,

"Second printing, April, 1928."

Desiccated alimentary vegetable substances : reports of two boards of navy officers, convened by order of William A. Graham, at the U.S. Navy yard, New York, in Nov. 1851, and at Washington City, in May, 1852 ... /

"To examine certain desiccated alimentary vegetable substances, prepared, after the process of M. Masson ... and, after the process of Dr. J.N. Gannal ... the conserve of milk, prepared by M. de Lignac ... and also the preserved potato of D. and H. Edwards and Co."

Latest contemporary portraits,

David Graham Phillips: the greatest American novelist.--Eleonora Duse.--Henri Barbusse.--Lord Bryce.--George Russell (A.E.)--Mrs. Humphry Ward.--Eugene V. Debs.--Charles Schwab: the master of Bethlehem.--Prince Peter Kropotkin.--Paul Bourget.--Thomas Hardy.--Ehrlich of "606".--Louis Sullivan: a great architect.--Eugene Fromentin: the painter writer.--Sir Herbert Tree.--Flaubert and his letters.--Hatred in art: Leon Bloy.--Three generations of Morgans.--The brothers de Goncourt and realism.--Lord Hartington.--Ambassador Bernstorff.--A talk with A.E. Housman.--Paul Deschanel.--Frederic Harrison: the last of the Victorians.--Annie Besant: rebel and reformer.--John Churton Collins.--Hyndman, the communist.--Horace Traubel.--Joseph Caillaux.