Alteração volumétrica por análise microtomográfica, solubilidade e capacidade seladora bacteriana de diferentes materiais retro-obturadores

Pós-graduação em Odontologia - FOAR

Estratégias tecnológicas para aumento de solubilidade e diminuição de toxicidade do fármaco antifúngico anfotericina B

A Anfotericina B é o fármaco antifúngico referência desde a sua descoberta na década de 50 até os dias atuais para o tratamento de infecções fúngicas sistêmicas. O objetivo do trabalho é realizar uma revisão bibliográfica que forneça os sistemas de liberação comercializados e os que estão em estudo, focando estratégias tecnológicas que possam servir para resolver os problemas da baixa solubilidade em água e da alta nefrotoxicidade da Anfotericina B. A AmB é um fármaco que apresenta inexpressiva solubilidade em meio-aquoso, principalmente na região de pH dos fluídos biológicos (7,4–8,0), sendo administrado atualmente por via endovenosa. Justificando a importância desse estudo para a área farmacêutica, novos sistemas de liberação que usem a via oral, aumentarão a adesão por crianças e idosos, além de aumentar o arsenal terapêutico e diminuir os gastos com hospitalizações. Por ter a sua utilidade clínica limitada em razão de sua alta toxicidade, tem-se buscado direcionar a AmB especificamente para o fungo ou pelo menos para o local da infecção, mantendo-se longe o fármaco das células hospedeiras. Para isso, se busca diferentes veículos que não o desoxicolato (Fungizone). Por fim, as formulações lipídicas mostram-se com maior eficácia e com menor toxicidade comparadas a Anfotericina B-desoxicolato, mas não fazem parte da rotina hospitalar em razão do seu alto custo

Exposição ambiental ao chumbo: um problema de áreas contaminadas próximas a fábricas de baterias

The concentration of metal pollutants such as lead (Pb), has grown and developed in populated areas due to pollution and other human activities. Consequently, the potential for achieve this element food chain has also increased. Lead is very toxic to humans, especially to children, and exposure to lead can cause adverse health effects mainly on human nervous system, bone marrow and kidneys, interfering with chromosomal or genetic processes. This paper presents an overview of the main aspects related to environmental contamination by lead from battery plants. The assessment of an area contaminated by lead in Bauru-SP next a battery factory was reported in this work as well as the entire history of monitoring, classification and application of processes applied by CETESB since 2002. Analyzing the issue in its economic aspects, we found that the degradation of the environment is directly related to the development model adopted by the capitalist system, which is based on the law of supply and demand for products and services. The data presented indicate that Brazil still needs a broader policy where government agencies, industries and population through awareness can be united for the same purpose: to preserve life

Análises de solos e sedimentos de corrente, nas áreas das usinas de fundição de chumbo do Calabouço (CIEM-CPRM) e de beneficiamento de minério aurífero do Morro do Ouro (Parque Municipal Morro do Ouro), no município de Apiaí - SP

Located in Apiaí, Vale do Ribeira, southern region of São Paulo state, the Usina do Calabouço areas (CIEM / CPRM) and Morro do Ouro (Parque Municipal do Morro do Ouro), were targeted for stud ies due to its old buildings, respectively a foundry in lead ore, called Experimental de Chumbo e Prata (Usina Calabouço), and a gold mine with processing plant of the gold-bearing ore produced there. Nowadays, the areas are used for public visitation, and in both places the rests of the buildings remains. Particularly in the CIEM/CPRM, due to the materials witch was produced before, it can suggest the existence of anomalous amounts of the involved metals (CIEM / CPRM) and possible contaminations by chemical products used in the improvement of the auriferous ore (P. M. Morro do Ouro). These potential contamination were confirmed with geochemical survey of soils and current sediments accomplished in both areas, for the elements arsenic, cadmium, lead, copper, mercury, silver and zinc, which were used as parameters guiding values for soil and groundwater the state of São Paulo (CETESB), and watershed values stipulated by CPRM (poor, background and anomalous), in it rising geochemistry during Folha Apiaí's execution (SG-22-X-B-V).

Exposição perinatal ao chumbo e desnutrição intra-uterina, isoladamente ou em associação: efeitos cardiovasculares em ratos recém-desmamados

Plumbism is considered the oldest occupational disease. Among the pathophysiological effects associated with lead (Pb) are cardiovascular disorders. Many diseases that develop later in life are determined during the early stages of life, under the influence of exposure and preferred diet of the mother. Still, one should consider that many environmental contaminants at levels not harmful can determine pathophysiological processes if physical or chemical stressors and/or pathological conditions are present. In this context, the intrauterine malnutrition may represent an additional risk factor in exposure to Pb during pregnancy and lactation. For these reasons, the objective of this study was to evaluate the cardiovascular risk of weaned rats that have suffered perinatal exposure to Pb and intrauterine malnutrition, alone or in combination. After mating, female rats were divided into control (ctrl, ad libitum), food restriction (RA, the same diet 50% of consumption in the control group during pregnancy), exposed to Pb (500 ppm Pb in drinking water during pregnancy and lactation) and association (As, received the last two procedures in combination). Cumulative concentration-effect curves (CECs) to CaCl2 and noradrenaline (NA) were obtained in rings with and without endothelium of the same thoracic aorta from male weaned rats (23-25 days old). Maternal weight, litter weight, weight and number of pups at birth, anogenital distance, arterial blood pressure (ABP) and weight of tissues (kidney, liver, aorta, left ventricle) were evaluated. Changes in vascular reactivity were assessed by the maximum response (MR) and 50% effective concentration (EC50). Data were presented as mean ± SEM. Statistical analysis was performed by multifactorial analysis of variance and Tukey's post test. Body weight of dams did not differ between the experimental groups, except on the...(Complete abstract click electronic access below)

Cádmio, chumbo, cromo, mercúrio e níquel nos rios do estado de São Paulo e em peixes do Rio Sorocaba (São Paulo, Brasil)

To verify the levels of concentration of some heavy metals in fishes from Sorocaba river (São Paulo, Brazil) and evaluate if this contamination offers health risks to the fishermen, 63 samples of fishes collected from four points along the river were studied for cadmium, lead, chromium, nickel and mercury, with emphasis in this last, since it is the most toxic and most probable as a fish contaminant. Analyzing muscle samples by cold vapor atomic absorption spectrometry it was shown that the fishes are not contaminated. None of the five metals studied were present in prohibitive level and the fishes could be judged secure for human consume. It was also analyzed data from four years of cadmium, lead, chromium, nickel and mercury monitoring made by CETESB, from 1997 to 2000, in water from the main rivers of the State of São Paulo. The study pointed out that the majority of the monitored rivers still present contamination by those metals in a level that requires an improvement of the pollution control actions.

Efeitos da exposição pré-natal ao etanol e ao chumbo, isoladamente e em associação, sobre a pressão arterial e a reatividade da aorta de ratos recém-desmamados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do trimetafosfato de sódio e do fluoreto sobre a solubilidade da hidroxiapatita: estudo in vitro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Determinação de chumbo em tubos de raios catódicos e em solo contaminado por espectrometria de absorção atômica

Pós-graduação em Ciência dos Materiais - FEIS

Mulheres silenciadas: vivências de viuvez nos anos de chumbo (1970-1980)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação do pH, da solubilidade e da infiltração marginal em retrobturações com o Sealer 26 puro ou acrescido de iodofórmio

Sealer 26® cement contains bisphenol epoxy resin associated with calcium hydroxide, presenting smaller radiopacity than other endodontic cements. Aiming to improve this property, iodoform has been added in its composition. However, this addition's possible changes in physical and chemical properties still need to be studied. OBJECTIVE: To evaluate the apical sealing ability, solubility, and pH of Sealer 26® alone or with iodoform, at several proportions. MATERIAL AND METHODS: Three experimental mixtures of Sealer 26®, alone or with iodoform, were prepared and subjected to solubility test. Additionally, these combinations were inserted into polyethylene tubes and immersed in distilled water, and, their pH was evaluated after 24-h and 7-day periods. Subsequently, forty roots of extracted lower incisors subdivided into four groups of 10 specimens each, were retrograde filled with one of the previously described mixtures and gutta-percha points. The roots were immersed in Rhodamine B, under vacuum, for 72 hours. After this period, the specimens were longitudinally sectioned, root fragments photographed, these images scanned, and apical infiltration measured by Image tool software. The obtained data were subjected to statistical analysis, at a significance level of 5%. RESULTS: Marginal leakage and solubility tests did not show any difference among the experimental groups (p > 0.05). pH analysis was only statistically different at 24-h period and between Sealer 26® alone and 1.1g iodoform group (p < 0.05). CONCLUSION: The presence of iodoform in Sealer 26®, at the used proportions, did not alter the solubility, apical marginal leakage and pH properties of the original cement.

Determinação de chumbo por análise voltamétrica de pulso diferencial por redissolução anódica em regiões de falhas geológicas com emissão de radônio e filhos de radônio no município de Presidente Prudente

Pós-graduação em Química - IBILCE

Avaliação do estresse oxidativo e atividade da δ-aminolevulínico desidratase em tecidos de tilápias do Nilo (Oreochromis niloticus) exposta a chumbo e benzo[a]pireno

Pós-graduação em Biologia Animal - IBILCE

Efeitos da doxicilina na hipertensão arterial induzida pela exposiçao ao chumbo: quantificação de pepídeos vasoativos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Adsorção de cádmio e chumbo em solução aquosa por lama vermelha natural e com diferentes ativações

Pós-graduação em Engenharia Civil e Ambiental - FEB