Complement 4 phenotypes and genotypes in Brazilian patients with classical 21-hydroxylase deficiency

The aim of this work was to analyse C4 genotypes, C4 protein levels, phenotypes and genotypes in patients with the classical form of 21-hydroxylase deficiency. Fifty-four patients from 46 families (36 female, 18 male; mean age 10.8 years) with different clinical manifestations (31 salt-wasting; 23 simple-virilizing) were studied. Taq I Southern blotting was used to perform molecular analysis of the C4/CYP21 gene cluster and the genotypes were defined according to gene organization within RCCX modules. Serum C4 isotypes were assayed by enzyme-linked immunosorbent assay. The results revealed 12 different haplotypes of the C4/CYP21 gene cluster. Total functional activity of the classical pathway (CH50) was reduced in individuals carrying different genotypes because of low C4 concentrations (43% of all patients) to complete or partial C4 allotype deficiency. Thirteen of 54 patients presented recurrent infections affecting the respiratory and/or the urinary tracts, none of them with severe infections. Low C4A or C4B correlated well with RCCX monomodular gene organization, but no association between C4 haplotypes and recurrent infections or autoimmunity was observed. Considering this redundant gene cluster, C4 seems to be a well-protected gene segment along the evolutionary process.

Software reuse: The Brazilian industry scenario

This paper aims at identifying some of the key factors in adopting an organization-wide software reuse program. The factors are derived from practical experience reported by industry professionals, through a survey involving 57 Brazilian small, medium and large software organizations. Some of them produce software with commonality between applications, and have mature processes, while others successfully achieved reuse through isolated, ad hoe efforts. The paper compiles the answers from the survey participants, showing which factors were more associated with reuse success. Based on this relationship, a guide is presented, pointing out which factors should be more strongly considered by small, medium and large organizations attempting to establish a reuse program. (C) 2007 Elsevier Inc. All rights reserved.

Association between particulate matter from biomass burning and respiratory diseases in the southern region of the Brazilian Amazon

Objective. To investigate the short-term effects of exposure to particulate matter from biomass burning in the Amazon on the daily demand for outpatient care due to respiratory diseases in children and the elderly. Methods. Epidemiologic study with ecologic time series design. Daily consultation records were obtained from the 14 primary health care clinics in the municipality of Alta Floresta, state of Mato Grosso, in the southern region of the Brazilian Amazon, between January 2004 and December 2005. Information on the daily levels of fine particulate matter was made available by the Brazilian National Institute for Spatial Research. To control for confounding factors ( situations in which a non-causal association between exposure and disease is observed due to a third variable), variables related to time trends, seasonality, temperature, relative humidity, rainfall, and calendar effects ( such as occurrence of holidays and weekends) were included in the model. Poisson regression with generalized additive models was used. Results. A 10 mu g/m(3) increase in the level of exposure to particulate matter was associated with increases of 2.9% and 2.6% in outpatient consultations due to respiratory diseases in children on the 6th and 7th days following exposure. Significant associations were not observed for elderly individuals. Conclusions. The results suggest that the levels of particulate matter from biomass burning in the Amazon are associated with adverse effects on the respiratory health of children.

POSTMARITAL RESIDENCE PRACTICE IN SOUTHERN BRAZILIAN COASTAL GROUPS: CONTINUITY AND CHANGE

The coastal plains of the States of Parana and Santa Catarina, in Southern Brazil, were first settled around 6000 B.P. by shellmound builders, a successful fisher-hunter-gatherer population that inhabited the coastal lowlands practically unchanged for almost five thousand years. Shellmounds were typically occupied as residential sites as well as cemeteries, and are usually associated with rich alimentary zones. Around 1200 B.P., the first evidence of ceramics brought from the interior is found in coastal areas, and together with ceramics there is a progressive abandonment of shellmound construction in favor of flat cold shallow sites. Here we consider if these changes were reflected in the postmarital residence practice of coastal groups, i.e., if the arrival or intensification of contact with groups from the interior resulted in changes in this aspect of social structure among the coastal groups. To test the postmarital residence practice we analyzed within-group variability ratios between males and females, following previous studies on the topic. and between-group, correlations between Mahalanobis distances and geographic distances. The results suggest that in the pre-ceramic series a matrilocal, postmarital residential system predominated, while in the ceramic period there was a shift toward patrilocality. This favors the hypothesis that the changes experienced by coastal groups after 1200 B.P. affected not only their economy and material culture, but important aspects of their sociopolitical organization as well.

University System Governance and Organization

University systems rely on organizational and governance structures to balance the interest, missions, and needs of constituent campuses. This report examines organizational and governance structures of four public university systems. It explores the organizational structures of governing boards and administrative offices, as well as the role of system offices in coordinating across constituent campuses and protecting mission differentiation.

Fatores da administração do sistema penitenciário do Rio de Janeiro que os impedem de cumprirem com sua missão de recuperação do detento?

Since some years ago, the penitentiany systen of Rio de Janeiro is going through the nuest sendus administrative crisis,leading more and more to chaotic situations, over imagined before by homan being. Nowadays all the factors and components of the existing models are still medievaIs, and even distant fron the human needs. The daily life ofthe condemned is a sway betuen lack of hygiene, disrespect to homan rigts, lack of modem corrective practices and also, lack of psychological support. How, then can me demand from the state ( Govemment) the rehabilitation of the imprisoned and their preparation to face society if they are treated manny times as victins of this same society? This society impose a life style enjoyed only by a privileged social class which forget about then when sent to the darkness. Many of then, join the penitentary systen because of minor crimes, and when they serve their tem, um for funately they go back to prison accused for move violent crimes. The penitentian models haven't developed the same way the society where they worked at has. There, the present brazilian penitentiary model has showed obsolete and inefficient alone its principal mission ofrehabilitation and re - education ofthe imprisoned. Our main objetive will be the construction and analysis of the penitential administrative model, as being able to fullfill the necesity of the penitentiary administrator (Manager). Analy zing on a specific reasoning which focus showld not be that of the theories and isolated projects of the topic, we will develop a progran far form religions, judiciary on political technics by building na administrtive penitentiary model strictly professional where we coul a have a deep analysis of the topic. We will try to approach the aspects of organization existing to day inorder to understand them and criate, a model wich will adjust betten to the necesitives of this thesis.

A gestão da organização social no contexto da reforma do estado no Brasil: o caso ABTLus (LNL/CNPq)

The present work has as its basic purpose observing the principal administrative changes originated from the implementation of the Social Organization Project, inserted in the recent administrative reforms in Brazil, proposed from the Director Plan of the State Reform and approved by the National Congress in November of 1995. In the course of the text will be presented the main factors of the transformation from a bureaucratic public administration to a managerial public administration, specifically focusing the change from a Government Organization to a Social Organization. To reach the proposed objective, a case study of the Brazilian Association of Light Sincrotron Technology - ABTLuS, that represented the first Social Organization installed in Brazil, responsible for the management of the National Laboratory of Light Sincrotron - LNLS, under form of administration contract signed with Nationl Research Council - CNPq and Science and Technology Ministry - MCT. Initially, was developed the theoretical framework, based on the existent literature. Proceeding, field researches were realized in the cities of Campinas - SP, in Brasília - DF and in Rio de Janeiro - RJ. As a consequence of the accomplished work, it was possible to observe that the implementation of the SO administrative model brought more administrative flexibility for the qualified institution. This fact induced to gains of agility and efficiency, with more responsibilities, for the leaders as well as for the employees of ABTLuS. As for the other two important items consisted in the Director Plan, related with the cultural change (from bureaucratic to managerial) and with the social control (larger interaction in the relationship State-society), it is important to stand out the need of a larger time for evaluation, considering that the LNLS presents peculiar characteristics (subject approached in the work). The Social Organization ABTLuS counts with a little more than two years of administration contract, therefore the process is still in course.

As "Confrarias" como um Fenômeno Organizacional Brasileiro: Notas Etnográficas de um Aprendiz de Bourdieu

Over the last years we have seen a significant increase in scholarly production within the organization studies field in Brazil. However it is still not representative. The tendency to consume foreign and fashionable ideas unrestrainedly, to make use of imported, universal and non-contextualized explanations to inquiry phenomenon which are essentially local and particular, make it difficult to develop a true Brazilian tradition. This work is a result of an ambitious ethnographic adventure" of an acknowledged apprentice of sociologist Pierre Bourdieu's large body of knowledge. It is about taking reflexivity to the limit. It is about learning "through the body" in an effort - both theoretical and empirical - to investigate a Brazilian organizational phenomenon which reproduces the hierarchical side of our society and, under the disguise of the legitimacy offered by organizational discourse, help keeping the very structure of our society in a silent but powerful way. I also want this work to be an alert for the importance of contextualization as a means to avoid a recurring distortion of the scholarly production in administrative science: the mobilization of theoretical references in such a safe way that make explicitness totally unnecessary, the appropriation of concepts whose essence is strange to the nature of the very phenomenon which they aim to explain, and the insistence in the impersonal style, in third-voice narratives, as if it were possible to produce knowledge in social sciences with absolute impartiality. "

A orientação para mercado e a capacidade de resposta das organizações

Este trabalho mostra caminhos para encontrar respostas práticas e objetivas para a aplicação de teorias, conceitos e dogmas, da teoria administrativa no sistema empresarial, com foco claro no binômio empresa e mercado. É a busca de uma relação que traga maior compartilhamento de informações entre estes mundos, procurando um comportamento empresarial que atenda as necessidades de um mercado mutante e em constante alteração. Assim esperamos atenuar o nível de impacto causado pela utilização das teOlias administrativas - consagradas ao sucesso - num universo de mercado que apresenta multiplicidade de aspectos, crescimento de forma desordenada, e no caso brasileiro, uma cultura heterogênea e diversificada. Como resultado final, observou-se que a percepção das empresas pesquisa das, por meio de seus executivos, quanto à Orientação para o Mercado na relação proposta das variáveis analisadas - Capacidade de Resposta - Geração de Inteligência - Disseminação da Inteligência - Orientação para Competidorapresenta uma forte dificuldade de ação em detrimento de uma crescente Geração e disseminação de Inteligência, com preocupações quanto ao Competidor. Outros resultados encontrados no modelo proposto deixam claro que o que os executivos acreditam que suas empresas são mais orientadas para mercado do que realmente ocorre.

Racionalidade comunicativa e processo administrativo em equipes funcionais: o caso do Banco Central do Brasil

o objetivo desta dissertação é analisar como se configuram as funções '< administrativas de planejamento, organização, direção e controle, nas equipes funcionais em nível operacional do Banco Central do Brasil, em função do grau de racionalidade comunicativa I. que referencia a ação gerencial. A partir dos conceitos de processo administrativo e de suas funções integrantes, decorrentes da teoria clássica da administração, a ação gerencial é analisada à luz da epistemologia crítica, particularmente quanto aos conceitos de racionalidade comunicativa e das categorias de ação social. A pesquisa classifica-se como explicativa quanto aos fins e utiliza-se do método de estudo de caso, pois a análise é ambientada nas equipes de trabalho em nível operacional do Banco Central do Brasil. Os dados foram coletados por meio de aplicação de questionário junto aos servidores da instituição que trabalham nos componentes administrativos denominados "Coordenadorias". A partir desses dados foi possível a validação", das escalas e das correlações estabelecidas entre os construtos integrantes do modelo de pesquisa. Os resultados obtidos permitiram confirmar e discutir a hipótese principal do presente estudo de que a racionalidade comunicativa é preditora dos atributos das funções administrativas de planejamento, organização, direção e controle nas equipes funcionais em nível operacional do Banco Central.

Participação nos lucros ou resultados nas empresas estatais federais: questões emergentes, problemas e desafios

Esta dissertação é um estudo de caso exploratório sobre a atuação do Departamento de Coordenação e Governança das Empresas Estatais (DEST), vinculado à Secretaria-Executiva do Ministério do Planejamento, Orçamento e Gestão, na análise e na aprovação das propostas de participação nos lucros ou resultados (PLR) dos empregados das empresas estatais em que a União é acionista majoritária. Quatro empresas estatais que apresentaram propostas de PLR para o exercício de 2008 foram selecionadas qualitativamente. As informações coletadas a partir das propostas das empresas, de documentos oficiais do DEST se manifestando sobre o assunto, do marco legal existente e das entrevistas com representantes do órgão foram analisadas criticamente com base na teoria da agência, da literatura sobre mensuração de desempenho no setor público, das reformas administrativas no Brasil e dos pressupostos do novo institucionalismo. Com isso, foi possível: (i) analisar o DEST e o marco legal da PLR enquanto as instituições intermediando o processo entre as propostas e as aprovações; (ii) caracterizar as preferências do DEST em relação aos programas de PLR; (iii) caracterizar as propostas de PLR das empresas estatais; (iv) caracterizar os resultados que as instituições em consideração estão produzindo; (v) analisar os fatores limitantes e/ou facilitadores para o funcionamento das instituições; e (vi) levantar as percepções de ex- e atuais envolvidos no processo de análise e aprovação das propostas no DEST acerca da PLR nas empresas estatais enquanto instrumento de incentivo à produtividade. Como resultado, verificou-se (i) que as aprovações do DEST refletem apenas parcialmente as preferências do órgão com relação ao formato dos programas e (ii) que a atuação do DEST varia de intensidade entre os eixos que compõem os programas (seleção de indicadores, estabelecimento de metas, definição do montante e forma de sua distribuição).

Pharmaceutical patent bargains: the Brazilian experience

In the backdrop of the strict patent regime flatly adopted by the World Trade Organization (WTO) for all countries, a few countries constantly challenge this system through aggressive patent bargains. Within the pharmaceutical sector, noticeably, some countries now threaten to issue or otherwise actually issue compulsory licenses that may sway large pharmaceutical companies into selling drugs with large discounts or into granting voluntary licenses domestically. That is conspicuously the negotiation strategy adopted by Brazil in its negotiations with big international pharmaceutical companies.This paper explains Brazil’s aggressive bargaining approach based on an analysis of two aspects of its political economy. The first has to do with the international context of patent bargaining in the post-WTO era. Accordingly, the existence of large and fast growing domestic markets position countries such as Brazil as strategic destinations for Foreign Direct Investment (FDI) and trade. Together with an absence of a propensity to innovate in pharmaceutical products, these conditions boost Brazil’s bargaining power for issuing compulsory licenses over pharmaceutical products. The second aspect is related to political economy dynamics inside Brazil. Accordingly, the political framework in Brazil undermines long-term policies and favors short-sighted ones also vis-a-vis R&D investments in the pharmaceutical industry. This remains true regardless of the strictness of the patent regime in place. The lesson of Brazil is relevant arguably for other more powerful developing countries which presently examine Brazil's approach while further challenging the WTO's strict patent policy for the future.

Cartel deterrence and settlements: the Brazilian experience

Settlements are an important part of a program of cartel deterrence, particularly when the likelihood of conviction and the litigation costs are higher. This type of negotiated procedure to reach finality is in essence complementary to the fully adversarial procedures associated to the trial by the administrative or judicial courts, and to other investigative instruments, such as the leniency agreement. The Brazilian experience provides some insights about the different models of direct settlement in cartel cases and the complex interaction among settlements, leniency agreements, and trial outcome. First, there is leeway for the complementary models of settlements, the first oriented mainly to increasing the likelihood of detection, and the second oriented to saving social costs of litigation. Second, the concern with the preservation of the demand for leniency agreements led the competition authority to restrict the use of settlements, which are effectively designed for the defendants that are likely guilty and give higher value to finality. The recent experience illustrates that the current settlement policy has not caused any adverse effect on leniency agreements, while reducing litigation costs and granting finality in some cases.

Regendo a atividade regulatória: a nova legislação das agências reguladoras federais no Brasil

Os processos e as instituições regulatórias são assuntos prioritários da agenda governamental, por tratarem-se de assunto dinâmico que envolve uma mudança na cultura administrativa do país. Um dos grandes desafios das agências reguladoras brasileiras tem sido desempenhar suas funções de forma autônoma e imparcial com o objetivo de promover confiança e transparência ao mercado e à sociedade. Este estudo buscou realizar uma análise do conteúdo e das repercussões das mudanças ora em curso no Brasil, em especial daquelas contidas na proposta enviada pelo governo federal brasileiro ao Congresso Nacional dispondo sobre a nova Lei Geral das Agências reguladoras (Projeto de Lei 3337/2004), com o fito de promover mudanças no modelo de organização institucional e funcionamento desses entes regulatórios. Com esse fim, de início, foram descritos os fundamentos teóricos da regulação, com a apresentação do processo de criação das agências reguladoras federais brasileiras e suas características determinantes. Após a fundamentação, foram detalhados os pontos principais do Projeto de Lei 3337/2004, e seu substitutivo, elaborado pelo Deputado Leonardo Picciani. O próximo capítulo, Governança Regulatória, apresentou as políticas de reforma regulatória, seus desafios no Brasil, e delineou o Programa de Fortalecimento da Capacidade Institucional para Gestão em Regulação (PRO-REG). O estudo deu prosseguimento à análise por meio da apresentação das boas práticas à qualidade regulatória, enfatizando a importância da participação social no processo regulatório, e também da abordagem da experiência internacional. Item complementar para a compreensão e visão geral do estudo, a supervisão regulatória foi também conceituada e justificada, seguida pela abordagem da criação da Unidade de Supervisão Central e da experiência internacional. Por último, em análise final do tema, apoiada por grande pesquisa bibliográfica e documental, e por entrevistas concedidas pelos ocupantes dos dois maiores cargos da Superintendência de Abastecimento da Agência Nacional do Petróleo, Gás Natural e Biocombustíveis, procurou-se mostrar a imprescindibilidade do desenvolvimento e implementação de uma estratégia de qualidade regulatória que permita uma abordagem consistente.

Modelo de organização adaptável a cenários turbulentos: setor empresarial energético brasileiro

O cenário geopolítico global de desenvolvimento assimétrico e novas fontes de energia constituem um desafio para a sustentabilidade organizacional, requerendo organizações com capacidade de adaptação a ambientes turbulentos. Os principais aspectos que afetam a sobrevivência das empresas de energia podem ser categorizados em geopolíticos, econômicos, sociais, tecnológicos, legais, ambientais, de segurança, de energia e administrativos. Esta tese doutoral apresenta um modelo de organizações com capacidade de adaptação a ambientes turbulentos que permite à empresa atingir sustentabilidade no tempo, como resposta à pergunta de partida. Essa pergunta procura as características determinantes de um modelo de organização adaptável, considerando o setor energético brasileiro, no cenário geopolítico global de desenvolvimento assimétrico e novas fontes de energia, segundo a percepção de gestores. A metodologia adotada tomou por base a Grounded Theory apoiada pelo software Atlas/ti e aplicada a entrevistas em profundidade. O método utilizado permitiu construir a teoria indutivamente, com base em categorias, propriedades e dimensões. O modelo proposto emergiu da pesquisa configurando a capacidade de adaptação aos cenários turbulentos para atingir sustentabilidade organizacional como fundamentada nas categorias de Planejamento Prospectivo, Sistemas Adaptativos e Integração Estrutural, identificando as propriedades e dimensões requeridas em cada uma dessas categorias.