The effects of ridging, row-spacing and seeding rate on carrot yield

Selostus: Maan muotoilun, kylvötavan ja siementiheyden vaikutus porkkanan satoon

Production of fungal volatile organic compounds in bedding materials

Selostus: Haihtuvien orgaanisten yhdisteiden muodostuminen kuivikkeissa

Propofoli-infuusion käyttö medetomidiinilla esilääkityillä koirilla

Summary: The use of propofol infusion anesthesia in dogs premedicated with medetomidine

Teknologia ja oppiminen - oppimisprosessin ulottuvuudet eri ympäristöissä

Artikkeli käsittelee Oulun opettajankoulutuslaitoksessa 19.-20.5.1997 pidettyä symposiumia "Learning and Technology - dimensions to learning processes in different learning environments"

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.