Perturbational Finite Volume Method For The Solution of 2-D Navier-Stokes Equations on Unstructured and Structured Colocated Meshes

Based on the first-order upwind and second-order central type of finite volume( UFV and CFV) scheme, upwind and central type of perturbation finite volume ( UPFV and CPFV) schemes of the Navier-Stokes equations were developed. In PFV method, the mass fluxes of across the cell faces of the control volume (CV) were expanded into power series of the grid spacing and the coefficients of the power series were determined by means of the conservation equation itself. The UPFV and CPFV scheme respectively uses the same nodes and expressions as those of the normal first-order upwind and second-order central scheme, which is apt to programming. The results of numerical experiments about the flow in a lid-driven cavity and the problem of transport of a scalar quantity in a known velocity field show that compared to the first-order UFV and second-order CFV schemes, upwind PFV scheme is higher accuracy and resolution, especially better robustness. The numerical computation to flow in a lid-driven cavity shows that the under-relaxation factor can be arbitrarily selected ranging from 0.3 to 0. 8 and convergence perform excellent with Reynolds number variation from 102 to 104.

Respuesta de cuarenta y nueve genotipos de frijol común (Phaseolus vulgaris L.) de fertilización mineral bajo condiciones de La Compañía, Carazo

El ensayo se realizó en el Centro Experimental La Compañía, San Marcos, Carazo en la época de primera (Junio-Agosto) del 2001, los suelos se caracterizan por ser de origen volcánico y con bajo contenido de fósforo (1l.O ppm). Se evaluaron 49 genotipos de fríjol con y sin fertilización, con el objetivo de seleccionar genotipos eficientes al fósforo y nitrógeno nativo; y que además presenten respuesta a la aplicación de fertilizantes. El ensayo se estableció en parcelas pareadas en un diseño de latice 7 x 7 con 6 repeticiones de las que 3 fueron fertilizadas y 3 no fertilizadas. Se estudió el rendimiento, sus componentes y las variables fenológicas días a floración y días a madurez fisiológica, se realizó análisis de varianza para las variables en estudio y se clasifico a los genotipos según su eficiencia a fósforo y nitrógeno y su respuesta a la aplicación de dos dosis de fertilizante mineral (O y 129 kg/ha de la fórmula 18-46-00). Los genotipos en estudio mostraron diferentes tipos de respuesta a la aplicación de fertilizantes, que incluyen comportamientos superior, similar e inferior al compararse con la condición sin fertilizante para las distintas variables estudiadas. Las variables fenológicas no presentaron diferencias bajo ambas condiciones de fertilización. El rendimiento de grano vario entre 1 883 kg/ha hasta 3 353 kg/ha en condiciones con fertilizante y 1 591 kg/ha hasta 2 878 kg/ha en condiciones sin fertilizante. El genotipo EAP 9508-41 mostró los mayores rendimientos en ambas condiciones. En el sistema sin fertilizante 18 genotipos superaron en rendimiento promedio al INTA Jinotepe, 26 al INTA Canela, 30 al INTA Masatepe, y 34 al DOR 364. En el sistema con fertilizante 15 genotipos superaron en rendimiento promedio al DOR 364, 31 al INTA Jinotepe, 33 al INTA Canela y 46 al INT A Masatepe. Según la eficiencia en la absorción de fósforo y nitrógeno nativo y respuesta a aplicaciones de fertilizante se identifican 1 2 genotipos eficientes con respuesta, l3 genotipos eficientes sin respuesta, 11 genotipos ineficientes con respuesta y 13 genotipos ineficientes sin respuesta.

Letras, 1988-1989, nº 19-20 (número completo)

Contenido: Las “gentiles casas” del libro de Pero Tafur / Sofía Carrizo Rueda – Una lectura de los “Cuatro cuartetos” e T. S. Eliot / Inés de Cassagne – La noción de función en las ciencias del lenguaje / Hugo Edgardo Lombardini – Los “Borges” del Fervor / Luis Martínez Cuitiño – El soneto primero de Garcilaso como afirmación doctrinaria / Graciela Maturo – Los símbolos de la culpa en “Cartas de mamá” / Graciela Pucciarelli de Colantonio – La anotación de la Soledad I (vv. 883-957) / Liliana Silvia Serviano – Un planto español para Roldán / Lía Noemí Uriarte Rebaudi – Notas – Reseñas bibliográficas

Toward canonical trophic aggregations

The attractiveness of the trophic concept is that it was the first attempt at a holistic perspective on an ecosystem which met with any degree of success. Just as temperature, pressure, and volume allow one to characterize the incomprehensible multitude of particulate motions in a simple gas, the hope is that a small set of figures, such as trophic storages or trophic efficiencies, permit one to compare two ecosystems with overwhelmingly disparate complexities. Thus, if it were possible to demonstrate that an arbitrary network of ecosystem flows could be reduced to a trophic configuration, the aggregation process thus defined would become a key component of the evolving discipline of "macroscopic ecology" (see also Odum 1977 and Ulanowicz 1979).

Distribution and Abundance of Juvenile Salmonids off Oregon and Washington, 1981-1985

This report is a summary of the results of 883 purse seine sets made for juvenile salmonids during 15 cruises off the coasts of Oregon and Washington during the springs and summers of 1981-1985. Juvenile coho salmon (Oncorhynchus kisutch) occurred most frequently, followed by chinook salmon (0. tshawytscha). The juveniles of these two species co-occurred more frequently than expected. Juvenile chum, pink and sockeye salmon (0. keta, O. gorbuscha, and O. nerka), steelhead (0. mykiss) and cutthroat trout (0. clarki clarki) were caught much less frequently and in lower numbers than coho or chinook salmon. We found no evidence of large schools ofjuvenile salmonids. A northerly movement of juvenile coho salmon wa~ suggested by decreased catches off Oregon and increased catches off Washington between early and late summer. Highest catch per set of juvenile coho salmon was usually found inshore of 37.2 km. Juvenile chinook salmon were usually found within 27.9 km of the coast. Juvenile salmonids were found over a broad range of surface salinities and temperatures. High catches of juvenile coho salmon occurred in both the low salinity waters of the Columbia River plume and in adjacent higher salinity waters. Preferences for specific salinities or temperatures were not obvious for any species, although catch rates of juvenile coho salmon were highest in years when chlorophyll content was also high. Based on expansions of fish with coded wire tags, we estimated that hatchery coho salmon smolts comprised 74%, on average, of the juvenile coho salmon catches. The remaining 26% were presumably wild fish or hatchery fish released as fingerlings. Hatchery coho salmon were caught roughly in proportion to the numbers released. However, hatchery fish from the Columbia River and private coastal facilities were caught at slightly higher rates while those from coastal Washington and public coastal Oregon hatcheries were caught at slightly lower rates than expected from the numbers released. No juvenile coho salmon with coded wire tags were caught that had originated from either California or Puget Sound hatcheries. (PDF file contains 88 pages.)

Evolución de los pacientes de leucemia linfocítica crónica : estudio de la concentración de hemoglobina, el recuento de plaquetas y el número de linfocitos

379 p. : il.

Avaliação das fendas marginais em restaurações de resina composta com variação de alguns determinanates clínicos

O objetivo deste estudo foi comparar, por meio de mensuração das fendas na interface dentina - restauração de resina composta com utilização de algumas variáveis: fotoativação com lâmpada halógena e com LED; utilização de resina microhíbrida com partículas nanométricas Filtek Z350 ou sem estas partículas Filtek Z250; variação do sistema adesivo (Adper Single Bond 2 ou Adper Scotchbond Multi Purpose); variação da temperatura da resina composta; uso de dessensibilizante dentinário ou não; remoção do colágeno da dentina ou não e variação da intensidade de luz na fotoativação. Foram utilizados 70 molares humanos recém-extraídos, com cavidades circulares na dentina superficial de cada face proximal, foram divididos em 10 amostras para cada variável citada acima. Os dentes foram devidamente restaurados, seguindo as instruções dos fabricantes, para todos os grupos e mantidos em estufa bacteriológica por um período de 7 dias, após este período, foram polidos e as réplicas de resina epoxídica foram confeccionadas a partir de uma moldagem com silicone por adição, as mesmas foram levadas ao MEV, para a análise. As fendas foram mensuradas com o auxílio do software UTHSCSA Image tool e os dados foram submetidos à análise estatística pelo teste t de Student para a obtenção dos resultados. Com base nos resultados obtidos pode-se concluir que: os menores valores de fendas marginais foram obtidos quando da utilização de luz halógena (t=3,246 e p= 0,02) e com variação da intensidade desta luz (t= - 8,808 e p= 0,00). Os menores valores relativos de fendas, mas sem diferença estatística significante, foram encontrados, também, quando a resina Filtek Z350 foi comparada com a resina Filtek Z250 (t=-0,426 e p= 0,672) e quando o adesivo Adper Scotchbond Multi Purpose foi comparado com o Sistema Adper Single Bond 2 (t= 0,883 e p= 0,382). Os maiores valores de fendas marginais foram obtidos com a resina Filtek Z350 préaquecida a 60oC (t= -3,961 e p=0,000); com o uso de dessensibilizante dentinário (t=-3,062 e p=0,004) e com a remoção do colágeno pelo hipoclorito de sódio (t= -8,808 e p= 0,000).

Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis

Background: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods: A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results: Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: p(M-H) = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [p(M-H) = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)]. Conclusion: Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts.