Suorituskyvyn analysointijärjestelmän implementointi pkt-yrityksessä

Työn tavoitteena oli kehittää prosessimalli, jonka avulla suorituskyvyn analysointijärjestelmä voidaan ottaa käyttöön pkt-yrityksessä. Lisäksi pyrittiin löytämään oikeita toimintatapoja, joilla järjestelmän suunnittelu ja käyttöönotto voidaan toteuttaa käytännössä. Samalla kartoitettiin potentiaalisia ongelmakohtia, joita implementointiprosessiin liittyy.Työn teoriaosassa käsitellään järjestelmän suunnittelua ja implementointiin vaikuttavia seikkoja. Lisäksi selvitetään suorituskyvyn mittaamisen teoriaa yleisemmin ja esitellään kirjallisuudesta löytyviä prosessimalleja implementointiin.Käytännön osassa suorituskyvyn analysointijärjestelmä suunniteltiin ja otettiin koekäyttöön kolmessa päijäthämäläisessä metallialan pkt-yrityksessä. Kohdeyritysten liikevaihto vaihtelee kymmenen ja sadan miljoonan markan välillä.Suorituskyvyn analysointijärjestelmän suunnittelun lähtökohta on, että mittariston on linkityttävä kiinteästi yrityksen strategiaan. Siten mittaristo voi ohjata yritystä strategian määrittelemään suuntaan. Ylimmän johdon vahva sitoutuminen implementointiprosessiin on ensiarvoisen tärkeää. Johdon on myös järjestettävä riittävät resurssit suunnittelutiimille, jotta onnistuminen on mahdollista. Suunniteltavan suorituskykymittariston on oltava pkt-yrityksessä helppokäyttöinen ja tietojen syöttämisen järjestelmään on oltava nopeaa, jotta siitä voi muodostua kiinteä osa yrityksen johtamista.

Botulinum neurotoxin type A blocks the morphological changes induced by chemical stimulation on the presynaptic membrane of Torpedo synaptosomes.

The action of botulinum neurotoxin on acetylcholine release, and on the structural changes at the presynaptic membrane associated with the transmitter release,was studied by using a subcellular fraction of cholinergic nerve terminals (synaptosomes) isolated from the Torpedo electric organ. Acetylcholine and ATP release were continuously monitored by chemiluminescent methods.To catch the membrane morphological changes, the quick-freezing method was applied. Our results show that botulinum neurotoxin inhibits the release of acetylcholine from these isolated nerve terminals in a dose-dependent manner, whereas ATP release is not affected. The maximal inhibition (70%) is achieved at neurotoxin concentrations as low as 125 pM with an incubation time of 6 min. This effect is not linked to an alteration of the integrity of the synaptosomes since, after poisoning by botulinum neurotoxin type A, they show a nonmodified occluded lactate dehydrogenase activity. Moreover, membrane potential is not altered by the toxin with respect to the control, either in resting condition or after potassium depolarization. In addition to acetylcholine release inhibition, botulinum neurotoxin blocks the rearrangement of the presynaptic intramembrane particles induced by potassium stimulation. The action of botulinum neurotoxin suggests that the intramembrane particle rearrangement is related to the acetylcholine secretion induced by potassium stimulation in synaptosomes isolated from the electric organ of Torpedo marmorata.

A Generic Framework Architecture for Portal Front End

A modem software development requires quick results and excellent quality, which leads to high demand for reusability in design and implementation of software components. The purpose of this thesis was to design and implement a reusable framework for portal front ends, including common portal features, such as authentication and authorization. The aim was also to evaluate frameworks as components of reuse and compare them to other reuse techniques. As the result of this thesis, a goo'd picture of framework's life cycle, problem domain and the actual implementation process of the framework, was obtained. It was also found out that frameworks fit well to solve recurrent and similar problems in a restricted problem domain. The outcome of this thesis was a prototype of a generic framework and an example application built on it. The implemented framework offered an abstract base for the portal front ends, using object-oriented methods and wellknown design patterns. The example application demonstrated the speed and ease of the application development based on the application frameworks.

Fetal laser therapy: applications in the management of fetal pathologies.

Fetoscopic coagulation of placental anastomoses is the treatment of choice for severe twin-to-twin transfusion syndrome. In the present day, fetal laser therapy is also used to treat amniotic bands, chorioangiomas, sacrococcygeal teratomas, lower urinary tract obstructions and chest masses, all of which will be reviewed in this article. Amniotic band syndrome can cause limb amputation by impairing downstream blood flow. Large chorioangiomas (>4 cm), sacrococcygeal teratomas or fetal hyperechoic lung lesions can lead to fetal compromise and hydrops by vascular steal phenomenon or compression. Renal damage, bladder dysfunction and lastly death because of pulmonary hypolasia may be the result of megacystis caused by a posterior urethral valve. The prognosis of these pathologies can be dismal, and therapy options are limited, which has brought fetal laser therapy to the forefront. Management options discussed here are laser release of amniotic bands, laser coagulation of the placental or fetal tumor feeding vessels and laser therapy by fetal cystoscopy. This review, largely based on case reports, does not intend to provide a level of evidence supporting laser therapy over other treatment options. Centralized evaluation by specialists using strict selection criteria and long-term follow-up of these rare cases are now needed to prove the value of endoscopic or ultrasound-guided laser therapy.

Architectural characterization of a delta-front reservoir analogue combining ground penetrating radar and electrical resistivity tomography: Roda Sandstone (Lower Eocene, Graus-Tremp basin, Spain)

Three-dimensional reconstruction of reservoir analogues can be improved combining data from different geophysical methods. Ground Penetrating Radar (GPR) and Electrical Resistivity Tomography (ERT) data are valuable tools, since they provide subsurface information from internal architecture and facies distribution of sedimentary rock bodies, enabling the upgrading of depositional models and heterogeneity reconstruction. The Lower Eocene Roda Sandstone is a well-known deltaic complex widely studied as a reservoir analogue that displays a series of sandstone wedges with a general NE to SW progradational trend. To provide a better understanding of internal heterogeneity of a 10m-thick progradational delta-front sandstone unit, 3D GPR data were acquired. In addition, common midpoints (CMP) to measure the sandstone subsoil velocity, test profiles with different frequency antennas (25, 50 and 100MHz) and topographic data for subsequent correction in the geophysical data were also obtained. Three ERT profiles were also acquired to further constrain GPR analysis. These geophysical results illustrate the geometry of reservoir analogue heterogeneities both depositional and diagenetic in nature, improving and complementing previous outcrop-derived data. GPR interpretation using radar stratigraphy principles and attributes analysis provided: 1)tridimensional geometry of major stratigraphic surfaces that define four units in the GPR Prism, 2) image the internal architecture of the units and their statistical study of azimuth and dips, useful for a quick determination of paleocurrent directions. These results were used to define the depositional architecture of the progradational sandbody that shows an arrangement in very-high-frequency sequences characterized by clockwise paleocurrent variations and decrease of the sedimentary flow, similar to those observed at a greater scale in the same system. This high-frequency sequential arrangement has been attributed to the autocyclic dynamics of a supply-dominated delta- front where fluvial and tidal currents are in competition. The resistivity models enhanced the viewing of reservoir quality associated with cement distribution caused by depositional and early diagenetic processes related to the development of transgressive and regressive systems tracts in igh-frequency sequences.

Occurrence of the "applause sign" in patients with amyotrophic lateral sclerosis.

The applause sign was originally described as a quick bedside test to discriminate progressive supranuclear palsy (PSP) (positive applause sign, PAS) from Parkinson's disease (PD) and frontotemporal dementia (FTD) (negative applause sign). However, recent research demonstrated that the test is positive not only in a subset of patients with PD and FTD, but also in other neurodegenerative diseases. We tested 22 patients with amyotrophic lateral sclerosis (ALS) together with 22 healthy sex- and age-matched controls for the occurrence of PAS. Furthermore, we performed neuropsychological testing with the EXIT-25 battery to correlate PAS with neuropsychological deficits, especially frontal lobe dysfunction. Five ALS patients (23%) and none of the controls displayed PAS (p≤0.05). The occurrence of PAS in ALS patients was not correlated with pathologic EXIT-25 scores or subtests for aberrant motor behaviour. We describe for the first time the occurrence of the applause sign in ALS and provide additional evidence that PAS is not specific for Parkinsonian disorders. Although its occurrence has been related to aberrant motor behaviour due to frontal involvement, in our study PAS did not correlate with executive dysfunction as tested by the EXIT-25 test battery, or with subtests of aberrant motor behaviour.

Accessory phases as a tool to investigate magmatic underplating in polymetamorphic metasediments : an example from a fossil lower crust : Ivrea Verbano zne, NW Italy

The Ivrea and the Strona-Ceneri zones, NW italy and S Switzerland, offer the possibility to study the continental crust of the Southern Alps. Because of its high metamorphic degree and the abundant Permo- Carboniferous mafic intrusions, the Ivrea Zone is classically interpreted an exposed section trough the Permian lower crust. The present work is focused here on metasedimentary slices (septa) intercalated within Permian gabbro (mafic complex). In particular I studied the evolution of accessory phases such as rutile and zircon and the chemistry of the metasediments. The septa build an irregular and discontinuous band that cut obliquely the mafic complex from its deepest part (N) to its roof (S). The chemistry of the metasediments evolves along the band and the chemical evolution can be compared with that observed in the country-rock surrounding the mafic intrusion to the NE and overprinted by a main regional metamorphic event. This suggests that the degree of chemical depletion of the septa was mainly established during the same regional metamorphic event. Moreover it suggests that incorporation of the septa within the gabbro did not modify their original stratigraphie distribution within the crust. It implies that the mafic complex has been emplaced following a dynamic substantially different from the classic model of « gabbro glacier » (Quick et al., 1992; Quick et al., 1994). It is more likely that it has been emplaced by repeated injections of sills at different depths during a protracted period of time. Zircon trace elements and U-Pb ages suggest that regional metamorphism occurred 330-320Ma, the first sills in the deepest part of the Mafic Complex are injected at ~300Ma, the mafic magmas reached higher levels in the crust at 285Ma and the magmatic activity continued locally until 275Ma. The ages of detrital cores in zircons fix the maximal sedimentation age at ~370Ma, this age corresponds therefore with the maximal age of the incorporation of the Ivrea zone within the lower crust. I propose that the Ivrea zone has been accreted to the lower crust during the Hercynian orogeny sensu lato. The analysis of detrital ages suggests that the source terrains for the Ivrea zone and those for the Strona-Ceneri zone have a completely different Palaeozoic history. The systematic analysis of rutile in partially molten metasediments of the Ivrea zone reveals the occurrence of two generations. The two generations are characterized by a different chemistry and textural distribution. A first generation is formed during pro-grade metamorphism in the restitic counterpart. The second generation is formed in the melts during cooling at the same time that part of the first generation re-equilibrate. Re-equilibration of the first generation seems to be spatially controlled by the presence of fluids. Locally the second generation forms overgrowths on the first generation. Considered the different diffusivity of U and Pb in rutile, U heterogeneities have important implication for U-Pb dating of rutile. ID-TIMS and LA-ICPMS dating coupled with a careful textural investigation (SEM) suggest that rutile grains are characterized by multiple path along which Pb diffusion can occur: volume diffusion is an important process, but intragrain and subgrain boundaries provide additional high diffusivity pathways for Pb escape and reduce drastically the effective diffusion length. -- La zone d'Ivrea et la zone de Strona-Ceneri, en Italie nord-occidentale et Suisse méridionale, offrent la possibilité d'étudier la croûte continentale des Alpes du Sud. En raison du haut degré métamorphique et l'abondance d'intrusions mafiques d'âge Permo-Carbonifère [complexe mafique), la zone d'Ivrea est interprétée classiquement comme de la croûte inférieure permienne. Ce travail ce concentre sur des bandes metasédimentaires (septa) incorporées dans les magmas mafiques lors de l'intrusion. Les septa forment une bande irrégulière qui coupe obliquement le complexe mafique du bas (N) vers le haut (S). La chimie des septa évolue du bas vers le haut et l'évolution chimique se rapproche de l'évolution observé dans la roche encaissante l'intrusion affecté par un événement métamorphique régionale. Cette relation suggère que le degré d'appauvrissement chimique des septa a été établit principalement lors de l'événement métamorphique régional. De plus l'incorporation dans les gabbros n'a pas perturbée la distribution stratigraphique originelle des septa. Ces deux observations impliquent que le métamorphisme dans la roche encaissante précède la mise en place du gabbro et que cette dernière ne se fait pas selon le modèle classique (« gabbro glacier » de Quick et al., 1992, 1994), mais se fait plutôt par injections répétées de sills a différentes profondeurs. Les âges U-Pb et les éléments traces des zircons suggèrent que le métamorphisme régionale a eu lieu 330-320Ma, alors que les premiers sills dans la partie profonde du Mafic Complex s'injectent à ~300Ma, le magmatisme mafique atteigne des niveaux supérieurs à 285Ma et continue localement jusqu'à 270Ma. Les âges des coeurs détritiques des zircons permettent de fixer l'âge maximale de sédimentation à ~370Ma ce qui correspond donc à l'âge maximale de l'incorporation de la zone d'Ivrea dans la croûte inférieur. L'analyse systématique des rutiles, nous a permit de montrer l'existence de plusieurs générations qui ont une répartition texturale et une chimie différente. Une génération se forme lors de l'événement UHT dans les restites, une autre génération se forme dans les liquides lors du refroidissement, au même temps qu'une partie de la première génération se rééquilibre au niveau du Zr. Localement la deuxième génération peut former des surcroissances autour de la première génération. Dans ces cas, des fortes différences en uranium entre les deux générations ont des importantes implications pour la datation U-Pb sur rutile. Classiquement les ratios Pb/U dans le rutile sont interprétés comme indiquant l'âges du refroidissement du minéral sous une température à la quelle la diffusion du Pb dans le minéral n'est plus détectable et la diffusion à plus hautes températures est assumée se faire par «volume diffusion» dans le grain (Mezger et al., 1989). Par des datations ID-TIMS (sur grain entier) et LA-ICPMS (in-situ) et une analyse texturale (MEB) approfondie nous montrons que cette supposition est trop simpliste et que le rutile est repartie en sous-domaines. Chacun de ces domaines a ça propre longueur ou chemin de diffusion spécifique. Nous proposons donc une nouvelle approche plus cohérente pour l'interprétation des âges U-Pb sur rutile.

La gestión de libros electrónicos de la Biblioteca Virtual de la Universitat Oberta de Catalunya

La comunicación que se presenta, muestra cómo se lleva a cabo la gestión de los procesos técnicos de los libros electrónicos en la Biblioteca Virtual (en adelante BV) de la Universitat Oberta de Catalunya (en adelante UOC). La BV está integrada en el Campus Virtual y en las aulas virtuales de la Universidad. La principal particularidad de la docencia en la UOC se encuentra en el hecho de que se realiza, en su totalidad, por medio de un Campus Virtual.La BV de la UOC pone especial énfasis en la adquisición de libros digitales para mejorar el acceso de los usuarios a sus recursos y colecciones en una universidad con un modelo de aprendizaje caracterizada por su virtualidad (el 13 de abril de 2011, el Consejo de Gobierno acordó priorizar la adquisición de documentos en formato electrónico). La irrupción de los libros electrónicos en la BV ha comportado una revisión de los procesos técnicos, de manera que los circuitos de adquisición, catalogación y gestión de la colección digital trabajen de forma coordinada. En primer lugar, se describe el entorno en el que se adquieren y se utilizan los libros electrónicos, los distintos escenarios de adquisición y modelos de compra con los que se puede encontrar la BV de la UOC. Se valora el importante papel que desempeña el proveedor en la compra de libros electrónicos. La BV siempre intenta encontrar un equilibrio entre las necesidades de los usuarios, las posibilidades del mercado y los recursos disponibles. Las compras pueden o no ser consorciadas. Cuando se trata de compra consorciada de libros electrónicos se han de sopesar las ventajas e inconvenientes que esta gestión conlleva, tanto económicas cómo de acceso a los contenidos. Cuando un libro está disponible desde distintas plataformas, hay que estudiar cuál es la que se adecúa mejor a las necesidades de la BV. A la hora de decidir el modelo de compra a utilizar hay que considerar diferentes elementos, como la adquisición individual o en paquetes, la compra directa o subscripción, etc. En segundo lugar, se describen los circuitos internos y tratamientos técnicos que experimentan los libros electrónicos. La gestión de estos procesos la llevan a cabo, en mayor o menor medida, los responsables de los servicios de Adquisición, Catalogación y gestión de la Colección Digital, dependiendo de cómo se haya realizado la adquisición (a perpetuidad o subscripción). Por último, se muestran las distintas opciones de acceso que tiene la BV de la UOC a los libros electrónicos, utilizando para ello un sistema de autenticación de usuarios mediante IP (a través de un porxy WAM). Los puntos de acceso a los libros electrónicos son: el catálogo de la BV, el quick set de libros electrónicos de Metalib, el listado A-Z de SFX, la herramienta de descubrimiento Summon y, además, un nuevo acceso desde el nuevo Web de la BV de la UOC. El acceso a los libros electrónicos de la BV de la UOC es una cuestión que aún no está totalmente resuelta. Desde la nueva Web de la BV se está trabajando para conseguir un punto de acceso único. La principal razón por la que no siempre es posible este único punto de acceso es la existencia o inexistencia de las funcionalidades de metabúsqueda en los libros electrónicos que ofrece cada proveedor. A pesar de la complejidad del nuevo contexto del libro electrónico, la BV de la UOC sigue apostando por los nuevos formatos de lectura, que en el 2013 ha representado el 32,30% del fondo bibliográfico y un 45% sobre el presupuesto dedicado para el 2013. Este proceso se realiza trabajando estrechamente con el profesorado, mediante los contenidos disponibles en la ¿Biblioteca en el aula¿ y potenciando la flexibilidad de los gestores y la construcción de nuevos flujos de trabajo que permitan optimizar y facilitar la transición de la lectura de libros tradicionales a la consulta de monografías en formato electrónico.

E-hankinta ja sen käyttö ja hyödyntäminen teollisuusyrityksessä

Tässä tutkimuksessa olen selvittänyt sähköisten työkalujen hyödyntämisen mandollisuuksista teollisuusyrityksessä epäsuorissa hankinnoissa. Tutkimuksessa olen paneuduttu e-hankinnan terminologiaan ja menetelmiin, joita markkinoilla on käytössä. E-hankinta on keskeisin tutkimusalue. Toimittajien etsintään ja niiden hallinnointiin keskittyvät työkalut olen rajannut pois tutkimuksestani. Tutkimuksessa olen selvittänyt e-hankinnan keskeisiä haasteita ja onnistumisen elementtejä, jotta e-hankinnan käyttöönotto olisi mandollisimman helposti tehtävissä. Lukuisten esimerkkien avulla pyrin kartoittamaan e-hankinnan levinneisyyttä ja lisäksi tuon esille niitä potentiaalisia säästökohteita ja kustannusten leikkauksia, joita on mandollista toteuttaa ottamalla käyttöön sähköisen hankintamallin. Tutkimuksen loppuosassa keskityn tutkimaan Perloksen hankintavolyymeja ja löytämään sieltä ne hankintakategoriat, joille tämä sähköinen hankintamalli olisi mandollista ottaa käyttöön. Tässä tutkimuksessa tulen esittämään sähköisen hankintamallin käyttöönottoa ja samalla merkittävän kehityshankkeen toteuttamista lähitulevaisuudessa. Lopullisen päätöksen sähköisen hankintamallin käyttöönotosta ja projektin toteuttamisesta tekee yrityksen johto. Yrityksen johdolle sitten lopulta jää punnittavaksi, kuinka strategisena ja ajankohtaan nähden sopivana tämän tyyppisen kehitysprojektin toteuttaminen nähdään.

Strategisen johtamisen omistajalähtöinen näkökulma

Tämän tutkimuksen tavoitteena oli analysoida strategisen johtamisen omistajalähtöistä johtamismallia kirjallisuuden valossa. Tutkimusmenetelmänä käytettiin olemassa olevaan tekstiaineistoon perustuvaa tulkitsevaa käsitetutkimusta, jolle on ominaista, ettei tutkija ole vuorovaikutuksessa aineiston tuottajan kanssa. Työ oli luonteeltaan teoreettinen, kuvaileva ja laadullinen Tutkimuksen aineistona toimi neljä omistajalähtöistä johtamista käsittelevää teosta, joista kahdessa annettiin kokonaiskuva omistajalähtöisestä johtamisesta, yhdessä aihetta lähestyttiin arvonmäärityksen näkökulmasta ja yhdessä riskien-hallinnan näkökulmasta. Strategiaviitekehys muodostettiin käyttäen hyväksi Chaffeen kolmea, Mintzbergin yhdeksää sekä Volberda ja Elfringin kolmea koulukuntaa. Koulukuntajakoa hyödynnettiin strategisen johtamisen historiallisiin taustoihin tutustumisessa. Yrityksen arvonmääritykselle muodostettiin viitekehys strategia-kirjallisuuden määrittelemistä arvostrategioista. Kasvustrategian viiitekehys muodostui monialaistumisesta ja kansainvälistymisstrategiasta. Tutkimustulokset osoittavat, että omistajalähtöisesti johdetun yrityksen kaiken toiminnan lähtökohtana on omistajien varallisuuden kasvattaminen. Omistajien yritykseen kohdistuvat odotukset ovat yrityksen markkina-arvossa. Hallituksen merkitys johdon ja omistajien rajapintana lisääntyy. Johdon palkkiot on kytketty osakekurssiin. Osakkeenomistajat voidaan jakaa kahteen ryhmään: pääomasijoittajiin ja pörssisijoittajiin. Pääomasijoittajat odottavat yritykseltä tasaista kasvua, maltillista osinkopolitiikkaa, kannattavaa liiketoimintaa sekä riskienhallintaa pitkällä aikavälillä. Pörssisijoittajien odotukset ovat yrityksen markkina-arvossa ja pikaisissa voitoissa.

A Collation of Recently published Western European Formulae for Age Estimation of Subadult Skeletal Remains: Recommendations For Forensic Anthropology and Osteoarchaeology

The aim of this study is to provide an effective and quick reference guide based on the most useful European formulae recently published for subadult age estimation. All of these formulae derive from studies on postnatal growth of the scapula, innominate, femur, and tibia, based on modern skeletal data (173 ♂, 173 ♀) from five documented collections from Spain, Portugal, and Britain. The formulae were calculated from Inverse Regression. For this reason, these formulae are especially useful for modern samples from Western Europe and in particular on 20th century human remains from the Iberian Peninsula. Eleven formulae were selected as the most useful because they can be applied to individuals from within a wide age range and in individuals of unknown sex. Due to their high reliability and because they derive from documented European skeletal samples, we recommend these formulae be used on individuals of Caucasoid ancestry from Western Europe.

Microparticles from stored red blood cells induce thrombin generation

Background: Microparticles are small phospholipid vesicles of <1 lm shed in blood flow by various cell types including red blood cells. Erythrocyte-derived microparticles (EMPs) accumulate in erythrocyte concentrates (ECs) during their storage time. EMPs are considered as part of storage lesion and as their exact role is not elucidated, they could be involved in these clinical outcomes. Aims: The aim of this study is to evaluate the impact and implication of EMPs isolate from ECs on coagulation. Methods: EMPs were first isolated from erythrocyte concentrates by centrifugation and counted by flow cytometry. Using a calibrated automated thrombogram, EMPs were then added to different type of plasmas in order to evaluate the potential of thrombin generation. Results: We demonstrate that EMPs isolated from ECs are capable to accelerate and amplify thrombin generation in presence of a low exogenous tissue factor concentration, thanks to their negatively charged membrane necessary for the assembly of coagulation complexes. Interestingly, in the absence of exogenous tissue factor, EMPs are also able to trigger thrombin generation. In addition, thrombin generation induced by EMPs is not affected by the presence of anti-TF antibodies. Finally, thrombin generation induced by EMPs is not affected by using plasma samples deficient in factor VII, XI or XII. However, thrombin generation is reduced in plasma deficient in factor VIII or IX and is completely abolished in plasma deficient in factor X, V or II. No thrombin generation was observed in plasma samples without EMPs. Summary/conclusion: Several studies have shown a link between storage time of blood products and post transfusion complications. We provide evidence that EMPs accumulated during storage of erythrocyte concentrates were not only able to accelerate and support thrombin generation in plasma in presence of a low exogenous tissue-factor concentration, but also to trigger thrombin generation in absence of exogenous TF. The impact of those transfused EMs is unknown on recipients, nevertheless it could be hypothesized that under certain circumstances, transfused EMPs could be involved in thrombin generation and could be linked to adverse clinical outcome. Further work is needed to determine whether procoagulant EMPs transfused with erythrocyte concentrate may account for some of the complications occurring after red blood cell transfusion, and more particularly after transfusion of ''older''stored blood, rich in EMPs.

Treatment of Retinoblastoma in 2015: Agreement and Disagreement.

The management of intraocular retinoblastoma is rapidly changing, and even recent reviews on the subject are behind existing practices. The 4 authors of this report collectively represent their management strategies with an emphasis on areas of agreement and disagreement. Ophthalmic artery chemosurgery and intravitreous chemotherapy have completely replaced external beam radiotherapy, reduced the use of systemic chemotherapy, and diminished enucleations by 90% without evidence of compromising patient survival.

Development of a systematic computer vision-based method to analyse and compare images of false identity documents for forensic intelligence purposes-Part I: acquisition, calibration and validation issues

Following their detection and seizure by police and border guard authorities, false identity and travel documents are usually scanned, producing digital images. This research investigates the potential of these images to classify false identity documents, highlight links between documents produced by a same modus operandi or same source, and thus support forensic intelligence efforts. Inspired by previous research work about digital images of Ecstasy tablets, a systematic and complete method has been developed to acquire, collect, process and compare images of false identity documents. This first part of the article highlights the critical steps of the method and the development of a prototype that processes regions of interest extracted from images. Acquisition conditions have been fine-tuned in order to optimise reproducibility and comparability of images. Different filters and comparison metrics have been evaluated and the performance of the method has been assessed using two calibration and validation sets of documents, made up of 101 Italian driving licenses and 96 Portuguese passports seized in Switzerland, among which some were known to come from common sources. Results indicate that the use of Hue and Edge filters or their combination to extract profiles from images, and then the comparison of profiles with a Canberra distance-based metric provides the most accurate classification of documents. The method appears also to be quick, efficient and inexpensive. It can be easily operated from remote locations and shared amongst different organisations, which makes it very convenient for future operational applications. The method could serve as a first fast triage method that may help target more resource-intensive profiling methods (based on a visual, physical or chemical examination of documents for instance). Its contribution to forensic intelligence and its application to several sets of false identity documents seized by police and border guards will be developed in a forthcoming article (part II).

Inactive matrix gla-protein is associated with arterial atiffness in an adult population-based study

La vitesse de l'onde de pouls (VOP) est la méthode pour mesurer la rigidité artérielle la plus répandue et la plus validée. C'est aussi un prédicteur indépendant de la mortalité. La Matrix Gla- protein (MGP) est une protein qui inhibe les calcifications vasculaires. MGP nécessite une enzyme dérivée de la vitamine K pour être activée, à l'instar de certains facteurs de coagulation. La forme inactive de MGP, connue sous le terme de « desphospho-uncarboxylated MGP » (dp-ucMGP), peut-être mesurée dans le plasma. Plus les apports de vitamine K sont importants plus les taux de dp-ucMGP diminue. Les taux de dp-ucMGP ont déjà été étudiés et associés à différents marqueurs cardiovasculaires (CV), aux événements CV et à la mortalité. Dans notre travail de recherche nous avons émis l'hypothèse que des taux élevés de dp-ucMGP seraient associés à une VOP élevée. Nous avons recruté les participants à travers une étude multicentrique suisse (SKIPOGH). Le processus de recrutement ciblait des familles dans lesquelles plusieurs membres étaient d'accord de participer. Nous avons mesuré la dp-ucMGP plasmatique grâce à la méthode immuno-enzymatique « ELISA ». Concernant la VOP, nous avons mesuré les ondes de pression au niveau carotidien et fémorale grâce à un tonomètre et calculer la vitesse de leurs propagations. Par la suite nous avons utilisé un modèle de régression linéaire multiple afin de déterminer le lien entre la VOP et dp- ucMGP. Le modèle était ajusté pour l'âge, la fonction rénale et les risques CV classiques. Nous avons inclut 1001 participants dans les analyses (475 hommes et 526 femmes). La valeur moyenne de la VOP était de 7.87 ± 2.10 (m/s) et celle de dp-ucMGP de 0.43 ± 0.20 (nmol/L). La VOP était positivement et significativement associée à dp-ucMGP avant comme après ajustement pour le sexe, l'âge, l'indice de masse corporel, la taille, la pression artérielle systolique et diastolique, la fréquence cardiaque, la fonction rénale, les taux de cholestérol (LDL, HDL), la glycémie, la consommation de tabac, la présence d'un diabète, l'utilisation de médicaments antihypertenseurs ou hypolipémiants et la présence d'antécédents CV (P<0.01). En conclusion, des taux élevés de dp-ucMGP sont positivement et indépendamment associés à la rigidité artérielle après ajustement pour les facteurs de risques CV traditionnels, la fonction rénale et l'âge. Des études expérimentales sont nécessaires afin de déterminer si une supplémentation en vitamine K permet de ralentir l'avancement de la rigidité artérielle grâce à son activation de la MGP.