Formulação de uma bebida ice a base de cachaça e quinino

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Incorporação de um sistema nobreak com ultracapacitor em um microcomputador

The objective of this work is to analyze the viability of incorporation in a microcomputer box of a nobreak with an ultracapacitor as energy storage device, substituting the conventional chemical battery. An advantage of this inclusion is cost reduction because a specific metallic or plastic frame won’t be necessary to protect the components of the nobreak; the microcomputer metallic frame offers the necessary protection for both equipments. Moreover, a large quantity of internal space of microcomputers box isn’t used, and is possible to use it to wrap up the nobreak. This work uses data about average power consumption of microcomputers; operation of switching mode power supplies for microcomputers; electrical and mechanical characteristics of ultracapacitors and operation of power circuits of nobreaks, with the purpose of present a study of energy storage capacity that an ultracapacitor should have to allow a safe switching off of a microcomputer in case of electrical network fail. It was noticed that the use of ultracapacitors is feasible to feed an 180 W load for 75 s, using a capacitive bank with sixteen ultracapacitors, with a total capacitance of 350 F and voltage of 10,8 V. The use of the proposed nobreak increases the reliability of the microcomputer by reducing the probability of user data losses in case of an electrical network fail, offering a high cost/benefit product. The substitution of the battery by an ultracapacitor allows a quick nobreak recharge, with low maintenance costs, since ultracapacitors have a lifetime bigger than batteries; beyond reducing the environmental impact, because they don’t use potentially toxic chemical compounds

Construindo novas referências: a comunicação aliada à formação do público interno

This paper addresses the issue of internal communication, especially with regard to its function formative and not merely informative. The objective of the research is to analyze to what purposes the organizations use their internal communication, as well as the viewpoint of communication professionals about building character and training of these means. As exploratory research method was used with a questionnaire to communications professionals who work or have worked in the area of internal communication in organizations. The issues addressed were aimed at verifying whether the communication is commonly fostered with other goals besides informing, which the media more used and is performed in an integrated manner with other departments. It was concluded that, although the internal communication is used most often to inform and ensure a good organizational climate, communication professionals understand the necessity of its use for the formation of the internal public and try to use it for this purpose

Estudo de um caso de tratamento de câncer com um produto alternativo às técnicas convencionais

This work consists of a case study, a qualitative methodology, which aims to show the effects of TIVALLEC, a supplement in vitamins, as an alternative treatment of cancer. This study had also the objective of evaluating one patient’s quality of life thirteen years after being diagnosed with an advanced prostate cancer, and having decided for an alternative treatment using TIVALLEC instead of conventional treatments, having obtained excellent results. An open interview was conducted with patient, evaluating various aspects of his life after the initial diagnosis and the chosen treatment. The answers were transcribed after being limitedly edited for readability. At the end of the study, with the support of recent literature, the interview allowed the conclusion that TIVALLEC was greatly effective, creating good quality of life and wellness for the patient during all the period of thirteen year after the diagnosis up to now. These alternative treatment results may be seen as demanding new studies to help cancer patients who embrace or not the conventional treatments

Estudo de caso: formulação de custo de um produto de usinagem em uma pequena empresa

Many variables are indirectly involved in the transformation of raw material into a metallurgical industry, such as machine hours, hours of hand labor directly and / or indirect, setup time, etc. This research focuses on the complexity of formulating the cost of metallurgical products, based on a case study, in which one has incurred a large loss on the sale of a product called Punch. The main objective of this work is to define the variables of the cost of members and other metallurgical products, so simplified general, checking what were the failures costing the case studied, in order to help others. The method of formulating cost was determined as recommended by SEBRAE guidance for small businesses. The results showed a loss R$ 13.201,00 in the batch of 15 units of punch. Possible improvements have been identified for reducing the production cost

Identificação e implementação de melhorias nas operações de transporte interno de matéria-prima de um aindústria de bens de consumo

The world is an environment in constant process of globalization, where physical boundaries are no longer limits. The competitiveness has also evolved, forcing companies to adopt efficient practices in order to increase productivity gains, reduce losses and improve quality. Nowadays, the supply chain management and its element, including the internal logistics, is regarded as a key element for gaining competitiveness. Thus, this study focused on identifying and implementing improvements in the internal raw materials transport operations of a consumer goods company, based on concepts and tools of the lean thinking. The results showed considerable gains in productivity with consequent cost reduction, proving the efficiency of the methodology lean even in support areas of an organization.

Estudos sobre atividade nociceptiva/antinociceptiva de peptídeos isolados do veneno bruto de abelha Apis mellifera

O veneno bruto de abelha Apis mellifera é composto por uma série de peptídeos, entre eles a melitina, adolapina, procamina A e B, apamina, tertiapina, secapina, peptídeos desgranuladores de mastócitos, entre outros. Estas substâncias apresentam diversos efeitos já estudadas, dentre elas, efeitos antitumorais, atividades hiperalgésicas ou analgésicas, inflamatórias ou anti-inflamatórias. O peptídeo secapina foi descrito há 35 anos atrás e, posteriormente nada mais foi relatado na literatura. Portanto, este é o primeiro trabalho que visa caracterizar o possível efeito hiperalgésico e/ou analgésico, inflamatório e/ou antiinflamatório, bem como analisar alguns dos mecanismos envolvidos nestes fenômenos. Para tanto, para caracterizar os possíveis efeitos hiperalgésicos/analgésicos da secapina, em diversas doses (0,005, 0,35, 1, 2, 10 e 30 μg / 50 μL), foi utilizado o teste de avaliação da sensibilidade dolorosa denominado teste do von Frey eletrônico. Para a caracterização do efeito inflamatório/anti-inflamatório da secapina foi utilizado o paquímetro digital determinando o volume da pata dos animais. Para investigar os possíveis mecanismos envolvidos nestes efeitos, foram realizados tratamentos farmacológicos utilizando indometacina, zileuton e zafirlikaste (inibidores da síntese da via da cicloxigenase, lipoxigenase e antagonista de receptor de leucotrieno, respectivamente). Os resultados mostraram que a secapina, em todas as doses testadas, induziu efeito hiperalgésico a partir dos primeiros 15 minutos após a administração deste peptídeo. Este efeito hiperalgésico persistiu por até 240 minutos nas doses de 0,005 e 0,35 μg/ 50μL e 480 minutos nas doses de 1 e 2 μg/ 50μL. O efeito edematogênico da secapina na dose de 0,35 μg/50 μL foi iniciado nos primeiros 15 minutos após a administração da secapina e persistiu por até 120 minutos, sendo... (Resumo completo, clicar acesso eletrônico abaixo)

Avaliação e comparação do perfil de dissolução do Fluconazol 150mg cápsulas produto referência, genérico e similar

Fármacos com alta permeabilidade intestinal, ampla faixa terapêutica e ausência de evidências documentadas de bioinequivalência ou problemas de biodisponibilidade devido à formulação, foram considerados bioisentos pela ANVISA (RDC 37/2011), ou seja, os fármacos que se encaixam nesta categoria não necessitam de estudos de biodisponibilidade relativa/bioequivalência para serem comercializados. Dentre os catorze produtos que receberam a bioisenção da ANVISA, encontra-se o fluconazol, antifúngico aprovado atualmente para ser comercializado em vários países, inclusive no Brasil, onde inúmeras opções comerciais do produto fluconazol cápsulas, genérico ou similar, podem ser adquiridas. Tendo em vista a bioisenção do produto fluconazol cápsulas e sua larga utilização no mercado brasileiro, o estudo do perfil de dissolução deste produto torna-se relevante. Sendo assim, este trabalho avaliou 2 produtos genéricos e 2 produtos similares frente ao medicamento referência em relação aos seus perfis de dissolução e a similaridade entre eles. Os resultados foram avaliados seguindo a RDC 31/2011 da ANVISA que prevê o cálculo do fator de similaridade entre os perfis de dissolução. E, pôde-se observar que apenas 1 medicamento genérico apresentou o fator de similaridade adequado (entre 50 e 100), sendo 51,60, os demais medicamentos testes apresentaram valores fora do intervalo adotado pela ANVISA. Através desses resultados, conclui-se que intercambialidade do medicamento referência pelo medicamento genérico ou similar não é adequada, uma vez que eles não são considerados iguais, salvo um dos medicamentos genéricos.

Plano real e a nova realidade brasileira

This paper analyzes the Real Plan and its effects on two administrations of President Fernando Henrique Cardoso (FHC), a period which extends from 1995 to 2002. To this end, the study includes a brief review of the problems faced by previous plans, especially the Cruzado Plan and the reasons for the belief that it has been successfull in relation to inflation control. Additionally, seeking to describe the process of moving to the new currency towards stabilization, the paper describes the theoretical foundations of the Plan. In sequence, it defines the backround of both international and domestic monetary reform which was one important part of the Plan and therefore the reasons for the implementation of the monetary reform. Subsequently the paper deals with the effects of the Plan on the economy as a whole, covering also the way the economic measures were taken concerning the Mexican and Asian crisis, the policies used fot the exchange rate, interest rate, fiscal accounts, balance of payments, among other factors and the relationship between them. Hence, it describes the immediate and the long-term consequences of stabilization program in terms of output, employment, public deficit and debt. Therefore, it is important to note the various junctures to which the economy was exposed, and also to point out the challenges and obstacles arising from these changes for growth, which was sometimes fast, sometimes slowing down - the so-called stop and go. Of course, facts as the moving to floating exchange rate regime, the adoption of inflation targeting regime and the adoption of fiscal responsibility law along with the primary surplus policy were able to create a new economic environment and to contribute to later success of the Cardoso years

Toxicidade de petróleo bruto sobre microcrustáceo Daphnia similis em água de rio e água de produção de petróleo

Aquatic ecosystems are suffering many impacts caused by human activities resulting from the activities occurring around them. With technological progress observed in recent years, this environment has received large amounts of chemicals from industries, agriculture and urban area that affect the aquatic biota. Among these sources of contamination, the oil industry has contributed to the pollution of aquatic environments with both effluents as produced water well as oil spills and their derivatives having toxicity to various organisms. With all the environmental issues has increased concern about water quality and has been used ecotoxicological tests with aquatic organisms to ecosystems to assess the toxicity of chemicals present in the water. In this context the microcrustacea Daphnia similis stands out as a freshwater organism very representative of the aquatic fauna of rivers and high sensitivity to environmental impacts. Thus, the present study aimed to evaluate the lethal toxicity of crude oil and produced water on this microcrustacea. The results showed that the microcrustacea presented high sensitivity to contaminants primarily crude oil. There was also the influence of environmental variables pH and temperature on the survival of organisms

Revestimento interno de tubulação por um processo de centrifugação utilizando resina éster-vinílica com adição de cargas

Being the corrosion one of the great problems facing the industry today, specifically the internal corrosion of pipes in chemical and petrochemical industries, hence this work proposes a new type of internal coating in order to avoid fouling and decrease the pressure loss in the flow. For this, we use a composition of vinyl ester resins and manometric loads, which after cleaning and preparation of the internal surface of the tube will be applied through a process of centrifugation, adjusted by a lathe. After curing the resin, a test of roughness will be realized in order to analyze the reduction of friction factor and thus be able to conclude whether there was a significant decrease in pressure drop. With test results in hand, we hope to obtain a coating that meets most of the properties required by the industry and to provide a reduction in operating costs and a visible improvement in the conditions of use of the pipe

Cachaça tradicional e bidestilada: aceitação e perfis sensoriais

O mercado da cachaça, bebida tipicamente brasileira, vem crescendo muito no Brasil e no mundo. Porém, apesar do grande volume de produção, nosso país ainda exporta uma quantidade muito pequena do produto, cerca de 1%. Visando atingir o mercado internacional, e também atender às crescentes exigências do mercado interno, é ainda necessária uma melhor padronização dessa bebida, além da obtenção de um produto com boas características físico-químicas e sensoriais. O principal objetivo deste trabalho foi realizar estudos, visando avaliar o efeito do processo de bidestilação e do envelhecimento, na padronização e na qualidade sensorial, da cachaça comparando-se a aceitação de amostras de cachaça obtidas tradicionalmente, por bidestilação e também envelhecidas. Assim, foram produzidas oito amostras de cachaça, por destilação simples e utilizando-se o processo de bidestilação, em alambiques de cobre, a partir do mesmo vinho de cana, e então envelhecidas em tonéis de carvalho durante seis meses. As referidas amostras foram submetidas a testes de aceitação sensorial utilizando-se sessenta provadores e os resultados obtidos, mostraram que a bidestilação produz uma aguardente mais padronizada e ainda que sua aceitação, aumenta de forma mais acentuada durante o processo de envelhecimento

Extensometria: estudo das microdeformações ao redor de três implantes de hexágono interno, com posicionamento linear, sob a influência da fundição de coifas plásticas e usinadas

The objective of this in vitro study was quantify the micro strain development around the internal hexagon implants, varying the type of prosthetic coping. For This reason, three implants of internal hexagon were inserted into one polyurethane block in line placement. Microunit abutments were screwed onto the implants. Tangentially the implants were bonded the strain gauges, two to the center implant. Ten structures, each one containing three copings were cast in Co-Cr alloy, that were divided into groups in the first group, plastic copings were used, and in the second group machined copings were used. The superstructure’s occlusal screws were tightened onto Microunit abutments with 10 Ncm torque, the magnitude of micro strain was recorded. The mean values of each strain gauge of each plastic copings were 363,37 ± 237,66 and the machined copings were 338,12 ± 223,01. The data were analyzed statistically by t- Student test. No statistically significant difference was found between the prosthetic copings (p= 0,867). It was concluded that to internal hexagon implants in line placement, the type of copings presented similar magnitude of micro strain after prosthetic occlusal screw was tightened

Decisão making or buying: uma aplicação em células de manufatura de uma indústria de produção mecânica

In order to maintain the competitiveness the companies seek for cost reduction and resource optimization. A product or service price is calculated considering direct and indirect costs involved in its fabrication, which means that if an intern indirect process is optimized, the final price of the product is also reduced and becomes more interesting to the final costumer. Considering this reasoning, the companies must evaluate each of their processes and optimize them. It is common to outsource intern products manufacturing as a cost reduction strategy, nevertheless when there are already resources and capability to produce the own goods, it becomes necessary to evaluate the economic gain that each strategy - make or buy - generates. This paper aims to evaluate the necessary support to take a decision regarding making or buying in a production cell of hoses based in the value of economic cost, system cost and decision process

Arrecadação de medicamentos como estratégia em educação e saúde

O Projeto de Extensão foi desenvolvido na Farmácia-Escola Prof. Dr. Antônio Alonso Martinez, que faz parte do NAC (Núcleo de Atendimento à Comunidade), pertencente à Faculdade de Ciências Farmacêuticas da UNESP. Desenvolveu-se um Sistema de Gestão Interno para o controle das amostras grátis e medicamentos que são destinados à doação para a população de Araraquara e região. Realizou-se a orientação e conscientização da população sobre o reaproveitamento de medicamentos e amostras grátis que não seriam mais utilizados e que estavam dentro do prazo de validade. A divulgação foi efetuada com folder explicativo que foi distribuído na Farmácia-Escola, em consultórios médicos e nas faculdades da UNESP do Câmpus de Araraquara. Além disso, houve divulgação na Semana de Atenção Farmacêutica Estudantil (SAFE) e no site e jornal da EPTV. O prazo de validade de cada produto foi verificado e a dispensação desses medicamentos foi feita mediante a apresentação de prescrição médica. Além disso, realizou-se a Assistência Farmacêutica ao informar ao paciente os detalhes da posologia e possíveis interações medicamentosas, de modo a esclarecer eventuais dúvidas dos pacientes. Os medicamentos mais doados foram anti-hipertensivos e hormônios, refletindo no maior número de formas farmacêuticas doadas como sendo comprimidos e cápsulas. O objetivo da divulgação foi alcançado com o aumento de doações realizadas nos meses subsequentes ao início da mesma e com o aumento de 61,9 % em relação ao ano de 2012