A DUPLA FACE DE SALOMÃO MEMÓRIAS DE UMA ESCOLA DE ESCRIBAS NO SÉCULO X A.C.

O memóravel rei Salomão passou para a história como um sábio por excelência. Ainda na atualidade, a maioria das pessoas relaciona o seu nome com a sabedoria. Mas a partir do momento que passamos a ter conhecimento dos textos que se referem a Salomão, de como foram construídos e quais as ideologias ali presentes (tanto as favoráveis quanto as contrárias), surgem muitos questionamentos, em especial, quando se busca metodicamente dissociar a história da memória. Ao que parece a historiografia tradicional sobre Salomão, ainda encontra-se muito dependente da figura idealizada de Salomão. Resultado de uma construção feita desde a sua época, pelas mãos de seus escribas, como também em tempos posteriores, de acordo com os interesses de cada época. Concluí-se que a sabedoria de Salomão nada mais é do que uma construção ideológica. A partir dessa perspectiva, surge o desafio de buscar outra memória de Salomão, a fim de propor um caminho alternativo, que nos permita produzir uma nova historiografia a respeito de Salomão. Uma historiografia que não se firma na memória oficial , mas que siga na direção contrária, a partir das memórias dos que não se deixaram influenciar pela ideologia do poder. Dessa forma, poderemos alcançar a comprovação de nossa tese: a existência de duas memórias conflitantes a respeito de Salomão, dentro da Escola de Escribas da corte de Jerusalém no século X a.C. Infelizmente, as fontes disponíveis sobre esse assunto são realmente escassas, o que temos são textos, isto é, memórias sobre Salomão. Escolheu-se um texto crítico a Salomão. Trata-se de 1Rs 1-2, texto que pertence a chamada História da Sucessão de Davi, acreditando-se que a partir dele, consiga-se produzir uma historiografia diferente da historiografia tradicional. Concluímos que dentro da Escola de Escribas Salomônica existiam duas ideologias conflitantes. Os que eram a favor de Salomão, defendiam os interesses urbanos. Aqueles que pertenciam à escola anti-Salomônica e anti-Jerusalém, representavam os interesses dos camponeses explorados e oprimidos pelo poder.

Higher-order factor structures and intercorrelations of the 16PF5 and FIRO-B

This study investigated the intercorrelations and the independent and combined factor structures of the Sixteen Personality Factor Questionnaire Fifth Edition (16PF5) and the Fundamental Interpersonal Orientation-Behaviour Scale (FIRO-B). Four thousand four hundred and fourteen U.S. participants completed these measures as part of executive assessments between 1994 and 2003. Exploratory factor analyses supported the five-factor higher-order structure of the 16PF5; however, the three-component structure for the FIRO-B was not supported. A six-factor structure was found to underlie the variance in the measures in combination. Five of these were close to the 16PF5 higher-order structure, but a sixth factor labelled Social Independence also emerged. This new factor consisted of the 16PF5 primaries of Liveliness and Social Boldness, and the FIRO-B Wanted Control scale.

Regulation of IL-1β-induced NFκB by hydroxylases links key hypoxic and inflammatory signaling pathways

Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor ?B (NF-?B), both of which can regulate the inflammatory response. Furthermore, pharmacologic hydroxylase inhibitors reduce inflammation in multiple animal models. However, the underlying mechanism(s) linking hydroxylase activity to inflammatory signaling remains unclear. IL-1ß, a major proinflammatory cytokine that regulates NF-?B, is associated with multiple inflammatory pathologies. We demonstrate that a combination of prolyl hydroxylase 1 and factor inhibiting HIF hydroxylase isoforms regulates IL-1ß-induced NF-?B at the level of (or downstream of) the tumor necrosis factor receptor-associated factor 6 complex. Multiple proteins of the distal IL-1ß-signaling pathway are subject to hydroxylation and form complexes with either prolyl hydroxylase 1 or factor inhibiting HIF. Thus, we hypothesize that hydroxylases regulate IL-1ß signaling and subsequent inflammatory gene expression. Furthermore, hydroxylase inhibition represents a unique approach to the inhibition of IL-1ß-dependent inflammatory signaling.

Studies of synthetic methodologies for introduction of hydroxy groups onto sterol ring C and ring D

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Impact of ATP-binding cassette, subfamily B, member 1 pharmacogenetics on tacrolimus-associated nephrotoxicity and dosage requirements in paediatric patients with liver transplant

Importance of the field: Tacrolimus is the most commonly used immunosuppressive agent following solid-organ transplantation in children. Its clinical use, however, is complicated by side effects (mainly nephrotoxicity), narrow therapeutic index and pharmacokinetic variability which can result in an increased risk of treatment failure or toxicity. Studies examining interindividual differences in the expression of the ABCB1 (ATP-binding cassette, subfamily B, member 1) gene (which encodes the drug transporter, P-gp) and its genetic polymorphisms have attempted to elucidate variations in tacrolimus response and disposition in children. Areas covered in this review: This review explores pharmacogenetic knowledge developed over the last decade regarding the impact of ABCB1 polymorphisms on tacrolimus toxicity and dosage requirements in children. What the reader will gain: A better understanding of the role of ABCB1 genetic polymorphisms (and corresponding haplotypes) and ABCB1 expression levels in various tissues and organs on tacrolimus outcomes in children with liver transplant. Take home message: Pharmacogenetics offers significant potential for optimising tacrolimus use. ABCB1 donor genotypes and ABCB1 expression level in the intestine and leukocytes may be useful in dosage selection. Large prospective studies are, however, required to further explore the potential of genetic testing in identifying children who are at risk of toxicity and to better individualise tacrolimus therapy.

High sensitivity sensors utilising characteristics of dispersion-turning-point of long-period gratings in B/Ge co-doped fibre

Systematically investigated the waveguide dispersion characteristics of LPFGs. It has been revealed that the coupled cladding modes resonating in the dispersion-turning-point region are intrinsically sensitive to the external perturbation. Thus, LPFG-based application devices requiring good stability should avoid this region. On the other hand, this mode ultra-sensitive-zone can be explored to realise sensors and tuneable filters of high efficiency.

Super-high temperature sensitivity of long-period gratings in B/Ge co-doped fiber

Long period fiber grating (LPFG) can be used as active gain controlling device in EDFA. However, LPFGs fabricated in the standard telecom fiber only have a typical temperature sensitivity of 3-10nm/100°C, which may not be sufficient for implementing tuneable filters capable of wide tuning range and high tuning efficiency. In this paper, we report a theoretical and experimental investigation of thermal properties of LPFGs fabricated in B/Ge co-doped optical fiber. We have found that the temperature sensitivity of the LPFGs in the B/Ge fiber is considerably increased compared with those produced in the standard fiber. The LPFGs written in the B/Ge fiber have achieved, on average, one order of magnitude higher sensitivity than that of the LPFGs produced in the standard telecom fiber. We have also identified that the thermal response of LPFG is strongly dependent on the order of the coupled resonant cladding mode. The maximum sensitivity of 1.75nm/°C achieved by the 10th cladding mode of the 240μm LPFG is nearly 24 times that of the minimum value (0.075nm/C) exhibited by the 30th mode of the 34μm LPFG. Such devices may lead to high-efficiency and low-cost thermal/electrical tunable loss filters or sensors with extremely high temperature resolution.

High-temperature sensitivity of long-period gratings in B-Ge codoped fiber

We report an investigation of thermal properties of long-period fiber gratings (LPFGs) of various periods fabricated in the conventional B-Ge codoped fiber. It has been found that the temperature sensitivity of the LPFGs produced in the B-Ge fiber can be significantly enhanced as compared with the standard telecom fiber. A total of 27.5-nm spectral shift was achieved from only 10 °C change in temperature for an LPFG with 240-μm period, demonstrating a first ever reported high sensitivity of 2.75 nm/°C. Such an LPFG may lead to high-efficiency and low-cost thermal/electrical tunable loss filters or sensors with extremely high-temperature resolution. The nonlinear thermal response of the supersensitive LPG was also reported and first explained.

Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes

Background: Omega-3 fatty acids (n-3) may be protective of cardiovascular risk factors for vulnerable populations. The purpose of this study was to assess the association between n-3 with, C-reactive protein (CRP), and homocysteine (HCY) in Black minorities with and without type 2 diabetes. Methods: A cross-sectional study was conducted with 406 participants: Haitian Americans (HA): n=238. African Americans (AA): n=172. Participants were recruited from a randomly generated mailing lists, local diabetes educators, community health practitioners and advertisements from 2008-2010. Sociodemographics and anthropometrics were collected and used to adjust analyses. All dietary variables were collected using the semi-quantitative food frequency questionnaire (FFQ) and used to quantify vitamin components. Blood was collected to measure CVD risk factors (blood lipids, HCY, and CRP). Results: African Americans had higher waist circumferences and C-reactive protein and consumed more calories as compared to Haitian Americans. Omega 3 fatty acid intake per calorie did not differ between these ethnicities, yet African Americans with low n-3 intake were three times more likely to have high C-reactive protein as compared to their counterparts [OR=3. 32 (1. 11, 9. 26) p=0.031]. Although homocysteine did not differ by ethnicity, African Americans with low omega 3 intake (<1 g/day) were four times as likely to have high homocysteine (>12 mg/L) as compared to their counterparts, adjusting for confounders [OR=4.63 (1.59, 12.0) p=0.004]. Consumption of n-3 by diabetes status was not associated with C-reactive protein or homocysteine levels. Conclusions: Consumption of n-3 may be protective of cardiovascular risk factors such as C-r

[In main hall of] NOW conference in Washington, D.C.

General note: Title and date provided by Bettye Lane.

[In main hall of] NOW conference in Washington, D.C.

General note: Title and date provided by Bettye Lane.

In main hall of NOW conference in Washington, D.C.

General note: Title and date provided by Bettye Lane.

[In main hall of] NOW conference in Washington, D.C.

General note: Title and date provided by Bettye Lane.