982 resultados para LEE, RAYMOND M.
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8th, 1875, 44th Cong., 1st sess., House ex. doc. no. 159
Wildlife and America : contributions to an understanding of American wildlife and its conservation /
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Cosponsored by U.S. Fish and Wildlife Service, Forest Service, and the National Oceanic and Atmospheric Administration.
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Mode of access: Internet.
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Mode of access: Internet.
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"Printed in Great Britain."
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Cover title.
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Compare, Library Company of Philadelphia. Afro-Americana, 1553-1906, entry 5755.
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Fil: Pappier, Viviana. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.
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Genes for peripheral tissue-restricted self-antigens are expressed in thymic and hematopoietic cells. In thymic medullary epithelial cells, self-antigen expression imposes selection on developing autoreactive T cells and regulates susceptibility to autoimmune disease in mouse models. Less is known about the role of self-antigen expression by hematopoietic cells. Here we demonstrate that one of the endocrine self-antigens expressed by human blood myeloid cells, proinsulin, is encoded by an RNA splice variant. The surface expression of immunoreactive proinsulin was significantly decreased after transfection of monocytes with small interfering RNA to proinsulin. Furthermore, analogous to proinsulin transcripts in the thymus, the abundance of the proinsulin RNA splice variant in blood cells corresponded with the length of the variable number of tandem repeats 5' of the proinsulin gene, known to be associated with type 1 diabetes susceptibility. Self-antigen expression by peripheral myeloid cells extends the umbrella of immunological self and, by analogy with the thymus, may be implicated in peripheral immune tolerance.
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Book review: CIUTI-Forum Paris 2005: Regards sur les aspects culturels de la communication. Martin Forstner and Hannelore Lee-Jahnke (eds). Bern: Peter Lang, 2006. xii + 307 pp. ISBN 978-3-03910-834-4.