980 resultados para Festphasensynthese, Diamino-D-Galactose-Scaffolds, RNA-Liganden


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Les Carnets de Brose. (1913. La Recomposition de la science de l'Homme,sous la direction de Christine Laurire).

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O estudo da perceo dos Profissionais I-D sobre a qualidade da informao no desempenho das suas funes insere-se numa estratgia de investigao emergente em Portugal de gesto baseada em evidncias, em que se pretende estudar e debater a problemtica da qualidade da informao na formao dos futuros Profissionais da Informao. O universo estudado o grupo de licenciados em Cincias da Informao e da Documentao pela Universidade Aberta que colaborou por meio da realizao de um questionrio atravs do Google Drive. objetivo deste trabalho determinar a importncia das dimenses da qualidade de informao em vrios e heterogneos domnios, nomeadamente; na tomada de deciso, na gesto da informao e no impacto no desempenho, seja em contexto privado ou laboral. As dimenses consideradas relevantes pelos respondentes foram as seguintes: qualidade da informao, quantidade de informao, acessibilidade, disponibilidade, usabilidade, compreenso, relevncia, formato, conciso, impacto individual, aprendizagem, eficcia na deciso, impacto organizacional, tempo de resposta, objetividade e credibilidade da informao. Existe uma perceo generalizada na amostra estudada para que a qualidade da informao seja associada s caractersticas de fiabilidade, organizao, conciso, facilidade de obteno, pertinncia, rapidez e segurana. Com efeito, relevante e de indesmentvel importncia discutir no contexto acadmico o valor da informao por meio da avaliao dos seus atributos de qualidade, a fim de se dinamizarem novos indicadores e desempenhos que apontem para a efetividade das informaes que so disponibilizadas em mltiplas situaes informacionais.

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INTRODUCTION: A decline in hepatitis D virus (HDV) occurrence was described in Europe and Asia. We estimated HDV prevalence in the Brazilian Amazon following hepatitis B vaccination. METHODS: This is a cross-sectional survey of HDV measured by total antibodies to HDV (anti-HD T). RESULTS: HDV prevalence was 41.9% whiting HBsAg carries and was associated with age (PR = 1.96; 95% CI 1.12-3.42; p = 0.01), hepatitis B virus (HBV) infection (PR = 4.38; 95% CI 3.12-6.13; p < 0.001), and clinical hepatitis (PR =1.44; 95% CI 1.03-2.00; p = 0.03). Risk factors were related to HDV biology, clinical or demographic aspects such as underlying HBV infection, clinical hepatitis and age. CONCLUSIONS: Our study demonstrated that HDV infection continues to be an important health issue in the Brazilian Amazon and that the implementation of the HBV vaccination in rural Lbrea had little or no impact on the spread of HDV. This shows that HDV has not yet disappeared from HBV hyperendemic areas and reminding that it is far from being a vanishing disease in the Amazon basin.

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The emergence of the so-called European Paradox shows that R&D investment is not maximally effective and that increasing the scale of public R&D expenditures is not sufficient to generate employment and sustained economic growth. Increasing Governmental R&D Investment is far from being a panacea for stagnant growth. It is worth noting that Government R&D Investment does not have a statistically significant impact on employment, indicating the need to assess the trade-offs of policies that could lead to significant increases in government expenditure. Surprisingly, Governmental R&D Employment does not contribute to mass-market employment, despite its quite important role in reducing Youth-Unemployment. Despite the negative side-effects of Governmental R&D Employment on both GVA and GDP, University R&D Employment appears to have a quite important role in reducing Unemployment, especially Youth-Unemployment, while it also does not have a downside in terms of economic growth. Technological Capacity enhancement is the most effective instrument for reducing Unemployment and is a policy without any downside regarding sustainable economical development. In terms of wider policy implications, the results reinforce the idea that European Commission Research and Innovation policies must be restructured, shifting from a transnational framework to a more localised, measurable and operational approach.

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Introduction: Hepatitis C virus (HCV) infection is diagnosed by the presence of antibodies and is supplemented by confirmatory testing methods, such as recombinant immunoblot assay (RIBA) and HCV-RNA detection. This study aimed to evaluate the efficacy of RIBA testing to diagnose HCV infection in blood donors positive for anti-HCV antibodies. Methods: A total of 102 subjects positive for anti-HCV determined by enzyme-linked immunosorbent assay (ELISA) at the Hematology and Hemotherapy Foundation of Bahia (HEMOBA) were later assessed with new samples using the Abbott Architect anti-HCV test (Abbott Diagnostics, Wiesbaden, Germany), the RIBA III test (Chiron RIBA HCV 3.0 SIA, Chiron Corp., Emeryville, CA, USA), the polymerase chain reaction (PCR; COBAS&#174; AMPLICOR HCV Roche Diagnostics Corp., Indianapolis, IN, USA) and line probe assay (LiPA - Siemens, Tarrytown, NY, USA) genotyping for HCV diagnosis. Results: Of these new samples, 38.2% (39/102) were positive, 57.8% (59/102) were negative and 3.9% (4/102) were indeterminate for anti-HCV; HCV-RNA was detected in 22.5% (23/102) of the samples. RIBA results were positive in 58.1% (25/43), negative in 9.3% (4/43) and indeterminate in 32.6% (14/43) of the samples. The prevailing genotypes were 1 (78.3%, 18/23), 3 (17.4%, 4/23) and 2 (4.3%, 1/23). All 14 samples with indeterminate RIBA results had undetectable viral loads (detection limit &#8804;50 IU/mL). Of these samples, 71.4% (10/14) were reevaluated six months later. Eighty percent (8/10) of these samples remained indeterminate by RIBA, and 20% (2/10) were negative. Conclusions: In this study, individuals with indeterminate RIBA results had no detectable HCV-RNA.

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The main objective of this thesis was the development of polymeric structures from the dissolution of FucoPol, a bacterial exopolysaccharide (EPS), in a biocompatible ionic liquid, choline acetate. The FucoPol was produced by the bacteria Enterobacter A47 using glycerol as carbon source at controlled temperature and pH (30C and 7, respectively). At the end of 3 days it was produced 7 g/L of FucoPol. The net yield of Fucopol in glycerol (YP/S) was 0.22 g/g and the maximum productivity 2.37 g/L.d This polymer was characterized about its composition in sugars and acyl groups (by High-Performance Liquid Chromatography - HPLC), containing fucose (35 % mol), galactose (21 % mol), glucose (29 % mol), rhamnose (3% mol) and glucuronic acid (12% mol) as well as acetate (14.28 % mol), pyruvate (2.15 % mol) and succinate (1.80 % mol). Its content of water and ash was 15% p/p and 2% p/p, respectively, and the chemical bonds (determined by Infrared Spectroscopy - FT-IR) are consistent to the literature reports. However, due to limitations in Differential Scanning Calorimetry (DSC) equipment it was not possible to determine the glass transition temperature. In turn, the ionic liquid showed the typical behavior of a Newtonian fluid, glass transition temperature (determined by DSC) -98.03C and density 1.1031 g/cm3. The study of chemical bonds by FT-IR showed that amount of water (8.80%) influenced the visualization of the bands predicted to in view of their chemical structure. After the dissolution of the FucoPol in the ionic liquid at different temperatures (50, 60, 80 and 100 C) it was promoted the removal of this by the phase inversion method using deionized water as a solvent, followed by drying in an oven at 70 C. The mixtures before and after the phase inversion method were characterized through the studies mentioned above. In order to explore possible application fields biocompatibility assays and collage on balsa wood tests were performed. It was found that the process of washing with water by the phase inversion method was not totally effective in removing the biocompatible ionic liquid, since all FucoPol IL mixtures still contained ionic liquid in their composition as can be seen by the DSC results and FT-IR. In addition, washing the mixtures with water significantly altered the composition of FucoPol. However, these mixtures, that developed a viscous behavior typical of a non-Newtonian fluid (shear-thinning), have the potential to be applied in the biomedical field as well as biological glues.

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Little is known regarding the swimming ability of the larvae of European plaice (Pleuronectes platessa) in relation to changes in total length (TL), dry weight (DW) and developmental stage, which is surprising given the importance of transport processes to the recruitment dynamics of this species in the North Sea and elsewhere. We investigated ontogenetic changes in the critical swimming speed (Ucrit) of plaice from hatching to the onset of metamorphosis (50 days post-hatch, dph) at 8 C. The mean (SD) TL and DW growth rates were 1.59 0.81 and 7.7 0.35 % d1, respectively. Larvae were unable to swim at against a minimum current speed of <0.5 cm s1 until 10 dph (7 mm TL), after which Ucrit significantly increased with increasing TL until the onset of metamorphosis and subsequent settlement. Mean (SD) Ucrit was 0.38(0.35), 1.59(0.54), 2.27(0.49) and 2.99(0.37) cm s1 for stage I (6.61 2.64 mm TL), stage II (7.75 0.60 mm TL), stage III (9.10 1.00 mm TL) and stage IV (11.59 0.85 mm TL) larvae, respectively. Larval TL, DW, DNA content, RNA content and Ucrit significantly increased, whereas sRD significantly declined as larvae developed from stage I to V. Although inter-individual differences in Ucrit (coefficient of variation, CV = 33 %) were as large as those in biochemical and morphological condition (CVs of 2142 %), differences in Ucrit were not significantly related to those in nutritional condition and larvae with lower DNA/DW had also better swimming abilities. These estimates should be useful to ongoing efforts to create individual- based models of the transport, foraging and growth of plaice larvae in the North Sea.

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Abstract: INTRODUCTION: This study assessed the prevalence of hypovitaminosis D and its association with oral candidiasis and clinical parameters of periodontitis (CPP) in HIV-infected patients. METHODS: Periodontal examinations for the 113 HIV-infected patients were recorded using the Community Periodontal Index. A cytological smear from the lateral borders of the tongue was performed to evaluate candidiasis. RESULTS: The frequency of hypovitaminosis D was 23.9%. In multivariate analysis, only the duration of exposure to HIV was associated with CPP [OR 4.72 (95% CI: 0.97-23.00)]. CONCLUSIONS: The prevalence of hypovitaminosis D was 23.9% and was not related with oral candidiasis or CPP.

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O presente trabalho tem como principal propsito selecionar novas metodologias de interveno a aplicar na obra Livro de Consultas e Decretos da Rainha D. Maria I pertencente Chancelaria Rgia do Arquivo Municipal de Lisboa. Para tal, desenvolveu-se a contextualizao histrica do livro e do Fundo e realizou-se o levantamento das problemticas como as tintas ferroglicas, manchas causadas por macro e microorganismos no papel, e reforos com papis transparentes resultantes de restauros antigos nos manuscritos do livro. Realizou-se ainda a caracterizao material dos substratos presentes no livro recorrendo a diferentes mtodos de exame e anlise. A escolha dos mtodos para a remoo dos reforos teve como principal preocupao a substituio de mtodos aquosos tradicionais, que no so controlveis, por novas metodologias de interveno mais controladas. Estes mtodos consistem na aplicao de humidade controlada atravs de tcnicas como: humidificador ultrasnico com temperatura, Gore-tex, gis rgidos, cataplasma enzimtico, e um ensaio experimental com dixido de carbono supercrtico (CO2). Os resultados mais relevantes incidem na identificao do tipo de adesivo utilizado nos restauros antigos, e na operabilidade dos gis rgidos e cataplasma que se revelaram favorveis no tratamento deste tipo de manuscritos. Tendo-se seleccionado os mtodos com melhor operabilidade, realizaram-se intervenes de restauro em apenas alguns flios, a partir do mtodo mais adequado para cada tipo de substrato, tendo em conta o estado de conservao. Por fim desenvolveram-se propostas de interveno para os restantes manuscritos e encadernao, assim como a execuo de um acondicionamento adequado, proposta de conservao preventiva e uma ficha de restrio de acesso obra.

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Fundao para a Cincia e a Tecnologia (FCT), Fundao Calouste Gulbenkian, Fundao Millennium bcp, Direco Geral do Livro e das Bibliotecas/MC

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A constituio de bibliotecas privadas a partir de D. Joo I ir, depois, relacionar-se com a importncia da corte da Borgonha, como centro artstico de Filipe o Bom e de Isabel de Portugal. Neste contexto, assume alguma relevncia o caso de dois manuscritos, que, embora atribudos a atelis diferentes, possuem relaes intrnsecas entre si: o Livro de Horas de D. Duarte (DGARQ/Torre do Tombo, C.F.140), atribudo ao ateli do Mestre aux rinceaux dor, a operar na regio de Bruges e datado de incios do sculo XV e o Livro de Horas dito de Joseph Bonaparte (BNF, Paris, manuscrito lat. 10538), atribudo por Gabrielle Bartz ao ateli do Mestre de Mazarine, situado na regio de Paris e datado de ca. de 1415. A sua procedncia confirmada, designadamente, pelos calendrios neles contidos. No entanto, a anlise de certas imagens, entre as quais as do Ofcio dos Mortos e de Pentecostes, revestiu-se de uma importncia decisiva, pois permitiu-nos evidenciar este conjunto, assim definido pelas semelhanas que apresentam, constituindo o seu estudo o cerne deste artigo.

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Iniciativa paralela galeria de pintura criada pelo rei D. Lus no Palcio da Ajuda, em 1867, o museu de antiguidades conservou e exps o essencial das coleces de numismtica e ourivesaria daquele monarca, acrescidas com diversas peas pertencentes ao tesouro da Casa Real, parte das quais provenientes dos conventos extintos pelo Liberalismo. Hoje disperso por diferentes instituies museolgicas, coleces particulares ou em paradeiro incerto, aquele acervo pretende ser dado a conhecer ao longo deste artigo, sobretudo no que diz respeito aos seus ncleos mais representativos, procurando-se simultaneamente reconstituir a apagada memria do espao que o albergou, o papel desempenhado pelo seu conservador, Teixeira de Arago, e as aquisies efectuadas. Em foco estaro tambm os catlogos editados, a cedncia de peas para exposies nacionais e internacionais e a ateno dada por D. Lus aos novos processos fotogrficos como forma de documentar e divulgar a coleco real.

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Neste artigo, o autor prope-se refletir sobre a chancelaria do rei D. Dinis apresentando novas perspetivas para o seu entendimento do ponto de vista diplomtico, ao mesmo tempo que valoriza, d notcia e publica um conjunto de documentao, pouco divulgada, que permite reavaliar a dimenso e o significado histricos da produo documental dionisina.

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A Exposio A Rainha D. Leonor foi organizada pela Fundao Calouste Gulbenkian, tendo sido inaugurada em Dezembro de 1958 no Mosteiro da Madre de Deus. Desde logo foi assumida a necessidade de proceder a reparaes no Mosteiro fundado por D. Leonor, tendo em vista no s a realizao da exposio evocativa da obra mecentica e caritativa da Rainha, mas tambm a instalao naquele edifcio centenrio do futuro Museu do Azulejo. Porm, as consequncias deste evento so mais amplas, pelo desenho dos elementos expositivos e pelo pensamento global que o orientou e tambm pelo que manifesta da aco da nova Fundao, criada em 1956. Esta instituio enuncia, atravs da Exposio da Madre de Deus, a ateno que ir dedicar preservao do patrimnio histrico, investindo simultaneamente numa representao de si prpria junto do pblico. A sua imagem retm-se na novidade da montagem da exposio e na identificao da misso da Fundao com o papel protagonizado pela Rainha D. Leonor no apoio s artes e na assistncia.