Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Profile of IL-2, IL-4, IL-10, IFN- ? , TNF- ? and KC-like cytokines in pregnant bitches

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Resistência de união, índice de remanescente adesivo e avaliação da presença de esmalte sobre a base de braquetes após descolagem: estudo in vitro

Pós-graduação em Ciências Odontológicas - FOAR

Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Corrosion-fatigue life of commercially pure titanium and Ti-6Al-4V alloys in different storage environments

Statement of problem. Removable partial dentures are affected by fatigue because of the cyclic mechanism of the masticatory system ansi frequent insertion and removal. Titanium and its alloys have been used in the manufacture of denture frameworks; however, preventive agents with fluorides are thought to attack titanium alloy surfaces.Purpose. This study evaluated, compared, analyzed the corrosion-fatigue life of commercially pure titanium and Ti-6Al-4V alloy in different storage environments.Material and methods. For each metal, 33 dumbbell rods, 2.3 mm in diameter at the central segment, were cast in the Rematitan system. Corrosion-fatigue strength test was carried out through a universal testing machine with a load 30% lon er than the 0.2% offset yield strength and a combined influence of different: environments: in air at room temperature, with synthetic saliva, and with fluoride synthetic saliva. After failure, the number of cycles were recorded, and fracture surfaces were examined with on SEM.Results. ANOVA and Tukey's multiple comparison rest indicated that Ti-6Al-4V alloy achieved 21,269 cycles (SD = 8,355) against 19,157 cycles (SD = 3,624) for the commercially purr Ti. There were no significant differences between either metal in the corrosion-fatigue life for dry specimens, but when the solutions were present, the fatigue life was significantly reduced, probably because of the product-ion of corrosion pits caused by superficial reactions.

Ineraction Model Between HRSV G-Protein and Flavonoids

Background: Acute respiratory infections (ARI) are the leading cause of infant mortality in the world, and human respiratory syncytial virus (HRSV) is one of the main agents of ARI. One of the key targets of the adaptive host immune response is the RSV G-protein, which is responsible for attachment to the host cell. There is evidence that compounds such as flavonoids can inhibit viral infection in vitro. With this in mind, the main purpose of this study was to determine, using computational tools, the potential sites for interactions between G-protein and flavonoids. Results: Our study allowed the recognition of an hRSV G-protein model, as well as a model of the interaction with flavonoids. These models were composed, mainly, of -helix and random coil proteins. The docking process showed that molecular interactions are likely to occur. The flavonoid kaempferol-3-O-α-L-arabinopyranosil-(2 → 1)-α-L-apiofuranoside-7-O-α-L-rhamnopyranoside was selected as a candidate inhibitor. The main forces of the interaction were hydrophobic, hydrogen and electrostatic. Conclusions: The model of G-protein is consistent with literature expectations, since it was mostly composed of random coils (highly glycosylated sites) and -helices (lipid regions), which are common in transmembrane proteins. The docking analysis showed that flavonoids interact with G-protein in an important ectodomain region, addressing experimental studies to these sites. The determination of the G-protein structure is of great importance to elucidate the mechanism of viral infectivity, and the results obtained in this study will allow us to propose mechanisms of cellular recognition and to coordinate further experimental studies in order to discover effective inhibitors of attachment proteins.

Análise sobre padrões de relacionamentos amorosos no livro Sex and The City

The researches on sexuality, especially from Foucault’s critical analysis, have been denouncing that the sexual repression also happens through the patterns that suggest a fixed happiness model to be followed, not considering the autonomous development of the subject. The aim of this descriptive-qualitative study was to make a critical analysis of the content of the book Sex and The City, which presents narratives about sexual and love relationships in New York. This analysis evidenciated the reproduction of outdated sexual concepts presented on the following thematic categories: (1) Comprehension of the single woman as lonely and unhappy; (2) Comprehension of the single woman as independent and consumerist; (3) Comprehension that the single woman needs a heterosexual relationship related to the happy romantic ideal; (4) Comprehension of the love relationships as commodities: people as objects of use and exchange. The sexual and love patterns presented by the book demonstrate the repression reproduced uncritically by the mass culture. The Psychology has been an important area of the science to denounce the control of the sexuality from these perverse and ideological patterns.

O preconceito como obstáculo à educação sexual: reflexões a partir de uma perspectiva ética

This paper developed a reflection about problems related to the establishment of ethical principles that guide the sexual education aiming at emancipation. Our theoretical framework is the Critical Theory of Society, in particular texts by T. W. Adorno on training, prejudice and education. It is understood that numerous difficulties are related to the achievement of an emancipatory education, and such difficulties are even greater when it comes to sex education since it is an issue that still raises irrational fears on educators, and is absent from the training they received. Following Adorno, it is understood that the current formation favors the development of subjects inclined to prejudice, and that an emancipatory sexual education involves a critique to the conditions under which such formation occurs and, at the same time, a continuous reflection about the relations between the desires and the social possibilities of their realization.

Psicologia, política e direitos humanos: ambiguidades e contradições

From a brief description of four different epistemological perspectives on human rights this article seeks to highlight the importance of critically discuss the history and the contradictions between these perspectives and the field of psychology both as science and professional practice. It is noteworthy that an ethical psychologist’s practice depends on a critical attitude towards science and human rights in its various interfaces.

Músicas populares urbanas, relaciones de género y persistencia de prejuicios: datos brasileños y españoles a partir de la escucha de cuatro canciones.

Las músicas populares urbanas participan en la construcción, transmisión y deconstrucción de las imágenes de género. Es trascendental comprender su influencia entre los oyentes. Para ello, realizamos una investigación basada en encuestas a jóvenes universitarios que mostró la permanencia de prejuicios y una escasa capacidad crítica, lo que refuerza algunas de las hipótesis de la sociología de la música de T. W. Adorno y plantea cuestiones importantes para la musicología feminista. Es necesario tener conciencia de la existencia de estos prejuicios si pretendemos una educación emancipatoria.

Relações entre gênero e escola no discurso de professoras do ensino fundamental

The school and its teachers have great responsibility in the formation of gender identities. Ten teachers of a public schools participated in a semi-structured interview for the analysis of the content. The teachers perceive gender relations among the students, by their behaviors in the classroom: how quickly are the boys and the whim of the girls, the choice of colors and academic performance distinguished. They also have a concerned about the supposed homosexuality of some boys. The justification on perceived gender differences in students were assigned to the influence of family and to the reproduction of hegemonic standards of gender. Most teachers believe that school has little responsibility in gender issues, highlighting the poor training they had to work with sexual education of their students.

O emprego da literatura na educação infantil: a investigação e intervenção com professores de pré-escola

INTRODUCTION: The children's schools are expanded spaces of education and care for infants. The educator's role as mediator in learning is crucial to child development, and the use of children's books can act as an important methodological and pedagogical resource in this process. METHODS: This paper describes a psychoeducational intervention performed with the educators of a public pre-school with the following objectives: (a) register the collection of children's books of the school, (b) investigate the acquisition and use of children's books by the teachers and (c) offer an intervention to teachers regarding the educational use of children's books. The participants were seven educators who worked with children from 2 to 6 years old. RESULTS: The results indicate that among the 315 books in the school, the majority was about animal stories (75 books), fantasy and mystery (38), fairy tales and fables (34), formal learning (33), learning rules (33) and about nature and environment (22). The educators reported that the choice of books was made mainly considering the age group to which the books were directed, and also from the themes found in texts and/ or illustrations. Although the teachers believe that the books can encourage reading among children, they don't describe their use in planned activities and they report lack of knowledge about their use. CONCLUSION: The proposed intervention to the teachers allowed them to rethink the use of books in pre-school, instructing them to the utilization of the books aiming to stimulate the imagination and creativity, improving the critical and reflexive capability of the children.

Resistência ao cisalhamento de bráquetes fotopolimerizados com arco de plasma, LED e luz halógena utilizando diferentes tempos

This study evaluated in vitro the shear bond strength of brackets bonded with xenon plasma arc light, light-emitting diode (LED) and conventional halogen light using different curing times. Brackets were bonded to the buccal surface of 60 human maxillary premolars allocated to five groups. In groups 1 and 2, the resin was cured with the plasma arc for three and six seconds (s), respectively; in groups 3 and 4, the LED was used for five and ten s, respectively; and in group 5, the halogen light was used for 40 s. The specimens were stored in water for 24 hours and subjected to a shear force until bracket failure. The debonding pattern was classified according to the adhesive remnant index (ARI). The results were assessed by Anova and the SNK post-hoc test. No differences were detected among groups 2, 4 and 5, which showed higher averages than groups 1 and 3, which were not different between themselves. The ARI scores showed no differences among the three types of light sources in all times tested. Plasma arc and LED lights can be used with shorter curing times, within certain limits, than conventional halogen light for bonding orthodontic brackets, without decreasing bond strength.