1000 resultados para Adenylation domain


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This article shows a transmission line model developed directly in the phase domain. The proposed model is based on the relationships between the phase currents and voltages at both the sending and receiving ends of a single-phase line. These relationships, established using an ABCD matrix, were extended to multi-phase lines. The proposed model was validated by using it to represent a transmission line during short-and open-circuit tests. The results obtained with the proposed model were compared with results obtained with a classical model based on modal decomposition. These comparisons show that proposed model was correctly developed. © 2013 Taylor and Francis Group, LLC.

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Resistance of Helicobacter pylori to clarithromycin is characterised by simple point mutations in the 23S ribosomal RNA (rRNA) gene and is responsible for the majority of cases of failure to eradicate this bacterium. In this paper, we characterised the variability of the 23S rRNA gene in biopsies of patients with gastric pathologies in the eastern Amazon (Northern Region of Brazil) using PCR and sequencing. A total of 49 sequences of H. pylori strains were analysed and of those, 75.6% presented nucleotide substitutions: A2142G (3.3%), T2182C (12.9%), G2224A (6.45%), T2215C (61.3%), A2192G (3.3%), G2204C (6.4%) and T2221C (6.4%). Of the mutations identified, four are known mutations related to cases of resistance and 16.1% are not yet described, revealing a high prevalence of mutations in the H. pylori 23S rRNA gene among the strains circulating in the in the eastern Amazon. The high prevalence in individuals with gastric pathologies in the Northern Region of Brazil demonstrates the need for characterising the profile of these strains to provide correct therapy for patients, considering that mutations in this gene are normally associated with resistance to the primary medication used in controlling H. pylori infection.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Along with the growth of scientific production, the bibliometric studies have become essential, providing relevant information about any domain while identifying, highlighting and viewing the scientific knowledge constructed within a theme, subject or knowledge area. This article approaches the bibliometric studies under the light of metatheory and domain analysis within the knowledge organization in information science. domain analysis and metatheory are considered significant contribution to bibliometric studies when emphasizing the need for epistemological, sociological and historical analyzes, as well as other qualitative approaches, encouraging researchers to reflect on the whole composition of the research object, by means of different methodological, theoretical and epistemological approaches. This study aims at contributing to the discourse of the theoretical aspects of bibliometric studies by presenting considerations concerning Hjorland's domain analysis, as well as Ritzer's metatheoretical approach, featuring discussions on major theories of a study field, since these approaches together provide a more complete qualitative view upon an area, here, represented by the bibliometric studies.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Author Cocitation Analysis (ACA) can be defined as the analysis of a group of actors, writers or researchers structurally organized in a (social and cognitive) network of a particular scientific community. The greater the number of researchers selected, the greater the amplitude and the domain boundary under consideration; the more restricted the number of researchers chosen as representative and appropriate, the less extensive the domain. From the perspective of the first axis of Tennis (2003), the selection of authors involves setting parameters on the extent of the domain, i.e., its total scope and amplitude. Thus, from the point of view of Tennis’s (2003) approach to Domain Analysis, the selection of authors for Author Cocitation Analysis is associated with the designations and boundaries of the domain, as well as to their goals (Tennis, 2003). Still, the selection of authors through the most cited authors in the literature, reflects the core elements of a domain and constitute the most specific foundation of a domain, aligning to the Degrees of Specialization characterized by Tennis (2003). It is concluded that the Author Cocitation Analysis (ACA) is a relevant procedure to the analysis of the underlying structure of a scientific knowledge domain, which meets the theories and concepts of Domain Analysis researchers, in that it allows characterizing the science, identifying, analyzing and assessing the conditions under which scientific knowledge is constructed and socialized.

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The purpose of this paper is to present the application of a three-phase harmonic propagation analysis time-domain tool, using the Norton model to approach the modeling of non-linear loads, making the harmonics currents flow more appropriate to the operation analysis and to the influence of mitigation elements analysis. This software makes it possible to obtain results closer to the real distribution network, considering voltages unbalances, currents imbalances and the application of mitigation elements for harmonic distortions. In this scenario, a real case study with network data and equipments connected to the network will be presented, as well as the modeling of non-linear loads based on real data obtained from some PCCs (Points of Common Coupling) of interests for a distribution company.

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Aiming at contributing to the epistemological characterization of the area of knowledge organization, our goal is to analyze the KO journal, since its creation in 1993, as a knowledge domain, from a nuclear community of the most productive and greater impact authors, analyzing the dialogue among citing authors and cited ones, and also the co-citations established by the citing authors. We worked with a corpus of 310 articles published between 1993 and 2011 produced by a total of 360 authors. The relatively more productive authors, a group geographically concentrated in Europe (37%), North America (44%) and Asia (19%), is clearly explained by the historical European origin of the ISKO and by an increasing North American presence along the years. Of the 33 most cited authors, 22 were co-cited in at least 6 works, which suggests that they are the theoretical referential nucleus of the area, in the studied journal. Finally, we observe that the area reveals theme cohesion and coherence in its production, enabling us to clearly visualize its theoretical referential nucleus and to confirm the role performed by the KO magazine as a catalyzing agent of international theoretical construction in the area.