Hybrid treatment of penetrating aortic ulcer

AbstractPenetrating atherosclerotic aortic ulcer is a rare entity with poor prognosis in the setting of acute aortic syndrome. In the literature, cases like the present one, located in the aortic arch, starting with chest pain and evolving with dysphonia, are even rarer. The present report emphasizes the role played by computed tomography in the diagnosis of penetrating atherosclerotic ulcer as well as in the differentiation of this condition from other acute aortic syndromes. Additionally, the authors describe a new therapeutic approach represented by a hybrid endovascular surgical procedure for treatment of the disease.

"Vedo il male e non lo posso schivare" : le rime di Antonio Brocardo tra classicismi e polemiche

Antonio Brocardo è ricordato per essere entrato in polemica con Pietro Bembo, suscitando clamore e indignazione. Le fonti antiche sulla vita del Bembo lo descrivono come un folle intento a distruggere qualcosa che non riusciva bene a comprendere Vitaliani lo definisce, nel titolo della sua monografia del 1902 (l'unica fino ad ora dedicata al poeta), «vittima del bembismo», probabilmente risentendo dei pesanti giudizi sul cardinale già presenti in Leopardi e poi nel De Sanctis. Eppure, già a partire da Croce, si cerca di ricostruire in maniera meno pregiudizievole la figura del poeta veneziano, considerando più da vicino i testi pervenuti. Ci si trova, però, di fronte ad uno scarto imponente: la tradizione lo vuole opposto al bembismo, mentre la lirica brocardiana non sembra per molti aspetti differenziarsi così platealmente dal canone bembesco, a giudizio di molte storie letterarie. Questa nuova edizione mira: a ricostruire scrupolosamente la biografia del poeta, l'ambiente frequentato ed i rapporti con altri poeti/intellettuali del suo tempo; a fare finalmente chiarezza sulle polemiche che videro il giovane veneziano come protagonista, a partire dalle fonti contemporanee (correggendo quanto riportato dalle biografìe del Bembo o dalle storie letterarie); a fornire un adeguato commento alle sue rime, dopo aver ristabilito un sicuro testo critico; a fare maggior chiarezza sul rapporto tra Brocardo ed il furbesco letterario; a collocare il poeta in una ben determinata fase del petrarchismo.

Identifying strategies for mitigating the global warming impact of the EU-25 economy using a multi-objective input-output approach

Global warming mitigation has recently become a priority worldwide. A large body of literature dealing with energy related problems has focused on reducing greenhouse gases emissions at an engineering scale. In contrast, the minimization of climate change at a wider macroeconomic level has so far received much less attention. We investigate here the issue of how to mitigate global warming by performing changes in an economy. To this end, we make use of a systematic tool that combines three methods: linear programming, environmentally extended input output models, and life cycle assessment principles. The problem of identifying key economic sectors that contribute significantly to global warming is posed in mathematical terms as a bi criteria linear program that seeks to optimize simultaneously the total economic output and the total life cycle CO2 emissions. We have applied this approach to the European Union economy, finding that significant reductions in global warming potential can be attained by regulating specific economic sectors. Our tool is intended to aid policymakers in the design of more effective public policies for achieving the environmental and economic targets sought.

Felisa Jordán, la madre de Estanislao Zeballos. Prácticas asociativas, espacio público y proyección femenina en Argentina (1870-1880)

La reconstrucción de la historia de la madre del conocido Estanislao Severo Zeballos es el objetivo de este artículo que se centra en la búsqueda del rol ejercido por Felisa Jordán durante la organización del Estado-Nación de la República Argentina. Zeballos divulgó algunos datos de su vida privada, como su parentesco con los Urquiza y los Ruiz Moreno, o su condición de propietario de 351.562 hectáreas en el Chaco Boreal gracias a la mediación que practicó en el transcurso de la firma del tratado boliviano-paraguayo que fijó la línea de statu-quo de 1907. Pero el relato más creativo del rosarino Estanislao fue la gestión de su madre Felisa Jordán de Zeballos en el marco del ámbito asociativo de la ciudad de Rosario. Para describir esta llamativa vinculación entre Zeballos y su madre Felisa Jordán me he centrado en dos fuentes documentales singulares que nos permiten abordar las prácticas asociativas, los espacios públicos y la proyección femenina en Argentina entre 1869 y 1872. En primer lugar en los documentos privados de las mujeres de élite de la Ciudad de Rosario, en particular las actas y la correspondencia de la asociación benéfica Damas de Caridad. Esta documentación signó durante años mi investigación sobre el Asilo de Huérfanos y Expósitos cuyo nombre fue modificado por Hogar del Huérfano por el peronismo, una institución que hoy día se encuentra en un futuro incierto. La secretaria de aquella asociación femenina fue la llamativa Felisa Jordán, la viuda del militar Estanislao Zeballos, que colaboraba activamente con la presidenta de la asociación Damas de Caridad, María de los Ángeles Rodríguez de Rosas, y con la tesorera Blanca Musch de Villegas en cuyo domicilio se reunieron por primera vez para formar la entidad en el año 1869, es decir, en plena Guerra de la Triple Alianza. La documentación de las hoy llamadas Damas de Protección al Huérfano se conserva en el archivo del Hogar del Huérfano, otrora denominado Hogar de Huérfanos y Expósitos, y hace referencia a aspectos de la vida cotidiana de la entidad, de la asociación femenina y de sus socias.

Sevillian transport jars in early colonial America: the case of Santa María La Antigua del Darién (Colombia)

Within the scope of the TECNOLONIAL (HAR2008-02834/HIST) project, an archaeologi- cal and archaeometric research is being conduct- ed in order to clarify and systematize transport jars production in the Iberian peninsula and their distribution abroad, especially to the Americas, from the 15th to the 17th century. The production centre of Seville, in the Crown of Castile, produced large glazed and unglazed transport jars, called botijas, which were mainly devoted to the Atlantic trade network. The pres- ent study accounts for the first results obtained from an initial sample of 34 transport jars dated around the 15th-16th centuries from the produc- tion centre of Seville and the reception site of Santa María de la Antigua del Darién (gulf of Urabá, Colombia). This latter site is especially significant since it was the first Spanish founda- tion (1510) in continental America that obtained the title of town, and was the seat for the Governor of the new region called Castilla de Oro, as well as for the first diocese. All individuals were analyzed by means of x-ray fluorescence and diffraction analyses and then compared with the majolica production database from Seville. The results enabled us to define the first refer- ence groups for such modern transport jars, and to get a first insight into the jars coming to the Americas in the early 16th century whose prove- nance can be linked to Seville, but not Triana.

Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells

Maintaining and acquiring the pluripotent cell state in plants is critical to tissue regeneration and vegetative multiplication. Histone-based epigenetic mechanisms are important for regulating this undifferentiated state. Here we report the use of genetic and pharmacological experimental approaches to show that Arabidopsis cell suspensions and calluses specifically repress some genes as a result of promoter DNA hypermethylation. We found that promoters of the MAPK12, GSTU10 and BXL1 genes become hypermethylated in callus cells and that hypermethylation also affects the TTG1, GSTF5, SUVH8, fimbrin and CCD7 genes in cell suspensions. Promoter hypermethylation in undifferentiated cells was associated with histone hypoacetylation and primarily occurred at CpG sites. Accordingly, we found that the process specifically depends on MET1 and DRM2 methyltransferases, as demonstrated with DNA methyltransferase mutants. Our results suggest that promoter DNA methylation may be another important epigenetic mechanism for the establishment and/or maintenance of the undifferentiated state in plant cells.

Epithelial-to-mesenchymal transition mediates docetaxel resistance and high risk of relapse in prostate cancer

Molecular characterization of radical prostatectomy specimens after systemic therapy may identify a gene expression profile for resistance to therapy. This study assessed tumor cells from patients with prostate cancer participating in a phase II neoadjuvant docetaxel and androgen deprivation trial to identify mediators of resistance. Transcriptional level of 93 genes from a docetaxel-resistant prostate cancer cell lines microarray study was analyzed by TaqMan low-density arrays in tumors from patients with high-risk localized prostate cancer (36 surgically treated, 28 with neoadjuvant docetaxel þ androgen deprivation). Gene expression was compared between groups and correlated with clinical outcome. VIM, AR and RELA were validated by immunohistochemistry. CD44 and ZEB1 expression was tested by immunofluorescence in cells and tumor samples. Parental and docetaxel-resistant castration-resistant prostate cancer cell lines were tested for epithelial-to-mesenchymal transition (EMT) markers before and after docetaxel exposure. Reversion of EMT phenotype was investigated as a docetaxel resistance reversion strategy. Expression of 63 (67.7%) genes differed between groups (P < 0.05), including genes related to androgen receptor, NF-k B transcription factor, and EMT. Increased expression of EMT markers correlated with radiologic relapse. Docetaxel-resistant cells had increased EMT and stem-like cell markers expression. ZEB1 siRNA transfection reverted docetaxel resistance and reduced CD44 expression in DU-145R and PC-3R. Before docetaxel exposure, a selected CD44 þ subpopulation of PC-3 cells exhibited EMT phenotype and intrinsic docetaxel resistance; ZEB1/CD44 þ subpopulations were found in tumor cell lines and primary tumors; this correlated with aggressive clinical behavior. This study identifies genes potentially related to chemotherapy resistance and supports evi-dence of the EMT role in docetaxel resistance and adverse clinical behavior in early prostate cancer.

De Francisco a Marco Antonio Aldana pasando por Gaspar

It is traditionally considered that the «Aldana», whom Gaspar Gil Polo praises at the end of his «Canto de Turia» (1564), was Francisco de Aldana, the «divino». It is nonetheless more probable that it was in fact rather the Valencian poet, Marco Antonio Aldana, almost forgotten today, but very much in the public eye within the cultivated circles of the end of the sixteenth century Valencia

Conxita Boncompte,"Iconografia picassiana (1905­-1907). Influencia de la pintura pompeiana". Goya, núm. 335 (2011), pp. 156­-179

La personalitat de Pablo Picasso es una de les més estudiades a la història de l"art, Per aquest motiu són destacables els estudis que hi ha dedicat la Dra. Conxita Boncompte, una aportació que te, a més el valor afegit, que és el resultat d"una tesi doctoral presentada a la Universitat de Barcelona. El llarg article, 24 pàgines de text amb 108 notes documentals, ha estat publicat a revista Goya, editada per la Fundación Lázaro Galdeano de Madrid, i una de les més prestigioses en llengua castellana en Història de l"Art.

Padecer y Transcender. La crítica de Zambrano al análisis heideggeriano del concepto de tiempo

[spa]El concepto de tiempo ha sido estudiado por Heidegger y Zambrano en dos sentidos muy diferentes. Si el filósofo alemán pensó que estaba relacionado con la cuestión del ser (problema principal de toda su investigación), Zambrano dijo que estaba ligado a la experiencia del sueño. El objetivo de este trabajo es analizar las coincidencias y divergencias entre estas dos aproximaciones y sus consecuencias teóricas, centrándose en algunas obras mayores (Sein und Zeit, El sueño creador y Los sueños y el tiempo), pero tomando también como referencia otros escritos de estos autores.

María Zambrano y Georges Bataille: variaciones de lo imposible

[spa]La intención de este artículo es explorar la relación entre poesía, filosofía y el concepto de "lo imposible". Para ello, me propongo revisar no sólo ciertos textos de Zambrano, sino también algunos momentos de la obra de Georges Bataille, en los que estos autores estudiaron, desde dos perspectivas muy distintas, la categoría mencionada.

Leaving the Dark ages with AMIGA

We present an Analytic Model of Intergalactic-medium and GAlaxy (AMIGA) evolution since the dark ages. AMIGA is in the spirit of the popular semi-analytic models of galaxy formation, although it does not use halo merger trees but interpolates halo properties in grids that are progressively built. This strategy is less memory-demanding and allows one to start modeling at sufficiently high redshifts and low halo masses to have trivial boundary conditions. The number of free parameters is minimized by making a causal connection between physical processes usually treated as independent of each other, which leads to more reliable predictions. However, the strongest points of AMIGA are the following: (1) the inclusion of molecular cooling and metal-poor, population III (Pop III) stars with the most dramatic feedback and (2) accurate follow up of the temperature and volume filling factor of neutral, singly ionized, and doubly ionized regions, taking into account the distinct halo mass functions in those environments. We find the following general results. Massive Pop III stars determine the intergalactic medium metallicity and temperature, and the growth of spheroids and disks is self-regulated by that of massive black holes (MBHs) developed from the remnants of those stars. However, the properties of normal galaxies and active galactic nuclei appear to be quite insensitive to Pop III star properties due to the much higher yield of ordinary stars compared to Pop III stars and the dramatic growth of MBHs when normal galaxies begin to develop, which cause the memory loss of the initial conditions.

Análisi d'un sistema informatitzat d'avaluació continuada en grups d'alta densitat de matrícula

Desenvolupar un sistema de seguimentindividualitzat i grupal de les activitatsdocents dels estudiants en assignatures d’alta densitat de matricula per tal de fer efectius els pressupostos d’una veritable avaluació continuada en aquestes condicions.

HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Results: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Conclusions: Siglec-1 on myeloid cells could fuel novel CD4+ T-cell infections and contribute to HIV-1 dissemination in vivo.