Laminar distribution of β-amyloid (Aβ) peptide deposits in the frontal lobe in familial and sporadic Alzheimer's disease

To determine whether genetic factors influence frontal lobe degeneration in Alzheimer's disease (AD), the laminar distributions of diffuse, primitive, and classic β-amyloid (Aβ) peptide deposits were compared in early-onset familial AD (EO-FAD) linked to mutations of the amyloid precursor protein (APP) or presenilin 1 (PSEN1) gene, late-onset familial AD (LO-FAD), and sporadic AD (SAD). The influence of apolipoprotein E (Apo E) genotype on laminar distribution was also studied. In the majority of FAD and SAD cases, maximum density of the diffuse and primitive Aβ deposits occurred in the upper cortical layers, whereas the distribution of the classic Aβ deposits was more variable, either occurring in the lower layers, or a double-peaked (bimodal) distribution was present, density peaks occurring in upper and lower layers. The cortical layer at which maximum density of Aβ deposits occurred and maximum density were similar in EO-FAD, LO-FAD and SAD. In addition, there were no significant differences in distributions in cases expressing Apo E ε4 alleles compared with cases expressing the ε2 or ε3 alleles. These results suggest that gene expression had relatively little effect on the laminar distribution of Aβ deposits in the frontal lobe of the AD cases studied. Hence, the pattern of frontal lobe degeneration in AD is similar regardless of whether it is associated with APP and PSEN1, mutation, allelic variation in Apo E, or with SAD.

The visual cortex in alzheimer's disease:laminar distribution of the pathological changes in visual areas V1 and V2

Alzheimer's disease (AD) is an important neurodegenerative disorder causing visual problems in the elderly population. The pathology of AD includes the deposition in the brain of abnormal aggregates of β-amyloid (Aβ) in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFT). A variety of visual problems have been reported in patients with AD including loss of visual acuity (VA), colour vision and visual fields; changes in pupillary responses to mydriatics, defects in fixation and in smooth and saccadic eye movements; changes in contrast sensitivity and in visual evoked potentials (VEP); and disturbances in complex visual tasks such as reading, visuospatial function, and in the naming and identification of objects. In addition, pathological changes have been observed to affect the eye, visual pathway, and visual cortex in AD. To better understand degeneration of the visual cortex in AD, the laminar distribution of the SP and NFT was studied in visual areas V1 and V2 in 18 cases of AD which varied in disease onset and duration. In area V1, the mean density of SP and NFT reached a maximum in lamina III and in laminae II and III respectively. In V2, mean SP density was maximal in laminae III and IV and NFT density in laminae II and III. The densities of SP in laminae I of V1 and NFT in lamina IV of V2 were negatively correlated with patient age. No significant correlations were observed in any cortical lamina between the density of NFT and disease onset or duration. However, in area V2, the densities of SP in lamina II and lamina V were negatively correlated with disease duration and disease onset respectively. In addition, there were several positive correlations between the densities of SP and NFT in V1 with those in area V2. The data suggest: (1) NFT pathology is greater in area V2 than V1, (2) laminae II/III of V1 and V2 are most affected by the pathology, (3) the formation of SP and NFT in V1 and V2 are interconnected, and (4) the pathology may spread between visual areas via the feed-forward short cortico-cortical connections. © 2012 by Nova Science Publishers, Inc. All rights reserved.

Radiation build-up in laminar and turbulent regimes in quasi-CW Raman fiber laser

We study the radiation build-up in laminar and turbulent generation regimes in quasi-CW Raman fiber laser. We found the resulted spectral shape and generation type is defined by the total spectral broadening/narrowing balance over laser cavity round-trip, which is substantially different in different regimes starting from first round-trips of the radiation build-up. In turbulent regime, the steady-state is reached only after a few round-trips, while in the laminar regime the laser approaches the equilibrium spectrum shape asymptotically.

Laminar-turbulent transition in Raman fiber lasers:a first passage statistics based analysis

Loss of coherence with increasing excitation amplitudes and spatial size modulation is a fundamental problem in designing Raman fiber lasers. While it is known that ramping up laser pump power increases the amplitude of stochastic excitations, such higher energy inputs can also lead to a transition from a linearly stable coherent laminar regime to a non-desirable disordered turbulent state. This report presents a new statistical methodology, based on first passage statistics, that classifies lasing regimes in Raman fiber lasers, thereby leading to a fast and highly accurate identification of a strong instability leading to a laminar-turbulent phase transition through a self-consistently defined order parameter. The results have been consistent across a wide range of pump power values, heralding a breakthrough in the non-invasive analysis of fiber laser dynamics.

Coastal geomorphology, processes and erosion at the tourist destination of Ferryland, Newfoundland and Labrador

The community of Ferryland is located on the southeastern coast of the Avalon Peninsula. The town traditionally relied on a fishing-based economy until the collapse of the fishery in the early 1990s. The present economy emphasizes sustainable development in the tourism sector with focus on archaeology, geotourism and other recreational uses. This paper discusses coastal erosion and impacts on sites and infrastructure using methods including: local knowledge, Real Time Kinematic (RTK) surveying and other survey techniques, seawater level measurement, meteorological data from a locally-installed station, custom-made drifter tube buoys, photography, HD video, and investigation using various modes of transport including inflatable boat. The major findings of the study include that the residents and stakeholders are genuinely interested in and knowledgeable of coastal erosion. The causes of coastal erosion include: large waves, surge, longshore currents, harbour oscillations, mass wasting, and location of infrastructure causing alterations of these processes. Freeze-thaw Cycles (FTC), rainfall, and gravity loosen and transport rock, till, and fill materials downslope. Large waves and currents transport the materials alongshore or into the nearshore. Harbour oscillations causing high velocity currents (> 2 m/s) are responsible for shoreline erosion and damage to property in The Pool. Historical resources such as gun batteries and ordnance pieces which date to the 1700s are being lost or threatened through coastal erosion of till and rock cliffs. Improper drainage and maintenance is responsible for erosion of roads and supporting shoulders, necessitating mitigation measures. Sediment transport and deposition during and after large wave and surge events lead to undercutting of infrastructure and increased risk of washover of existing infrastructure. Erosion is ongoing at Bois Island and Ferryland Head Isthmus through slope processes and undercutting; The Pool and the lower Colony of Avalon site through harbour oscillations and related undermining; the tombolo and the main breakwater through wave attack; and Meade’s Cove including the East Coast Trail through wave attack and undercutting. The floor of the latrine in the lower Colony of Avalon site indicates that sea level was approximately 1.25m below present in the 1620s, a relative sea level rise rate of 3.2 mm/y. The recommendations include suggested mitigation to reduce impacts specific to each site.

Climate changes, lead pollution and soil erosion in south Greenland over the past 700 years

Date of Acceptance: 05/06/2015 This research was made possible through funding provided by the Leverhulme Trust, the Spanish Ministry of Science and Innovation (Project CGL2010–20672) and Xunta de Galicia (grants R2014/001 and GPC2014/009). N Silva-Sánchez is currently supported by a FPU pre-doctoral grant (AP2010–3264) funded by the Spanish Government. Kirsty Golding, Andy McMullen, and Ian Simpson are thanked for their assistance with fieldwork. Alison Sandison produced the maps. Pete Langdon and two anonymous referees are thanked for comments that helped to improve the paper.

Climate changes, lead pollution and soil erosion in south Greenland over the past 700 years

Date of Acceptance: 05/06/2015 This research was made possible through funding provided by the Leverhulme Trust, the Spanish Ministry of Science and Innovation (Project CGL2010–20672) and Xunta de Galicia (grants R2014/001 and GPC2014/009). N Silva-Sánchez is currently supported by a FPU pre-doctoral grant (AP2010–3264) funded by the Spanish Government. Kirsty Golding, Andy McMullen, and Ian Simpson are thanked for their assistance with fieldwork. Alison Sandison produced the maps. Pete Langdon and two anonymous referees are thanked for comments that helped to improve the paper.

Climate changes, lead pollution and soil erosion in south Greenland over the past 700 years

Date of Acceptance: 05/06/2015 This research was made possible through funding provided by the Leverhulme Trust, the Spanish Ministry of Science and Innovation (Project CGL2010–20672) and Xunta de Galicia (grants R2014/001 and GPC2014/009). N Silva-Sánchez is currently supported by a FPU pre-doctoral grant (AP2010–3264) funded by the Spanish Government. Kirsty Golding, Andy McMullen, and Ian Simpson are thanked for their assistance with fieldwork. Alison Sandison produced the maps. Pete Langdon and two anonymous referees are thanked for comments that helped to improve the paper.

Role of Hydrological Process Representation on Erosion, Deposition, and Sediment Yield Estimate

Soil erosion by water is a major driven force causing land degradation. Laboratory experiments, on-site field study, and suspended sediments measurements were major fundamental approaches to study the mechanisms of soil water erosion and to quantify the erosive losses during rain events. The experimental research faces the challenge to extent the result to a wider spatial scale. Soil water erosion modeling provides possible solutions for scaling problems in erosion research, and is of principal importance to better understanding the governing processes of water erosion. However, soil water erosion models were considered to have limited value in practice. Uncertainties in hydrological simulations are among the reasons that hindering the development of water erosion model. Hydrological models gained substantial improvement recently and several water erosion models took advantages of the improvement of hydrological models. It is crucial to know the impact of changes in hydrological processes modeling on soil erosion simulation.

This dissertation work first created an erosion modeling tool (GEOtopSed) that takes advantage of the comprehensive hydrological model (GEOtop). The newly created tool was then tested and evaluated at an experimental watershed. The GEOtopSed model showed its ability to estimate multi-year soil erosion rate with varied hydrological conditions. To investigate the impact of different hydrological representations on soil erosion simulation, a 11-year simulation experiment was conducted for six models with varied configurations. The results were compared at varied temporal and spatial scales to highlight the roles of hydrological feedbacks on erosion. Models with simplified hydrological representations showed agreement with GEOtopSed model on long temporal scale (longer than annual). This result led to an investigation for erosion simulation at different rainfall regimes to check whether models with different hydrological representations have agreement on the soil water erosion responses to the changing climate. Multi-year ensemble simulations with different extreme precipitation scenarios were conducted at seven climate regions. The differences in erosion simulation results showed the influences of hydrological feedbacks which cannot be seen by purely rainfall erosivity method.

Palliser Rockslide cosmogenic 36Cl exposure ages (raw data) and erosion effect on the cosmogenic

This paper presents the results of a combined study, using cosmogenic 36Cl exposure dating and terrestrial digital photogrammetry, of the Palliser Rockslide located in the southeastern Canadian Rocky Mountains. This site is particularly well-suited to demonstrate how this multi-disciplinary approach can be used to differentiate distinct rocksliding events, estimate their volume, and establish their chronology and recurrence interval. Observations suggest that rocksliding has been ongoing since the late Pleistocene deglaciation. Two major rockslide events have been dated at 10.0 ± 1.2 kyr and 7.7 ± 0.8 kyr before present, with failure volumes of 40 Mm3 and 8 Mm3, respectively. The results have important implications concerning our understanding of the temporal distribution of paraglacial rockslides and rock avalanches; they provide a better understanding of the volumes and failure mechanisms of recurrent failure events; and they represent the first absolute ages of a prehistoric high magnitude event in the Canadian Rocky Mountains.

A laboratory study of water ice erosion by low-energy ions

Water ice covers the surface of various objects in the outer Solar system.Within the heliopause, surface ice is constantly bombarded and sputtered by energetic particles from the solar wind and magnetospheres. We report a laboratory investigation of the sputtering yield of water ice when irradiated at 10 K by 4 keV singly (13C+, N+, O+, Ar+) and doubly charged ions (13C2+, N2+, O2+). The experimental values for the sputtering yields are in good agreement with the prediction of a theoretical model. There is no significant difference in the yield for singly and doubly charged ions. Using these yields, we estimate the rate of water ice erosion in the outer Solar system objects due to solar wind sputtering. Temperature-programmed desorption of the ice after irradiation with 13C+ and 13C2+ demonstrated the formation of 13CO and 13CO2, with 13CO being the dominant formed species.

Roadside erosion research in selected Iowa counties, 1972

This research project discusses roadside stabilization along secondary roads. Another objective was to investigate various commercial soil stabilizers, as a replacement for straw mulch, to control soil erosion before vegetation.

Efectos de los sistemas de cultivo-arboles-pastos sobre la erosión laminar y la calidad de suelo en la micro cuenca Tecomapa, municipio de Somotillo-Nicaragua

Con el objetivo de evaluar los efectos de los sistemas de cultivo - arboles - pastos sobre la erosión laminar y la calidad de suelo, en tres fincas de la micro cuenca Tecomapa, municipio de Somotillo - Nicaragua ; f ueron estable cidas en cinco usos de la tierra: q uema tradicional (Q); sistema agroforestal Quesungual (SAQ ); bosque secundario (Bs ); potreros mejorados con Brachiaria sp - Marandú , (Pm); y sistema silvopastoril (SSP), 30 sub parcelas de 10 m 2 con 10 varillas cada una , y monitoreados diez indicadores de calidad de suelo durante 2011, 2012 y 2013 . Como resultado , la tasa de erosión neta positiva (ganancia) fue clasificada de moderada (10 a 50 t ha - 1 a - 1 ) en los sistemas de BS y Pm, y de alta (50 a 200 t ha - 1 a - 1 ) en los sistemas SAQ y SSP . La tasa de erosión neta (pérdida) fue clasificada de moderado únicamente en el sistema de q uema agrícola (28.3 t ha - 1 a - 1 ) . Procesos qu e ocurrieron mayormente en pendientes de 26 y 57% . La tasa de erosión dentro ( ganancia ) representó un 61.5% del total de la erosión neta, fenómeno asociado al uso de la tierra y probablemente a la forma del micro relieve. Estas tasas de erosión dentro de las parcelas ocurrieron mayormente en pendientes de 15 y 52%, en las partes bajas . La calidad de los suelos fue influenciada por l os contenidos de MOS , contenidos que fueron mayores a 4000 kg ha - 1 en los sistemas SAQ, SSP y Bs . Este indicador fue correlacionado negativamente con el incremento de arcilla en el horizonte superficial de los suelos utilizados en pasturas por erosión previa . Finalmente, l os indicadores de calidad de suelo que incrementan el rendimiento del cultivo de maíz y frijol fueron los altos contenidos de MOS, tasas de infiltraciones rápidas , y la presencia de sue los con pendientes altas únicamente para frijol