867 resultados para Hardy, Thomas, 1840-1928 -- Criticism and interpretation


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Cosponsored by U.S. Fish and Wildlife Service, Forest Service, and the National Oceanic and Atmospheric Administration.

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Mode of access: Internet.

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Vols. 3-8, 3d ser., include the 16th-21st annual reports of the British and foreign anti-slavery society. The 22d-24th annual reports are appended to v. 9-11, 3d ser. Series 4 contains annual reports of the British and Foreign Anti-Slavery Society. Series 5 contains annual reports of the Anti-Slavery and Aborigines Protection Society.

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En el presente trabajo exploramos las consecuencias de la lectura del argumento del lenguaje privado realizada por Kripke en el terreno del pensamiento social y político. Ello reviste un interés particular, debido a que lleva a revisar el encuadre en el que usualmente se ha situado la discusión sobre la relevancia político-social del pensamiento de Wittgenstein. La discusión ha estado centrada en el rol del acuerdo comunitario, sus consecuencias conservadoras o relativistas, el ahogo de la crítica y el disenso que resultaría, y otras cuestiones conexas. En ello vemos el síntoma de una problemática epistemológica (la de las garantías del conocimiento) que no termina de superarse, a pesar de la jerga semántica. Mostraremos que el escenario que resulta de la lectura de Kripke, en cambio, rompe con esta problemática, habilitando nuevas preocupaciones, próximas, a nuestro juicio, con las de lo que en el pensamiento francés se han denominado las "filosofías de la sujeción del sujeto"

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Thesis (Master's)--University of Washington, 2016-06

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When direct observations are used to study animal behavior the presence of the observer may alter the animal and hence influence the data being collected, yet few studies have quantified this effect. We conducted direct observation studies in the glasshouse to assess the relative influence of observer presence on the behavior of Pacific damsel bugs, Nabis kinbergii, a potentially important predator of crop pests. Comparisons of predator activity, predator distribution, prey (Helicoverpa armigera) mortality and prey distribution between frequently observed and minimally observed treatments, during diurnal and nocturnal observation sessions showed that the frequency of observer presence had no apparent impact on Pacific damsel bug behavior. This is the first documented test of the impact of observer presence in an insect system. To place our results in context, we reviewed 15 papers on the influence of observer presence in a range of animals. We established that just over half of these papers found evidence for an effect. Nevertheless, direct observations should be useful in further studies of Pacific damsel bug behavior, and researchers using direct observations to study the behavior of other animals should be cognizant of observer effects during design and interpretation of their study.

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For most of the past century, the prospect of replacing lost or damaged cells in the central nervous system (CNS) was hampered by the opinion that the adult mammalian CNS was incapable of generating new nerve cells. This belief, Like most dogmas, was essentially founded on a lack of experimental evidence to the contrary. The overturning of this 'no new neuron' hypothesis began midway through the twentieth century with a series of reports documenting neurogenesis in the postnatal and adult brain(1), continued with the isolation and in vitro culture of neurogenic cells from the adult mammalian brain(2,3), and culminated in the discovery of a population of muttipotent, selfrenewing cells in the adult CNS (that is, bona fide neural stem cells)(3-5). Although a variety of techniques were initially used, the neurosphere assay (NSA)(3,6) rapidly emerged as the assay of choice and has since become a valuable toot for isolating, and understanding the biology of, embryonic and adult CNS stem cells. Like all technologies, it is not without its limitations. In this article we will hightight several shortcomings of the assay related to its application and interpretation that we believe have led to a significant body of research whose conclusions may well be misleading.

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The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that is currently undergoing clinical evaluation in cancer patients. As well as it's anticancer properties, 1 displays a number of other interesting biological activities. A series of analogues of 1 were synthesized with a single carbon (pentasaccharide) backbone to facilitate structural characterization and interpretation of biological results. In a fashion similar to 1, all compounds were able to inhibit heparanase and to bind tightly to the proangiogenic growth factors FGF-1, FGF-2, and VEGF. The compounds also inhibited the infection of cells and cell-to-cell spread of herpes simplex virus (HSV-1). Preliminary pharmacokinetic data indicated that the compounds displayed different pharmacokinetic behavior compared with 1. Of particular note was the n-octyl derivative, which was cleared 3 times less rapidly than 1 and may provide increased systemic exposure.