998 resultados para Cyro dos Anjos
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
The effect of indomethacin (Indo), a cyclo-oxygenase inhibitor, on the monocyte-mediated killing of a low- (Pb265) and a high- (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non-activated or interferon-gamma (IFN-gamma) -activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN-gamma, tumour necrosis factor-alpha (TNF-alpha) was very effective at stimulating the fungicidal activity of monocytes. While the low-virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN-gamma demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo-oxygenase pathway, in the regulation of monocyte-mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF-alpha generation during the fungus-monocyte interaction is more important in the killing of Pb265 than Pb18.
Resumo:
Pós-graduação em Engenharia Mecânica - FEB
Resumo:
Considering the discussions about the inclusion of disabled people in the regular education and the need to find methodologies that meet the diverse needs of students, this work brings to the discussion the multisensory didactic perspective as an alternative to science inclusive teaching.
Resumo:
Despite of intense discussion over recent decades about the inclusion of disabled people and the influence of conception of teachers about that inclusion for the effectuation of it, this work sought to identify conceptions of science teachers regarding the inclusion of students with visual impairment in the classes of astronomy providing basis for future studies.
Resumo:
The work completed on the use of para-didactic texts do not address the issue of education in a state that considers the presence of students with visual impairments. Therefore, this article discusses an innovative situation, investigating if the use of para-didactic texts provide the necessary conditions for the inclusion of students with visual impairment in physics education classes. The response indicates a discreet participation of these students, however a significant one, in this application the students were motivated and interested in all of the topics discussed. This prudent participation may have occurred for reasons such as shyness and the behavior of teachers, as they tended to to be more talkative to these students.
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
Chega uma idade dos filhos em que surge a pergunta que os pais tanto temem: Mãe/Pai, de onde eu vim? Imagine tal questão para um aluno com deficiência visual? Com base nesse questionamento e nos princípios da didática multissensorial, foi confeccionado um material abordando o tema fecundação humana. O presente trabalho relata como esse material foi construído, detalhando passo a passo sua confecção, além de propor uma metodologia, baseada na pedagogia histórico-crítica, para a utilização desse material. Cabe destacar que trata-se de uma sugestão de metodologia, ficando a critério de cada professor utilizá-la ou não, com as adaptações necessárias a sua turma.
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
This study aims to determine physical properties of particleboard made of sawmill waste, as a mix of several wood species, and two adhesives: urea-formaldehyde, usually employed in industry (even with drawbacks or formaldehyde emission during pressing) and FASTBOND®, water based resin, still poorly referenced in literature. Sixteen panels have been produced, in four experimental conditions, defined by using two adhesives and a 12 mm thick limiter (or not). Variance analysis was adopted to evaluate influence of experimental conditions on physical properties of produced panels, manufactured in nominal dimensions 350x350mm; 10% resin related to particles mass (at 5% moisture); 3.5 MPa compaction pressure, temperature 130°C, in a 10 min cycle. Tests to determine density, moisture content, swelling and water absorption were carried out based on normative parameters of ABNT NBR 14810:2006. Results have been satisfactory to panels produced with urea-formaldehyde but those manufactured with polychloroprene based resin (FASTBOND®) not meet regulatory requirements. Best results have been obtained without limiter.
Resumo:
Pós-graduação em Economia - FCLAR
Resumo:
Acute respiratory distress syndrome is the most severe manifestation of acute lung injury and it is associated with high mortality rate. Despite better understanding of ARDS pathophysiology, its mechanism is still unclear. Mechanical ventilation is the main ARDS supportive treatment. However, mechanical ventilation is a non-physiologic process and complications are associated with its application. Mechanical ventilation may induce lung injury, referred to as ventilator-induced lung injury. Frequently, VILI is related to macroscopic injuries associated with alveolar rupture. The present article is a review of the literature on ventilator-induced lung injury in acute respiratory distress syndrome. Animal and human studies were reviewed. We mainly selected publications in the past 5 years, but did not exclude commonly referenced and highly regarded older publications.
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
Amazonian gold mining activity results in human exposure to mercury vapor. We evaluated the visual system of two Amazonian gold miners (29 and 37 years old) by recording the transient pattern electroretinogram (tPERG) and transient pattern visual evoked potential (tPVEP). We compared these results with those obtained from a regional group of control subjects. For both tPERG and tPVEP, checkerboards with 0.5 or 2 cycles per degree (cpd) of spatial frequency were presented in a 16 degrees squared area, 100% Michelson contrast, 50cd/m(2) mean luminance, and 1 Hz square-wave pattern-reversal presentation. Two averaged waveforms (n = 240 sweeps, Is each) were monocularly obtained for each subject in each condition. Both eyes were monocularly tested only in gold miners. Normative data were calculated using a final pooled waveforin with 480 sweeps. The first gold miner, LCS, had normal tPERG responses. The second one, RNP, showed low tPERG (P50 component) amplitudes at 0.5cpd for both eyes, outside the normative data, and absence of response at 2 cpd for his right eye. Delayed tPVEP responses (P 100 component) were found at 2 cpd for LCS but the implicit times were inside the normative data. Subject RNP also showed delayed tPVEP responses (all components), but only the implicit time obtained with his right eye was outside the normative data at 2cpd. We conclude that mercury exposure levels found in the Amazon gold miners is high enough to damage the visual system and can be assessed by non-invasive electrophysiological techniques. (C) 2007 Elsevier Inc. All rights reserved.