Histoire ecclésiastique des Francs. Suivie d'un sommaire de ses autres ouvrages, et précédée de sa vie écrite au Xe siècle. Tome 1 / par saint Grégoire,... ; par Odon,... ; traduction nouvelle, par Henri Bordier

[Historia Francorum (français). 1859-1862]

[Engagement de Léo Staats]

Engagement de Léo Staats comme maître de ballet. Contrat passé entre le directeur de l'Opéra, Jacques Rouché, et Léo Saats. Contrat non signé. Annotations manuscrites au crayon. - Le contrat est établi pour l'année 1915. Ancienne cote : "Dossier d'artiste Staats, Léo"

[Engagement de Léo Staats]

Engagement de Léo Staats comme maître de ballet. Contrat passé entre le directeur de l'Opéra, Jacques Rouché, et Léo Saats. Contrat non signé. Annotations manuscrites au crayon. - Le contrat est établi pour l'année 1919. Ancienne cote : "Dossier d'artiste Staats, Léo"

Proteomic and transcriptomic analysis of human CD8(+) T lymphocytes over-expressing telomerase.

Human T lymphocytes have a finite life span resulting from progressive telomere shortening that occurs at each cell division, eventually leading to chromosomal instability. It has been shown that ectopic expression of the human telomerase reverse transcriptase (hTERT) gene into various human cells results in the extension of their replicative life span, without inducing changes associated with transformation. However, it is still unclear whether cells that over-express telomerase are physiologically and biochemically indistinguishable from normal cells. To address this question, we compared the proteome of young and aged human CD8(+) T lymphocytes with that of T cells transduced with hTERT. Interestingly, we found no global changes in the protein pattern in young T cells, irrespective of telomerase expression. In contrast, several relevant proteins with differential expression patterns were observed in hTERT-transduced T cells with extended life span upon long-term culture. Altogether, our data revealed that T lymphocytes over-expressing telomerase displayed an intermediate protein pattern, sharing a similar protein expression not only with young T cells, but also with aged T cells. Finally, the results obtained from this global proteomic approach are in agreement with the overall gene transcription profiling performed on the same T-cell derived clones.