Contribution relative des sous-types 1 et 5 des récepteurs métabotropes du glutamate dans la potentialisation à long terme des interneurones hippocampiques chez la souris

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Contribution relative des sous-types 1 et 5 des récepteurs métabotropes du glutamate dans la potentialisation à long terme des interneurones hippocampiques chez la souris

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

(Table 1) Water column silicic acid concentrations and Si isotopic composition during Marion Dufresne cruise MD166 off South Africa

Silicon isotopic signatures (d30Si) of water column silicic acid (Si(OH)4) were measured in the Southern Ocean, along a meridional transect from South Africa (Subtropical Zone) down to 57° S (northern Weddell Gyre). This provides the first reported data of a summer transect across the whole Antarctic Circumpolar Current (ACC). d30Si variations are large in the upper 1000 m, reflecting the effect of the silica pump superimposed upon meridional water transfer across the ACC: the transport of Antarctic surface waters northward by a net Ekman drift and their convergence and mixing with warmer upper-ocean Si-depleted waters to the north. Using Si isotopic signatures, we determine different mixing interfaces: the Antarctic Surface Water (AASW), the Antarctic Intermediate Water (AAIW), and thermoclines in the low latitude areas. The residual silicic acid concentrations of end-members control the d30Si alteration of the mixing products and with the exception of AASW, all mixing interfaces have a highly Si-depleted mixed layer end-member. These processes deplete the silicic acid AASW concentration northward, across the different interfaces, without significantly changing the AASW d30Si composition. By comparing our new results with a previous study in the Australian sector we show that during the circumpolar transport of the ACC eastward, the d30Si composition of the silicic acid pools is getting slightly, but significantly lighter from the Atlantic to the Australian sectors. This results either from the dissolution of biogenic silica in the deeper layers and/or from an isopycnal mixing with the deep water masses in the different oceanic basins: North Atlantic Deep Water in the Atlantic, and Indian Ocean deep water in the Indo-Australian sector. This isotopic trend is further transmitted to the subsurface waters, representing mixing interfaces between the surface and deeper layers. Through the use of d30Si constraints, net biogenic silica production (representative of annual export), at the Greenwich Meridian is estimated to be 5.2 ± 1.3 and 1.1 ± 0.3 mol Si/m**2 for the Antarctic Zone and Polar Front Zone, respectively. This is in good agreement with previous estimations. Furthermore, summertime Si-supply into the mixed layer of both zones, via vertical mixing, is estimated to be 1.6 ± 0.4 and 0.1 ± 0.5 mol Si/m**2, respectively.

Sedimentology of core M74/4_1143-1

Periplatform ooze is an admixture of pelagic carbonate and sediment derived from neritic carbonate platforms. Compositional variations of periplatform ooze allow the rectonstruction of past sea-level changes. Periplatform ooze formed during sea-level highstands is finer grained and richer in aragonit through the elevated input of material from the flooded platform compared to periplatform ooze formed during the episodes of lowered sea level. In many cases, however, the sea floor around carbonate platforms is subjected to bottom currents which are expected to affect sediment composition, i.e. through winnowing of the fine fraction. The interaction of sea-level driven highstand shedding and current impact on the formation of periplatform ooze is influenced or even distorted by changing current activity, an integrated study using seismic, hydroacoustic and sedimentological data has been performed on periplatform ooze deposited in the Inner Sea of the Maldives. The Miocene to Pleistocene succession of drift deposits is subdivided into nine units; limits of seismostratigraphic units correspond to changes or turnarounds in grain size trends in cores recovered at ODP Site 716 and NEOMA Site 1143. For the Pleistocene it can be shown how changes in grain size occur in concert with sea-level changes and changes of the monsoonal system, which is thought to be a major driver bottom currents in the Maldives. A clear hightstand shedding pattern only appears in the data at a time of of relaxation of monsoonal strength during the last 315 ky. Results imply (1) that drift sediments provide a potential target for analyzing past changes in oceanic currents and (2) that the ooze composition bears a mixed signal of input and physical winnowing at the sea floor.

Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of mucin staining, TTF-1, cytokeratin 5/6, and P63, and EGFR mutation analysis.

INTRODUCTION: The dichotomization of non-small cell carcinoma (NSCLC) subtype into squamous (SQCC) and adenocarcinoma (ADC) has become important in recent years and is increasingly required with regard to management. The aim of this study was to determine the utility of a panel of commercially available antibodies in refining the diagnosis on small biopsies and also to determine whether cytologic material is suitable for somatic EGFR genotyping in a prospectively analyzed series of patients undergoing investigation for suspected lung cancer. METHODS: Thirty-two consecutive cases of NSCLC were first tested using a panel comprising cytokeratin 5/6, P63, thyroid transcription factor-1, 34betaE12, and a D-PAS stain for mucin, to determine their value in refining diagnosis of NSCLC. After this test phase, two further pathologists independently reviewed the cases using a refined panel that excluded 34betaE12 because of its low specificity for SQCC, and refinement of diagnosis and concordance were assessed. Ten cases of ADC, including eight derived from cytologic samples, were sent for EGFR mutation analysis. RESULTS: There was refinement of diagnosis in 65% of cases of NSCLC to either SQCC or ADC in the test phase. This included 10 of 13 cases where cell pellets had been prepared from transbronchial needle aspirates. Validation by two further pathologists with varying expertise in lung pathology confirmed increased refinement and concordance of diagnosis. All samples were adequate for analysis, and they all showed a wild-type EGFR genotype. CONCLUSION: A panel comprising cytokeratin 5/6, P63, thyroid transcription factor-1, and a D-PAS stain for mucin increases diagnostic accuracy and agreement between pathologists when faced with refining a diagnosis of NSCLC to SQCC or ADC. These small samples, even cell pellets derived from transbronchial needle aspirates, seem to be adequate for EGFR mutation analysis.

Conjugalidade e Parentalidade: estudo sobre a influência das preocupações parentais na satisfação conjugal em pais de crianças com 1 a 5 anos de idade em educação pré-escolar

Segundo a abordagem sistémica, a transição para a parentalidade demarca uma das mais intensas mudanças do ciclo de vida de uma família. A melhor forma de compreender a família, é tentar entendê-la como um sistema, um todo, uma globalidade, como uma rede complexa de relações e emoções que não são susceptíveis de serem pensadas isoladamente (Oliveira, 2002). Porém, é relevante a forma como cada indivíduo, passa pela transição para a parentalidade. Considerou-se pertinente realizar um estudo que englobe a influência que as preocupações parentais apresentam na relação conjugal, tendo como objectivo clarificar a interacção entre as variáveis já referidas e, ainda, a influência que o sexo dos indivíduos, o tempo de casamento e a idade dos filhos exerce nessa interacção. Para tal, recorreu-se a uma amostra de 42 indivíduos, casados e com um único filho, que responderam à Escala de Avaliação da Satisfação em Áreas da Vida Conjugal (EASAVC) (Narciso & Costa, 1996), para avaliação da satisfação conjugal, e à Escala de Preocupações Parentais (EPP) (Algarvio, Leal, & Maroco, in press). Os resultados demonstram que a satisfação conjugal e as preocupações parentais se encontram relacionadas entre si, não apresentando uma forte correlação. Contudo, constata-se que a satisfação conjugal aumenta diante de uma preocupação parental, do mesmo modo, se a preocupação parental for fraca, a satisfação conjugal tem valores médios mais baixos. Os resultados apontam para que o género e os anos de casamento não influenciem os níveis de satisfação conjugal, bem como a idade dos filhos não influência estas preocupações, tendo-se ainda verificado que não existem diferenças entre sexos ao nível das preocupações parentais.

Diseño e implementación de un sistema de dosificación para un tipo de bebida alcohólica de 1 a 5 onzas

Tesis (Ingeniero(a) en Automaziación).--Universidad de La Salle. Facultad de Ingeniería. Programa de Ingeniería en Automatización

Importancia del juego como herramienta en el aprendizaje y desarrollo motor mediante la estimulaci?n temprana en ni?os de primera infancia (0-5 a?os)

La estimulaci?n es un tema que tiene gran importancia no solo por los beneficios que de ella obtienen los ni?os y ni?as que han tenido la oportunidad de acceder a ella, sino por el v?nculo afectivo que se desarrolla entre padres e hijos cuando son los padres quienes se involucran en ella. Para los docentes la estimulaci?n temprana significa una serie de oportunidades con las cuales lograr aprendizajes en mejor y mayor grado. Argumentamos mediante el apoyo de biograf?as sobre el tema, como el juego y la estimulaci?n temprana influyen en el desarrollo motor y de aprendizaje en ni?os de temprana edad (de 0 a 5 a?os), mostrando todos sus aspectos y sus diferencias.

Desde la opulencia y la miseria a la delincuencia juvenil: estudio realizado con j?venes pertenecientes a estratos socio-econ?micos 1 y 5 de la ciudad de Cali [recurso electr?nico]

El estudio de la delincuencia juvenil ha sido llevado a cabo generalmente con poblaciones pertenecientes a estratos socioecon?micos bajos, lo cual ha limitado su marco compresivo y explicativo. De tal forma que se han promovido los elevados niveles de pobreza y desigualdad social en los que vive gran parte de la poblaci?n del pa?s y de Latinoam?rica, como causa determinante de la participaci?n de j?venes en pr?cticas delincuenciales. Consideramos pertinente realizar un acercamiento a esta problem?tica, con el objetivo de comprender aquellos elementos, tanto del contexto socioecon?mico como del plano psicol?gico individual, que subyacen a la participaci?n de j?venes, de estratos altos y bajos, en din?micas delincuenciales

Optimization and improvement of NSCU 1.0. Universal Functional Tester produced by Evoleo Technologi

The aim of the project was to improve an existing testing machine that is produced by the company EVOLEO Technologies. New conceptions of each part have been invented in order to produce an innovative unit that combines optimal segments from the old construction with the new, improved ones. The machine is meant to be testing different kind of devices that use specific elements like: buttons, knobs, monitors. The main purpose is to create various concepts of components that could be changed in order to lower the cost, weight or to simplify the operating process. Figure 1. shows the already existing discussed device.

qué darle de comer a su niño de 1 a 5 años de edad

This brochure, printed in Spanish, describes what to feed children ages one to five. Included are tips on how to make mealtimes happy, normal behavior and growth and appetite. A chart of daily recommended amounts from different food groups and a sample menu are included.

Aplicación de los criterios RIFLE (Risk, Injury, Failure, Loss y End) para determinar la falla renal aguda en pacientes de 1 a 5 años hospitalizados en la unidad de cuidados intensivos del Hospital de Niños Benjamín Bloom en el año 2013.

La Falla Renal Aguda (FRA) es un síndrome multifactorial de etiología variada e incidencia que difiere según países y poblaciones de estudio. A nivel mundial no existe un consenso en cuanto a una definición universal. Últimamente se ha reconocido la importancia que tiene la reducción leve a moderada de la función renal en la morbimortalidad especialmente en los pacientes críticos. En 2004, la Acute Dialysis Quality Initiative, realizó un consenso para definir la falla renal aguda, a través del criterio de RIFLE (Riesgo, Injuria, Falla, Pérdida y Estado final de la falla), el cual utilizó los criterios de los adultos y lo extrapoló hacia los pacientes pediátricos. Objetivo: diagnosticar falla renal aguda de acuerdo con los criterios RIFLE en los pacientes de 1 a 5 años hospitalizados en la Unidad de Cuidados Intensivos Pediátricos del Hospital Bloom en el año 2013, identificación de la prevalencia y de las principales causas etiológicas en las cuales se presenta. Muestra: pacientes de 1 a 5 años hospitalizados en la Unidad de Cuidados Intensivos del Hospital Nacional de Niños Benjamín Bloom, los cuales no fueron sometidos a procedimientos quirúrgicos o presentaron insuficiencia renal crónica. Método: se realizó un estudio retrospectivo, descriptivo, desarrollado en la unidad de cuidados intensivos de dicho hospital, haciendo el diagnóstico de falla renal aguda mediante la aplicación los criterios RIFLE para demostrar la utilidad de ésta metodología en el diagnóstico temprano de FRA. Se analizaron los datos epidemiológicos, clínicos y analíticos de todos los pacientes con falla renal aguda. Consideraciones éticas: el presente estudio se evaluó y aprobó por el comité de ética del HNNBB considerándolo adecuado y de bajo riesgo para los pacientes. Resultados: hubo 27 episodios de FRA en 43 pacientes con edad de 1 a 5 años lo cual corresponde al 62.7% de los casos estudiados, el 52% sexo femenino. La patología primaria más frecuente fueron las patologías de origen infeccioso, más común en las neumonías; la media de edad de presentación son los 26 meses. Mediante la aplicación de los criterios RIFLE se permitió diagnosticar de forma más temprana la FRA.

Testing the level of interactivity of institutional websites: From museums 1.0 to museums 2.0

The Internet has changed the way in which organizations communicate with their publics, and museums are not an exception. The consolidation of Web 2.0 has not only given museums access to a powerful new tool for disseminating information, but has involved significant changes in the relationship between institutions and their publics, facilitating and enhancing the interaction between them. The overall objective of this paper is to analyze the degree of interactivity implemented in the websites of major international art museums, in order to assess if museums are evolving towards more dialogic systems with relation to their publics. The results indicate that museums still have a low level of interactivity on their websites, both in the tools used to present information and the resources available for interaction with virtual visitors. But it has also observed that museums are progressively implementing interactive and dialogic sources, suggesting a clear trend towards new ways of managing these platforms in order to establish more participatory and collaborative communication systems with virtual users.

"1/0"

Combined media on photographic paper. 55" x 93", Jargomatique Series. Private Collection